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Protein

Notchless protein homolog

Gene

NLE1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for female gametophyte development.1 Publication

GO - Biological processi

  • embryo sac development Source: TAIR
  • ribosomal large subunit assembly Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
Notchless protein homolog1 Publication
Gene namesi
Name:NLE11 Publication
Ordered Locus Names:At5g52820Imported
ORF Names:MXC20.4Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G52820
TAIRilocus:2176897 AT5G52820

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Female semisterility due to strongly delayed development of female gametophyte.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002848931 – 473Notchless protein homologAdd BLAST473

Proteomic databases

PaxDbiQ9FLX9

Expressioni

Tissue specificityi

Constitutively and ubiquitously expressed.1 Publication

Gene expression databases

ExpressionAtlasiQ9FLX9 baseline and differential
GenevisibleiQ9FLX9 AT

Interactioni

Subunit structurei

Associates with the pre-60S ribosomal particle.By similarity

Protein-protein interaction databases

STRINGi3702.AT5G52820.1

Structurei

3D structure databases

ProteinModelPortaliQ9FLX9
SMRiQ9FLX9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati107 – 146WD 1Sequence analysisAdd BLAST40
Repeati149 – 188WD 2Sequence analysisAdd BLAST40
Repeati192 – 236WD 3Sequence analysisAdd BLAST45
Repeati239 – 277WD 4Sequence analysisAdd BLAST39
Repeati313 – 354WD 5Sequence analysisAdd BLAST42
Repeati358 – 399WD 6Sequence analysisAdd BLAST42
Repeati400 – 439WD 7Sequence analysisAdd BLAST40
Repeati442 – 473WD 8Sequence analysisAdd BLAST32

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni9 – 91Ubiquitin-like (UBL) domainBy similarityAdd BLAST83

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi417 – 432DWD box1 PublicationAdd BLAST16

Domaini

The DWD box is required for interaction with DDB1A.1 Publication

Sequence similaritiesi

Belongs to the NLE1/RSA4 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0271 Eukaryota
ENOG410XP3K LUCA
HOGENOMiHOG000091641
InParanoidiQ9FLX9
KOiK14855
OMAiLNTETPH
OrthoDBiEOG0936075G
PhylomeDBiQ9FLX9

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR001632 Gprotein_B
IPR012972 NLE
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF08154 NLE, 1 hit
PF00400 WD40, 8 hits
PRINTSiPR00319 GPROTEINB
PR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 8 hits
SUPFAMiSSF50978 SSF50978, 2 hits
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 4 hits
PS50082 WD_REPEATS_2, 7 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q9FLX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMMDTDEGK TVMCLLTDPE GTHLGSAMYI PQKAGPLQLT QLVNRFLDNE
60 70 80 90 100
EMLPYSFYVS DEELLVPVGT YLEKNKVSVE KVLTIVYQQQ AVFRIRPVNR
110 120 130 140 150
CSQTIAGHAE AVLCVSFSPD GKQLASGSGD TTVRLWDLYT ETPLFTCKGH
160 170 180 190 200
KNWVLTVAWS PDGKHLVSGS KSGEICCWNP KKGELEGSPL TGHKKWITGI
210 220 230 240 250
SWEPVHLSSP CRRFVTSSKD GDARIWDITL KKSIICLSGH TLAVTCVKWG
260 270 280 290 300
GDGIIYTGSQ DCTIKMWETT QGKLIRELKG HGHWINSLAL STEYVLRTGA
310 320 330 340 350
FDHTGRQYPP NEEKQKALER YNKTKGDSPE RLVSGSDDFT MFLWEPSVSK
360 370 380 390 400
QPKKRLTGHQ QLVNHVYFSP DGKWIASASF DKSVRLWNGI TGQFVTVFRG
410 420 430 440 450
HVGPVYQVSW SADSRLLLSG SKDSTLKIWE IRTKKLKQDL PGHADEVFAV
460 470
DWSPDGEKVV SGGKDRVLKL WKG
Length:473
Mass (Da):52,897
Last modified:March 1, 2001 - v1
Checksum:i8D5AAC83BE9EBFE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009055 Genomic DNA Translation: BAB10430.1
CP002688 Genomic DNA Translation: AED96265.1
AK227330 mRNA Translation: BAE99344.1
BT004562 mRNA Translation: AAO42808.1
RefSeqiNP_200094.1, NM_124660.4
UniGeneiAt.29592

Genome annotation databases

EnsemblPlantsiAT5G52820.1; AT5G52820.1; AT5G52820
GeneIDi835359
GrameneiAT5G52820.1; AT5G52820.1; AT5G52820
KEGGiath:AT5G52820

Similar proteinsi

Entry informationi

Entry nameiNLE1_ARATH
AccessioniPrimary (citable) accession number: Q9FLX9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 1, 2001
Last modified: April 25, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health