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Protein

Mitochondrial phosphate carrier protein 3, mitochondrial

Gene

MPT3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transport of phosphate groups from the cytosol to the mitochondrial matrix. Mediates salt stress tolerance through an ATP-dependent pathway and via modulation of the gibberellin metabolism.2 Publications

GO - Biological processi

  1. response to salt stress Source: TAIR
  2. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.29.4.6. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial phosphate carrier protein 3, mitochondrial
Alternative name(s):
Mitochondrial phosphate transporter 3
Short name:
MPT3
Phosphate transporter 3;1
Gene namesi
Name:MPT3
Synonyms:AT5, PHT3;1
Ordered Locus Names:At5g14040
ORF Names:MUA22_4
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G14040.

Subcellular locationi

  1. Mitochondrion inner membrane 2 Publications; Multi-pass membrane protein 2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini? – 75Mitochondrial intermembraneSequence Analysis
Transmembranei76 – 9621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini97 – 13438Mitochondrial matrixSequence AnalysisAdd
BLAST
Transmembranei135 – 15420Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini155 – 17521Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Transmembranei176 – 19621Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini197 – 23135Mitochondrial matrixSequence AnalysisAdd
BLAST
Transmembranei232 – 25120Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini252 – 27221Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Transmembranei273 – 29321Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini294 – 33239Mitochondrial matrixSequence AnalysisAdd
BLAST
Transmembranei333 – 35321Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini354 – 37522Mitochondrial intermembraneSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell wall Source: TAIR
  2. chloroplast Source: TAIR
  3. integral component of membrane Source: UniProtKB-KW
  4. membrane Source: TAIR
  5. mitochondrial inner membrane Source: UniProtKB-SubCell
  6. mitochondrion Source: TAIR
  7. vacuolar membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 375Mitochondrial phosphate carrier protein 3, mitochondrialPRO_0000421697
Transit peptidei1 – ?MitochondrionSequence Analysis

Proteomic databases

PRIDEiQ9FMU6.

Expressioni

Tissue specificityi

Expressed in stems, leaves and flowers. Strong expression in vascular tissues.1 Publication

Inductioni

By salt stress.1 Publication

Gene expression databases

GenevestigatoriQ9FMU6.

Interactioni

Protein-protein interaction databases

IntActiQ9FMU6. 1 interaction.
STRINGi3702.AT5G14040.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9FMU6.
SMRiQ9FMU6. Positions 83-300.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati76 – 16085Solcar 1Add
BLAST
Repeati173 – 25785Solcar 2Add
BLAST
Repeati274 – 35380Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG265500.
HOGENOMiHOG000164438.
InParanoidiQ9FMU6.
KOiK15102.
OMAiVENANRW.
PhylomeDBiQ9FMU6.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 2 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9FMU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESPKNSLIP SFLYSSSSSP RSFLLDQVLN SNSNAAFEKS PSPAPRSSPT
60 70 80 90 100
SMISRKNFLI ASPTEPGKGI EMYSPAFYAA CTFGGILSCG LTHMTVTPLD
110 120 130 140 150
LVKCNMQIDP AKYKSISSGF GILLKEQGVK GFFRGWVPTL LGYSAQGACK
160 170 180 190 200
FGFYEYFKKT YSDLAGPEYT AKYKTLIYLA GSASAEIIAD IALCPFEAVK
210 220 230 240 250
VRVQTQPGFA RGMSDGFPKF IKSEGYGGLY KGLAPLWGRQ IPYTMMKFAS
260 270 280 290 300
FETIVEMIYK YAIPNPKSEC SKGLQLGVSF AGGYVAGVFC AIVSHPADNL
310 320 330 340 350
VSFLNNAKGA TVGDAVKKIG MVGLFTRGLP LRIVMIGTLT GAQWGLYDAF
360 370
KVFVGLPTTG GVAPAPAIAA TEAKA
Length:375
Mass (Da):40,090
Last modified:March 1, 2001 - v1
Checksum:iC58B3057954C9CF6
GO

Sequence cautioni

The sequence BAD94852.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007650 Genomic DNA. Translation: BAB08283.1.
CP002688 Genomic DNA. Translation: AED91980.1.
AY058848 mRNA. Translation: AAL24236.1.
AY143869 mRNA. Translation: AAN28808.1.
AB016066 mRNA. Translation: BAA31585.1.
AK222060 mRNA. Translation: BAD94852.1. Different initiation.
PIRiT51595.
RefSeqiNP_196908.1. NM_121407.2.
UniGeneiAt.47569.
At.486.

Genome annotation databases

EnsemblPlantsiAT5G14040.1; AT5G14040.1; AT5G14040.
GeneIDi831252.
KEGGiath:AT5G14040.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007650 Genomic DNA. Translation: BAB08283.1.
CP002688 Genomic DNA. Translation: AED91980.1.
AY058848 mRNA. Translation: AAL24236.1.
AY143869 mRNA. Translation: AAN28808.1.
AB016066 mRNA. Translation: BAA31585.1.
AK222060 mRNA. Translation: BAD94852.1. Different initiation.
PIRiT51595.
RefSeqiNP_196908.1. NM_121407.2.
UniGeneiAt.47569.
At.486.

3D structure databases

ProteinModelPortaliQ9FMU6.
SMRiQ9FMU6. Positions 83-300.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9FMU6. 1 interaction.
STRINGi3702.AT5G14040.1-P.

Protein family/group databases

TCDBi2.A.29.4.6. the mitochondrial carrier (mc) family.

Proteomic databases

PRIDEiQ9FMU6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G14040.1; AT5G14040.1; AT5G14040.
GeneIDi831252.
KEGGiath:AT5G14040.

Organism-specific databases

GeneFarmi3804. 380.
TAIRiAT5G14040.

Phylogenomic databases

eggNOGiNOG265500.
HOGENOMiHOG000164438.
InParanoidiQ9FMU6.
KOiK15102.
OMAiVENANRW.
PhylomeDBiQ9FMU6.

Miscellaneous databases

PROiQ9FMU6.

Gene expression databases

GenevestigatoriQ9FMU6.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 2 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis of Arabidopsis thaliana chromosome 5. III. Sequence features of the regions of 1,191,918 bp covered by seventeen physically assigned P1 clones."
    Nakamura Y., Sato S., Kaneko T., Kotani H., Asamizu E., Miyajima N., Tabata S.
    DNA Res. 4:401-414(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Isolation and characterization of cDNAs encoding mitochondrial phosphate transporters in soybean, maize, rice, and Arabidopis."
    Takabatake R., Hata S., Taniguchi M., Kouchi H., Sugiyama T., Izui K.
    Plant Mol. Biol. 40:479-486(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 88-375.
    Strain: cv. Columbia.
  5. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
    , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 220-375.
    Strain: cv. Columbia.
  6. "Redundancy in the function of mitochondrial phosphate transport in Saccharomyces cerevisiae and Arabidopsis thaliana."
    Hamel P., Saint-Georges Y., de Pinto B., Lachacinski N., Altamura N., Dujardin G.
    Mol. Microbiol. 51:307-317(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  8. "Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins."
    Heazlewood J.L., Tonti-Filippini J.S., Gout A.M., Day D.A., Whelan J., Millar A.H.
    Plant Cell 16:241-256(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  9. "The growing family of mitochondrial carriers in Arabidopsis."
    Picault N., Hodges M., Palmieri L., Palmieri F.
    Trends Plant Sci. 9:138-146(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY.
  10. "The mitochondrial phosphate transporters modulate plant responses to salt stress via affecting ATP and gibberellin metabolism in Arabidopsis thaliana."
    Zhu W., Miao Q., Sun D., Yang G., Wu C., Huang J., Zheng C.
    PLoS ONE 7:E43530-E43530(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, TISSUE SPECIFICITY, INDUCTION BY SALT, FUNCTION.

Entry informationi

Entry nameiMPCP3_ARATH
AccessioniPrimary (citable) accession number: Q9FMU6
Secondary accession number(s): O80415, Q56WI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2013
Last sequence update: March 1, 2001
Last modified: April 29, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Plants overexpressing MPT3/PHT3;1 display increased sensitivity to salt stress.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.