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Protein

Mitochondrial outer membrane protein porin 4

Gene

VDAC4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity). Involved in plant growth and development at the vegetative and reproductive stages. Is important for leaf and pollen development and mitochondrial membrane potential steady state. May be involved in disease resistance.By similarity1 Publication

GO - Molecular functioni

  • porin activity Source: UniProtKB-KW
  • voltage-gated anion channel activity Source: TAIR

GO - Biological processi

  • regulation of growth Source: UniProtKB-KW
  • response to bacterium Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Porin

Keywords - Biological processi

Growth regulation, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial outer membrane protein porin 4
Alternative name(s):
Voltage-dependent anion-selective channel protein 4
Short name:
AtVDAC4
Short name:
VDAC-4
Gene namesi
Name:VDAC4
Ordered Locus Names:At5g57490
ORF Names:MUA2.6
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G57490.

Subcellular locationi

GO - Cellular componenti

  • membrane Source: TAIR
  • mitochondrial outer membrane Source: UniProtKB-SubCell
  • mitochondrion Source: TAIR
  • plasma membrane Source: TAIR
  • pore complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Disruption phenotypei

Dwarf plants with lesion mimic phenotype and increased expression of the pathogenesis-related genes PR1, PR2 and PR5. Delayed flowering, impaired development of anthers and short siliques with sterile seeds.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 274273Mitochondrial outer membrane protein porin 4PRO_0000414082Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylglycineCombined sources
Modified residuei76 – 761PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9FKM2.
PRIDEiQ9FKM2.

PTM databases

SwissPalmiQ9FKM2.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Inductioni

By the bacterial pathogen P.syringae pv. tomato.1 Publication

Gene expression databases

GenevisibleiQ9FKM2. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G57490.1.

Structurei

3D structure databases

ProteinModelPortaliQ9FKM2.
SMRiQ9FKM2. Positions 5-273.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Consists mainly of membrane-spanning sided beta-sheets.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiKOG3126. Eukaryota.
ENOG410ZBK1. LUCA.
HOGENOMiHOG000238012.
InParanoidiQ9FKM2.
KOiK15040.
OMAiTEFVATG.
OrthoDBiEOG09360J2F.
PhylomeDBiQ9FKM2.

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR027246. Porin_Euk/Tom40.
[Graphical view]
PfamiPF01459. Porin_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9FKM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSSPAPFAD IGKKAKDLLN KDYIFDHKFT LTMLSATGTE FVATGLKKDD
60 70 80 90 100
FFFGDISTLY KGQNTIVDLK IDSHSSVSTK VTLKNLLPSA KAVISFKIPD
110 120 130 140 150
HKSGKLDVQY VHPHATLNSS IGLNPTPLLD LSATIGSQNV CLGGEVSFDT
160 170 180 190 200
ASSSLTKYNA GIGFNNQGVS AALILEDKGE SLRATYVHTV NPTTSFGAEL
210 220 230 240 250
IRRFSNYNNS FTVGSSHSVD QFTVVKTRFS NSGKAGMVVQ REWRPKSHIT
260 270
FSAEYDSKAV TSSPKLGLAL ALKP
Length:274
Mass (Da):29,505
Last modified:March 1, 2001 - v1
Checksum:i20404992240902CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011482 Genomic DNA. Translation: BAB08784.1.
CP002688 Genomic DNA. Translation: AED96907.1.
AY034928 mRNA. Translation: AAK59435.1.
AY059112 mRNA. Translation: AAL15218.1.
AY086306 mRNA. Translation: AAM64378.1.
RefSeqiNP_200557.1. NM_125130.2.
UniGeneiAt.23756.

Genome annotation databases

EnsemblPlantsiAT5G57490.1; AT5G57490.1; AT5G57490.
GeneIDi835853.
GrameneiAT5G57490.1; AT5G57490.1; AT5G57490.
KEGGiath:AT5G57490.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011482 Genomic DNA. Translation: BAB08784.1.
CP002688 Genomic DNA. Translation: AED96907.1.
AY034928 mRNA. Translation: AAK59435.1.
AY059112 mRNA. Translation: AAL15218.1.
AY086306 mRNA. Translation: AAM64378.1.
RefSeqiNP_200557.1. NM_125130.2.
UniGeneiAt.23756.

3D structure databases

ProteinModelPortaliQ9FKM2.
SMRiQ9FKM2. Positions 5-273.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT5G57490.1.

PTM databases

SwissPalmiQ9FKM2.

Proteomic databases

PaxDbiQ9FKM2.
PRIDEiQ9FKM2.

Protocols and materials databases

DNASUi835853.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G57490.1; AT5G57490.1; AT5G57490.
GeneIDi835853.
GrameneiAT5G57490.1; AT5G57490.1; AT5G57490.
KEGGiath:AT5G57490.

Organism-specific databases

TAIRiAT5G57490.

Phylogenomic databases

eggNOGiKOG3126. Eukaryota.
ENOG410ZBK1. LUCA.
HOGENOMiHOG000238012.
InParanoidiQ9FKM2.
KOiK15040.
OMAiTEFVATG.
OrthoDBiEOG09360J2F.
PhylomeDBiQ9FKM2.

Miscellaneous databases

PROiQ9FKM2.

Gene expression databases

GenevisibleiQ9FKM2. AT.

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR027246. Porin_Euk/Tom40.
[Graphical view]
PfamiPF01459. Porin_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVDAC4_ARATH
AccessioniPrimary (citable) accession number: Q9FKM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 14, 2011
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.