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Protein

Zinc-finger homeodomain protein 1

Gene

ZHD1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Putative transcription factor.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei243Required for DNA-bindingBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri75 – 124ZF-HD dimerization-typePROSITE-ProRule annotationAdd BLAST50
DNA bindingi191 – 254Homeobox; atypicalAdd BLAST64

GO - Molecular functioni

GO - Biological processi

  • regulation of gibberellin biosynthetic process Source: TAIR
  • regulation of transcription, DNA-templated Source: TAIR
  • seed maturation Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc-finger homeodomain protein 1
Short name:
AtZHD1
Alternative name(s):
Homeobox protein 25
Short name:
AtHB-25
Zinc finger homeodomain transcription factor 2
Gene namesi
Name:ZHD1
Synonyms:HB25, ZFHD2
Ordered Locus Names:At5g65410
ORF Names:MNA5.14
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G65410
TAIRilocus:2168240 AT5G65410

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000568471 – 279Zinc-finger homeodomain protein 1Add BLAST279

Proteomic databases

PaxDbiQ9FKP8

PTM databases

iPTMnetiQ9FKP8

Expressioni

Tissue specificityi

Mostly expressed in flowers and inflorescence.1 Publication

Gene expression databases

ExpressionAtlasiQ9FKP8 baseline and differential
GenevisibleiQ9FKP8 AT

Interactioni

Subunit structurei

Homo- and heterodimer with other ZFHD proteins (By similarity). Interacts with MIF1 and MIF2; these interactions prevent nuclear localization and DNA-binding to inhibit transcription regulation activity. Binds to ZHD2, ZHD3, ZHD4, ZHD5, ZHD6, ZHD7, ZHD8, ZHD9, ZHD10 and ZHD11.By similarity2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi21908, 13 interactors
IntActiQ9FKP8, 13 interactors
STRINGi3702.AT5G65410.1

Structurei

Secondary structure

1279
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi200 – 213Combined sources14
Turni219 – 221Combined sources3
Helixi222 – 231Combined sources10
Helixi236 – 246Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WH5NMR-A182-248[»]
ProteinModelPortaliQ9FKP8
SMRiQ9FKP8
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9FKP8

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi6 – 10Poly-Asn5
Compositional biasi22 – 25Poly-Glu4
Compositional biasi52 – 104Gly-richAdd BLAST53
Compositional biasi132 – 170Pro-richAdd BLAST39
Compositional biasi254 – 268Pro-richAdd BLAST15

Domaini

The homeodomain differs form the typical one by having namely 4 instead of 3 extra amino acids inserted in the loop between helix 1 and helix 2.

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri75 – 124ZF-HD dimerization-typePROSITE-ProRule annotationAdd BLAST50

Keywords - Domaini

Homeobox, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IVYH Eukaryota
ENOG410YEN7 LUCA
HOGENOMiHOG000238105
InParanoidiQ9FKP8
OMAiDEMNLHE
OrthoDBiEOG09360PCW
PhylomeDBiQ9FKP8

Family and domain databases

InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR006455 Homeodomain_ZF_HD
IPR006456 ZF_HD_homeobox_Cys/His_dimer
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF04770 ZF-HD_dimer, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD125774 ZF_HD_N, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
TIGRFAMsiTIGR01565 homeo_ZF_HD, 1 hit
TIGR01566 ZF_HD_prot_N, 1 hit
PROSITEiView protein in PROSITE
PS51523 ZF_HD_DIMER, 1 hit

Sequencei

Sequence statusi: Complete.

Q9FKP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFEDNNNNN DEEQEEDMNL HEEEEDDDAV YDSPPLSRVL PKASTESHET
60 70 80 90 100
TGTTSTGGGG GFMVVHGGGG SRFRFRECLK NQAVNIGGHA VDGCGEFMPA
110 120 130 140 150
GIEGTIDALK CAACGCHRNF HRKELPYFHH APPQHQPPPP PPGFYRLPAP
160 170 180 190 200
VSYRPPPSQA PPLQLALPPP QRERSEDPME TSSAEAGGGI RKRHRTKFTA
210 220 230 240 250
EQKERMLALA ERIGWRIQRQ DDEVIQRFCQ ETGVPRQVLK VWLHNNKHTL
260 270
GKSPSPLHHH QAPPPPPPQS SFHHEQDQP
Length:279
Mass (Da):31,098
Last modified:March 1, 2001 - v1
Checksum:iB9809820DD45B780
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011479 Genomic DNA Translation: BAB11563.1
CP002688 Genomic DNA Translation: AED98048.1
BT002385 mRNA Translation: AAO00745.1
BT006304 mRNA Translation: AAP13412.1
RefSeqiNP_201344.1, NM_125939.3
UniGeneiAt.43744

Genome annotation databases

EnsemblPlantsiAT5G65410.1; AT5G65410.1; AT5G65410
GeneIDi836666
GrameneiAT5G65410.1; AT5G65410.1; AT5G65410
KEGGiath:AT5G65410

Similar proteinsi

Entry informationi

Entry nameiZHD1_ARATH
AccessioniPrimary (citable) accession number: Q9FKP8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 1, 2001
Last modified: April 25, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health