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Q9FLF7

- MYST1_ARATH

UniProt

Q9FLF7 - MYST1_ARATH

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Protein

Probable MYST-like histone acetyltransferase 1

Gene

HAG4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Histone acetyltransferase which may be involved in transcriptional activation.By similarity

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei345 – 3451Proton donor/acceptorBy similarity
Binding sitei349 – 3491Acetyl-CoABy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri203 – 22523C2HC-typeAdd
BLAST

GO - Molecular functioni

  1. histone acetyltransferase activity Source: TAIR
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA repair Source: TAIR
  2. histone acetylation Source: GOC
  3. regulation of transcription, DNA-templated Source: UniProtKB-KW
  4. response to UV-B Source: TAIR
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Acyltransferase, Chromatin regulator, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciARA:AT5G64610-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable MYST-like histone acetyltransferase 1 (EC:2.3.1.48By similarity)
Gene namesi
Name:HAG4
Ordered Locus Names:At5g64610
ORF Names:MUB3.13
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G64610.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Probable MYST-like histone acetyltransferase 1PRO_0000238464Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei269 – 2691N6-acetyllysine; by autocatalysisBy similarity

Post-translational modificationi

Autoacetylation at Lys-269 is required for proper function.By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9FLF7.
PRIDEiQ9FLF7.

Expressioni

Gene expression databases

ExpressionAtlasiQ9FLF7. baseline and differential.
GenevestigatoriQ9FLF7.

Interactioni

Protein-protein interaction databases

BioGridi21824. 1 interaction.
IntActiQ9FLF7. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9FLF7.
SMRiQ9FLF7. Positions 172-440.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini74 – 13360ChromoAdd
BLAST
Domaini169 – 440272MYST-type HATAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni312 – 3143Acetyl-CoA bindingBy similarity
Regioni319 – 3257Acetyl-CoA bindingBy similarity

Sequence similaritiesi

Belongs to the MYST (SAS/MOZ) family.Curated
Contains 1 C2HC-type zinc finger.Curated
Contains 1 chromo domain.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri203 – 22523C2HC-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG5027.
HOGENOMiHOG000182457.
InParanoidiQ9FLF7.
KOiK11308.
OMAiRRLDEWI.
PhylomeDBiQ9FLF7.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR002717. MOZ_SAS.
IPR025995. Tudor-knot.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF01853. MOZ_SAS. 1 hit.
PF11717. Tudor-knot. 1 hit.
[Graphical view]
SMARTiSM00298. CHROMO. 1 hit.
SM00355. ZnF_C2H2. 1 hit.
[Graphical view]
SUPFAMiSSF54160. SSF54160. 1 hit.
SSF55729. SSF55729. 1 hit.
PROSITEiPS51726. MYST_HAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9FLF7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSSADTETA MIIATPASNH NNPATNGGDA NQNHTSGAIL ALTNSESDAS
60 70 80 90 100
KKRRMGVLPL EVGTRVMCQW RDGKYHPVKV IERRKNYNGG HNDYEYYVHY
110 120 130 140 150
TEFNRRLDEW IKLEQLDLDS VECALDEKVE DKVTSLKMTR HQKRKIDETH
160 170 180 190 200
VEGHEELDAA SLREHEEFTK VKNIATIELG KYEIETWYFS PFPPEYNDCV
210 220 230 240 250
KLFFCEFCLS FMKRKEQLQR HMRKCDLKHP PGDEIYRSST LSMFEVDGKK
260 270 280 290 300
NKVYAQNLCY LAKLFLDHKT LYYDVDLFLF YILCECDDRG CHMVGYFSKE
310 320 330 340 350
KHSEEAYNLA CILTLPPYQR KGYGKFLIAF SYELSKKEGK VGTPERPLSD
360 370 380 390 400
LGLVSYRGYW TRILLDILKK HKGNISIKEL SDMTAIKAED ILSTLQSLEL
410 420 430 440
IQYRKGQHVI CADPKVLDRH LKAAGRGGLD VDVSKMIWTP YKEQS
Length:445
Mass (Da):51,438
Last modified:March 1, 2001 - v1
Checksum:iF2243F5808ADE207
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010076 Genomic DNA. Translation: BAB11428.1.
CP002688 Genomic DNA. Translation: AED97926.1.
AY099684 mRNA. Translation: AAM20535.1.
BT000277 mRNA. Translation: AAN15596.1.
RefSeqiNP_201266.1. NM_125857.2.
UniGeneiAt.28949.
At.49220.

Genome annotation databases

EnsemblPlantsiAT5G64610.1; AT5G64610.1; AT5G64610.
GeneIDi836582.
KEGGiath:AT5G64610.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010076 Genomic DNA. Translation: BAB11428.1 .
CP002688 Genomic DNA. Translation: AED97926.1 .
AY099684 mRNA. Translation: AAM20535.1 .
BT000277 mRNA. Translation: AAN15596.1 .
RefSeqi NP_201266.1. NM_125857.2.
UniGenei At.28949.
At.49220.

3D structure databases

ProteinModelPortali Q9FLF7.
SMRi Q9FLF7. Positions 172-440.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 21824. 1 interaction.
IntActi Q9FLF7. 1 interaction.

Proteomic databases

PaxDbi Q9FLF7.
PRIDEi Q9FLF7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G64610.1 ; AT5G64610.1 ; AT5G64610 .
GeneIDi 836582.
KEGGi ath:AT5G64610.

Organism-specific databases

TAIRi AT5G64610.

Phylogenomic databases

eggNOGi COG5027.
HOGENOMi HOG000182457.
InParanoidi Q9FLF7.
KOi K11308.
OMAi RRLDEWI.
PhylomeDBi Q9FLF7.

Enzyme and pathway databases

BioCyci ARA:AT5G64610-MONOMER.

Gene expression databases

ExpressionAtlasi Q9FLF7. baseline and differential.
Genevestigatori Q9FLF7.

Family and domain databases

Gene3Di 3.40.630.30. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR002717. MOZ_SAS.
IPR025995. Tudor-knot.
IPR015880. Znf_C2H2-like.
[Graphical view ]
Pfami PF01853. MOZ_SAS. 1 hit.
PF11717. Tudor-knot. 1 hit.
[Graphical view ]
SMARTi SM00298. CHROMO. 1 hit.
SM00355. ZnF_C2H2. 1 hit.
[Graphical view ]
SUPFAMi SSF54160. SSF54160. 1 hit.
SSF55729. SSF55729. 1 hit.
PROSITEi PS51726. MYST_HAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis of Arabidopsis thaliana chromosome 5. IV. Sequence features of the regions of 1,456,315 bp covered by nineteen physically assigned P1 and TAC clones."
    Sato S., Kaneko T., Kotani H., Nakamura Y., Asamizu E., Miyajima N., Tabata S.
    DNA Res. 5:41-54(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes."
    Pandey R., Mueller A., Napoli C.A., Selinger D.A., Pikaard C.S., Richards E.J., Bender J., Mount D.W., Jorgensen R.A.
    Nucleic Acids Res. 30:5036-5055(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, NOMENCLATURE.

Entry informationi

Entry nameiMYST1_ARATH
AccessioniPrimary (citable) accession number: Q9FLF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3