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Protein

Probable inactive histone-lysine N-methyltransferase SUVR2

Gene

SUVR2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable inactive histone-lysine methyltransferase that acts as regulator of transctiptional gene silencing independently of histone H3K9 methylation. Contributes to transcriptional gene silencing at RNA-directed DNA methylation (RdDM) target loci but also at RdDM-independent target loci. Forms a complex with SUVR1 and associates with the SNF2-related chromatin-remodeling proteins CHR19, CHR27, and CHR28, thereby mediating nucleosome positioning and transcriptional silencing. Does not possess histone-lysine methyltransferase activity in vitro, and the conserved catalytic sites of SUVR2 are dispensable for its function in transcriptional gene silencing.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi445 – 4451Zinc 1By similarity
Metal bindingi445 – 4451Zinc 2By similarity
Metal bindingi446 – 4461Zinc 1By similarity
Metal bindingi449 – 4491Zinc 1By similarity
Metal bindingi449 – 4491Zinc 3By similarity
Metal bindingi453 – 4531Zinc 1By similarity
Metal bindingi462 – 4621Zinc 2By similarity
Metal bindingi529 – 5291Zinc 2By similarity
Metal bindingi529 – 5291Zinc 3By similarity
Metal bindingi533 – 5331Zinc 2By similarity
Metal bindingi535 – 5351Zinc 3By similarity
Metal bindingi539 – 5391Zinc 3By similarity
Metal bindingi638 – 6381Zinc 4By similarity
Binding sitei678 – 6781S-adenosyl-L-methioninePROSITE-ProRule annotation
Metal bindingi694 – 6941Zinc 4By similarity
Metal bindingi696 – 6961Zinc 4By similarity
Metal bindingi701 – 7011Zinc 4By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Transferase

Keywords - Biological processi

RNA-mediated gene silencing

Keywords - Ligandi

Metal-binding, S-adenosyl-L-methionine, Zinc

Enzyme and pathway databases

BioCyciARA:AT5G43990-MONOMER.
ARA:GQT-242-MONOMER.
ARA:GQT-243-MONOMER.
ARA:GQT-244-MONOMER.
ARA:GQT-245-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable inactive histone-lysine N-methyltransferase SUVR2
Alternative name(s):
Protein SET DOMAIN GROUP 18
Suppressor of variegation 3-9-related protein 2
Short name:
Su(var)3-9-related protein 2
Gene namesi
Name:SUVR2
Synonyms:SDG18, SET18
Ordered Locus Names:At5g43990
ORF Names:MRH10.10
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G43990.

Subcellular locationi

  • Nucleus 1 Publication
  • Chromosome 1 Publication

  • Note: Displays two nuclear localization patterns, one forming condensed foci and the other showing diffused signals.1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi32 – 321L → A: No effect on its function in transcriptional gene silencing; when associated with A52, A636 and A638. 1 Publication
Mutagenesisi52 – 521D → A: No effect on its function in transcriptional gene silencing; when associated with A32, A636 and A638. 1 Publication
Mutagenesisi636 – 6361H → A: No effect on its function in transcriptional gene silencing; when associated with A32, A52 and A638. 1 Publication
Mutagenesisi638 – 6381C → A: No effect on its function in transcriptional gene silencing; when associated with A32, A52 and A636. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 717717Probable inactive histone-lysine N-methyltransferase SUVR2PRO_0000233366Add
BLAST

Proteomic databases

PaxDbiQ9FNC7.
PRIDEiQ9FNC7.

Expressioni

Gene expression databases

ExpressionAtlasiQ9FNC7. baseline and differential.
GenevisibleiQ9FNC7. AT.

Interactioni

Subunit structurei

Interacts with SUVR1, CHR19, CHR28 and itself (PubMed:25420628). Interacts with CHR27 (PubMed:25420628, PubMed:25425661).2 Publications

Protein-protein interaction databases

BioGridi19672. 8 interactions.
STRINGi3702.AT5G43990.2.

Structurei

3D structure databases

ProteinModelPortaliQ9FNC7.
SMRiQ9FNC7. Positions 395-702.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini458 – 54790Pre-SETAdd
BLAST
Domaini550 – 679130SETPROSITE-ProRule annotationAdd
BLAST
Domaini690 – 70617Post-SETAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni561 – 5633S-adenosyl-L-methionine bindingBy similarity
Regioni635 – 6362S-adenosyl-L-methionine bindingBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi445 – 46218Cys-richAdd
BLAST

Domaini

In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.By similarity

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family.PROSITE-ProRule annotation
Contains 1 post-SET domain.Curated
Contains 1 pre-SET domain.Curated
Contains 1 SET domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1082. Eukaryota.
COG2940. LUCA.
HOGENOMiHOG000029715.
InParanoidiQ9FNC7.
PhylomeDBiQ9FNC7.

Family and domain databases

InterProiIPR007728. Pre-SET_dom.
IPR001214. SET_dom.
IPR025776. SUVR4/1/2.
IPR018848. WIYLD_domain.
[Graphical view]
PfamiPF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
PF10440. WIYLD. 1 hit.
[Graphical view]
SMARTiSM00468. PreSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS51580. SAM_MT43_3. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: Q9FNC7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPNLHIKKA FMAMRAMGIE DARVKPVLKN LLALYEKNWE LIAEDNYRVL
60 70 80 90 100
ADAIFDSHED QAIQESEEKK ADEVKEDEGC AAEVDRGKKK LHESIEDDED
110 120 130 140 150
VMAESDRPLK RLRRRGEGGS ALASPSLGSP TLEGPSINDE ENAPILLPYH
160 170 180 190 200
PVPIENDHDA GELILTKVEP ITNMPLSSIP DSVDRGDSSM LEIDKSNGHV
210 220 230 240 250
EEKAGETVST ADGTTNDISP TTVARFSDHK LAATIEEPPA LELASSASGE
260 270 280 290 300
VKINLSFAPA TGGSNPHLPS MEELRRAMEE KCLRSYKILD PNFSVLGFMN
310 320 330 340 350
DICSCYLDLA TNGRDSANQL PKNLPFVTTN IDALKKSAAR MAYTSQASND
360 370 380 390 400
VVEICSNEHM RDAENGAVGD SMALVVVPEC QLSADEWRLI SSVGDISLGK
410 420 430 440 450
ETVEIPWVNE VNDKVPPVFH YIAQSLVYQD AAVKFSLGNI RDDQCCSSCC
460 470 480 490 500
GDCLAPSMAC RCATAFNGFA YTVDGLLQED FLEQCISEAR DPRKQMLLYC
510 520 530 540 550
KECPLEKAKK EVILEPCKGH LKRKAIKECW SKCGCMKNCG NRVVQQGIHN
560 570 580 590 600
KLQVFFTPNG RGWGLRTLEK LPKGAFVCEL AGEILTIPEL FQRISDRPTS
610 620 630 640 650
PVILDAYWGS EDISGDDKAL SLEGTHYGNI SRFINHRCLD ANLIEIPVHA
660 670 680 690 700
ETTDSHYYHL AFFTTREIDA MEELTWDYGV PFNQDVFPTS PFHCQCGSDF
710
CRVRKQISKG KNVKKRA
Length:717
Mass (Da):79,363
Last modified:May 2, 2006 - v2
Checksum:i20B82033F384EC54
GO

Sequence cautioni

The sequence BAB09059 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231R → Q in AAK92218 (PubMed:11691919).Curated
Sequence conflicti32 – 321L → P in BAF02262 (Ref. 4) Curated
Sequence conflicti36 – 361E → D in AAK92218 (PubMed:11691919).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY045576 mRNA. Translation: AAK92218.1.
AB006703 Genomic DNA. Translation: BAB09059.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED95042.1.
CP002688 Genomic DNA. Translation: AED95043.1.
CP002688 Genomic DNA. Translation: AED95044.1.
AK230468 mRNA. Translation: BAF02262.1.
RefSeqiNP_001078702.1. NM_001085233.1. [Q9FNC7-1]
NP_001078703.1. NM_001085234.1. [Q9FNC7-1]
NP_568631.1. NM_123766.2. [Q9FNC7-1]
UniGeneiAt.26569.

Genome annotation databases

EnsemblPlantsiAT5G43990.1; AT5G43990.1; AT5G43990. [Q9FNC7-1]
AT5G43990.3; AT5G43990.3; AT5G43990. [Q9FNC7-1]
AT5G43990.4; AT5G43990.4; AT5G43990. [Q9FNC7-1]
GeneIDi834422.
KEGGiath:AT5G43990.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY045576 mRNA. Translation: AAK92218.1.
AB006703 Genomic DNA. Translation: BAB09059.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED95042.1.
CP002688 Genomic DNA. Translation: AED95043.1.
CP002688 Genomic DNA. Translation: AED95044.1.
AK230468 mRNA. Translation: BAF02262.1.
RefSeqiNP_001078702.1. NM_001085233.1. [Q9FNC7-1]
NP_001078703.1. NM_001085234.1. [Q9FNC7-1]
NP_568631.1. NM_123766.2. [Q9FNC7-1]
UniGeneiAt.26569.

3D structure databases

ProteinModelPortaliQ9FNC7.
SMRiQ9FNC7. Positions 395-702.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi19672. 8 interactions.
STRINGi3702.AT5G43990.2.

Proteomic databases

PaxDbiQ9FNC7.
PRIDEiQ9FNC7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G43990.1; AT5G43990.1; AT5G43990. [Q9FNC7-1]
AT5G43990.3; AT5G43990.3; AT5G43990. [Q9FNC7-1]
AT5G43990.4; AT5G43990.4; AT5G43990. [Q9FNC7-1]
GeneIDi834422.
KEGGiath:AT5G43990.

Organism-specific databases

TAIRiAT5G43990.

Phylogenomic databases

eggNOGiKOG1082. Eukaryota.
COG2940. LUCA.
HOGENOMiHOG000029715.
InParanoidiQ9FNC7.
PhylomeDBiQ9FNC7.

Enzyme and pathway databases

BioCyciARA:AT5G43990-MONOMER.
ARA:GQT-242-MONOMER.
ARA:GQT-243-MONOMER.
ARA:GQT-244-MONOMER.
ARA:GQT-245-MONOMER.

Miscellaneous databases

PROiQ9FNC7.

Gene expression databases

ExpressionAtlasiQ9FNC7. baseline and differential.
GenevisibleiQ9FNC7. AT.

Family and domain databases

InterProiIPR007728. Pre-SET_dom.
IPR001214. SET_dom.
IPR025776. SUVR4/1/2.
IPR018848. WIYLD_domain.
[Graphical view]
PfamiPF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
PF10440. WIYLD. 1 hit.
[Graphical view]
SMARTiSM00468. PreSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS51580. SAM_MT43_3. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSUVR2_ARATH
AccessioniPrimary (citable) accession number: Q9FNC7
Secondary accession number(s): Q0WKU5, Q941L4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: September 7, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.