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Q9FKP5

- UBP17_ARATH

UniProt

Q9FKP5 - UBP17_ARATH

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Protein
Ubiquitin carboxyl-terminal hydrolase 17
Gene
UBP17, At5g65450, MNA5.19
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei338 – 3381Nucleophile By similarity
Active sitei592 – 5921Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri57 – 9438MYND-type
Add
BLAST

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. ubiquitinyl hydrolase activity Source: InterPro

GO - Biological processi

  1. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciARA:AT5G65450-MONOMER.

Protein family/group databases

MEROPSiC19.A06.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 17 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 17
Short name:
AtUBP17
Ubiquitin thioesterase 17
Ubiquitin-specific-processing protease 17
Gene namesi
Name:UBP17
Ordered Locus Names:At5g65450
ORF Names:MNA5.19
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G65450.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 731731Ubiquitin carboxyl-terminal hydrolase 17
PRO_0000313043Add
BLAST

Proteomic databases

PaxDbiQ9FKP5.
PRIDEiQ9FKP5.

Expressioni

Gene expression databases

GenevestigatoriQ9FKP5.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G65450.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9FKP5.
SMRiQ9FKP5. Positions 330-630.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini329 – 633305USP
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi245 – 31268Ser-rich
Add
BLAST
Compositional biasi679 – 70224Ser-rich
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 1 USP domain.

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG5533.
HOGENOMiHOG000242869.
InParanoidiQ9FKP5.
KOiK11855.
OMAiQSICLKE.
PhylomeDBiQ9FKP5.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR002893. Znf_MYND.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
PF01753. zf-MYND. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS50235. USP_3. 1 hit.
PS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9FKP5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MMLVFLLIRR QWRSASVRRE EVIRLIALAT EESYLAEEVR PATVDYGGDS    50
VSDVYRCAVC LYPTTTRCSQ CKSVRYCSSK CQILHWRRGH KEECRSPDYD 100
EEKEEYVQSD YDAKESNVDF PSRGTAYESS SNVSVDVACD MSTSRPSIHK 150
VQPRSEAVDF TTSLNIKDNL YETRPLSRKK SRNRTDKVES ASNYSKGKTD 200
AKLRKLGNQN SRRSGDSANM SISDQFLSVG FEEEMNALKH ERITSEPSSA 250
SAAMSSSSTL LLPSKANSKP KVSQASSSGL KTSVQKVVQH FRPPQSSKKS 300
QPSSSIDEMS FSYELFVKLY CDRVELQPFG LVNLGNSCYA NAVLQCLAFT 350
RPLISYLIRG LHSKTCRKKS WCFVCEFEHL ILKARGGESP LSPIKILSKL 400
QKIGKHLGPG KEEDAHEFLR CAVDTMQSVF LKEAPAAGPF AEETTLVGLT 450
FGGYLHSKIK CMACLHKSER PELMMDLTVE IDGDIGSLEE ALAQFTAYEV 500
LDGENRYFCG RCKSYQKAKK KLMILEGPNI LTVVLKRFQS DNFGKLSKPI 550
HFPELLDISP YMSDPNHGDH PVYSLYAVVV HLDAMSTLFS GHYVCYIKTL 600
DGDWFKIDDS NVFPVQLETV LLEGAYMLLY ARDSPRPVSK NGGRKSKQRR 650
NLAAIPSRKG NKKQRDGDNN SLLPRVDWSS GSLSSMFSSS DTTSSCSTKD 700
SSGIENLSDY LFGGVEPVWK WDRHNKSQTF D 731
Length:731
Mass (Da):81,999
Last modified:March 1, 2001 - v1
Checksum:iD17844AC368057B5
GO
Isoform 2 (identifier: Q9FKP5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     421-448: CAVDTMQSVFLKEAPAAGPFAEETTLVG → MPGVLLIQCNLFFSKRLLQLVRLLKKLL
     449-731: Missing.

Note: May be due to a competing acceptor splice site. No experimental confirmation available.

Show »
Length:448
Mass (Da):50,543
Checksum:iC10389FE47E17BA5
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei421 – 44828CAVDT…TTLVG → MPGVLLIQCNLFFSKRLLQL VRLLKKLL in isoform 2.
VSP_029990Add
BLAST
Alternative sequencei449 – 731283Missing in isoform 2.
VSP_029991Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF302667 mRNA. No translation available.
AB011479 Genomic DNA. Translation: BAB11567.1.
CP002688 Genomic DNA. Translation: AED98058.1.
RefSeqiNP_201348.1. NM_125943.1. [Q9FKP5-1]
UniGeneiAt.16943.

Genome annotation databases

EnsemblPlantsiAT5G65450.1; AT5G65450.1; AT5G65450. [Q9FKP5-1]
GeneIDi836670.
KEGGiath:AT5G65450.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF302667 mRNA. No translation available.
AB011479 Genomic DNA. Translation: BAB11567.1 .
CP002688 Genomic DNA. Translation: AED98058.1 .
RefSeqi NP_201348.1. NM_125943.1. [Q9FKP5-1 ]
UniGenei At.16943.

3D structure databases

ProteinModelPortali Q9FKP5.
SMRi Q9FKP5. Positions 330-630.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT5G65450.1-P.

Protein family/group databases

MEROPSi C19.A06.

Proteomic databases

PaxDbi Q9FKP5.
PRIDEi Q9FKP5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G65450.1 ; AT5G65450.1 ; AT5G65450 . [Q9FKP5-1 ]
GeneIDi 836670.
KEGGi ath:AT5G65450.

Organism-specific databases

TAIRi AT5G65450.

Phylogenomic databases

eggNOGi COG5533.
HOGENOMi HOG000242869.
InParanoidi Q9FKP5.
KOi K11855.
OMAi QSICLKE.
PhylomeDBi Q9FKP5.

Enzyme and pathway databases

BioCyci ARA:AT5G65450-MONOMER.

Gene expression databases

Genevestigatori Q9FKP5.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR002893. Znf_MYND.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
PF01753. zf-MYND. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS50235. USP_3. 1 hit.
PS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The ubiquitin-specific protease family from Arabidopsis. AtUBP1 and 2 are required for the resistance to the amino acid analog canavanine."
    Yan N., Doelling J.H., Falbel T.G., Durski A.M., Vierstra R.D.
    Plant Physiol. 124:1828-1843(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), GENE FAMILY ORGANIZATION, NOMENCLATURE.
    Strain: cv. Columbia.
  2. "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence features of the regions of 1,381,565 bp covered by twenty one physically assigned P1 and TAC clones."
    Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N., Tabata S.
    DNA Res. 5:131-145(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.

Entry informationi

Entry nameiUBP17_ARATH
AccessioniPrimary (citable) accession number: Q9FKP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2001
Last modified: September 3, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi