Reviewed,
UniProtKB/Swiss-Prot Q9FM01 (UGDH2_ARATH)
Last modified
June 16, 2009.
Version 56.
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Probable UDP-glucose 6-dehydrogenase 2 Short name=UDP-Glc dehydrogenase 2 Short name=UDP-GlcDH 2 Short name=UDPGDH 2 EC=1.1.1.22 | ||||||
| Gene names |
| ||||||
| Organism | Arabidopsis thaliana (Mouse-ear cress) [Complete proteome] | ||||||
| Taxonomic identifier | 3702 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis |
Protein attributes
| Sequence length | 480 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Provides UDP-glucuronic acid for hemicellulose precursors By similarity. |
| Catalytic activity | UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH. |
| Pathway | |
| Sequence similarities | Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| PTM | Phosphoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytosol Inferred from direct assay. Source: TAIR nucleusInferred from direct assay. Source: TAIR |
| Molecular function | NAD or NADH binding Inferred from electronic annotation. Source: InterPro UDP-glucose 6-dehydrogenase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 480 | 480 | Probable UDP-glucose 6-dehydrogenase 2 | PRO_0000312028 | |||||
Regions | |||||||||
| Nucleotide binding | 3 – 20 | 18 | NAD By similarity | ||||||
| Region | 158 – 161 | 4 | Substrate binding By similarity | ||||||
Sites | |||||||||
| Active site | 272 | 1 | Nucleophile By similarity | ||||||
| Binding site | 33 | 1 | NAD By similarity | ||||||
| Binding site | 38 | 1 | NAD By similarity | ||||||
| Binding site | 90 | 1 | NAD By similarity | ||||||
| Binding site | 128 | 1 | NAD; via amide nitrogen By similarity | ||||||
| Binding site | 161 | 1 | NAD By similarity | ||||||
| Binding site | 216 | 1 | Substrate By similarity | ||||||
| Binding site | 269 | 1 | Substrate; via amide nitrogen By similarity | ||||||
| Binding site | 275 | 1 | NAD By similarity | ||||||
| Binding site | 335 | 1 | Substrate By similarity | ||||||
| Binding site | 342 | 1 | NAD By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 393 | 1 | Phosphoserine By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 92 | 1 | Missing in AAP21188. Ref.2 | ||||||
Sequences
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References
| [1] | "Structural analysis of Arabidopsis thaliana chromosome 5. IV. Sequence features of the regions of 1,456,315 bp covered by nineteen physically assigned P1 and TAC clones." Sato S., Kaneko T., Kotani H., Nakamura Y., Asamizu E., Miyajima N., Tabata S. DNA Res. 5:41-54(1998) [PubMed: 9628582] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia. |
| [2] | "Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.  Ecker J.R.Science 302:842-846(2003) [PubMed: 14593172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia. |
Cross-references
Sequence databases | |
|---|---|
| AB009054, AB010694 Genomic DNA. Translation: BAB11006.1. BT006380 mRNA. Translation: AAP21188.1. | |
| IPI | IPI00539067. |
| RefSeq | NP_198748.1. |
| UniGene | At.20102 At.71506 |
3D structure databases | |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | Q9FM01. |
Genome annotation databases | |
| GeneID | 833928. |
| GenomeReviews | Gene locus AT5G39320 in contig BA000015_GR. |
| KEGG | ath:AT5G39320. |
| NMPDR | fig|3702.1.peg.25628. |
Organism-specific databases | |
| TAIR | At5g39320. |
Phylogenomic databases | |
| OMA | Q9FM01. YEHWIPK. |
Enzyme and pathway databases | |
| BRENDA | 1.1.1.22. 302. |
Family and domain databases | |
| InterPro | IPR016040. NAD(P)-bd_dom. IPR017476. Nucleotide_sugar_DH. IPR014027. UDP-Glc/GDP-Man_DH_C. IPR014026. UDP-Glc/GDP-Man_DH_dimer. IPR014028. UDP-Glc/GDP-Man_DH_dimer-bd. IPR001732. UDP-Glc/GDP-Man_DH_N. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:3.40.50.1870. UDP-Glc/GDP-Man_DH_C. 1 hit. |
| PANTHER | PTHR11374. UDPG_MGDP_DH_Creg. 1 hit. |
| Pfam | PF00984. UDPG_MGDP_dh. 1 hit. PF03720. UDPG_MGDP_dh_C. 1 hit. PF03721. UDPG_MGDP_dh_N. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR03026. NDP-sugDHase. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | UGDH2_ARATH | ||||||||
| Accession | Primary (citable) accession number: Q9FM01 Secondary accession number(s): Q84MD5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | PPAP (Plant Proteome Annotation Project) | ||||||||
Relevant documents
| Arabidopsis thaliana Arabidopsis thaliana: entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |
