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Protein

Mitochondrial outer membrane protein porin 4

Gene

VDAC4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity). Involved in plant growth and development at the vegetative and reproductive stages. Is important for leaf and pollen development and mitochondrial membrane potential steady state. May be involved in disease resistance.By similarity1 Publication

GO - Molecular functioni

  • porin activity Source: UniProtKB-KW
  • voltage-gated anion channel activity Source: TAIR

GO - Biological processi

  • regulation of growth Source: UniProtKB-KW
  • response to bacterium Source: TAIR

Keywordsi

Molecular functionPorin
Biological processGrowth regulation, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial outer membrane protein porin 4
Alternative name(s):
Voltage-dependent anion-selective channel protein 4
Short name:
AtVDAC4
Short name:
VDAC-4
Gene namesi
Name:VDAC4
Ordered Locus Names:At5g57490
ORF Names:MUA2.6
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G57490
TAIRilocus:2174517 AT5G57490

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Disruption phenotypei

Dwarf plants with lesion mimic phenotype and increased expression of the pathogenesis-related genes PR1, PR2 and PR5. Delayed flowering, impaired development of anthers and short siliques with sterile seeds.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00004140822 – 274Mitochondrial outer membrane protein porin 4Add BLAST273

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylglycineCombined sources1
Modified residuei76PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9FKM2
PRIDEiQ9FKM2

PTM databases

iPTMnetiQ9FKM2
SwissPalmiQ9FKM2

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Inductioni

By the bacterial pathogen P.syringae pv. tomato.1 Publication

Gene expression databases

ExpressionAtlasiQ9FKM2 baseline and differential
GenevisibleiQ9FKM2 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G57490.1

Structurei

3D structure databases

ProteinModelPortaliQ9FKM2
SMRiQ9FKM2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Consists mainly of membrane-spanning sided beta-sheets.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiKOG3126 Eukaryota
ENOG410ZBK1 LUCA
HOGENOMiHOG000238012
InParanoidiQ9FKM2
KOiK15040
OMAiAKINNAG
OrthoDBiEOG09360J2F
PhylomeDBiQ9FKM2

Family and domain databases

Gene3Di2.40.160.10, 1 hit
InterProiView protein in InterPro
IPR023614 Porin_dom_sf
IPR027246 Porin_Euk/Tom40
PfamiView protein in Pfam
PF01459 Porin_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9FKM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSSPAPFAD IGKKAKDLLN KDYIFDHKFT LTMLSATGTE FVATGLKKDD
60 70 80 90 100
FFFGDISTLY KGQNTIVDLK IDSHSSVSTK VTLKNLLPSA KAVISFKIPD
110 120 130 140 150
HKSGKLDVQY VHPHATLNSS IGLNPTPLLD LSATIGSQNV CLGGEVSFDT
160 170 180 190 200
ASSSLTKYNA GIGFNNQGVS AALILEDKGE SLRATYVHTV NPTTSFGAEL
210 220 230 240 250
IRRFSNYNNS FTVGSSHSVD QFTVVKTRFS NSGKAGMVVQ REWRPKSHIT
260 270
FSAEYDSKAV TSSPKLGLAL ALKP
Length:274
Mass (Da):29,505
Last modified:March 1, 2001 - v1
Checksum:i20404992240902CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011482 Genomic DNA Translation: BAB08784.1
CP002688 Genomic DNA Translation: AED96907.1
AY034928 mRNA Translation: AAK59435.1
AY059112 mRNA Translation: AAL15218.1
AY086306 mRNA Translation: AAM64378.1
RefSeqiNP_200557.1, NM_125130.3
UniGeneiAt.23756

Genome annotation databases

EnsemblPlantsiAT5G57490.1; AT5G57490.1; AT5G57490
GeneIDi835853
GrameneiAT5G57490.1; AT5G57490.1; AT5G57490
KEGGiath:AT5G57490

Similar proteinsi

Entry informationi

Entry nameiVDAC4_ARATH
AccessioniPrimary (citable) accession number: Q9FKM2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 14, 2011
Last sequence update: March 1, 2001
Last modified: April 25, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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