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Protein

Ornithine aminotransferase, mitochondrial

Gene

DELTA-OAT

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates degradation of arginine for nitrogen recycling. Plays a role in non-host disease resistance by regulating pyrroline-5-carboxylate metabolism-induced hypersensitive response.2 Publications

Catalytic activityi

L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid.

Cofactori

Kineticsi

The activity was enhanced in young plants under salt-stress conditions.
  1. KM=91 mM for L-ornithine1 Publication
  1. Vmax=28 µmol/h/mg enzyme toward L-glutamate 5-semialdehyde1 Publication

Pathwayi: L-proline biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-glutamate 5-semialdehyde from L-ornithine.
Proteins known to be involved in this subpathway in this organism are:
  1. Ornithine aminotransferase, mitochondrial (DELTA-OAT)
This subpathway is part of the pathway L-proline biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate 5-semialdehyde from L-ornithine, the pathway L-proline biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

  • identical protein binding Source: GO_Central
  • ornithine-oxo-acid transaminase activity Source: UniProtKB
  • pyridoxal phosphate binding Source: GO_Central
  • zinc ion binding Source: TAIR

GO - Biological processi

  • arginine catabolic process to glutamate Source: TAIR
  • defense response to bacterium, incompatible interaction Source: UniProtKB
  • hyperosmotic salinity response Source: TAIR
  • mitochondrion localization Source: CACAO
  • ornithine catabolic process Source: UniProtKB
  • plant-type hypersensitive response Source: UniProtKB
  • proline biosynthetic process Source: TAIR
  • response to abscisic acid Source: EnsemblPlants
  • response to auxin Source: EnsemblPlants
  • response to brassinosteroid Source: EnsemblPlants
  • response to flooding Source: EnsemblPlants
  • response to heat Source: EnsemblPlants
  • response to jasmonic acid Source: EnsemblPlants
  • response to oxidative stress Source: EnsemblPlants
  • response to salt stress Source: UniProtKB
  • response to water deprivation Source: EnsemblPlants

Keywordsi

Molecular functionAminotransferase, Transferase
Biological processPlant defense
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciARA:AT5G46180-MONOMER
MetaCyc:AT5G46180-MONOMER
BRENDAi2.6.1.13 399
ReactomeiR-ATH-70614 Amino acid synthesis and interconversion (transamination)
UniPathwayiUPA00098; UER00358

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine aminotransferase, mitochondrial (EC:2.6.1.13)
Alternative name(s):
Ornithine delta-aminotransferase
Ornithine--oxo-acid aminotransferase
Gene namesi
Name:DELTA-OAT
Ordered Locus Names:At5g46180
ORF Names:MCL19.24
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi

Organism-specific databases

AraportiAT5G46180
TAIRilocus:2161398 AT5G46180

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Disruption phenotypei

Unable to use arginine or ornithine as nitrogen source. Displays sensitivity against type II non-host pathogen infection.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 16MitochondrionSequence analysisAdd BLAST16
ChainiPRO_000042129817 – 475Ornithine aminotransferase, mitochondrialAdd BLAST459

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei294N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiQ9FNK4
PRIDEiQ9FNK4

PTM databases

iPTMnetiQ9FNK4
SwissPalmiQ9FNK4

Expressioni

Inductioni

By salt stress in young plants. Up-regulated during low water potential. Induced upon non-host pathogen infection.3 Publications

Gene expression databases

ExpressionAtlasiQ9FNK4 baseline and differential
GenevisibleiQ9FNK4 AT

Interactioni

Subunit structurei

Homotetramer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi3702.AT5G46180.1

Structurei

3D structure databases

ProteinModelPortaliQ9FNK4
SMRiQ9FNK4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1402 Eukaryota
COG4992 LUCA
HOGENOMiHOG000020206
InParanoidiQ9FNK4
KOiK00819
OMAiRTAWDLC
OrthoDBiEOG093609WJ
PhylomeDBiQ9FNK4

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR005814 Aminotrans_3
IPR010164 Orn_aminotrans
IPR034758 Orn_aminotrans_mito
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11986:SF18 PTHR11986:SF18, 1 hit
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
PIRSFiPIRSF000521 Transaminase_4ab_Lys_Orn, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01885 Orn_aminotrans, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9FNK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATTRRLLY YVSKRFSTAG VRRSYGGLPQ SNSKSPPSSS QRLMELESEF
60 70 80 90 100
SAHNYHPVPV VFSRANGSTI WDPEGKRYID FLAAYSAVNQ GHCHPKIMKA
110 120 130 140 150
LQEQVEKLTL SSRAFYNDKF PVFAERLTNM FGYDMVLPMN TGAEGVETAL
160 170 180 190 200
KLARKWGHEK KNIPKDEAII VSCCGCFHGR TLAIVSMSCD NDATRGFGPL
210 220 230 240 250
LPGNLKVDFG DADSLEKIFK EKGDRIAGFL FEPIQGEAGV IIPPDGYLKA
260 270 280 290 300
VRELCTKYNV LMIADEVQSG LARSGKMLAC DWEEIRPDMV ILGKALGGGV
310 320 330 340 350
IPVSAVLADK DVMLHIKPGQ HGSTFGGNPL ASAVAMASLD VIVEEKLVER
360 370 380 390 400
SASLGEELRI QLNEIKKQFP KYIKEVRGRG LFNAIEFNSE SLSPVSAYDI
410 420 430 440 450
CLSLKERGVL AKPTHNTIVR LTPPLSISSD ELRDGSEALH DVLELDLPNL
460 470
LKINSGKTPV SHITECDRCG RNLYA
Length:475
Mass (Da):52,178
Last modified:March 1, 2001 - v1
Checksum:iA886C999AB0B68CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006698 Genomic DNA Translation: BAB08263.1
CP002688 Genomic DNA Translation: AED95350.1
BT023421 mRNA Translation: AAY56412.1
BT029160 mRNA Translation: ABJ17095.1
RefSeqiNP_199430.1, NM_123987.4
UniGeneiAt.28104

Genome annotation databases

EnsemblPlantsiAT5G46180.1; AT5G46180.1; AT5G46180
GeneIDi834660
GrameneiAT5G46180.1; AT5G46180.1; AT5G46180
KEGGiath:AT5G46180

Similar proteinsi

Entry informationi

Entry nameiOAT_ARATH
AccessioniPrimary (citable) accession number: Q9FNK4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2013
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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