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Q9FNN5 (NDUV1_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

EC=1.6.5.3
EC=1.6.99.3
Gene names
Ordered Locus Names:At5g08530
ORF Names:MAH20.9
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length486 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

NADH + acceptor = NAD+ + reduced acceptor.

Cofactor

Binds 1 FMN Potential.

Binds 1 4Fe-4S cluster Potential.

Subunit structure

Complex I is composed of at least 49 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.

Subcellular location

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side By similarity.

Sequence similarities

Belongs to the complex I 51 kDa subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3030Mitochondrion Potential
Chain31 – 486456NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
PRO_0000410789

Regions

Nucleotide binding110 – 11910NAD(H) By similarity
Nucleotide binding222 – 27049FMN By similarity
Compositional bias41 – 5010Pro-rich

Sites

Metal binding4021Iron-sulfur (4Fe-4S) Potential
Metal binding4051Iron-sulfur (4Fe-4S) Potential
Metal binding4081Iron-sulfur (4Fe-4S) Potential
Metal binding4481Iron-sulfur (4Fe-4S) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9FNN5 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: DC751ADE75F7E9CE

FASTA48653,449
        10         20         30         40         50         60 
MAPVRGILGL QRAVSIWKES NRLTPALRSF STQAASTSTT PQPPPPPPPP EKTHFGGLKD 

        70         80         90        100        110        120 
EDRIFTNLYG LHDPFLKGAM KRGDWHRTKD LVLKGTDWIV NEMKKSGLRG RGGAGFPSGL 

       130        140        150        160        170        180 
KWSFMPKVSD GRPSYLVVNA DESEPGTCKD REIMRHDPHK LLEGCLIAGV GMRASAAYIY 

       190        200        210        220        230        240 
IRGEYVNERL NLEKARREAY AAGLLGKNAC GSGYDFEVYI HFGAGAYICG EETALLESLE 

       250        260        270        280        290        300 
GKQGKPRLKP PFPANAGLYG CPTTVTNVET VAVSPTILRR GPEWFSSFGR KNNAGTKLFC 

       310        320        330        340        350        360 
ISGHVNKPCT VEEEMSIPLK ELIERHCGGV RGGWDNLLAI IPGGSSVPLI PKNICEDVLM 

       370        380        390        400        410        420 
DFDALKAVQS GLGTAAVIVM DKSTDVVDAI ARLSYFYKHE SCGQCTPCRE GTGWLWMIME 

       430        440        450        460        470        480 
RMKVGNAKLE EIDMLQEVTK QIEGHTICAL GDAAAWPVQG LIRHFRPELE RRIRERAERE 


LLQAAA 

« Hide

References

« Hide 'large scale' references
[1]"Structural analysis of Arabidopsis thaliana chromosome 5. II. Sequence features of the regions of 1,044,062 bp covered by thirteen physically assigned P1 clones."
Kotani H., Nakamura Y., Sato S., Kaneko T., Asamizu E., Miyajima N., Tabata S.
DNA Res. 4:291-300(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[4]"Full-length cDNA from Arabidopsis thaliana."
Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB006697 Genomic DNA. Translation: BAB10002.1.
CP002688 Genomic DNA. Translation: AED91315.1.
AY092971 mRNA. Translation: AAM12970.1.
BT006620 mRNA. Translation: AAP31964.1.
AY087737 mRNA. Translation: AAM65274.1.
RefSeqNP_196470.1. NM_120938.3.
UniGeneAt.8763.

3D structure databases

ProteinModelPortalQ9FNN5.
SMRQ9FNN5. Positions 80-476.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9FNN5. 2 interactions.
STRING3702.AT5G08530.1-P.

Protein family/group databases

TCDB3.D.1.6.3. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Proteomic databases

PRIDEQ9FNN5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT5G08530.1; AT5G08530.1; AT5G08530.
GeneID830752.
KEGGath:AT5G08530.

Organism-specific databases

GeneFarm1810.
TAIRAT5G08530.

Phylogenomic databases

eggNOGCOG1894.
HOGENOMHOG000251534.
InParanoidQ9FNN5.
KOK03942.
OMAKWSFMNP.
PhylomeDBQ9FNN5.

Enzyme and pathway databases

BioCycARA:AT5G08530-MONOMER.
MetaCyc:AT5G08530-MONOMER.

Gene expression databases

GenevestigatorQ9FNN5.

Family and domain databases

InterProIPR001949. NADH-UbQ_OxRdtase_51kDa_CS.
IPR019575. NADH-UbQ_OxRdtase_Fsu_4Fe4S-bd.
IPR011537. NADH-UbQ_OxRdtase_suF.
IPR011538. NADH_UbQ_OxRdtase_51kDa_su.
IPR019554. Soluble_ligand-bd.
[Graphical view]
PfamPF01512. Complex1_51K. 1 hit.
PF10589. NADH_4Fe-4S. 1 hit.
PF10531. SLBB. 1 hit.
[Graphical view]
SMARTSM00928. NADH_4Fe-4S. 1 hit.
[Graphical view]
TIGRFAMsTIGR01959. nuoF_fam. 1 hit.
PROSITEPS00644. COMPLEX1_51K_1. 1 hit.
PS00645. COMPLEX1_51K_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ9FNN5.

Entry information

Entry nameNDUV1_ARATH
AccessionPrimary (citable) accession number: Q9FNN5
Secondary accession number(s): Q8LAL7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: March 1, 2001
Last modified: May 14, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names