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Q9FMM0

- UBC18_ARATH

UniProt

Q9FMM0 - UBC18_ARATH

Protein

Probable ubiquitin-conjugating enzyme E2 18

Gene

UBC18

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.By similarity

    Catalytic activityi

    ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei99 – 991Glycyl thioester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. acid-amino acid ligase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. protein ubiquitination Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciARA:AT5G42990-MONOMER.
    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable ubiquitin-conjugating enzyme E2 18 (EC:6.3.2.19)
    Alternative name(s):
    Ubiquitin carrier protein 18
    Gene namesi
    Name:UBC18
    Ordered Locus Names:At5g42990
    ORF Names:MBD2.19
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 5

    Organism-specific databases

    TAIRiAT5G42990.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 161161Probable ubiquitin-conjugating enzyme E2 18PRO_0000345184Add
    BLAST

    Proteomic databases

    PRIDEiQ9FMM0.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9FMM0.

    Interactioni

    Protein-protein interaction databases

    BioGridi19564. 4 interactions.
    IntActiQ9FMM0. 4 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9FMM0.
    SMRiQ9FMM0. Positions 19-125.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi3 – 86Poly-Ser

    Sequence similaritiesi

    Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5078.
    HOGENOMiHOG000233453.
    InParanoidiQ9FMM0.
    KOiK10688.
    OMAiFTGDNIP.
    PhylomeDBiQ9FMM0.

    Family and domain databases

    Gene3Di3.10.110.10. 1 hit.
    InterProiIPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view]
    PfamiPF00179. UQ_con. 1 hit.
    [Graphical view]
    SUPFAMiSSF54495. SSF54495. 1 hit.
    PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9FMM0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSSSSPSRK ALSKIACNRL QKELSEWQVN PPTGFKHRVT DNLQKWVIEV    50
    TGAPGTLYAN ETYNLQVEFP QHYPMEAPQV IFVPPAPLHP HIYSNGHICL 100
    DILYDSWSPA MTVSSVCISI LSMLSSSPEK QRPTDNDRYV KNCKNGRSPK 150
    ETRWWFHDDK V 161
    Length:161
    Mass (Da):18,372
    Last modified:March 1, 2001 - v1
    Checksum:i04A773CB44F5F60E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ027032 mRNA. Translation: AAY44858.1.
    AB008264 Genomic DNA. Translation: BAB09201.1.
    CP002688 Genomic DNA. Translation: AED94898.1.
    AY058137 mRNA. Translation: AAL25553.1.
    AY101537 mRNA. Translation: AAM26658.1.
    AF028341 mRNA. Translation: AAC39327.1.
    PIRiT52052.
    RefSeqiNP_568619.1. NM_123665.5.
    UniGeneiAt.6530.

    Genome annotation databases

    EnsemblPlantsiAT5G42990.1; AT5G42990.1; AT5G42990.
    GeneIDi834314.
    KEGGiath:AT5G42990.

    Cross-referencesi

    Web resourcesi

    PlantsUBQ

    A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ027032 mRNA. Translation: AAY44858.1 .
    AB008264 Genomic DNA. Translation: BAB09201.1 .
    CP002688 Genomic DNA. Translation: AED94898.1 .
    AY058137 mRNA. Translation: AAL25553.1 .
    AY101537 mRNA. Translation: AAM26658.1 .
    AF028341 mRNA. Translation: AAC39327.1 .
    PIRi T52052.
    RefSeqi NP_568619.1. NM_123665.5.
    UniGenei At.6530.

    3D structure databases

    ProteinModelPortali Q9FMM0.
    SMRi Q9FMM0. Positions 19-125.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 19564. 4 interactions.
    IntActi Q9FMM0. 4 interactions.

    Proteomic databases

    PRIDEi Q9FMM0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT5G42990.1 ; AT5G42990.1 ; AT5G42990 .
    GeneIDi 834314.
    KEGGi ath:AT5G42990.

    Organism-specific databases

    TAIRi AT5G42990.

    Phylogenomic databases

    eggNOGi COG5078.
    HOGENOMi HOG000233453.
    InParanoidi Q9FMM0.
    KOi K10688.
    OMAi FTGDNIP.
    PhylomeDBi Q9FMM0.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .
    BioCyci ARA:AT5G42990-MONOMER.

    Gene expression databases

    Genevestigatori Q9FMM0.

    Family and domain databases

    Gene3Di 3.10.110.10. 1 hit.
    InterProi IPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view ]
    Pfami PF00179. UQ_con. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54495. SSF54495. 1 hit.
    PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome analysis and functional characterization of the E2 and RING-type E3 ligase ubiquitination enzymes of Arabidopsis."
      Kraft E., Stone S.L., Ma L., Su N., Gao Y., Lau O.-S., Deng X.-W., Callis J.
      Plant Physiol. 139:1597-1611(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, NOMENCLATURE.
    2. "Structural analysis of Arabidopsis thaliana chromosome 5. III. Sequence features of the regions of 1,191,918 bp covered by seventeen physically assigned P1 clones."
      Nakamura Y., Sato S., Kaneko T., Kotani H., Asamizu E., Miyajima N., Tabata S.
      DNA Res. 4:401-414(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "A new family of ubiquitin-conjugating enzymes (E2S) AtUBC15/16/17/18 in Arabidopsis thaliana."
      Yan N., Doelling J., Vierstra R.D.
      Plant Gene Register PGR97-174
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 65-161.
      Strain: cv. Columbia.

    Entry informationi

    Entry nameiUBC18_ARATH
    AccessioniPrimary (citable) accession number: Q9FMM0
    Secondary accession number(s): O48954
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 22, 2008
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3