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Protein

Pyruvate kinase

Gene

MAH20.13

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 5 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase GAPC2, cytosolic (GAPC2), Glyceraldehyde-3-phosphate dehydrogenase GAPC1, cytosolic (GAPC1)
  2. Phosphoglycerate kinase 3, cytosolic (PGK3)
  3. Probable 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 2 (At3g08590), 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 1 (PGM1)
  4. Enolase 1, chloroplastic (ENO1), Cytosolic enolase 3 (ENO3), Bifunctional enolase 2/transcriptional activator (ENO2)
  5. Pyruvate kinase (AXX17_At5g51800), Pyruvate kinase (AXX17_At3g24740), Pyruvate kinase (At5g63680), Pyruvate kinase (AXX17_At3g50280), Pyruvate kinase (AXX17_ATUG04870), Pyruvate kinase (MAH20.13), Pyruvate kinase (MCD7.8), Pyruvate kinase (MBK5.16), Pyruvate kinase (At3g25960), Pyruvate kinase (F1I16_60), Pyruvate kinase (AXX17_At3g50440), Plastidial pyruvate kinase 3, chloroplastic (PKP3), Pyruvate kinase (At3g52990), Pyruvate kinase (At5g08570), Pyruvate kinase (At5g56350), Pyruvate kinase (AXX17_At3g28070), Pyruvate kinase (At2g36580), Pyruvate kinase (AXX17_At3g47400), Pyruvate kinase, Probable pyruvate kinase, cytosolic isozyme (At4g26390), Pyruvate kinase (F8J2_160), Pyruvate kinase (At3g52990), Pyruvate kinase (AXX17_At3g03460), Plastidial pyruvate kinase 2 (PKP2), Pyruvate kinase (At2g36580), Pyruvate kinase (At3g04050), Pyruvate kinase (AXX17_At4g30430), Pyruvate kinase (F1I16_220), Plastidial pyruvate kinase 1, chloroplastic (PKP1), Pyruvate kinase (AXX17_At1g33230), Pyruvate kinase (At5g63680), Pyruvate kinase, Plastidial pyruvate kinase 4, chloroplastic (PKP4)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processGlycolysisUniRule annotation
LigandMagnesiumUniRule annotation, PyruvateImported

Enzyme and pathway databases

BioCyciARA:AT5G08570-MONOMER.
ReactomeiR-ATH-6798695. Neutrophil degranulation.
R-ATH-70171. Glycolysis.
UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinaseUniRule annotation (EC:2.7.1.40UniRule annotation)
Gene namesi
Name:MAH20.13Imported
Synonyms:MAH20_13Imported
Ordered Locus Names:At5g08570Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G08570.
TAIRilocus:2159577. AT5G08570.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G08570.1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 364PKInterPro annotationAdd BLAST345
Domaini380 – 506PK_CInterPro annotationAdd BLAST127

Sequence similaritiesi

Belongs to the pyruvate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2323. Eukaryota.
COG0469. LUCA.
HOGENOMiHOG000021559.
KOiK00873.
OMAiKHEAIEQ.
OrthoDBiEOG093607JW.

Family and domain databases

CDDicd00288. Pyruvate_Kinase. 1 hit.
Gene3Di3.40.1380.20. 1 hit.
InterProiView protein in InterPro
IPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiView protein in Pfam
PF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
PROSITEiView protein in PROSITE
PS00110. PYRUVATE_KINASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9FNN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNIDIEGIL KELPNDGRIP KTKIVCTLGP ASRTVSMIEK LLKAGMNVAR
60 70 80 90 100
FNFSHGSHEY HQETLDNLRS AMHNTGILAA VMLDTKGPEI RTGFLKDGNP
110 120 130 140 150
IQLKEGQEIT ITTDYDIQGD ESTISMSYKK LPLDVKPGNT ILCADGSISL
160 170 180 190 200
AVLSCDPESG TVRCRCENSA MLGERKNVNL PGVVVDLPTL TDKDIEDILG
210 220 230 240 250
WGVPNSIDMI ALSFVRKGSD LVNVRKVLGS HAKSIMLMSK VENQEGVINF
260 270 280 290 300
DEILRETDAF MVARGDLGME IPIEKIFLAQ KLMIYKCNLA GKPVVTATQM
310 320 330 340 350
LESMIKSPRP TRAEATDVAN AVLDGTDCVM LSGESAAGAY PEIAVKVMAK
360 370 380 390 400
ICIEAESSLD YNTIFKEMIR ATPLPMSPLE SLASSAVRTA NKARAKLIIV
410 420 430 440 450
LTRGGSTANL VAKYRPAVPI LSVVVPVMTT DSFDWSCSDE SPARHSLIYR
460 470 480 490 500
GLIPMLAEGS AKATDSEATE VIIEAALKSA TQRGLCNRGD AIVALHRIGA
510
ASVIKICVVK
Length:510
Mass (Da):54,977
Last modified:March 1, 2001 - v1
Checksum:iDB6247FC6C8BBA66
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT006165 mRNA. Translation: AAP04149.1.
BT008536 mRNA. Translation: AAP40363.1.
CP002688 Genomic DNA. Translation: AED91324.1.
CP002688 Genomic DNA. Translation: ANM69444.1.
CP002688 Genomic DNA. Translation: ANM69445.1.
AB006697 Genomic DNA. Translation: BAB10006.1.
AK229614 mRNA. Translation: BAF01459.1.
RefSeqiNP_001318514.1. NM_001343019.1.
NP_001331120.1. NM_001343020.1.
NP_196474.1. NM_120944.3.
UniGeneiAt.8766.

Genome annotation databases

EnsemblPlantsiAT5G08570.1; AT5G08570.1; AT5G08570.
AT5G08570.2; AT5G08570.2; AT5G08570.
AT5G08570.3; AT5G08570.3; AT5G08570.
GeneIDi830758.
GrameneiAT5G08570.1; AT5G08570.1; AT5G08570.
AT5G08570.2; AT5G08570.2; AT5G08570.
AT5G08570.3; AT5G08570.3; AT5G08570.
KEGGiath:AT5G08570.

Similar proteinsi

Entry informationi

Entry nameiQ9FNN1_ARATH
AccessioniPrimary (citable) accession number: Q9FNN1
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: August 30, 2017
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported