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Protein

Pyruvate kinase

Gene

MCD7.8

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 5 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase GAPC2, cytosolic (GAPC2), Glyceraldehyde-3-phosphate dehydrogenase GAPC1, cytosolic (GAPC1)
  2. Phosphoglycerate kinase 3, cytosolic (PGK3)
  3. Probable 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 2 (At3g08590), 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 1 (PGM1)
  4. Enolase 1, chloroplastic (ENO1), Cytosolic enolase 3 (ENO3), Bifunctional enolase 2/transcriptional activator (ENO2)
  5. Pyruvate kinase (AXX17_At5g51800), Pyruvate kinase (AXX17_At3g24740), Pyruvate kinase (AXX17_At5g63250), Pyruvate kinase (AXX17_At3g50280), Pyruvate kinase (AXX17_ATUG04870), Pyruvate kinase (MAH20.13), Pyruvate kinase (MCD7.8), Pyruvate kinase (MBK5.16), Pyruvate kinase (F1I16_60), Pyruvate kinase (At3g25960), Pyruvate kinase (AXX17_At3g50440), Plastidial pyruvate kinase 3, chloroplastic (PKP3), Pyruvate kinase (At3g52990), Pyruvate kinase (AXX17_At5g08490), Pyruvate kinase (AXX17_At5g55530), Pyruvate kinase (AXX17_At3g28070), Pyruvate kinase (At2g36580), Pyruvate kinase (AXX17_At3g47400), Pyruvate kinase, Probable pyruvate kinase, cytosolic isozyme (At4g26390), Pyruvate kinase (F8J2_160), Pyruvate kinase (At3g52990), Pyruvate kinase (AXX17_At3g03460), Plastidial pyruvate kinase 2 (PKP2), Pyruvate kinase (AXX17_At2g33300), Pyruvate kinase (At3g04050), Pyruvate kinase (AXX17_At4g30430), Pyruvate kinase (F1I16_220), Plastidial pyruvate kinase 1, chloroplastic (PKP1), Pyruvate kinase (AXX17_At1g33230), Pyruvate kinase (At5g63680), Pyruvate kinase, Plastidial pyruvate kinase 4, chloroplastic (PKP4)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processGlycolysisUniRule annotation
LigandMagnesiumUniRule annotation, PyruvateImported

Enzyme and pathway databases

BioCyciARA:AT5G56350-MONOMER
ReactomeiR-ATH-6798695 Neutrophil degranulation
R-ATH-70171 Glycolysis
UniPathwayiUPA00109; UER00188

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinaseUniRule annotation (EC:2.7.1.40UniRule annotation)
Gene namesi
Name:MCD7.8Imported
Synonyms:MCD7_8Imported
Ordered Locus Names:At5g56350Imported, At5g56350/MCD7.8Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G56350
TAIRilocus:2161068 AT5G56350

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiQ9FM97

Expressioni

Gene expression databases

ExpressionAtlasiQ9FM97 baseline and differential

Interactioni

Protein-protein interaction databases

IntActiQ9FM97, 2 interactors
STRINGi3702.AT5G56350.1

Structurei

3D structure databases

SMRiQ9FM97
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 351PKInterPro annotationAdd BLAST343
Domaini368 – 494PK_CInterPro annotationAdd BLAST127

Sequence similaritiesi

Belongs to the pyruvate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2323 Eukaryota
COG0469 LUCA
HOGENOMiHOG000021559
KOiK00873
OMAiKHEAIEQ
OrthoDBiEOG093607JW

Family and domain databases

CDDicd00288 Pyruvate_Kinase, 1 hit
Gene3Di2.40.33.10, 1 hit
3.40.1380.20, 1 hit
InterProiView protein in InterPro
IPR001697 Pyr_Knase
IPR015813 Pyrv/PenolPyrv_Kinase-like_dom
IPR011037 Pyrv_Knase-like_insert_dom_sf
IPR018209 Pyrv_Knase_AS
IPR015793 Pyrv_Knase_brl
IPR015795 Pyrv_Knase_C
IPR036918 Pyrv_Knase_C_sf
IPR015806 Pyrv_Knase_insert_dom_sf
PANTHERiPTHR11817 PTHR11817, 1 hit
PfamiView protein in Pfam
PF00224 PK, 1 hit
PF02887 PK_C, 1 hit
PRINTSiPR01050 PYRUVTKNASE
SUPFAMiSSF50800 SSF50800, 1 hit
SSF51621 SSF51621, 2 hits
SSF52935 SSF52935, 1 hit
TIGRFAMsiTIGR01064 pyruv_kin, 1 hit
PROSITEiView protein in PROSITE
PS00110 PYRUVATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9FM97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMIEQRPKT KIVCTLGPAS RSVPMVEKLL RAGMNVARFN FSHGSHEYHQ
60 70 80 90 100
ETLDNLHQAM LNTGILCAVM LDTKGPEIRT GFLKDGKPIQ LKQGQEITIS
110 120 130 140 150
TDYDLKGDEN TICMSYKKLA VDVNPGMVIL CADGTISLLV LSCDKENGTV
160 170 180 190 200
RCRCENSAML GERKNVNLPG VVVDLPTLTE KDKEDIMQWG VPNQIDMIAL
210 220 230 240 250
SFVRKGSDLV QVRKLLGKHA KNILLMSKVE NQEGVANFDD ILVNSDAFMI
260 270 280 290 300
ARGDLGMEIP IEKIFLAQKV MIYKCNIQGK PVVTATQMLE SMIKSPRPTR
310 320 330 340 350
AEATDVANAV LDGTDCVMLS GETAAGAYPE LAVRTMAKIC VEAESTLDYG
360 370 380 390 400
DVFKRIMLYS PVPMSPLESL ASSAVRTANS ARATLIMVLT RGGSTARLVA
410 420 430 440 450
KYRPGMPILS VVVPEIKTDF FDWSCSDESP ARHSLIFRGL IPVLYAGSAR
460 470 480 490
ASHDESTEEA IEFATQYGKE KELCKTGDSV VALLRVGNAS VIKILTVK
Length:498
Mass (Da):54,411
Last modified:March 1, 2001 - v1
Checksum:i90C1374AC09079B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY054551 mRNA Translation: AAK96742.1
AY064679 mRNA Translation: AAL47384.1
AY087091 mRNA Translation: AAM64651.1
CP002688 Genomic DNA Translation: AED96752.1
AB009049 Genomic DNA Translation: BAB11262.1
RefSeqiNP_200446.1, NM_125018.3
UniGeneiAt.20243
At.74779

Genome annotation databases

EnsemblPlantsiAT5G56350.1; AT5G56350.1; AT5G56350
GeneIDi835735
GrameneiAT5G56350.1; AT5G56350.1; AT5G56350
KEGGiath:AT5G56350

Similar proteinsi

Entry informationi

Entry nameiQ9FM97_ARATH
AccessioniPrimary (citable) accession number: Q9FM97
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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