Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc-finger homeodomain protein 1

Gene

ZHD1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Putative transcription factor.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei243 – 2431Required for DNA-bindingBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri75 – 12450ZF-HD dimerization-typePROSITE-ProRule annotationAdd
BLAST
DNA bindingi191 – 25464Homeobox; atypicalAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • regulation of gibberellin biosynthetic process Source: TAIR
  • regulation of transcription, DNA-templated Source: TAIR
  • seed maturation Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc-finger homeodomain protein 1
Short name:
AtZHD1
Alternative name(s):
Homeobox protein 25
Short name:
AtHB-25
Zinc finger homeodomain transcription factor 2
Gene namesi
Name:ZHD1
Synonyms:HB25, ZFHD2
Ordered Locus Names:At5g65410
ORF Names:MNA5.14
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G65410.

Subcellular locationi

  • Nucleus Curated

  • Note: Interactions with MIF proteins prevent nuclear subcellular location and leads to a scattered repartition throughout the cytoplasm.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 279279Zinc-finger homeodomain protein 1PRO_0000056847Add
BLAST

Proteomic databases

PaxDbiQ9FKP8.
PRIDEiQ9FKP8.

PTM databases

iPTMnetiQ9FKP8.

Expressioni

Tissue specificityi

Mostly expressed in flowers and inflorescence.1 Publication

Gene expression databases

GenevisibleiQ9FKP8. AT.

Interactioni

Subunit structurei

Homo- and heterodimer with other ZFHD proteins (By similarity). Interacts with MIF1 and MIF2; these interactions prevent nuclear localization and DNA-binding to inhibit transcription regulation activity. Binds to ZHD2, ZHD3, ZHD4, ZHD5, ZHD6, ZHD7, ZHD8, ZHD9, ZHD10 and ZHD11.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ZHD10Q9FIW93EBI-766685,EBI-1806298

GO - Molecular functioni

Protein-protein interaction databases

BioGridi21908. 13 interactions.
IntActiQ9FKP8. 13 interactions.
MINTiMINT-1366403.
STRINGi3702.AT5G65410.1.

Structurei

Secondary structure

1
279
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi200 – 21314Combined sources
Turni219 – 2213Combined sources
Helixi222 – 23110Combined sources
Helixi236 – 24611Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WH5NMR-A182-248[»]
ProteinModelPortaliQ9FKP8.
SMRiQ9FKP8. Positions 190-249.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9FKP8.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi6 – 105Poly-Asn
Compositional biasi22 – 254Poly-Glu
Compositional biasi52 – 10453Gly-richAdd
BLAST
Compositional biasi132 – 17039Pro-richAdd
BLAST
Compositional biasi254 – 26815Pro-richAdd
BLAST

Domaini

The homeodomain differs form the typical one by having namely 4 instead of 3 extra amino acids inserted in the loop between helix 1 and helix 2.

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.Curated
Contains 1 ZF-HD dimerization-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri75 – 12450ZF-HD dimerization-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Homeobox, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IVYH. Eukaryota.
ENOG410YEN7. LUCA.
HOGENOMiHOG000238105.
InParanoidiQ9FKP8.
OMAiFMPAGIE.
OrthoDBiEOG09360PCW.
PhylomeDBiQ9FKP8.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR006455. Homeodomain_ZF_HD.
IPR006456. ZF_HD_homeobox_Cys/His_dimer.
IPR007087. Znf_C2H2.
[Graphical view]
PfamiPF04770. ZF-HD_dimer. 1 hit.
[Graphical view]
ProDomiPD125774. ZF_HD_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF46689. SSF46689. 1 hit.
TIGRFAMsiTIGR01565. homeo_ZF_HD. 1 hit.
TIGR01566. ZF_HD_prot_N. 1 hit.
PROSITEiPS51523. ZF_HD_DIMER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9FKP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFEDNNNNN DEEQEEDMNL HEEEEDDDAV YDSPPLSRVL PKASTESHET
60 70 80 90 100
TGTTSTGGGG GFMVVHGGGG SRFRFRECLK NQAVNIGGHA VDGCGEFMPA
110 120 130 140 150
GIEGTIDALK CAACGCHRNF HRKELPYFHH APPQHQPPPP PPGFYRLPAP
160 170 180 190 200
VSYRPPPSQA PPLQLALPPP QRERSEDPME TSSAEAGGGI RKRHRTKFTA
210 220 230 240 250
EQKERMLALA ERIGWRIQRQ DDEVIQRFCQ ETGVPRQVLK VWLHNNKHTL
260 270
GKSPSPLHHH QAPPPPPPQS SFHHEQDQP
Length:279
Mass (Da):31,098
Last modified:March 1, 2001 - v1
Checksum:iB9809820DD45B780
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011479 Genomic DNA. Translation: BAB11563.1.
CP002688 Genomic DNA. Translation: AED98048.1.
BT002385 mRNA. Translation: AAO00745.1.
BT006304 mRNA. Translation: AAP13412.1.
RefSeqiNP_201344.1. NM_125939.2.
UniGeneiAt.43744.

Genome annotation databases

EnsemblPlantsiAT5G65410.1; AT5G65410.1; AT5G65410.
GeneIDi836666.
GrameneiAT5G65410.1; AT5G65410.1; AT5G65410.
KEGGiath:AT5G65410.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011479 Genomic DNA. Translation: BAB11563.1.
CP002688 Genomic DNA. Translation: AED98048.1.
BT002385 mRNA. Translation: AAO00745.1.
BT006304 mRNA. Translation: AAP13412.1.
RefSeqiNP_201344.1. NM_125939.2.
UniGeneiAt.43744.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WH5NMR-A182-248[»]
ProteinModelPortaliQ9FKP8.
SMRiQ9FKP8. Positions 190-249.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi21908. 13 interactions.
IntActiQ9FKP8. 13 interactions.
MINTiMINT-1366403.
STRINGi3702.AT5G65410.1.

PTM databases

iPTMnetiQ9FKP8.

Proteomic databases

PaxDbiQ9FKP8.
PRIDEiQ9FKP8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G65410.1; AT5G65410.1; AT5G65410.
GeneIDi836666.
GrameneiAT5G65410.1; AT5G65410.1; AT5G65410.
KEGGiath:AT5G65410.

Organism-specific databases

TAIRiAT5G65410.

Phylogenomic databases

eggNOGiENOG410IVYH. Eukaryota.
ENOG410YEN7. LUCA.
HOGENOMiHOG000238105.
InParanoidiQ9FKP8.
OMAiFMPAGIE.
OrthoDBiEOG09360PCW.
PhylomeDBiQ9FKP8.

Miscellaneous databases

EvolutionaryTraceiQ9FKP8.
PROiQ9FKP8.

Gene expression databases

GenevisibleiQ9FKP8. AT.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR006455. Homeodomain_ZF_HD.
IPR006456. ZF_HD_homeobox_Cys/His_dimer.
IPR007087. Znf_C2H2.
[Graphical view]
PfamiPF04770. ZF-HD_dimer. 1 hit.
[Graphical view]
ProDomiPD125774. ZF_HD_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF46689. SSF46689. 1 hit.
TIGRFAMsiTIGR01565. homeo_ZF_HD. 1 hit.
TIGR01566. ZF_HD_prot_N. 1 hit.
PROSITEiPS51523. ZF_HD_DIMER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZHD1_ARATH
AccessioniPrimary (citable) accession number: Q9FKP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.