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Q9FMM0

- UBC18_ARATH

UniProt

Q9FMM0 - UBC18_ARATH

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Protein

Probable ubiquitin-conjugating enzyme E2 18

Gene

UBC18

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.By similarity

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei99 – 991Glycyl thioester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. acid-amino acid ligase activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT5G42990-MONOMER.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin-conjugating enzyme E2 18 (EC:6.3.2.19)
Alternative name(s):
Ubiquitin carrier protein 18
Gene namesi
Name:UBC18
Ordered Locus Names:At5g42990
ORF Names:MBD2.19
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G42990.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 161161Probable ubiquitin-conjugating enzyme E2 18PRO_0000345184Add
BLAST

Proteomic databases

PRIDEiQ9FMM0.

Expressioni

Gene expression databases

GenevestigatoriQ9FMM0.

Interactioni

Protein-protein interaction databases

BioGridi19564. 4 interactions.
IntActiQ9FMM0. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9FMM0.
SMRiQ9FMM0. Positions 19-125.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3 – 86Poly-Ser

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5078.
HOGENOMiHOG000233453.
InParanoidiQ9FMM0.
KOiK10688.
OMAiFTGDNIP.
PhylomeDBiQ9FMM0.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9FMM0 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSSSSPSRK ALSKIACNRL QKELSEWQVN PPTGFKHRVT DNLQKWVIEV
60 70 80 90 100
TGAPGTLYAN ETYNLQVEFP QHYPMEAPQV IFVPPAPLHP HIYSNGHICL
110 120 130 140 150
DILYDSWSPA MTVSSVCISI LSMLSSSPEK QRPTDNDRYV KNCKNGRSPK
160
ETRWWFHDDK V
Length:161
Mass (Da):18,372
Last modified:March 1, 2001 - v1
Checksum:i04A773CB44F5F60E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ027032 mRNA. Translation: AAY44858.1.
AB008264 Genomic DNA. Translation: BAB09201.1.
CP002688 Genomic DNA. Translation: AED94898.1.
AY058137 mRNA. Translation: AAL25553.1.
AY101537 mRNA. Translation: AAM26658.1.
AF028341 mRNA. Translation: AAC39327.1.
PIRiT52052.
RefSeqiNP_568619.1. NM_123665.5.
UniGeneiAt.6530.

Genome annotation databases

EnsemblPlantsiAT5G42990.1; AT5G42990.1; AT5G42990.
GeneIDi834314.
KEGGiath:AT5G42990.

Cross-referencesi

Web resourcesi

PlantsUBQ

A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ027032 mRNA. Translation: AAY44858.1 .
AB008264 Genomic DNA. Translation: BAB09201.1 .
CP002688 Genomic DNA. Translation: AED94898.1 .
AY058137 mRNA. Translation: AAL25553.1 .
AY101537 mRNA. Translation: AAM26658.1 .
AF028341 mRNA. Translation: AAC39327.1 .
PIRi T52052.
RefSeqi NP_568619.1. NM_123665.5.
UniGenei At.6530.

3D structure databases

ProteinModelPortali Q9FMM0.
SMRi Q9FMM0. Positions 19-125.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 19564. 4 interactions.
IntActi Q9FMM0. 4 interactions.

Proteomic databases

PRIDEi Q9FMM0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G42990.1 ; AT5G42990.1 ; AT5G42990 .
GeneIDi 834314.
KEGGi ath:AT5G42990.

Organism-specific databases

TAIRi AT5G42990.

Phylogenomic databases

eggNOGi COG5078.
HOGENOMi HOG000233453.
InParanoidi Q9FMM0.
KOi K10688.
OMAi FTGDNIP.
PhylomeDBi Q9FMM0.

Enzyme and pathway databases

UniPathwayi UPA00143 .
BioCyci ARA:AT5G42990-MONOMER.

Gene expression databases

Genevestigatori Q9FMM0.

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
InterProi IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00179. UQ_con. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 1 hit.
PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome analysis and functional characterization of the E2 and RING-type E3 ligase ubiquitination enzymes of Arabidopsis."
    Kraft E., Stone S.L., Ma L., Su N., Gao Y., Lau O.-S., Deng X.-W., Callis J.
    Plant Physiol. 139:1597-1611(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, NOMENCLATURE.
  2. "Structural analysis of Arabidopsis thaliana chromosome 5. III. Sequence features of the regions of 1,191,918 bp covered by seventeen physically assigned P1 clones."
    Nakamura Y., Sato S., Kaneko T., Kotani H., Asamizu E., Miyajima N., Tabata S.
    DNA Res. 4:401-414(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "A new family of ubiquitin-conjugating enzymes (E2S) AtUBC15/16/17/18 in Arabidopsis thaliana."
    Yan N., Doelling J., Vierstra R.D.
    Plant Gene Register PGR97-174
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 65-161.
    Strain: cv. Columbia.

Entry informationi

Entry nameiUBC18_ARATH
AccessioniPrimary (citable) accession number: Q9FMM0
Secondary accession number(s): O48954
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: March 1, 2001
Last modified: October 1, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3