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Q9FLF7 (MYST1_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable MYST-like histone acetyltransferase 1
EC=2.3.1.48
Gene names
Name:HAG4
Ordered Locus Names:At5g64610
ORF Names:MUB3.13
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length445 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Histone acetyltransferase which may be involved in transcriptional activation By similarity.

Catalytic activity

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Subcellular location

Nucleus Probable.

Post-translational modification

Autoacetylation at Lys-269 is required for proper function By similarity.

Sequence similarities

Belongs to the MYST (SAS/MOZ) family.

Contains 1 C2HC-type zinc finger.

Contains 1 chromo domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 445445Probable MYST-like histone acetyltransferase 1
PRO_0000238464

Regions

Domain74 – 13360Chromo
Zinc finger203 – 22523C2HC-type
Region319 – 3257Acetyl-CoA binding By similarity

Sites

Active site2691 By similarity
Active site3111Nucleophile By similarity
Binding site3141Acetyl-CoA By similarity
Binding site3491Acetyl-CoA By similarity

Amino acid modifications

Modified residue2691N6-acetyllysine; by autocatalysis By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9FLF7 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: F2243F5808ADE207

FASTA44551,438
        10         20         30         40         50         60 
MGSSADTETA MIIATPASNH NNPATNGGDA NQNHTSGAIL ALTNSESDAS KKRRMGVLPL 

        70         80         90        100        110        120 
EVGTRVMCQW RDGKYHPVKV IERRKNYNGG HNDYEYYVHY TEFNRRLDEW IKLEQLDLDS 

       130        140        150        160        170        180 
VECALDEKVE DKVTSLKMTR HQKRKIDETH VEGHEELDAA SLREHEEFTK VKNIATIELG 

       190        200        210        220        230        240 
KYEIETWYFS PFPPEYNDCV KLFFCEFCLS FMKRKEQLQR HMRKCDLKHP PGDEIYRSST 

       250        260        270        280        290        300 
LSMFEVDGKK NKVYAQNLCY LAKLFLDHKT LYYDVDLFLF YILCECDDRG CHMVGYFSKE 

       310        320        330        340        350        360 
KHSEEAYNLA CILTLPPYQR KGYGKFLIAF SYELSKKEGK VGTPERPLSD LGLVSYRGYW 

       370        380        390        400        410        420 
TRILLDILKK HKGNISIKEL SDMTAIKAED ILSTLQSLEL IQYRKGQHVI CADPKVLDRH 

       430        440 
LKAAGRGGLD VDVSKMIWTP YKEQS

« Hide

References

« Hide 'large scale' references
[1]"Structural analysis of Arabidopsis thaliana chromosome 5. IV. Sequence features of the regions of 1,456,315 bp covered by nineteen physically assigned P1 and TAC clones."
Sato S., Kaneko T., Kotani H., Nakamura Y., Asamizu E., Miyajima N., Tabata S.
DNA Res. 5:41-54(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[4]"Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes."
Pandey R., Mueller A., Napoli C.A., Selinger D.A., Pikaard C.S., Richards E.J., Bender J., Mount D.W., Jorgensen R.A.
Nucleic Acids Res. 30:5036-5055(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, NOMENCLATURE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB010076 Genomic DNA. Translation: BAB11428.1.
CP002688 Genomic DNA. Translation: AED97926.1.
AY099684 mRNA. Translation: AAM20535.1.
BT000277 mRNA. Translation: AAN15596.1.
IPIIPI00525918.
RefSeqNP_201266.1. NM_125857.2.
UniGeneAt.28949.
At.49220.

3D structure databases

ProteinModelPortalQ9FLF7.
SMRQ9FLF7. Positions 172-440.
ModBaseSearch...

Protein-protein interaction databases

IntActQ9FLF7. 1 interaction.

Proteomic databases

PaxDbQ9FLF7.
PRIDEQ9FLF7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT5G64610.1; AT5G64610.1; AT5G64610.
GeneID836582.
KEGGath:AT5G64610.

Organism-specific databases

TAIRAt5g64610.

Phylogenomic databases

eggNOGCOG5027.
HOGENOMHOG000182457.
InParanoidQ9FLF7.
KOK11308.
OMAEEDEKGH.
PhylomeDBQ9FLF7.
ProtClustDBPLN00104.

Gene expression databases

ArrayExpressQ9FLF7.
GenevestigatorQ9FLF7.
GermOnlineAT5G64610. Arabidopsis thaliana.

Family and domain databases

Gene3D3.40.630.30. 1 hit.
InterProIPR016181. Acyl_CoA_acyltransferase.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR002717. MOZ_SAS.
IPR025995. Tudor-knot.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamPF01853. MOZ_SAS. 1 hit.
PF11717. Tudor-knot. 1 hit.
[Graphical view]
SMARTSM00298. CHROMO. 1 hit.
SM00355. ZnF_C2H2. 1 hit.
[Graphical view]
SUPFAMSSF55729. Acyl_CoA_acyltransferase. 1 hit.
SSF54160. Chromodomain-like. 1 hit.
PROSITEPS00598. CHROMO_1. False negative.
PS50013. CHROMO_2. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMYST1_ARATH
AccessionPrimary (citable) accession number: Q9FLF7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 1, 2001
Last modified: May 1, 2013
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents