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Protein

Probable ubiquitin-conjugating enzyme E2 18

Gene

UBC18

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.By similarity

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei99Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin-conjugating enzyme E2 18 (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme 18
Ubiquitin carrier protein 18
Gene namesi
Name:UBC18
Ordered Locus Names:At5g42990
ORF Names:MBD2.19
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G42990.
TAIRilocus:2159981. AT5G42990.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003451841 – 161Probable ubiquitin-conjugating enzyme E2 18Add BLAST161

Proteomic databases

PaxDbiQ9FMM0.

Expressioni

Gene expression databases

ExpressionAtlasiQ9FMM0. baseline and differential.
GenevisibleiQ9FMM0. AT.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi19564. 6 interactors.
IntActiQ9FMM0. 4 interactors.
STRINGi3702.AT5G42990.1.

Structurei

3D structure databases

ProteinModelPortaliQ9FMM0.
SMRiQ9FMM0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 8Poly-Ser6

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0427. Eukaryota.
COG5078. LUCA.
HOGENOMiHOG000233453.
InParanoidiQ9FMM0.
KOiK10688.
OMAiNTITEWF.
OrthoDBiEOG09360P07.
PhylomeDBiQ9FMM0.

Family and domain databases

CDDicd00195. UBCc. 1 hit.
Gene3Di3.10.110.10. 1 hit.
InterProiView protein in InterPro
IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
PfamiView protein in Pfam
PF00179. UQ_con. 1 hit.
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiView protein in PROSITE
PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9FMM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSSSSPSRK ALSKIACNRL QKELSEWQVN PPTGFKHRVT DNLQKWVIEV
60 70 80 90 100
TGAPGTLYAN ETYNLQVEFP QHYPMEAPQV IFVPPAPLHP HIYSNGHICL
110 120 130 140 150
DILYDSWSPA MTVSSVCISI LSMLSSSPEK QRPTDNDRYV KNCKNGRSPK
160
ETRWWFHDDK V
Length:161
Mass (Da):18,372
Last modified:March 1, 2001 - v1
Checksum:i04A773CB44F5F60E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ027032 mRNA. Translation: AAY44858.1.
AB008264 Genomic DNA. Translation: BAB09201.1.
CP002688 Genomic DNA. Translation: AED94898.1.
AY058137 mRNA. Translation: AAL25553.1.
AY101537 mRNA. Translation: AAM26658.1.
AF028341 mRNA. Translation: AAC39327.1.
PIRiT52052.
RefSeqiNP_568619.1. NM_123665.5.
UniGeneiAt.6530.

Genome annotation databases

EnsemblPlantsiAT5G42990.1; AT5G42990.1; AT5G42990.
GeneIDi834314.
GrameneiAT5G42990.1; AT5G42990.1; AT5G42990.
KEGGiath:AT5G42990.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiUBC18_ARATH
AccessioniPrimary (citable) accession number: Q9FMM0
Secondary accession number(s): O48954
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: March 1, 2001
Last modified: June 7, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families