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Q9FLF7

- MYST1_ARATH

UniProt

Q9FLF7 - MYST1_ARATH

Protein

Probable MYST-like histone acetyltransferase 1

Gene

HAG4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Histone acetyltransferase which may be involved in transcriptional activation.By similarity

    Catalytic activityi

    Acetyl-CoA + [histone] = CoA + acetyl-[histone].

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei269 – 2691By similarity
    Active sitei311 – 3111NucleophileBy similarity
    Binding sitei314 – 3141Acetyl-CoABy similarity
    Binding sitei349 – 3491Acetyl-CoABy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri203 – 22523C2HC-typeAdd
    BLAST

    GO - Molecular functioni

    1. histone acetyltransferase activity Source: TAIR
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. DNA repair Source: TAIR
    2. histone acetylation Source: GOC
    3. regulation of transcription, DNA-templated Source: UniProtKB-KW
    4. response to UV-B Source: TAIR
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Acyltransferase, Chromatin regulator, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciARA:AT5G64610-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable MYST-like histone acetyltransferase 1 (EC:2.3.1.48)
    Gene namesi
    Name:HAG4
    Ordered Locus Names:At5g64610
    ORF Names:MUB3.13
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 5

    Organism-specific databases

    TAIRiAT5G64610.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: TAIR

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 445445Probable MYST-like histone acetyltransferase 1PRO_0000238464Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei269 – 2691N6-acetyllysine; by autocatalysisBy similarity

    Post-translational modificationi

    Autoacetylation at Lys-269 is required for proper function.By similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ9FLF7.
    PRIDEiQ9FLF7.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9FLF7.

    Interactioni

    Protein-protein interaction databases

    BioGridi21824. 1 interaction.
    IntActiQ9FLF7. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9FLF7.
    SMRiQ9FLF7. Positions 172-440.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini74 – 13360ChromoAdd
    BLAST
    Domaini169 – 440272MYST-type HATAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni319 – 3257Acetyl-CoA bindingBy similarity

    Sequence similaritiesi

    Belongs to the MYST (SAS/MOZ) family.Curated
    Contains 1 C2HC-type zinc finger.Curated
    Contains 1 chromo domain.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri203 – 22523C2HC-typeAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5027.
    HOGENOMiHOG000182457.
    InParanoidiQ9FLF7.
    KOiK11308.
    OMAiRRLDEWI.
    PhylomeDBiQ9FLF7.

    Family and domain databases

    Gene3Di3.40.630.30. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR000953. Chromo_domain/shadow.
    IPR016197. Chromodomain-like.
    IPR002717. MOZ_SAS.
    IPR025995. Tudor-knot.
    IPR015880. Znf_C2H2-like.
    [Graphical view]
    PfamiPF01853. MOZ_SAS. 1 hit.
    PF11717. Tudor-knot. 1 hit.
    [Graphical view]
    SMARTiSM00298. CHROMO. 1 hit.
    SM00355. ZnF_C2H2. 1 hit.
    [Graphical view]
    SUPFAMiSSF54160. SSF54160. 1 hit.
    SSF55729. SSF55729. 1 hit.
    PROSITEiPS51726. MYST_HAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9FLF7-1 [UniParc]FASTAAdd to Basket

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    MGSSADTETA MIIATPASNH NNPATNGGDA NQNHTSGAIL ALTNSESDAS    50
    KKRRMGVLPL EVGTRVMCQW RDGKYHPVKV IERRKNYNGG HNDYEYYVHY 100
    TEFNRRLDEW IKLEQLDLDS VECALDEKVE DKVTSLKMTR HQKRKIDETH 150
    VEGHEELDAA SLREHEEFTK VKNIATIELG KYEIETWYFS PFPPEYNDCV 200
    KLFFCEFCLS FMKRKEQLQR HMRKCDLKHP PGDEIYRSST LSMFEVDGKK 250
    NKVYAQNLCY LAKLFLDHKT LYYDVDLFLF YILCECDDRG CHMVGYFSKE 300
    KHSEEAYNLA CILTLPPYQR KGYGKFLIAF SYELSKKEGK VGTPERPLSD 350
    LGLVSYRGYW TRILLDILKK HKGNISIKEL SDMTAIKAED ILSTLQSLEL 400
    IQYRKGQHVI CADPKVLDRH LKAAGRGGLD VDVSKMIWTP YKEQS 445
    Length:445
    Mass (Da):51,438
    Last modified:March 1, 2001 - v1
    Checksum:iF2243F5808ADE207
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB010076 Genomic DNA. Translation: BAB11428.1.
    CP002688 Genomic DNA. Translation: AED97926.1.
    AY099684 mRNA. Translation: AAM20535.1.
    BT000277 mRNA. Translation: AAN15596.1.
    RefSeqiNP_201266.1. NM_125857.2.
    UniGeneiAt.28949.
    At.49220.

    Genome annotation databases

    EnsemblPlantsiAT5G64610.1; AT5G64610.1; AT5G64610.
    GeneIDi836582.
    KEGGiath:AT5G64610.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB010076 Genomic DNA. Translation: BAB11428.1 .
    CP002688 Genomic DNA. Translation: AED97926.1 .
    AY099684 mRNA. Translation: AAM20535.1 .
    BT000277 mRNA. Translation: AAN15596.1 .
    RefSeqi NP_201266.1. NM_125857.2.
    UniGenei At.28949.
    At.49220.

    3D structure databases

    ProteinModelPortali Q9FLF7.
    SMRi Q9FLF7. Positions 172-440.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 21824. 1 interaction.
    IntActi Q9FLF7. 1 interaction.

    Proteomic databases

    PaxDbi Q9FLF7.
    PRIDEi Q9FLF7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT5G64610.1 ; AT5G64610.1 ; AT5G64610 .
    GeneIDi 836582.
    KEGGi ath:AT5G64610.

    Organism-specific databases

    TAIRi AT5G64610.

    Phylogenomic databases

    eggNOGi COG5027.
    HOGENOMi HOG000182457.
    InParanoidi Q9FLF7.
    KOi K11308.
    OMAi RRLDEWI.
    PhylomeDBi Q9FLF7.

    Enzyme and pathway databases

    BioCyci ARA:AT5G64610-MONOMER.

    Gene expression databases

    Genevestigatori Q9FLF7.

    Family and domain databases

    Gene3Di 3.40.630.30. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR000953. Chromo_domain/shadow.
    IPR016197. Chromodomain-like.
    IPR002717. MOZ_SAS.
    IPR025995. Tudor-knot.
    IPR015880. Znf_C2H2-like.
    [Graphical view ]
    Pfami PF01853. MOZ_SAS. 1 hit.
    PF11717. Tudor-knot. 1 hit.
    [Graphical view ]
    SMARTi SM00298. CHROMO. 1 hit.
    SM00355. ZnF_C2H2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54160. SSF54160. 1 hit.
    SSF55729. SSF55729. 1 hit.
    PROSITEi PS51726. MYST_HAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structural analysis of Arabidopsis thaliana chromosome 5. IV. Sequence features of the regions of 1,456,315 bp covered by nineteen physically assigned P1 and TAC clones."
      Sato S., Kaneko T., Kotani H., Nakamura Y., Asamizu E., Miyajima N., Tabata S.
      DNA Res. 5:41-54(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes."
      Pandey R., Mueller A., Napoli C.A., Selinger D.A., Pikaard C.S., Richards E.J., Bender J., Mount D.W., Jorgensen R.A.
      Nucleic Acids Res. 30:5036-5055(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, NOMENCLATURE.

    Entry informationi

    Entry nameiMYST1_ARATH
    AccessioniPrimary (citable) accession number: Q9FLF7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3