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Protein

Probable ubiquitin-conjugating enzyme E2 18

Gene

UBC18

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.By similarity

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei99Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-ATH-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin-conjugating enzyme E2 18 (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme 18
Ubiquitin carrier protein 18
Gene namesi
Name:UBC18
Ordered Locus Names:At5g42990
ORF Names:MBD2.19
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G42990
TAIRilocus:2159981 AT5G42990

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003451841 – 161Probable ubiquitin-conjugating enzyme E2 18Add BLAST161

Proteomic databases

PaxDbiQ9FMM0
PRIDEiQ9FMM0

Expressioni

Gene expression databases

ExpressionAtlasiQ9FMM0 baseline and differential
GenevisibleiQ9FMM0 AT

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi19564, 6 interactors
IntActiQ9FMM0, 4 interactors
STRINGi3702.AT5G42990.1

Structurei

3D structure databases

ProteinModelPortaliQ9FMM0
SMRiQ9FMM0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 8Poly-Ser6

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0427 Eukaryota
COG5078 LUCA
HOGENOMiHOG000233453
InParanoidiQ9FMM0
KOiK10688
OMAiEDWTPAC
OrthoDBiEOG09360P07
PhylomeDBiQ9FMM0

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9FMM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSSSSPSRK ALSKIACNRL QKELSEWQVN PPTGFKHRVT DNLQKWVIEV
60 70 80 90 100
TGAPGTLYAN ETYNLQVEFP QHYPMEAPQV IFVPPAPLHP HIYSNGHICL
110 120 130 140 150
DILYDSWSPA MTVSSVCISI LSMLSSSPEK QRPTDNDRYV KNCKNGRSPK
160
ETRWWFHDDK V
Length:161
Mass (Da):18,372
Last modified:March 1, 2001 - v1
Checksum:i04A773CB44F5F60E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ027032 mRNA Translation: AAY44858.1
AB008264 Genomic DNA Translation: BAB09201.1
CP002688 Genomic DNA Translation: AED94898.1
AY058137 mRNA Translation: AAL25553.1
AY101537 mRNA Translation: AAM26658.1
AF028341 mRNA Translation: AAC39327.1
PIRiT52052
RefSeqiNP_568619.1, NM_123665.5
UniGeneiAt.6530

Genome annotation databases

EnsemblPlantsiAT5G42990.1; AT5G42990.1; AT5G42990
GeneIDi834314
GrameneiAT5G42990.1; AT5G42990.1; AT5G42990
KEGGiath:AT5G42990

Similar proteinsi

Entry informationi

Entry nameiUBC18_ARATH
AccessioniPrimary (citable) accession number: Q9FMM0
Secondary accession number(s): O48954
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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