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Protein

Notchless protein homolog

Gene

NLE1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • embryo sac development Source: TAIR
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Notchless protein homolog
Gene namesi
Name:NLE1
Ordered Locus Names:At5g52820
ORF Names:MXC20.4
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G52820.

Subcellular locationi

GO - Cellular componenti

  • Cul4-RING E3 ubiquitin ligase complex Source: TAIR
  • nucleolus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002848931 – 473Notchless protein homologAdd BLAST473

Proteomic databases

PaxDbiQ9FLX9.

Expressioni

Gene expression databases

GenevisibleiQ9FLX9. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G52820.1.

Structurei

3D structure databases

ProteinModelPortaliQ9FLX9.
SMRiQ9FLX9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati107 – 146WD 1Add BLAST40
Repeati149 – 188WD 2Add BLAST40
Repeati192 – 236WD 3Add BLAST45
Repeati239 – 277WD 4Add BLAST39
Repeati313 – 354WD 5Add BLAST42
Repeati358 – 399WD 6Add BLAST42
Repeati400 – 439WD 7Add BLAST40
Repeati442 – 473WD 8Add BLAST32

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi417 – 432DWD boxAdd BLAST16

Domaini

The DWD box is required for interaction with DDB1A.By similarity

Sequence similaritiesi

Belongs to the NLE1/RSA4 family.Curated
Contains 8 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0271. Eukaryota.
ENOG410XP3K. LUCA.
HOGENOMiHOG000091641.
InParanoidiQ9FLX9.
KOiK14855.
OMAiVTSLAWE.
OrthoDBiEOG0936075G.
PhylomeDBiQ9FLX9.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR001632. Gprotein_B.
IPR012972. NLE.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08154. NLE. 1 hit.
PF00400. WD40. 8 hits.
[Graphical view]
PRINTSiPR00319. GPROTEINB.
PR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 8 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9FLX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMMDTDEGK TVMCLLTDPE GTHLGSAMYI PQKAGPLQLT QLVNRFLDNE
60 70 80 90 100
EMLPYSFYVS DEELLVPVGT YLEKNKVSVE KVLTIVYQQQ AVFRIRPVNR
110 120 130 140 150
CSQTIAGHAE AVLCVSFSPD GKQLASGSGD TTVRLWDLYT ETPLFTCKGH
160 170 180 190 200
KNWVLTVAWS PDGKHLVSGS KSGEICCWNP KKGELEGSPL TGHKKWITGI
210 220 230 240 250
SWEPVHLSSP CRRFVTSSKD GDARIWDITL KKSIICLSGH TLAVTCVKWG
260 270 280 290 300
GDGIIYTGSQ DCTIKMWETT QGKLIRELKG HGHWINSLAL STEYVLRTGA
310 320 330 340 350
FDHTGRQYPP NEEKQKALER YNKTKGDSPE RLVSGSDDFT MFLWEPSVSK
360 370 380 390 400
QPKKRLTGHQ QLVNHVYFSP DGKWIASASF DKSVRLWNGI TGQFVTVFRG
410 420 430 440 450
HVGPVYQVSW SADSRLLLSG SKDSTLKIWE IRTKKLKQDL PGHADEVFAV
460 470
DWSPDGEKVV SGGKDRVLKL WKG
Length:473
Mass (Da):52,897
Last modified:March 1, 2001 - v1
Checksum:i8D5AAC83BE9EBFE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009055 Genomic DNA. Translation: BAB10430.1.
CP002688 Genomic DNA. Translation: AED96265.1.
AK227330 mRNA. Translation: BAE99344.1.
BT004562 mRNA. Translation: AAO42808.1.
RefSeqiNP_200094.1. NM_124660.4.
UniGeneiAt.29592.

Genome annotation databases

EnsemblPlantsiAT5G52820.1; AT5G52820.1; AT5G52820.
GeneIDi835359.
GrameneiAT5G52820.1; AT5G52820.1; AT5G52820.
KEGGiath:AT5G52820.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009055 Genomic DNA. Translation: BAB10430.1.
CP002688 Genomic DNA. Translation: AED96265.1.
AK227330 mRNA. Translation: BAE99344.1.
BT004562 mRNA. Translation: AAO42808.1.
RefSeqiNP_200094.1. NM_124660.4.
UniGeneiAt.29592.

3D structure databases

ProteinModelPortaliQ9FLX9.
SMRiQ9FLX9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT5G52820.1.

Proteomic databases

PaxDbiQ9FLX9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G52820.1; AT5G52820.1; AT5G52820.
GeneIDi835359.
GrameneiAT5G52820.1; AT5G52820.1; AT5G52820.
KEGGiath:AT5G52820.

Organism-specific databases

TAIRiAT5G52820.

Phylogenomic databases

eggNOGiKOG0271. Eukaryota.
ENOG410XP3K. LUCA.
HOGENOMiHOG000091641.
InParanoidiQ9FLX9.
KOiK14855.
OMAiVTSLAWE.
OrthoDBiEOG0936075G.
PhylomeDBiQ9FLX9.

Miscellaneous databases

PROiQ9FLX9.

Gene expression databases

GenevisibleiQ9FLX9. AT.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR001632. Gprotein_B.
IPR012972. NLE.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08154. NLE. 1 hit.
PF00400. WD40. 8 hits.
[Graphical view]
PRINTSiPR00319. GPROTEINB.
PR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 8 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNLE1_ARATH
AccessioniPrimary (citable) accession number: Q9FLX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.