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Protein

Histone deacetylase 6

Gene

HDA6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Might remove acetyl residues only from specific targets, such as rDNA repeats or complex transgenes. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Required for rRNA gene silencing in nucleolar dominance. Plays a role in transgene silencing, but this effect seems to bee independent of the histone deacetylase activity (PubMed:11340181, PubMed:12486004, PubMed:15037732, PubMed:16648464). Part of the AS1 repressor complex to regulate the KNOX expression in leaf development (PubMed:23271976). Binds to KNAT1, KNAT2, and KNATM chromatin (PubMed:23271976).5 Publications

Miscellaneous

HDA6 mutations induce high acetylation of histone H4, increased methylation of histone H3 'Lys-4' and hypomethylation of DNA at particular loci, such as the rDNA repeats.

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.

Enzyme regulationi

Inhibited by trichostatin A.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei153By similarity1

GO - Molecular functioni

  • histone deacetylase activity Source: TAIR
  • NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC

GO - Biological processi

  • embryo development ending in seed dormancy Source: TAIR
  • gene silencing Source: TAIR
  • histone deacetylation Source: TAIR
  • posttranscriptional gene silencing Source: TAIR
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • response to abscisic acid Source: TAIR
  • response to salt stress Source: TAIR
  • seed maturation Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW
  • vegetative to reproductive phase transition of meristem Source: TAIR

Keywordsi

Molecular functionChromatin regulator, Hydrolase, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-ATH-1538133 G0 and Early G1
R-ATH-4551638 SUMOylation of chromatin organization proteins
R-ATH-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 6 (EC:3.5.1.98)
Gene namesi
Name:HDA6
Synonyms:RPD3B
Ordered Locus Names:At5g63110
ORF Names:MDC12.7
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G63110
TAIRilocus:2162017 AT5G63110

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Curling and serrated leaves. Down curling phenotype on both the distal and lateral axis.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi16G → R in sil1; suppression of transgene silencing. 1 Publication1
Mutagenesisi127G → R in axe1-1; suppression of transgene silencing. 1 Publication1
Mutagenesisi284G → D in axe1-2; suppression of transgene silencing. 1 Publication1
Mutagenesisi294A → V in axe1-3; suppression of transgene silencing. 1 Publication1
Mutagenesisi459 – 471Missing in rts1-2; suppression of transgene silencing. 1 PublicationAdd BLAST13

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002800851 – 471Histone deacetylase 6Add BLAST471

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9FML2

PTM databases

iPTMnetiQ9FML2

Expressioni

Tissue specificityi

Not detected in leaves, stems, flowers and young siliques.1 Publication

Inductioni

By jasmonic acid and ethylene.1 Publication

Gene expression databases

ExpressionAtlasiQ9FML2 baseline and differential
GenevisibleiQ9FML2 AT

Interactioni

Subunit structurei

Interacts with Coi1, which functions in an SCF complex that recruits regulators for ubiquitination. Interacts with AHL22 (PubMed:12445118, PubMed:22442143). Interacts with AS1 (PubMed:23271976). Part of the AS1 repressor complex composed of AS1, LBD6/AS2 and HDA6 (PubMed:23271976). Binds to EBS and SHL (PubMed:25281686).4 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi21674, 20 interactors
DIPiDIP-33452N
IntActiQ9FML2, 7 interactors
STRINGi3702.AT5G63110.1

Structurei

3D structure databases

ProteinModelPortaliQ9FML2
SMRiQ9FML2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni20 – 333Histone deacetylaseAdd BLAST314

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi311 – 314Poly-Gly4
Compositional biasi428 – 465Asp-richAdd BLAST38

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1342 Eukaryota
COG0123 LUCA
HOGENOMiHOG000225180
InParanoidiQ9FML2
KOiK06067
OMAiMDTSKPK
OrthoDBiEOG093609CH
PhylomeDBiQ9FML2

Family and domain databases

Gene3Di3.40.800.20, 1 hit
InterProiView protein in InterPro
IPR000286 His_deacetylse
IPR003084 His_deacetylse_1
IPR023801 His_deacetylse_dom
IPR037138 His_deacetylse_dom_sf
IPR023696 Ureohydrolase_dom_sf
PANTHERiPTHR10625 PTHR10625, 1 hit
PfamiView protein in Pfam
PF00850 Hist_deacetyl, 1 hit
PIRSFiPIRSF037913 His_deacetylse_1, 1 hit
PRINTSiPR01270 HDASUPER
PR01271 HISDACETLASE
SUPFAMiSSF52768 SSF52768, 1 hit

Sequencei

Sequence statusi: Complete.

Q9FML2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEADESGISL PSGPDGRKRR VSYFYEPTIG DYYYGQGHPM KPHRIRMAHS
60 70 80 90 100
LIIHYHLHRR LEISRPSLAD ASDIGRFHSP EYVDFLASVS PESMGDPSAA
110 120 130 140 150
RNLRRFNVGE DCPVFDGLFD FCRASAGGSI GAAVKLNRQD ADIAINWGGG
160 170 180 190 200
LHHAKKSEAS GFCYVNDIVL GILELLKMFK RVLYIDIDVH HGDGVEEAFY
210 220 230 240 250
TTDRVMTVSF HKFGDFFPGT GHIRDVGAEK GKYYALNVPL NDGMDDESFR
260 270 280 290 300
SLFRPLIQKV MEVYQPEAVV LQCGADSLSG DRLGCFNLSV KGHADCLRFL
310 320 330 340 350
RSYNVPLMVL GGGGYTIRNV ARCWCYETAV AVGVEPDNKL PYNEYFEYFG
360 370 380 390 400
PDYTLHVDPS PMENLNTPKD MERIRNTLLE QLSGLIHAPS VQFQHTPPVN
410 420 430 440 450
RVLDEPEDDM ETRPKPRIWS GTATYESDSD DDDKPLHGYS CRGGATTDRD
460 470
STGEDEMDDD NPEPDVNPPS S
Length:471
Mass (Da):52,652
Last modified:March 1, 2001 - v1
Checksum:iCA16C2640D1B1732
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti313G → E in AAG28475 (PubMed:11117260).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF195548 mRNA Translation: AAG28475.1
AB008265 Genomic DNA Translation: BAB10553.1
CP002688 Genomic DNA Translation: AED97705.1
AY142660 mRNA Translation: AAN13198.1
AY072201 mRNA Translation: AAL60022.1
AY088314 mRNA Translation: AAM65853.1
RefSeqiNP_201116.1, NM_125705.4
UniGeneiAt.8834

Genome annotation databases

EnsemblPlantsiAT5G63110.1; AT5G63110.1; AT5G63110
GeneIDi836431
GrameneiAT5G63110.1; AT5G63110.1; AT5G63110
KEGGiath:AT5G63110

Similar proteinsi

Entry informationi

Entry nameiHDA6_ARATH
AccessioniPrimary (citable) accession number: Q9FML2
Secondary accession number(s): Q9FVE5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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