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Protein

Protein DA1-related 4

Gene

DAR4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

NB-LRR receptor-like protein that modulates growth, cell death and freezing tolerance in a temperature-dependent manner. May be involved in defense responses.1 Publication

GO - Molecular functioni

GO - Biological processi

  • defense response Source: TAIR
  • response to cold Source: TAIR
  • signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein DA1-related 41 Publication
Alternative name(s):
Protein CHILLING SENSITIVE 31 Publication
Gene namesi
Name:DAR41 Publication
Synonyms:CHS31 Publication
Ordered Locus Names:At5g17890
ORF Names:MPI7.5, MPI7.6
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G17890.

Pathology & Biotechi

Disruption phenotypei

No visible phenotype under normal growth conditions.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi201 – 2011G → D in chs3-r1; suppression of the chs3-1 phenotype. 1 Publication
Mutagenesisi278 – 2781D → N in chs3-r2; suppression of the chs3-1 phenotype. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16131613Protein DA1-related 4PRO_0000396939Add
BLAST

Proteomic databases

PaxDbiQ9FKN7.
PRIDEiQ9FKN7.

PTM databases

iPTMnetiQ9FKN7.

Expressioni

Gene expression databases

GenevisibleiQ9FKN7. AT.

Interactioni

Protein-protein interaction databases

BioGridi16933. 1 interaction.
STRINGi3702.AT5G17890.1.

Structurei

3D structure databases

ProteinModelPortaliQ9FKN7.
SMRiQ9FKN7. Positions 20-160, 748-822, 1235-1367.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini178 – 427250NB-ARCAdd
BLAST
Repeati448 – 47326LRR 1Add
BLAST
Repeati516 – 54025LRR 2Add
BLAST
Repeati569 – 59224LRR 3Add
BLAST
Repeati594 – 61522LRR 4Add
BLAST
Repeati617 – 63721LRR 5Add
BLAST
Repeati638 – 66124LRR 6Add
BLAST
Repeati662 – 68221LRR 7Add
BLAST
Repeati683 – 70321LRR 8Add
BLAST
Repeati723 – 74725LRR 9Add
BLAST
Repeati748 – 77023LRR 10Add
BLAST
Repeati771 – 79121LRR 11Add
BLAST
Repeati792 – 81625LRR 12Add
BLAST
Repeati822 – 84726LRR 13Add
BLAST
Repeati888 – 91124LRR 14Add
BLAST
Domaini1238 – 129760LIM zinc-bindingPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1109 – 1234126Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 LIM zinc-binding domain.PROSITE-ProRule annotation
Contains 14 LRR (leucine-rich) repeats.Curated
Contains 1 NB-ARC domain.Curated

Keywords - Domaini

Coiled coil, Leucine-rich repeat, LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG1703. Eukaryota.
ENOG410XRD4. LUCA.
HOGENOMiHOG000115011.
InParanoidiQ9FKN7.
OMAiWAPTEAP.
OrthoDBiEOG093612C1.
PhylomeDBiQ9FKN7.

Family and domain databases

Gene3Di2.10.110.10. 1 hit.
3.40.50.300. 2 hits.
3.80.10.10. 1 hit.
InterProiIPR022087. DA1-like.
IPR032675. L_dom-like.
IPR011713. Leu-rich_rpt_3.
IPR002182. NB-ARC.
IPR027417. P-loop_NTPase.
IPR000157. TIR_dom.
IPR011991. WHTH_DNA-bd_dom.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF12315. DUF3633. 1 hit.
PF00412. LIM. 1 hit.
PF07725. LRR_3. 1 hit.
PF00931. NB-ARC. 1 hit.
[Graphical view]
SMARTiSM00132. LIM. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF52058. SSF52058. 1 hit.
SSF52200. SSF52200. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9FKN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPPAARVTP SIKADCSHSV NIICEETVLH SLVSHLSAAL RREGISVFVD
60 70 80 90 100
ACGLQETKFF SIKQNQPLTD GARVLVVVIS DEVEFYDPWF PKFLKVIQGW
110 120 130 140 150
QNNGHVVVPV FYGVDSLTRV YGWANSWLEA EKLTSHQSKI LSNNVLTDSE
160 170 180 190 200
LVEEIVRDVY GKLYPAERVG IYARLLEIEK LLYKQHRDIR SIGIWGMPGI
210 220 230 240 250
GKTTLAKAVF NHMSTDYDAS CFIENFDEAF HKEGLHRLLK ERIGKILKDE
260 270 280 290 300
FDIESSYIMR PTLHRDKLYD KRILVVLDDV RDSLAAESFL KRLDWFGSGS
310 320 330 340 350
LIIITSVDKQ VFAFCQINQI YTVQGLNVHE ALQLFSQSVF GINEPEQNDR
360 370 380 390 400
KLSMKVIDYV NGNPLALSIY GRELMGKKSE METAFFELKH CPPLKIQDVL
410 420 430 440 450
KNAYSALSDN EKNIVLDIAF FFKGETVNYV MQLLEESHYF PRLAIDVLVD
460 470 480 490 500
KCVLTISENT VQMNNLIQDT CQEIFNGEIE TCTRMWEPSR IRYLLEYDEL
510 520 530 540 550
EGSGETKAMP KSGLVAEHIE SIFLDTSNVK FDVKHDAFKN MFNLKFLKIY
560 570 580 590 600
NSCSKYISGL NFPKGLDSLP YELRLLHWEN YPLQSLPQDF DFGHLVKLSM
610 620 630 640 650
PYSQLHKLGT RVKDLVMLKR LILSHSLQLV ECDILIYAQN IELIDLQGCT
660 670 680 690 700
GLQRFPDTSQ LQNLRVVNLS GCTEIKCFSG VPPNIEELHL QGTRIREIPI
710 720 730 740 750
FNATHPPKVK LDRKKLWNLL ENFSDVEHID LECVTNLATV TSNNHVMGKL
760 770 780 790 800
VCLNMKYCSN LRGLPDMVSL ESLKVLYLSG CSELEKIMGF PRNLKKLYVG
810 820 830 840 850
GTAIRELPQL PNSLEFLNAH GCKHLKSINL DFEQLPRHFI FSNCYRFSSQ
860 870 880 890 900
VIAEFVEKGL VASLARAKQE ELIKAPEVII CIPMDTRQRS SFRLQAGRNA
910 920 930 940 950
MTDLVPWMQK PISGFSMSVV VSFQDDYHND VGLRIRCVGT WKTWNNQPDR
960 970 980 990 1000
IVERFFQCWA PTEAPKVVAD HIFVLYDTKM HPSDSEENHI SMWAHEVKFE
1010 1020 1030 1040 1050
FHTVSGENNP LGASCKVTEC GVEVITAATG DTSVSGIIRE SETITIIEKE
1060 1070 1080 1090 1100
DTIIDEEDTP LLSRKPEETN RSRSSSELQK LSSTSSKVRS KGNVFWKWLG
1110 1120 1130 1140 1150
CFPLQPKNLR SRSRRTTALE EALEEALKER EKLEDTRELQ IALIESKKIK
1160 1170 1180 1190 1200
KIKQADERDQ IKHADEREQR KHSKDHEEEE IESNEKEERR HSKDYVIEEL
1210 1220 1230 1240 1250
VLKGKGKRKQ LDDDKADEKE QIKHSKDHVE EEVNPPLSKC KDCKSAIEDG
1260 1270 1280 1290 1300
ISINAYGSVW HPQCFCCLRC REPIAMNEIS DLRGMYHKPC YKELRHPNCY
1310 1320 1330 1340 1350
VCEKKIPRTA EGLKYHEHPF WMETYCPSHD GDGTPKCCSC ERLEHCGTQY
1360 1370 1380 1390 1400
VMLADFRWLC RECMDSAIMD SDECQPLHFE IREFFEGLHM KIEEEFPVYL
1410 1420 1430 1440 1450
VEKNALNKAE KEEKIDKQGD QCLMVVRGIC LSEEQIVTSV SQGVRRMLNK
1460 1470 1480 1490 1500
QILDTVTESQ RVVRKCEVTA ILILYGLPRL LTGYILAHEM MHAYLRLNGY
1510 1520 1530 1540 1550
RNLNMVLEEG LCQVLGYMWL ECQTYVFDTA TIASSSSSSR TPLSTTTSKK
1560 1570 1580 1590 1600
VDPSDFEKRL VNFCKHQIET DESPFFGDGF RKVNKMMASN NHSLKDTLKE
1610
IISISKTPQY SKL
Length:1,613
Mass (Da):185,137
Last modified:August 10, 2010 - v2
Checksum:i9E55F0B203DC79A8
GO

Sequence cautioni

The sequence AY079160 differs from that shown. Reason: Frameshift at positions 1077 and 1521. Curated
The sequence BAB11222 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence BAB11223 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti251 – 2511F → L in AY079160 (PubMed:14593172).Curated
Sequence conflicti640 – 6401N → S in AY079160 (PubMed:14593172).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011480 Genomic DNA. Translation: BAB11222.1. Sequence problems.
AB011480 Genomic DNA. Translation: BAB11223.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED92482.1.
AY079160 mRNA. No translation available.
RefSeqiNP_197291.2. NM_121795.3.
UniGeneiAt.43401.

Genome annotation databases

EnsemblPlantsiAT5G17890.1; AT5G17890.1; AT5G17890.
GeneIDi831657.
GrameneiAT5G17890.1; AT5G17890.1; AT5G17890.
KEGGiath:AT5G17890.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011480 Genomic DNA. Translation: BAB11222.1. Sequence problems.
AB011480 Genomic DNA. Translation: BAB11223.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED92482.1.
AY079160 mRNA. No translation available.
RefSeqiNP_197291.2. NM_121795.3.
UniGeneiAt.43401.

3D structure databases

ProteinModelPortaliQ9FKN7.
SMRiQ9FKN7. Positions 20-160, 748-822, 1235-1367.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi16933. 1 interaction.
STRINGi3702.AT5G17890.1.

PTM databases

iPTMnetiQ9FKN7.

Proteomic databases

PaxDbiQ9FKN7.
PRIDEiQ9FKN7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G17890.1; AT5G17890.1; AT5G17890.
GeneIDi831657.
GrameneiAT5G17890.1; AT5G17890.1; AT5G17890.
KEGGiath:AT5G17890.

Organism-specific databases

TAIRiAT5G17890.

Phylogenomic databases

eggNOGiKOG1703. Eukaryota.
ENOG410XRD4. LUCA.
HOGENOMiHOG000115011.
InParanoidiQ9FKN7.
OMAiWAPTEAP.
OrthoDBiEOG093612C1.
PhylomeDBiQ9FKN7.

Miscellaneous databases

PROiQ9FKN7.

Gene expression databases

GenevisibleiQ9FKN7. AT.

Family and domain databases

Gene3Di2.10.110.10. 1 hit.
3.40.50.300. 2 hits.
3.80.10.10. 1 hit.
InterProiIPR022087. DA1-like.
IPR032675. L_dom-like.
IPR011713. Leu-rich_rpt_3.
IPR002182. NB-ARC.
IPR027417. P-loop_NTPase.
IPR000157. TIR_dom.
IPR011991. WHTH_DNA-bd_dom.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF12315. DUF3633. 1 hit.
PF00412. LIM. 1 hit.
PF07725. LRR_3. 1 hit.
PF00931. NB-ARC. 1 hit.
[Graphical view]
SMARTiSM00132. LIM. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF52058. SSF52058. 1 hit.
SSF52200. SSF52200. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDAR4_ARATH
AccessioniPrimary (citable) accession number: Q9FKN7
Secondary accession number(s): Q9FKN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: August 10, 2010
Last modified: September 7, 2016
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

The gain-of-function mutants chs3-1 show no visible phenotype when grown at the permissive temperature of 22 degrees Celsius. Mutant plants (chs3-1) germinated and grown at 16 degrees Celsius show developmental defects, including dwarfism, with small and curly leaves, early senescence of cotyledons, constitutively activated defense responses and enhanced tolerance to freezing temperatures.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.