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Reviewed, UniProtKB/Swiss-Prot Q9FM01 (UGDH2_ARATH)

Last modified June 16, 2009. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Probable UDP-glucose 6-dehydrogenase 2
      Short name=UDP-Glc dehydrogenase 2
      Short name=UDP-GlcDH 2
      Short name=UDPGDH 2
    EC=1.1.1.22
Gene names
Name: UGD2
Ordered Locus Names: At5g39320
ORF Names: K3K3.170
OrganismArabidopsis thaliana (Mouse-ear cress) [Complete proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonscore eudicotyledonsrosidseurosids IIBrassicalesBrassicaceaeArabidopsis

Protein attributes

Sequence length480 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Provides UDP-glucuronic acid for hemicellulose precursors By similarity.

Catalytic activity

UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.

Pathway

Nucleotide-sugar biosynthesis; UDP-glucuronic acid biosynthesis; UDP-glucuronic acid from UDP-glucose: step 1/1.

Sequence similarities

Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   PTMPhosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytosol

Inferred from direct assay. Source: TAIR

nucleus

Inferred from direct assay. Source: TAIR

   Molecular functionNAD or NADH binding

Inferred from electronic annotation. Source: InterPro

UDP-glucose 6-dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 480480Probable UDP-glucose 6-dehydrogenase 2
PRO_0000312028

Regions

Nucleotide binding3 – 2018NAD By similarity
Region158 – 1614Substrate binding By similarity

Sites

Active site2721Nucleophile By similarity
Binding site331NAD By similarity
Binding site381NAD By similarity
Binding site901NAD By similarity
Binding site1281NAD; via amide nitrogen By similarity
Binding site1611NAD By similarity
Binding site2161Substrate By similarity
Binding site2691Substrate; via amide nitrogen By similarity
Binding site2751NAD By similarity
Binding site3351Substrate By similarity
Binding site3421NAD By similarity

Amino acid modifications

Modified residue3931Phosphoserine By similarity

Experimental info

Sequence conflict921Missing in AAP21188. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9FM01-1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 3FC4FEB2CB647BCB

FASTA48053,097
        10         20         30         40         50         60 
MVKICCIGAG YVGGPTMAVI ALKCPDIEVA VVDISVPRIN AWNSDQLPIY EPGLDDIVKQ 

        70         80         90        100        110        120 
CRGKNLFFST DVEKHVREAD IVFVSVNTPT KTTGLGAGKA ADLTYWESAA RMIADVSVSD 

       130        140        150        160        170        180 
KIVVEKSTVP VKTAEAIEKI LMHNSKGIKF QILSNPEFLA EGTAIADLFN PDRVLIGGRE 

       190        200        210        220        230        240 
TPEGFKAVQT LKEVYANWVP EGQIITTNLW SAELSKLAAN AFLAQRISSV NAMSALCEST 

       250        260        270        280        290        300 
GADVTQVSYA VGTDSRIGSK FLNASVGFGG SCFQKDILNL VYICQCNGLP EVAEYWKQVI 

       310        320        330        340        350        360 
KINDYQKNRF VNRIVSSMFN TVSNKKVAIL GFAFKKDTGD TRETPAIDVC KGLLGDKAQI 

       370        380        390        400        410        420 
SIYDPQVTEE QIQRDLSMKK FDWDHPLHLQ PMSPTTVKQV SVTWDAYEAT KDAHAVCVLT 

       430        440        450        460        470        480 
EWDEFKSLDY QKIFDNMQKP AFIFDGRNIM NVNKLREIGF IVYSIGKPLD PWLKDMPAFV 

« Hide

Cross-references

Sequence databases

AB009054, AB010694 Genomic DNA. Translation: BAB11006.1.
BT006380 mRNA. Translation: AAP21188.1.
IPIIPI00539067.
RefSeqNP_198748.1.
UniGeneAt.20102
At.71506

3D structure databases

ModBaseSearch...

Proteomic databases

PRIDEQ9FM01.

Genome annotation databases

GeneID833928.
GenomeReviewsGene locus AT5G39320 in contig BA000015_GR.
KEGGath:AT5G39320.
NMPDRfig|3702.1.peg.25628.

Organism-specific databases

TAIRAt5g39320.

Phylogenomic databases

OMAQ9FM01. YEHWIPK.

Enzyme and pathway databases

BRENDA1.1.1.22. 302.

Family and domain databases

InterProIPR016040. NAD(P)-bd_dom.
IPR017476. Nucleotide_sugar_DH.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR014028. UDP-Glc/GDP-Man_DH_dimer-bd.
IPR001732. UDP-Glc/GDP-Man_DH_N.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:3.40.50.1870. UDP-Glc/GDP-Man_DH_C. 1 hit.
PANTHERPTHR11374. UDPG_MGDP_DH_Creg. 1 hit.
PfamPF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR03026. NDP-sugDHase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUGDH2_ARATH
AccessionPrimary (citable) accession number: Q9FM01
Secondary accession number(s): Q84MD5
Entry history
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: March 1, 2001
Last modified: June 16, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectPPAP (Plant Proteome Annotation Project)

Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents