SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9FLB5

- LAC12_ARATH

UniProt

Q9FLB5 - LAC12_ARATH

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Laccase-12
Gene
LAC12, At5g05390, K18I23.20
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products By similarity.

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Binds 4 copper ions per monomer By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi82 – 821Copper 1; type 2 By similarity
Metal bindingi84 – 841Copper 2; type 3 By similarity
Metal bindingi127 – 1271Copper 2; type 3 By similarity
Metal bindingi129 – 1291Copper 3; type 3 By similarity
Metal bindingi466 – 4661Copper 4; type 1 By similarity
Metal bindingi469 – 4691Copper 1; type 2 By similarity
Metal bindingi471 – 4711Copper 3; type 3 By similarity
Metal bindingi528 – 5281Copper 3; type 3 By similarity
Metal bindingi529 – 5291Copper 4; type 1 By similarity
Metal bindingi530 – 5301Copper 2; type 3 By similarity
Metal bindingi534 – 5341Copper 4; type 1 By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. lignin catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT5G05390-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-12 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 12
Diphenol oxidase 12
Urishiol oxidase 12
Gene namesi
Name:LAC12
Ordered Locus Names:At5g05390
ORF Names:K18I23.20
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G05390.

Subcellular locationi

Secretedextracellular spaceapoplast Reviewed prediction

GO - Cellular componenti

  1. apoplast Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed prediction
Add
BLAST
Chaini25 – 565541Laccase-12
PRO_0000283640Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi78 – 781N-linked (GlcNAc...) Reviewed prediction
Glycosylationi187 – 1871N-linked (GlcNAc...) Reviewed prediction
Glycosylationi203 – 2031N-linked (GlcNAc...) Reviewed prediction
Glycosylationi298 – 2981N-linked (GlcNAc...) Reviewed prediction
Glycosylationi325 – 3251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi377 – 3771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi387 – 3871N-linked (GlcNAc...) Reviewed prediction
Glycosylationi395 – 3951N-linked (GlcNAc...) Reviewed prediction
Glycosylationi428 – 4281N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9FLB5.
PRIDEiQ9FLB5.

Expressioni

Tissue specificityi

Predominantly expressed in the inflorescence stem.2 Publications

Gene expression databases

GenevestigatoriQ9FLB5.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G05390.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9FLB5.
SMRiQ9FLB5. Positions 24-544.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 148117Plastocyanin-like 1
Add
BLAST
Domaini158 – 310153Plastocyanin-like 2
Add
BLAST
Domaini413 – 549137Plastocyanin-like 3
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG2132.
HOGENOMiHOG000241916.
InParanoidiQ9FLB5.
OMAiNISRALF.
PhylomeDBiQ9FLB5.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 4 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9FLB5-1 [UniParc]FASTAAdd to Basket

« Hide

MTTVHTFSIL LFFCSLFSAS LIIAKVQHHD FVIQETPVKR LCKTRNAITV    50
NGMFPGPTLE VNNGDTLEVK VHNRARYNIT IHWHGVRQIR TGWADGPEFV 100
TQCPIRPGKS YTYRFTIQGQ EGTLWWHAHS SWLRATVYGA LIIHPTPGSS 150
FPFPKPDRQT ALMLGEWWNA NPVDVINQAT RTGAAPNISD AYTINGQPGD 200
LYNCSTKETV VVPINSGETS LLRVINAALN QPLFFTVANH KLTVVGADAS 250
YLKPFTTKVL MLGPGQTTDV LLTADQPPKR YYIAARAYQS AQNAPFDNTT 300
TTAILQYKKT TTTSKPIMPV LPAFNDTNTV TSFSRKFKSL RNVVVPKTID 350
DNLFFTIGLG LDNCPKKFPK SRCQGLNGTR FTASMNNVSF VLPSNFSLLQ 400
AHSNGIPGVF TTDFPSKPPV KFDYTGNNIS RALFQPVKGT KLYKLKYGSR 450
VQVVLQDTNI VTSENHPIHL HGYDFYIVGE GFGNFNPKKD TSKFNLVDPP 500
LRNTVAVPVN GWAVIRFVAD NPGVWLMHCH LDVHIKWGLA MAFLVDNGVG 550
ELETLEAPPH DLPIC 565
Length:565
Mass (Da):62,734
Last modified:March 1, 2001 - v1
Checksum:i15DA9DDD5CA8932E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB010692 Genomic DNA. Translation: BAB09982.1.
CP002688 Genomic DNA. Translation: AED90868.1.
RefSeqiNP_196158.1. NM_120621.1.
UniGeneiAt.54730.

Genome annotation databases

EnsemblPlantsiAT5G05390.1; AT5G05390.1; AT5G05390.
GeneIDi830421.
KEGGiath:AT5G05390.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB010692 Genomic DNA. Translation: BAB09982.1 .
CP002688 Genomic DNA. Translation: AED90868.1 .
RefSeqi NP_196158.1. NM_120621.1.
UniGenei At.54730.

3D structure databases

ProteinModelPortali Q9FLB5.
SMRi Q9FLB5. Positions 24-544.
ModBasei Search...

Protein-protein interaction databases

STRINGi 3702.AT5G05390.1-P.

Proteomic databases

PaxDbi Q9FLB5.
PRIDEi Q9FLB5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G05390.1 ; AT5G05390.1 ; AT5G05390 .
GeneIDi 830421.
KEGGi ath:AT5G05390.

Organism-specific databases

TAIRi AT5G05390.

Phylogenomic databases

eggNOGi COG2132.
HOGENOMi HOG000241916.
InParanoidi Q9FLB5.
OMAi NISRALF.
PhylomeDBi Q9FLB5.

Enzyme and pathway databases

BioCyci ARA:AT5G05390-MONOMER.

Gene expression databases

Genevestigatori Q9FLB5.

Family and domain databases

Gene3Di 2.60.40.420. 3 hits.
InterProi IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view ]
Pfami PF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 4 hits.
TIGRFAMsi TIGR03389. laccase. 1 hit.
PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence features of the regions of 1,381,565 bp covered by twenty one physically assigned P1 and TAC clones."
    Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N., Tabata S.
    DNA Res. 5:131-145(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Gene structure and molecular analysis of the laccase-like multicopper oxidase (LMCO) gene family in Arabidopsis thaliana."
    McCaig B.C., Meagher R.B., Dean J.F.D.
    Planta 221:619-636(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  4. "Mutant identification and characterization of the laccase gene family in Arabidopsis."
    Cai X., Davis E.J., Ballif J., Liang M., Bushman E., Haroldsen V., Torabinejad J., Wu Y.
    J. Exp. Bot. 57:2563-2569(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiLAC12_ARATH
AccessioniPrimary (citable) accession number: Q9FLB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 1, 2001
Last modified: May 14, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi