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Protein

Histone acetyltransferase of the MYST family 1

Gene

HAM1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Histone acetyltransferase which may be involved in transcriptional activation. Acetylates 'Lys-5' of histone H4 (H4K5ac) (PubMed:17877703, PubMed:19040736, PubMed:22170978, PubMed:23273925). Essential for gametophyte development (PubMed:19040736). Involved in DNA repair after UV-B exposure (PubMed:22170978). Negative regulator of flowering controlling the H4K5ac levels in the FLC chromatin (PubMed:23273925).4 Publications

Miscellaneous

Knockdown expression of both HAM1 and HAM2 results in earlier flowering.1 Publication

Catalytic activityi

Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei345Proton donor/acceptorBy similarity1
Binding sitei349Acetyl-CoABy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri202 – 227C2HC MYST-typePROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

  • histone acetyltransferase activity Source: TAIR
  • histone acetyltransferase activity (H4-K5 specific) Source: CACAO
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • DNA repair Source: TAIR
  • regulation of photoperiodism, flowering Source: CACAO
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • response to UV-B Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, Acyltransferase, Chromatin regulator, Transferase
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDAi2.3.1.48 399
ReactomeiR-ATH-2559586 DNA Damage/Telomere Stress Induced Senescence
R-ATH-5693548 Sensing of DNA Double Strand Breaks
R-ATH-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-ATH-5693607 Processing of DNA double-strand break ends
R-ATH-5693616 Presynaptic phase of homologous DNA pairing and strand exchange

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase of the MYST family 11 Publication (EC:2.3.1.48UniRule annotation)
Alternative name(s):
Histone acetyltransferase of the GNAT/MYST superfamily 41 Publication
MYST-like histone acetyltransferase 11 Publication
Gene namesi
Name:HAM11 Publication
Synonyms:HAG41 Publication
Ordered Locus Names:At5g64610Imported
ORF Names:MUB3.13Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G64610
TAIRilocus:2174764 AT5G64610

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

No visible phenotype, due to the redundancy with HAM2. Ham1 and ham2 double mutants are lethal.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002384641 – 445Histone acetyltransferase of the MYST family 1Add BLAST445

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei269N6-acetyllysine; by autocatalysisBy similarity1

Post-translational modificationi

Autoacetylation at Lys-269 is required for proper function.By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9FLF7
PRIDEiQ9FLF7

Expressioni

Tissue specificityi

Expressed in cotyledons, leaves, stems, roots and, at higher levels in developing flowers, particularly in the anthers and gynoecia (PubMed:19040736). Constitutively expressed in all tissues, predominantly in shoot apical meristem (PubMed:23273925).2 Publications

Inductioni

Up-regulated upon UV-B exposure.1 Publication

Gene expression databases

ExpressionAtlasiQ9FLF7 baseline and differential
GenevisibleiQ9FLF7 AT

Interactioni

Subunit structurei

Interacts with MRG1 and MRG2 (PubMed:25183522). Component of the NuA4 histone acetyltransferase complex (Ref. 11).2 Publications

Protein-protein interaction databases

BioGridi21824, 3 interactors
IntActiQ9FLF7, 8 interactors
STRINGi3702.AT5G64610.1

Structurei

3D structure databases

ProteinModelPortaliQ9FLF7
SMRiQ9FLF7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 133ChromoAdd BLAST60
Domaini169 – 440MYST-type HATPROSITE-ProRule annotationAdd BLAST272

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni312 – 314Acetyl-CoA bindingBy similarity3
Regioni319 – 325Acetyl-CoA bindingBy similarity7

Sequence similaritiesi

Belongs to the MYST (SAS/MOZ) family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri202 – 227C2HC MYST-typePROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2747 Eukaryota
COG5027 LUCA
HOGENOMiHOG000182457
InParanoidiQ9FLF7
KOiK11308
OMAiMVGHSED
OrthoDBiEOG09360B38
PhylomeDBiQ9FLF7

Family and domain databases

CDDicd00024 CHROMO, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR002717 HAT_MYST-type
IPR025995 Tudor-knot
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF01853 MOZ_SAS, 1 hit
PF11717 Tudor-knot, 1 hit
SMARTiView protein in SMART
SM00298 CHROMO, 1 hit
SUPFAMiSSF54160 SSF54160, 1 hit
SSF55729 SSF55729, 1 hit
PROSITEiView protein in PROSITE
PS51726 MYST_HAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q9FLF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSSADTETA MIIATPASNH NNPATNGGDA NQNHTSGAIL ALTNSESDAS
60 70 80 90 100
KKRRMGVLPL EVGTRVMCQW RDGKYHPVKV IERRKNYNGG HNDYEYYVHY
110 120 130 140 150
TEFNRRLDEW IKLEQLDLDS VECALDEKVE DKVTSLKMTR HQKRKIDETH
160 170 180 190 200
VEGHEELDAA SLREHEEFTK VKNIATIELG KYEIETWYFS PFPPEYNDCV
210 220 230 240 250
KLFFCEFCLS FMKRKEQLQR HMRKCDLKHP PGDEIYRSST LSMFEVDGKK
260 270 280 290 300
NKVYAQNLCY LAKLFLDHKT LYYDVDLFLF YILCECDDRG CHMVGYFSKE
310 320 330 340 350
KHSEEAYNLA CILTLPPYQR KGYGKFLIAF SYELSKKEGK VGTPERPLSD
360 370 380 390 400
LGLVSYRGYW TRILLDILKK HKGNISIKEL SDMTAIKAED ILSTLQSLEL
410 420 430 440
IQYRKGQHVI CADPKVLDRH LKAAGRGGLD VDVSKMIWTP YKEQS
Length:445
Mass (Da):51,438
Last modified:March 1, 2001 - v1
Checksum:iF2243F5808ADE207
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010076 Genomic DNA Translation: BAB11428.1
CP002688 Genomic DNA Translation: AED97926.1
AY099684 mRNA Translation: AAM20535.1
BT000277 mRNA Translation: AAN15596.1
AB493812 mRNA Translation: BAH30650.1
RefSeqiNP_201266.1, NM_125857.3
UniGeneiAt.28949
At.49220

Genome annotation databases

EnsemblPlantsiAT5G64610.1; AT5G64610.1; AT5G64610
GeneIDi836582
GrameneiAT5G64610.1; AT5G64610.1; AT5G64610
KEGGiath:AT5G64610

Similar proteinsi

Entry informationi

Entry nameiMYST1_ARATH
AccessioniPrimary (citable) accession number: Q9FLF7
Secondary accession number(s): C0SVV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 1, 2001
Last modified: April 25, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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