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Q9FLB5

- LAC12_ARATH

UniProt

Q9FLB5 - LAC12_ARATH

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Protein

Laccase-12

Gene

LAC12

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi82 – 821Copper 1; type 2By similarity
Metal bindingi84 – 841Copper 2; type 3By similarity
Metal bindingi127 – 1271Copper 2; type 3By similarity
Metal bindingi129 – 1291Copper 3; type 3By similarity
Metal bindingi466 – 4661Copper 4; type 1By similarity
Metal bindingi469 – 4691Copper 1; type 2By similarity
Metal bindingi471 – 4711Copper 3; type 3By similarity
Metal bindingi528 – 5281Copper 3; type 3By similarity
Metal bindingi529 – 5291Copper 4; type 1By similarity
Metal bindingi530 – 5301Copper 2; type 3By similarity
Metal bindingi534 – 5341Copper 4; type 1By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

GO - Biological processi

  1. lignin catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT5G05390-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-12 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 12
Diphenol oxidase 12
Urishiol oxidase 12
Gene namesi
Name:LAC12
Ordered Locus Names:At5g05390
ORF Names:K18I23.20
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G05390.

Subcellular locationi

GO - Cellular componenti

  1. apoplast Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 565541Laccase-12PRO_0000283640Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi78 – 781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi187 – 1871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi203 – 2031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi298 – 2981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi325 – 3251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi377 – 3771N-linked (GlcNAc...)Sequence Analysis
Glycosylationi387 – 3871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi395 – 3951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi428 – 4281N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9FLB5.
PRIDEiQ9FLB5.

Expressioni

Tissue specificityi

Predominantly expressed in the inflorescence stem.2 Publications

Gene expression databases

GenevestigatoriQ9FLB5.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G05390.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9FLB5.
SMRiQ9FLB5. Positions 24-544.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 148117Plastocyanin-like 1Add
BLAST
Domaini158 – 310153Plastocyanin-like 2Add
BLAST
Domaini413 – 549137Plastocyanin-like 3Add
BLAST

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated
Contains 3 plastocyanin-like domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG2132.
HOGENOMiHOG000241916.
InParanoidiQ9FLB5.
OMAiNISRALF.
PhylomeDBiQ9FLB5.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 4 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9FLB5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTVHTFSIL LFFCSLFSAS LIIAKVQHHD FVIQETPVKR LCKTRNAITV
60 70 80 90 100
NGMFPGPTLE VNNGDTLEVK VHNRARYNIT IHWHGVRQIR TGWADGPEFV
110 120 130 140 150
TQCPIRPGKS YTYRFTIQGQ EGTLWWHAHS SWLRATVYGA LIIHPTPGSS
160 170 180 190 200
FPFPKPDRQT ALMLGEWWNA NPVDVINQAT RTGAAPNISD AYTINGQPGD
210 220 230 240 250
LYNCSTKETV VVPINSGETS LLRVINAALN QPLFFTVANH KLTVVGADAS
260 270 280 290 300
YLKPFTTKVL MLGPGQTTDV LLTADQPPKR YYIAARAYQS AQNAPFDNTT
310 320 330 340 350
TTAILQYKKT TTTSKPIMPV LPAFNDTNTV TSFSRKFKSL RNVVVPKTID
360 370 380 390 400
DNLFFTIGLG LDNCPKKFPK SRCQGLNGTR FTASMNNVSF VLPSNFSLLQ
410 420 430 440 450
AHSNGIPGVF TTDFPSKPPV KFDYTGNNIS RALFQPVKGT KLYKLKYGSR
460 470 480 490 500
VQVVLQDTNI VTSENHPIHL HGYDFYIVGE GFGNFNPKKD TSKFNLVDPP
510 520 530 540 550
LRNTVAVPVN GWAVIRFVAD NPGVWLMHCH LDVHIKWGLA MAFLVDNGVG
560
ELETLEAPPH DLPIC
Length:565
Mass (Da):62,734
Last modified:March 1, 2001 - v1
Checksum:i15DA9DDD5CA8932E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010692 Genomic DNA. Translation: BAB09982.1.
CP002688 Genomic DNA. Translation: AED90868.1.
RefSeqiNP_196158.1. NM_120621.1.
UniGeneiAt.54730.

Genome annotation databases

EnsemblPlantsiAT5G05390.1; AT5G05390.1; AT5G05390.
GeneIDi830421.
KEGGiath:AT5G05390.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010692 Genomic DNA. Translation: BAB09982.1 .
CP002688 Genomic DNA. Translation: AED90868.1 .
RefSeqi NP_196158.1. NM_120621.1.
UniGenei At.54730.

3D structure databases

ProteinModelPortali Q9FLB5.
SMRi Q9FLB5. Positions 24-544.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT5G05390.1-P.

Proteomic databases

PaxDbi Q9FLB5.
PRIDEi Q9FLB5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G05390.1 ; AT5G05390.1 ; AT5G05390 .
GeneIDi 830421.
KEGGi ath:AT5G05390.

Organism-specific databases

TAIRi AT5G05390.

Phylogenomic databases

eggNOGi COG2132.
HOGENOMi HOG000241916.
InParanoidi Q9FLB5.
OMAi NISRALF.
PhylomeDBi Q9FLB5.

Enzyme and pathway databases

BioCyci ARA:AT5G05390-MONOMER.

Gene expression databases

Genevestigatori Q9FLB5.

Family and domain databases

Gene3Di 2.60.40.420. 3 hits.
InterProi IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view ]
Pfami PF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 4 hits.
TIGRFAMsi TIGR03389. laccase. 1 hit.
PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence features of the regions of 1,381,565 bp covered by twenty one physically assigned P1 and TAC clones."
    Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N., Tabata S.
    DNA Res. 5:131-145(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Gene structure and molecular analysis of the laccase-like multicopper oxidase (LMCO) gene family in Arabidopsis thaliana."
    McCaig B.C., Meagher R.B., Dean J.F.D.
    Planta 221:619-636(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  4. "Mutant identification and characterization of the laccase gene family in Arabidopsis."
    Cai X., Davis E.J., Ballif J., Liang M., Bushman E., Haroldsen V., Torabinejad J., Wu Y.
    J. Exp. Bot. 57:2563-2569(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiLAC12_ARATH
AccessioniPrimary (citable) accession number: Q9FLB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 1, 2001
Last modified: November 26, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3