Q9FNE9 (ATXR6_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone-lysine N-methyltransferase ATXR6
EC=2.1.1.43

Alternative name(s):
Protein SET DOMAIN GROUP 34
Trithorax-related protein 6
Short name=TRX-related protein 6

Gene names

Name:	ATXR6
Synonyms:	SDG34, SET34
Ordered Locus Names:	At5g24330
ORF Names:	MOP9.18

Organism

Arabidopsis thaliana (Mouse-ear cress)

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	349 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Histone methyltransferase By similarity.
Catalytic activity	S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily. Contains 1 PHD-type zinc finger. Contains 1 SET domain.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Zinc-finger
Ligand	Metal-binding S-adenosyl-L-methionine Zinc
Molecular function	Chromatin regulator Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	anther dehiscence Inferred from mutant phenotype. Source: TAIR regulation of DNA replication Inferred from genetic interaction. Source: TAIR regulation of cell cycle Inferred from expression pattern. Source: TAIR
Cellular component	nucleus Inferred from direct assay. Source: TAIR
Molecular function	histone methyltransferase activity (H3-K27 specific) Inferred from direct assay. Source: TAIR protein binding Inferred from physical interaction. Source: TAIR zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 349	349	Histone-lysine N-methyltransferase ATXR6		PRO_0000233363
Regions
	Domain	213 – 341	129	SET
	Zinc finger	32 – 82	51	PHD-type

Sequences

	Sequence		Length	Mass (Da)
	Q9FNE9 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: ED8D4FA7C92283BA	FASTA	349	39,640
	10 20 30 40 50 60 MVAVRRRRTQ ASNPRSEPPQ HMSDHDSDSD WDTVCEECSS GKQPAKLLLC DKCDKGFHLF 70 80 90 100 110 120 CLRPILVSVP KGSWFCPSCS KHQIPKSFPL IQTKIIDFFR IKRSPDSSQI SSSSDSIGKK 130 140 150 160 170 180 RKKTSLVMSK KKRRLLPYNP SNDPQRRLEQ MASLATALRA SNTKFSNELT YVSGKAPRSA 190 200 210 220 230 240 NQAAFEKGGM QVLSKEGVET LALCKKMMDL GECPPLMVVF DPYEGFTVEA DRFIKDWTII 250 260 270 280 290 300 TEYVGDVDYL SNREDDYDGD SMMTLLHASD PSQCLVICPD RRSNIARFIS GINNHSPEGR 310 320 330 340 KKQNLKCVRF NINGEARVLL VANRDISKGE RLYYDYNGYE HEYPTEHFV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structural analysis of Arabidopsis thaliana chromosome 5. II. Sequence features of the regions of 1,044,062 bp covered by thirteen physically assigned P1 clones." Kotani H., Nakamura Y., Sato S., Kaneko T., Asamizu E., Miyajima N., Tabata S. DNA Res. 4:291-300(1997) [PubMed: 9405937] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	"Structural analysis of Arabidopsis thaliana chromosome 5. VIII. Sequence features of the regions of 1,081,958 bp covered by seventeen physically assigned P1 and TAC clones." Asamizu E., Sato S., Kaneko T., Nakamura Y., Kotani H., Miyajima N., Tabata S. DNA Res. 5:379-391(1998) [PubMed: 10048488] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[3]	"Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana." Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K. , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F. Nature 408:823-826(2000) [PubMed: 11130714] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[4]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[5]	"Arabidopsis ORF clones." Shinn P., Chen H., Cheuk R.F., Kim C.J., Ecker J.R. Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[6]	"The Arabidopsis thaliana genome contains at least 29 active genes encoding SET domain proteins that can be assigned to four evolutionarily conserved classes." Baumbusch L.O., Thorstensen T., Krauss V., Fischer A., Naumann K., Assalkhou R., Schulz I., Reuter G., Aalen R.B. Nucleic Acids Res. 29:4319-4333(2001) [PubMed: 11691919] [Abstract] Cited for: NOMENCLATURE.
+	Additional computationally mapped references.

Web resources

PlantsUBQ

A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB006701, AB016884 Genomic DNA. Translation: BAB10399.1. CP002688 Genomic DNA. Translation: AED93294.1. BT012223 mRNA. Translation: AAS76710.1. BT012421 mRNA. Translation: AAS92337.1.
IPI	IPI00543408.
RefSeq	NP_197821.1. NM_122341.2.
UniGene	At.30965.
3D structure databases
ProteinModelPortal	Q9FNE9.
SMR	Q9FNE9. Positions 34-82, 192-341.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-48530N.
STRING	Q9FNE9.
Proteomic databases
PRIDE	Q9FNE9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT5G24330.1; AT5G24330.1; AT5G24330.
GeneID	832503.
GenomeReviews	Gene locus AT5G24330 in contig BA000015_GR.
KEGG	ath:AT5G24330.
NMPDR	fig|3702.1.peg.24624.
Organism-specific databases
TAIR	At5g24330.
Phylogenomic databases
eggNOG	KOG1083.
GeneTree	EPGT00050000005656.
HOGENOM	HBG316330.
InParanoid	Q9FNE9.
OMA	FFRIQRS.
PhylomeDB	Q9FNE9.
ProtClustDB	CLSN2686326.
Gene expression databases
Genevestigator	Q9FNE9.
GermOnline	AT5G24330. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR001214. SET_dom. IPR019786. Zinc_finger_PHD-type_CS. IPR011011. Znf_FYVE_PHD. IPR001965. Znf_PHD. IPR019787. Znf_PHD-finger. IPR013083. Znf_RING/FYVE/PHD. [Graphical view]
Gene3D	G3DSA:3.30.40.10. Znf_RING/FYVE/PHD. 1 hit.
Pfam	PF00628. PHD. 1 hit. PF00856. SET. 1 hit. [Graphical view]
SMART	SM00249. PHD. 1 hit. SM00317. SET. 1 hit. [Graphical view]
SUPFAM	SSF57903. FYVE_PHD_ZnF. 1 hit.
PROSITE	PS50280. SET. 1 hit. PS01359. ZF_PHD_1. 1 hit. PS50016. ZF_PHD_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATXR6_ARATH

Accession

Primary (citable) accession number: Q9FNE9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2006
Last sequence update:	March 1, 2001
Last modified:	January 25, 2012
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program