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Q9FKT9

- NAS2_ARATH

UniProt

Q9FKT9 - NAS2_ARATH

Protein

Nicotianamine synthase 2

Gene

NAS2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Synthesizes nicotianamine, a polyamine which serves as a sensor for the physiological iron status within the plant, and/or might be involved in the transport of iron.

    Catalytic activityi

    3 S-adenosyl-L-methionine = 3 S-methyl-5'-thioadenosine + nicotianamine.

    GO - Molecular functioni

    1. nicotianamine synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular response to ethylene stimulus Source: TAIR
    2. cellular response to iron ion Source: TAIR
    3. cellular response to nitric oxide Source: TAIR
    4. nicotianamine biosynthetic process Source: InterPro
    5. phloem transport Source: TAIR
    6. pollen development Source: TAIR
    7. pollen tube growth Source: TAIR
    8. response to zinc ion Source: TAIR

    Keywords - Molecular functioni

    Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciARA:AT5G56080-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nicotianamine synthase 2 (EC:2.5.1.43)
    Alternative name(s):
    S-adenosyl-L-methionine:S-adenosyl-L-methionine:S-adenosyl-methionine 3-amino-3-carboxypropyltransferase 2
    Short name:
    AtNAS2
    Gene namesi
    Name:NAS2
    Ordered Locus Names:At5g56080
    ORF Names:MDA7.14
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 5

    Organism-specific databases

    TAIRiAT5G56080.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 320320Nicotianamine synthase 2PRO_0000212701Add
    BLAST

    Proteomic databases

    PaxDbiQ9FKT9.
    PRIDEiQ9FKT9.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9FKT9.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT5G56080.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9FKT9.
    SMRiQ9FKT9. Positions 90-274.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0500.
    HOGENOMiHOG000025525.
    InParanoidiQ9FKT9.
    KOiK05953.
    OMAiMACENNL.
    PhylomeDBiQ9FKT9.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR004298. Nicotian_synth.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF03059. NAS. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51142. NAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9FKT9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MACENNLVVK QIMDLYNQIS NLESLKPSKN VDTLFRQLVS TCLPTDTNID    50
    VTEIHDEKVK DMRSHLIKLC GEAEGYLEQH FSAILGSFED NPLNHLHIFP 100
    YYNNYLKLGK LEFDLLSQHT THVPTKVAFI GSGPMPLTSI VLAKFHLPNT 150
    TFHNFDIDSH ANTLASNLVS RDSDLSKRMI FHTTDVLNAK EGLDQYDVVF 200
    LAALVGMDKE SKVKAIEHLE KHMAPGAVVM LRSAHGLRAF LYPIVDSCDL 250
    KGFEVLTIYH PSDDVVNSVV IARKLGGSNG ARGSQIGRCV VMPCNCSKVH 300
    AILNNRGMEK NLIEEYSAIE 320
    Length:320
    Mass (Da):35,679
    Last modified:March 1, 2001 - v1
    Checksum:i0F089819D3C05FCA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti4 – 41E → Q in BAA74590. 1 PublicationCurated
    Sequence conflicti316 – 3161Y → F in BAA74590. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB021935 Genomic DNA. Translation: BAA74590.1.
    AB011476 Genomic DNA. Translation: BAB09290.1.
    CP002688 Genomic DNA. Translation: AED96719.1.
    BT030013 mRNA. Translation: ABN04751.1.
    RefSeqiNP_200419.1. NM_124990.1.
    UniGeneiAt.49799.

    Genome annotation databases

    EnsemblPlantsiAT5G56080.1; AT5G56080.1; AT5G56080.
    GeneIDi835707.
    KEGGiath:AT5G56080.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB021935 Genomic DNA. Translation: BAA74590.1 .
    AB011476 Genomic DNA. Translation: BAB09290.1 .
    CP002688 Genomic DNA. Translation: AED96719.1 .
    BT030013 mRNA. Translation: ABN04751.1 .
    RefSeqi NP_200419.1. NM_124990.1.
    UniGenei At.49799.

    3D structure databases

    ProteinModelPortali Q9FKT9.
    SMRi Q9FKT9. Positions 90-274.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT5G56080.1-P.

    Proteomic databases

    PaxDbi Q9FKT9.
    PRIDEi Q9FKT9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT5G56080.1 ; AT5G56080.1 ; AT5G56080 .
    GeneIDi 835707.
    KEGGi ath:AT5G56080.

    Organism-specific databases

    TAIRi AT5G56080.

    Phylogenomic databases

    eggNOGi COG0500.
    HOGENOMi HOG000025525.
    InParanoidi Q9FKT9.
    KOi K05953.
    OMAi MACENNL.
    PhylomeDBi Q9FKT9.

    Enzyme and pathway databases

    BioCyci ARA:AT5G56080-MONOMER.

    Gene expression databases

    Genevestigatori Q9FKT9.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR004298. Nicotian_synth.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF03059. NAS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51142. NAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of nicotianamine synthase genes from Arabidopsis thaliana."
      Suzuki K., Higuchi K., Nakanishi H., Nishizawa N.-K., Mori S.
      Soil Sci. Plant Nutr. 45:993-1002(1999)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: cv. Columbia.
    2. "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence features of the regions of 1,381,565 bp covered by twenty one physically assigned P1 and TAC clones."
      Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N., Tabata S.
      DNA Res. 5:131-145(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Arabidopsis ORF clones."
      Bautista V.R., Kim C.J., Chen H., Wu S.Y., De Los Reyes C., Ecker J.R.
      Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.

    Entry informationi

    Entry nameiNAS2_ARATH
    AccessioniPrimary (citable) accession number: Q9FKT9
    Secondary accession number(s): A2RVM2, Q9ZWF7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 13, 2002
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3