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Protein

Sugar transport protein 11

Gene

STP11

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Mediates an active uptake of hexoses, probably by sugar/hydrogen symport. Can transport glucose, galactose, mannose, xylose and 3-O-methylglucose, but not fructose and ribose.1 Publication

Enzyme regulationi

Inhibited by uncouplers such as 2,4-dinitrophenol and carbonyl cyanide-m-chlorophenyl-hydrazone.1 Publication

Kineticsi

  1. KM=25 µM for glucose (at pH 5.5)1 Publication

    pH dependencei

    Optimum pH is 5.5.1 Publication

    GO - Molecular functioni

    GO - Biological processi

    Complete GO annotation...

    Keywords - Biological processi

    Sugar transport, Symport, Transport

    Protein family/group databases

    TCDBi2.A.1.1.61. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sugar transport protein 11
    Alternative name(s):
    Hexose transporter 11
    Gene namesi
    Name:STP11
    Ordered Locus Names:At5g23270
    ORF Names:MKD15.13
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    Proteomesi
    • UP000006548 Componenti: Chromosome 5

    Organism-specific databases

    TAIRiAT5G23270.

    Subcellular locationi

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Topological domaini1 – 19CytoplasmicSequence analysisAdd BLAST19
    Transmembranei20 – 40Helical; Name=1Sequence analysisAdd BLAST21
    Topological domaini41 – 82ExtracellularSequence analysisAdd BLAST42
    Transmembranei83 – 103Helical; Name=2Sequence analysisAdd BLAST21
    Topological domaini104 – 112CytoplasmicSequence analysis9
    Transmembranei113 – 133Helical; Name=3Sequence analysisAdd BLAST21
    Topological domaini134 – 137ExtracellularSequence analysis4
    Transmembranei138 – 158Helical; Name=4Sequence analysisAdd BLAST21
    Topological domaini159 – 169CytoplasmicSequence analysisAdd BLAST11
    Transmembranei170 – 190Helical; Name=5Sequence analysisAdd BLAST21
    Topological domaini191 – 204ExtracellularSequence analysisAdd BLAST14
    Transmembranei205 – 225Helical; Name=6Sequence analysisAdd BLAST21
    Topological domaini226 – 290CytoplasmicSequence analysisAdd BLAST65
    Transmembranei291 – 311Helical; Name=7Sequence analysisAdd BLAST21
    Topological domaini312 – 320ExtracellularSequence analysis9
    Transmembranei321 – 341Helical; Name=8Sequence analysisAdd BLAST21
    Topological domaini342 – 350CytoplasmicSequence analysis9
    Transmembranei351 – 371Helical; Name=9Sequence analysisAdd BLAST21
    Topological domaini372 – 389ExtracellularSequence analysisAdd BLAST18
    Transmembranei390 – 410Helical; Name=10Sequence analysisAdd BLAST21
    Topological domaini411 – 428CytoplasmicSequence analysisAdd BLAST18
    Transmembranei429 – 449Helical; Name=11Sequence analysisAdd BLAST21
    Topological domaini450 – 453ExtracellularSequence analysis4
    Transmembranei454 – 474Helical; Name=12Sequence analysisAdd BLAST21
    Topological domaini475 – 514CytoplasmicSequence analysisAdd BLAST40

    GO - Cellular componenti

    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00000504411 – 514Sugar transport protein 11Add BLAST514

    Proteomic databases

    PaxDbiQ9FMX3.

    Expressioni

    Tissue specificityi

    Specifically expressed in germinating pollen and pollen tube (at protein level).1 Publication

    Gene expression databases

    GenevisibleiQ9FMX3. AT.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT5G23270.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9FMX3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG0254. Eukaryota.
    ENOG410XNQK. LUCA.
    HOGENOMiHOG000202867.
    InParanoidiQ9FMX3.
    OMAiCTFIPFF.
    OrthoDBiEOG093608DR.
    PhylomeDBiQ9FMX3.

    Family and domain databases

    CDDicd06174. MFS. 1 hit.
    InterProiIPR020846. MFS_dom.
    IPR005828. MFS_sugar_transport-like.
    IPR003663. Sugar/inositol_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 1 hit.
    [Graphical view]
    PRINTSiPR00171. SUGRTRNSPORT.
    SUPFAMiSSF103473. SSF103473. 1 hit.
    TIGRFAMsiTIGR00879. SP. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 1 hit.
    PS00217. SUGAR_TRANSPORT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9FMX3-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MAGGAFIDES GHGGDYEGRV TAFVMITCIV AAMGGLLFGY DIGISGGVIS
    60 70 80 90 100
    MEDFLTKFFP DVLRQMQNKR GRETEYCKYD NELLTLFTSS LYLAALFASF
    110 120 130 140 150
    LASTITRLFG RKVSMVIGSL AFLSGALLNG LAINLEMLII GRLFLGVGVG
    160 170 180 190 200
    FANQSVPLYL SEMAPAKIRG ALNIGFQLAI TIGILAANIV NYVTPKLQNG
    210 220 230 240 250
    IGWRLSLGLA GVPAVMMLVG CFFLPDTPNS ILERGNKEKA KEMLQKIRGT
    260 270 280 290 300
    MEVEHEFNEL CNACEAAKKV KHPWTNIMQA RYRPQLTFCT FIPFFQQLTG
    310 320 330 340 350
    INVIMFYAPV LFKTIGFGND ASLISAVITG LVNVLSTIVS IYSVDKFGRR
    360 370 380 390 400
    ALFLQGGFQM IVTQIAVGSM IGWKFGFNGE GNLSGVDADI ILALICLYVA
    410 420 430 440 450
    GFAWSWGPLG WLVPSEICPL EIRSAGQSLN VSVNMFFTFF IGQFFLTMLC
    460 470 480 490 500
    HMKFGLFYFF AGMVLIMTIF IYFLLPETKG VPIEEMGKVW KEHRYWGKYS
    510
    NNDDGDDVDD DAYF
    Length:514
    Mass (Da):56,725
    Last modified:March 1, 2001 - v1
    Checksum:i0F9A05F0D7808C8D
    GO

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AJ344339 mRNA. Translation: CAC69075.1.
    AB007648 Genomic DNA. Translation: BAB11182.1.
    CP002688 Genomic DNA. Translation: AED93146.1.
    AK175890 mRNA. Translation: BAD43653.1.
    AJ001664 Genomic DNA. Translation: CAA04909.1.
    RefSeqiNP_197718.1. NM_122233.4.
    UniGeneiAt.26444.

    Genome annotation databases

    EnsemblPlantsiAT5G23270.1; AT5G23270.1; AT5G23270.
    GeneIDi832391.
    GrameneiAT5G23270.1; AT5G23270.1; AT5G23270.
    KEGGiath:AT5G23270.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AJ344339 mRNA. Translation: CAC69075.1.
    AB007648 Genomic DNA. Translation: BAB11182.1.
    CP002688 Genomic DNA. Translation: AED93146.1.
    AK175890 mRNA. Translation: BAD43653.1.
    AJ001664 Genomic DNA. Translation: CAA04909.1.
    RefSeqiNP_197718.1. NM_122233.4.
    UniGeneiAt.26444.

    3D structure databases

    ProteinModelPortaliQ9FMX3.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    STRINGi3702.AT5G23270.1.

    Protein family/group databases

    TCDBi2.A.1.1.61. the major facilitator superfamily (mfs).

    Proteomic databases

    PaxDbiQ9FMX3.

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsemblPlantsiAT5G23270.1; AT5G23270.1; AT5G23270.
    GeneIDi832391.
    GrameneiAT5G23270.1; AT5G23270.1; AT5G23270.
    KEGGiath:AT5G23270.

    Organism-specific databases

    TAIRiAT5G23270.

    Phylogenomic databases

    eggNOGiKOG0254. Eukaryota.
    ENOG410XNQK. LUCA.
    HOGENOMiHOG000202867.
    InParanoidiQ9FMX3.
    OMAiCTFIPFF.
    OrthoDBiEOG093608DR.
    PhylomeDBiQ9FMX3.

    Miscellaneous databases

    PROiQ9FMX3.

    Gene expression databases

    GenevisibleiQ9FMX3. AT.

    Family and domain databases

    CDDicd06174. MFS. 1 hit.
    InterProiIPR020846. MFS_dom.
    IPR005828. MFS_sugar_transport-like.
    IPR003663. Sugar/inositol_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 1 hit.
    [Graphical view]
    PRINTSiPR00171. SUGRTRNSPORT.
    SUPFAMiSSF103473. SSF103473. 1 hit.
    TIGRFAMsiTIGR00879. SP. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 1 hit.
    PS00217. SUGAR_TRANSPORT_2. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Entry informationi

    Entry nameiSTP11_ARATH
    AccessioniPrimary (citable) accession number: Q9FMX3
    Secondary accession number(s): O81708
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: March 1, 2001
    Last modified: November 30, 2016
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.