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Protein

Superoxide dismutase [Fe] 3, chloroplastic

Gene

FSD3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems (By similarity). Plays important role in chloroplast development, particularly in the maintenance of thylakoids membranes. Seems to act as a heterodimer with FSD2.By similarity1 Publication

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Fe cationBy similarityNote: Binds 1 Fe cation per subunit.By similarity

Enzyme regulationi

Activated by cpn20/cpn21 (in vitro).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi74IronBy similarity1
Metal bindingi127IronBy similarity1
Metal bindingi211IronBy similarity1
Metal bindingi215IronBy similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • superoxide dismutase activity Source: UniProtKB

GO - Biological processi

  • oxidation-reduction process Source: UniProtKB

Keywordsi

Molecular functionOxidoreductase
LigandIron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Fe] 3, chloroplastic (EC:1.15.1.1)
Alternative name(s):
Protein FE SUPEROXIDE DISMUTASE 3
Gene namesi
Name:FSD3
Ordered Locus Names:At5g23310
ORF Names:MKD15.17
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G23310
TAIRilocus:2166953 AT5G23310

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Plastid, Thylakoid

Pathology & Biotechi

Disruption phenotypei

Pale green phenotype. Abnormal plastids, highly vacuolated and without internal membrane structures like thylakoids.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 41ChloroplastSequence analysisAdd BLAST41
ChainiPRO_000042126642 – 263Superoxide dismutase [Fe] 3, chloroplasticAdd BLAST222

Proteomic databases

PaxDbiQ9FMX0
PRIDEiQ9FMX0
ProMEXiQ9FMX0

Expressioni

Gene expression databases

ExpressionAtlasiQ9FMX0 baseline and differential
GenevisibleiQ9FMX0 AT

Interactioni

Subunit structurei

Homodimer. Heterodimer with FSD2 (PubMed:18996978). Interacts with MRL7 (PubMed:23956074).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FSD2Q9LU647EBI-4430441,EBI-4424866

Protein-protein interaction databases

BioGridi17670, 4 interactors
IntActiQ9FMX0, 4 interactors
STRINGi3702.AT5G23310.1

Structurei

3D structure databases

ProteinModelPortaliQ9FMX0
SMRiQ9FMX0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0876 Eukaryota
COG0605 LUCA
HOGENOMiHOG000013584
InParanoidiQ9FMX0
KOiK04564
OMAiYLHSIFW
OrthoDBiEOG09360IDF
PhylomeDBiQ9FMX0

Family and domain databases

Gene3Di1.10.287.990, 1 hit
2.40.500.20, 1 hit
InterProiView protein in InterPro
IPR001189 Mn/Fe_SOD
IPR019833 Mn/Fe_SOD_BS
IPR019832 Mn/Fe_SOD_C
IPR019831 Mn/Fe_SOD_N
IPR036324 Mn/Fe_SOD_N_sf
IPR036314 SOD_C_sf
PfamiView protein in Pfam
PF02777 Sod_Fe_C, 1 hit
PF00081 Sod_Fe_N, 1 hit
PIRSFiPIRSF000349 SODismutase, 1 hit
PRINTSiPR01703 MNSODISMTASE
SUPFAMiSSF46609 SSF46609, 1 hit
SSF54719 SSF54719, 1 hit
PROSITEiView protein in PROSITE
PS00088 SOD_MN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9FMX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSCVVTTSC FYTISDSSIR LKSPKLLNLS NQQRRRSLRS RGGLKVEAYY
60 70 80 90 100
GLKTPPYPLD ALEPYMSRRT LEVHWGKHHR GYVDNLNKQL GKDDRLYGYT
110 120 130 140 150
MEELIKATYN NGNPLPEFNN AAQVYNHDFF WESMQPGGGD TPQKGVLEQI
160 170 180 190 200
DKDFGSFTNF REKFTNAALT QFGSGWVWLV LKREERRLEV VKTSNAINPL
210 220 230 240 250
VWDDIPIICV DVWEHSYYLD YKNDRAKYIN TFLNHLVSWN AAMSRMARAE
260
AFVNLGEPNI PIA
Length:263
Mass (Da):30,360
Last modified:March 1, 2001 - v1
Checksum:i33B1BBDEC9EF0B0C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti227K → N in AAM63713 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007648 Genomic DNA Translation: BAB11186.1
CP002688 Genomic DNA Translation: AED93150.1
AY065458 mRNA Translation: AAL38899.1
AY091225 mRNA Translation: AAM14164.1
AY086656 mRNA Translation: AAM63713.1
AF061852 mRNA Translation: AAC24834.1
PIRiT51732
RefSeqiNP_197722.1, NM_122237.4
UniGeneiAt.28472

Genome annotation databases

EnsemblPlantsiAT5G23310.1; AT5G23310.1; AT5G23310
GeneIDi832395
GrameneiAT5G23310.1; AT5G23310.1; AT5G23310
KEGGiath:AT5G23310

Similar proteinsi

Entry informationi

Entry nameiSODF3_ARATH
AccessioniPrimary (citable) accession number: Q9FMX0
Secondary accession number(s): O81240, Q8LCD9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2013
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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