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Protein

Laccase-12

Gene

LAC12

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi82Copper 1; type 2By similarity1
Metal bindingi84Copper 2; type 3By similarity1
Metal bindingi127Copper 2; type 3By similarity1
Metal bindingi129Copper 3; type 3By similarity1
Metal bindingi466Copper 4; type 1By similarity1
Metal bindingi469Copper 1; type 2By similarity1
Metal bindingi471Copper 3; type 3By similarity1
Metal bindingi528Copper 3; type 3By similarity1
Metal bindingi529Copper 4; type 1By similarity1
Metal bindingi530Copper 2; type 3By similarity1
Metal bindingi534Copper 4; type 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processLignin degradation
LigandCopper, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT5G05390-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-12 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 12
Diphenol oxidase 12
Urishiol oxidase 12
Gene namesi
Name:LAC12
Ordered Locus Names:At5g05390
ORF Names:K18I23.20
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G05390
TAIRilocus:2153469 AT5G05390

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000028364025 – 565Laccase-12Add BLAST541

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi78N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi187N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi203N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi298N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi325N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi377N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi387N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi395N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi428N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9FLB5

Expressioni

Tissue specificityi

Predominantly expressed in the inflorescence stem.2 Publications

Gene expression databases

ExpressionAtlasiQ9FLB5 baseline and differential
GenevisibleiQ9FLB5 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G05390.1

Structurei

3D structure databases

ProteinModelPortaliQ9FLB5
SMRiQ9FLB5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 148Plastocyanin-like 1Add BLAST117
Domaini158 – 310Plastocyanin-like 2Add BLAST153
Domaini413 – 549Plastocyanin-like 3Add BLAST137

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1263 Eukaryota
COG2132 LUCA
HOGENOMiHOG000241916
InParanoidiQ9FLB5
KOiK05909
OMAiVPINSGE
OrthoDBiEOG093605O6
PhylomeDBiQ9FLB5

Family and domain databases

CDDicd13849 CuRO_1_LCC_plant, 1 hit
cd13875 CuRO_2_LCC_plant, 1 hit
cd13897 CuRO_3_LCC_plant, 1 hit
Gene3Di2.60.40.420, 3 hits
InterProiView protein in InterPro
IPR001117 Cu-oxidase
IPR011706 Cu-oxidase_2
IPR011707 Cu-oxidase_3
IPR033138 Cu_oxidase_CS
IPR002355 Cu_oxidase_Cu_BS
IPR008972 Cupredoxin
IPR034288 CuRO_1_LCC
IPR034285 CuRO_2_LCC
IPR034289 CuRO_3_LCC
IPR017761 Laccase
PfamiView protein in Pfam
PF00394 Cu-oxidase, 1 hit
PF07731 Cu-oxidase_2, 1 hit
PF07732 Cu-oxidase_3, 1 hit
SUPFAMiSSF49503 SSF49503, 4 hits
TIGRFAMsiTIGR03389 laccase, 1 hit
PROSITEiView protein in PROSITE
PS00079 MULTICOPPER_OXIDASE1, 1 hit
PS00080 MULTICOPPER_OXIDASE2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9FLB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTVHTFSIL LFFCSLFSAS LIIAKVQHHD FVIQETPVKR LCKTRNAITV
60 70 80 90 100
NGMFPGPTLE VNNGDTLEVK VHNRARYNIT IHWHGVRQIR TGWADGPEFV
110 120 130 140 150
TQCPIRPGKS YTYRFTIQGQ EGTLWWHAHS SWLRATVYGA LIIHPTPGSS
160 170 180 190 200
FPFPKPDRQT ALMLGEWWNA NPVDVINQAT RTGAAPNISD AYTINGQPGD
210 220 230 240 250
LYNCSTKETV VVPINSGETS LLRVINAALN QPLFFTVANH KLTVVGADAS
260 270 280 290 300
YLKPFTTKVL MLGPGQTTDV LLTADQPPKR YYIAARAYQS AQNAPFDNTT
310 320 330 340 350
TTAILQYKKT TTTSKPIMPV LPAFNDTNTV TSFSRKFKSL RNVVVPKTID
360 370 380 390 400
DNLFFTIGLG LDNCPKKFPK SRCQGLNGTR FTASMNNVSF VLPSNFSLLQ
410 420 430 440 450
AHSNGIPGVF TTDFPSKPPV KFDYTGNNIS RALFQPVKGT KLYKLKYGSR
460 470 480 490 500
VQVVLQDTNI VTSENHPIHL HGYDFYIVGE GFGNFNPKKD TSKFNLVDPP
510 520 530 540 550
LRNTVAVPVN GWAVIRFVAD NPGVWLMHCH LDVHIKWGLA MAFLVDNGVG
560
ELETLEAPPH DLPIC
Length:565
Mass (Da):62,734
Last modified:March 1, 2001 - v1
Checksum:i15DA9DDD5CA8932E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010692 Genomic DNA Translation: BAB09982.1
CP002688 Genomic DNA Translation: AED90868.1
RefSeqiNP_196158.1, NM_120621.2

Genome annotation databases

EnsemblPlantsiAT5G05390.1; AT5G05390.1; AT5G05390
GeneIDi830421
GrameneiAT5G05390.1; AT5G05390.1; AT5G05390
KEGGiath:AT5G05390

Similar proteinsi

Entry informationi

Entry nameiLAC12_ARATH
AccessioniPrimary (citable) accession number: Q9FLB5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 1, 2001
Last modified: April 25, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health