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Protein

Ubiquitin carboxyl-terminal hydrolase 17

Gene

UBP17

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei338NucleophilePROSITE-ProRule annotation1
Active sitei592Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri57 – 94MYND-typePROSITE-ProRule annotationAdd BLAST38

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiC19.A06

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 17 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 17
Short name:
AtUBP17
Ubiquitin thioesterase 17
Ubiquitin-specific-processing protease 17
Gene namesi
Name:UBP17
Ordered Locus Names:At5g65450
ORF Names:MNA5.19
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G65450
TAIRilocus:2168282 AT5G65450

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003130431 – 731Ubiquitin carboxyl-terminal hydrolase 17Add BLAST731

Proteomic databases

PaxDbiQ9FKP5

Expressioni

Gene expression databases

ExpressionAtlasiQ9FKP5 baseline and differential
GenevisibleiQ9FKP5 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G65450.1

Structurei

3D structure databases

ProteinModelPortaliQ9FKP5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini329 – 633USPAdd BLAST305

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi245 – 312Ser-richAdd BLAST68
Compositional biasi679 – 702Ser-richAdd BLAST24

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri57 – 94MYND-typePROSITE-ProRule annotationAdd BLAST38

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1865 Eukaryota
ENOG410XQ92 LUCA
HOGENOMiHOG000242869
InParanoidiQ9FKP5
KOiK11855
OMAiYVCYIKT
OrthoDBiEOG093604WY
PhylomeDBiQ9FKP5

Family and domain databases

InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
IPR002893 Znf_MYND
PfamiView protein in Pfam
PF00443 UCH, 1 hit
PF01753 zf-MYND, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00972 USP_1, 1 hit
PS50235 USP_3, 1 hit
PS01360 ZF_MYND_1, 1 hit
PS50865 ZF_MYND_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9FKP5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMLVFLLIRR QWRSASVRRE EVIRLIALAT EESYLAEEVR PATVDYGGDS
60 70 80 90 100
VSDVYRCAVC LYPTTTRCSQ CKSVRYCSSK CQILHWRRGH KEECRSPDYD
110 120 130 140 150
EEKEEYVQSD YDAKESNVDF PSRGTAYESS SNVSVDVACD MSTSRPSIHK
160 170 180 190 200
VQPRSEAVDF TTSLNIKDNL YETRPLSRKK SRNRTDKVES ASNYSKGKTD
210 220 230 240 250
AKLRKLGNQN SRRSGDSANM SISDQFLSVG FEEEMNALKH ERITSEPSSA
260 270 280 290 300
SAAMSSSSTL LLPSKANSKP KVSQASSSGL KTSVQKVVQH FRPPQSSKKS
310 320 330 340 350
QPSSSIDEMS FSYELFVKLY CDRVELQPFG LVNLGNSCYA NAVLQCLAFT
360 370 380 390 400
RPLISYLIRG LHSKTCRKKS WCFVCEFEHL ILKARGGESP LSPIKILSKL
410 420 430 440 450
QKIGKHLGPG KEEDAHEFLR CAVDTMQSVF LKEAPAAGPF AEETTLVGLT
460 470 480 490 500
FGGYLHSKIK CMACLHKSER PELMMDLTVE IDGDIGSLEE ALAQFTAYEV
510 520 530 540 550
LDGENRYFCG RCKSYQKAKK KLMILEGPNI LTVVLKRFQS DNFGKLSKPI
560 570 580 590 600
HFPELLDISP YMSDPNHGDH PVYSLYAVVV HLDAMSTLFS GHYVCYIKTL
610 620 630 640 650
DGDWFKIDDS NVFPVQLETV LLEGAYMLLY ARDSPRPVSK NGGRKSKQRR
660 670 680 690 700
NLAAIPSRKG NKKQRDGDNN SLLPRVDWSS GSLSSMFSSS DTTSSCSTKD
710 720 730
SSGIENLSDY LFGGVEPVWK WDRHNKSQTF D
Length:731
Mass (Da):81,999
Last modified:March 1, 2001 - v1
Checksum:iD17844AC368057B5
GO
Isoform 2 (identifier: Q9FKP5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     421-448: CAVDTMQSVFLKEAPAAGPFAEETTLVG → MPGVLLIQCNLFFSKRLLQLVRLLKKLL
     449-731: Missing.

Note: May be due to a competing acceptor splice site. No experimental confirmation available.
Show »
Length:448
Mass (Da):50,543
Checksum:iC10389FE47E17BA5
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_029990421 – 448CAVDT…TTLVG → MPGVLLIQCNLFFSKRLLQL VRLLKKLL in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_029991449 – 731Missing in isoform 2. 1 PublicationAdd BLAST283

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF302667 mRNA No translation available.
AB011479 Genomic DNA Translation: BAB11567.1
CP002688 Genomic DNA Translation: AED98058.1
RefSeqiNP_201348.1, NM_125943.2 [Q9FKP5-1]
UniGeneiAt.16943

Genome annotation databases

EnsemblPlantsiAT5G65450.1; AT5G65450.1; AT5G65450 [Q9FKP5-1]
GeneIDi836670
GrameneiAT5G65450.1; AT5G65450.1; AT5G65450 [Q9FKP5-1]
KEGGiath:AT5G65450

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiUBP17_ARATH
AccessioniPrimary (citable) accession number: Q9FKP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2001
Last modified: June 20, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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