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Q9FKP5

- UBP17_ARATH

UniProt

Q9FKP5 - UBP17_ARATH

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Protein

Ubiquitin carboxyl-terminal hydrolase 17

Gene

UBP17

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei338 – 3381NucleophilePROSITE-ProRule annotation
Active sitei592 – 5921Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri57 – 9438MYND-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. ubiquitinyl hydrolase activity Source: InterPro

GO - Biological processi

  1. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciARA:AT5G65450-MONOMER.

Protein family/group databases

MEROPSiC19.A06.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 17 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 17
Short name:
AtUBP17
Ubiquitin thioesterase 17
Ubiquitin-specific-processing protease 17
Gene namesi
Name:UBP17
Ordered Locus Names:At5g65450
ORF Names:MNA5.19
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G65450.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 731731Ubiquitin carboxyl-terminal hydrolase 17PRO_0000313043Add
BLAST

Proteomic databases

PaxDbiQ9FKP5.
PRIDEiQ9FKP5.

Expressioni

Gene expression databases

GenevestigatoriQ9FKP5.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G65450.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9FKP5.
SMRiQ9FKP5. Positions 330-630.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini329 – 633305USPAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi245 – 31268Ser-richAdd
BLAST
Compositional biasi679 – 70224Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 MYND-type zinc finger.PROSITE-ProRule annotation
Contains 1 USP domain.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri57 – 9438MYND-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG5533.
HOGENOMiHOG000242869.
InParanoidiQ9FKP5.
KOiK11855.
OMAiQSICLKE.
PhylomeDBiQ9FKP5.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR002893. Znf_MYND.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
PF01753. zf-MYND. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS50235. USP_3. 1 hit.
PS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9FKP5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMLVFLLIRR QWRSASVRRE EVIRLIALAT EESYLAEEVR PATVDYGGDS
60 70 80 90 100
VSDVYRCAVC LYPTTTRCSQ CKSVRYCSSK CQILHWRRGH KEECRSPDYD
110 120 130 140 150
EEKEEYVQSD YDAKESNVDF PSRGTAYESS SNVSVDVACD MSTSRPSIHK
160 170 180 190 200
VQPRSEAVDF TTSLNIKDNL YETRPLSRKK SRNRTDKVES ASNYSKGKTD
210 220 230 240 250
AKLRKLGNQN SRRSGDSANM SISDQFLSVG FEEEMNALKH ERITSEPSSA
260 270 280 290 300
SAAMSSSSTL LLPSKANSKP KVSQASSSGL KTSVQKVVQH FRPPQSSKKS
310 320 330 340 350
QPSSSIDEMS FSYELFVKLY CDRVELQPFG LVNLGNSCYA NAVLQCLAFT
360 370 380 390 400
RPLISYLIRG LHSKTCRKKS WCFVCEFEHL ILKARGGESP LSPIKILSKL
410 420 430 440 450
QKIGKHLGPG KEEDAHEFLR CAVDTMQSVF LKEAPAAGPF AEETTLVGLT
460 470 480 490 500
FGGYLHSKIK CMACLHKSER PELMMDLTVE IDGDIGSLEE ALAQFTAYEV
510 520 530 540 550
LDGENRYFCG RCKSYQKAKK KLMILEGPNI LTVVLKRFQS DNFGKLSKPI
560 570 580 590 600
HFPELLDISP YMSDPNHGDH PVYSLYAVVV HLDAMSTLFS GHYVCYIKTL
610 620 630 640 650
DGDWFKIDDS NVFPVQLETV LLEGAYMLLY ARDSPRPVSK NGGRKSKQRR
660 670 680 690 700
NLAAIPSRKG NKKQRDGDNN SLLPRVDWSS GSLSSMFSSS DTTSSCSTKD
710 720 730
SSGIENLSDY LFGGVEPVWK WDRHNKSQTF D
Length:731
Mass (Da):81,999
Last modified:March 1, 2001 - v1
Checksum:iD17844AC368057B5
GO
Isoform 2 (identifier: Q9FKP5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     421-448: CAVDTMQSVFLKEAPAAGPFAEETTLVG → MPGVLLIQCNLFFSKRLLQLVRLLKKLL
     449-731: Missing.

Note: May be due to a competing acceptor splice site. No experimental confirmation available.

Show »
Length:448
Mass (Da):50,543
Checksum:iC10389FE47E17BA5
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei421 – 44828CAVDT…TTLVG → MPGVLLIQCNLFFSKRLLQL VRLLKKLL in isoform 2. 1 PublicationVSP_029990Add
BLAST
Alternative sequencei449 – 731283Missing in isoform 2. 1 PublicationVSP_029991Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF302667 mRNA. No translation available.
AB011479 Genomic DNA. Translation: BAB11567.1.
CP002688 Genomic DNA. Translation: AED98058.1.
RefSeqiNP_201348.1. NM_125943.1. [Q9FKP5-1]
UniGeneiAt.16943.

Genome annotation databases

EnsemblPlantsiAT5G65450.1; AT5G65450.1; AT5G65450. [Q9FKP5-1]
GeneIDi836670.
KEGGiath:AT5G65450.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF302667 mRNA. No translation available.
AB011479 Genomic DNA. Translation: BAB11567.1 .
CP002688 Genomic DNA. Translation: AED98058.1 .
RefSeqi NP_201348.1. NM_125943.1. [Q9FKP5-1 ]
UniGenei At.16943.

3D structure databases

ProteinModelPortali Q9FKP5.
SMRi Q9FKP5. Positions 330-630.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT5G65450.1-P.

Protein family/group databases

MEROPSi C19.A06.

Proteomic databases

PaxDbi Q9FKP5.
PRIDEi Q9FKP5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G65450.1 ; AT5G65450.1 ; AT5G65450 . [Q9FKP5-1 ]
GeneIDi 836670.
KEGGi ath:AT5G65450.

Organism-specific databases

TAIRi AT5G65450.

Phylogenomic databases

eggNOGi COG5533.
HOGENOMi HOG000242869.
InParanoidi Q9FKP5.
KOi K11855.
OMAi QSICLKE.
PhylomeDBi Q9FKP5.

Enzyme and pathway databases

BioCyci ARA:AT5G65450-MONOMER.

Gene expression databases

Genevestigatori Q9FKP5.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR002893. Znf_MYND.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
PF01753. zf-MYND. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS50235. USP_3. 1 hit.
PS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The ubiquitin-specific protease family from Arabidopsis. AtUBP1 and 2 are required for the resistance to the amino acid analog canavanine."
    Yan N., Doelling J.H., Falbel T.G., Durski A.M., Vierstra R.D.
    Plant Physiol. 124:1828-1843(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), GENE FAMILY ORGANIZATION, NOMENCLATURE.
    Strain: cv. Columbia.
  2. "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence features of the regions of 1,381,565 bp covered by twenty one physically assigned P1 and TAC clones."
    Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N., Tabata S.
    DNA Res. 5:131-145(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.

Entry informationi

Entry nameiUBP17_ARATH
AccessioniPrimary (citable) accession number: Q9FKP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2001
Last modified: October 1, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3