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Protein

Transcription factor MYB36

Gene

MYB36

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factors that activates genes required for endodermal differentiation but represses genes involved in proliferative divisions, thus regulating the transition from proliferation to differentiation in root endodermis (PubMed:26371322). Required for Casparian strip formation by positively regulating the expression of the Casparian strip genes CASP1, PER64 and ESB1 and other endodermis-specific genes, thus triggering correct localized lignin biosynthesis in root endodermis and subsequently regulating global ion homeostasis (PubMed:26124109, PubMed:26371322).2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi38 – 62H-T-H motifPROSITE-ProRule annotationAdd BLAST25
DNA bindingi90 – 113H-T-H motifPROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: TAIR
  • endodermal cell differentiation Source: UniProtKB
  • negative regulation of cell proliferation Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of cell differentiation Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • regulation of ion homeostasis Source: UniProtKB
  • regulation of root morphogenesis Source: UniProtKB
  • regulation of transcription from RNA polymerase II promoter Source: GO_Central
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor MYB361 Publication
Alternative name(s):
Myb-related protein 361 Publication
Short name:
AtMYB361 Publication
Gene namesi
Name:MYB361 Publication
Ordered Locus Names:At5g57620Imported
ORF Names:MUA2.20Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G57620.
TAIRilocus:2174557. AT5G57620.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

In myb36-1, myb36-2 and myb36-4, impaired Casparian strips formation replaced by ectopic lignin-like material in the corners of endodermal cells, associated with reduced expression of several endodermis-specific genes and abnormal CASP1 localization in the plasma membrane (PubMed:26124109, PubMed:26371322). Multiple changes to leaf ionome, including elevated concentrations of sodium, magnesium, and zinc and decreased calcium, manganese, and iron. Longer root hairs (PubMed:26124109). Delayed and defective barrier (Casparian strips) formation as well as extra cell divisions in the meristem in roots (PubMed:26371322).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi89R → W in myb36-3; impaired accumulation of CASP1 in Casparian strips and longer root hairs. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004354751 – 333Transcription factor MYB36Add BLAST333

Proteomic databases

PaxDbiQ9FKL2.

Expressioni

Tissue specificityi

Expressed in leaves, roots (endodermis-specific) and seedlings.4 Publications

Developmental stagei

In roots, expressed in endodermal cells from the late elongation zones to the differentiation zone and, to a lower extent, in endodermal cells of the meristematic zone.2 Publications

Inductioni

Directly up-regulated by SCARECROW (SCR), as part of the differentiation program controlled by SHORT-ROOT (SHR).2 Publications

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G57620.1.

Structurei

3D structure databases

ProteinModelPortaliQ9FKL2.
SMRiQ9FKL2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 62HTH myb-type 1PROSITE-ProRule annotationAdd BLAST54
Domaini63 – 117HTH myb-type 2PROSITE-ProRule annotationAdd BLAST55

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi136 – 152Asn-richPROSITE-ProRule annotationAdd BLAST17

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0048. Eukaryota.
COG5147. LUCA.
HOGENOMiHOG000237600.
KOiK09422.
OMAiNPAHEFQ.
OrthoDBiEOG09360I5P.
PhylomeDBiQ9FKL2.

Family and domain databases

CDDicd00167. SANT. 2 hits.
InterProiView protein in InterPro
IPR009057. Homeobox-like_sf.
IPR017930. Myb_dom.
IPR001005. SANT/Myb.
PfamiView protein in Pfam
PF00249. Myb_DNA-binding. 2 hits.
SMARTiView protein in SMART
SM00717. SANT. 2 hits.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS51294. HTH_MYB. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9FKL2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRAPCCDKA NVKKGPWSPE EDVKLKDYID KYGTGGNWIA LPQKIGLKRC
60 70 80 90 100
GKSCRLRWLN YLRPNIKHGG FSEEEDRIIL SLYISIGSRW SIIAAQLPGR
110 120 130 140 150
TDNDIKNYWN TKLKKKLLGR QKQMNRQDSI TDSTENNLSN NNNNKSPQNL
160 170 180 190 200
SNSALERLQL HMQLQNLQSP FSSFYNNPIL WPKLHPLLQS TTTNQNPKLA
210 220 230 240 250
SQESFHPLGV NVDHQHNNTK LAQINNGASS LYSENVEQSQ NPAHEFQPNF
260 270 280 290 300
GFSQDLRLDN HNMDFMNRGV SKELFQVGNE FELTNGSSWW SEEVELERKT
310 320 330
TSSSSWGSAS VLDQTTEGMV MLQDYAQMSY HSV
Length:333
Mass (Da):37,980
Last modified:March 1, 2001 - v1
Checksum:iCA296E9C64299240
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti157R → K in AAC83600 (PubMed:9839469).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF062878 mRNA. Translation: AAC83600.1.
AY519640 mRNA. Translation: AAS10110.1.
AB011482 Genomic DNA. Translation: BAB08797.1.
CP002688 Genomic DNA. Translation: AED96926.1.
AK228818 mRNA. Translation: BAF00714.1.
BT030331 mRNA. Translation: ABO09894.1.
PIRiT51650.
RefSeqiNP_200570.1. NM_125143.4.
UniGeneiAt.7489.

Genome annotation databases

EnsemblPlantsiAT5G57620.1; AT5G57620.1; AT5G57620.
GeneIDi835866.
GrameneiAT5G57620.1; AT5G57620.1; AT5G57620.
KEGGiath:AT5G57620.

Similar proteinsi

Entry informationi

Entry nameiMYB36_ARATH
AccessioniPrimary (citable) accession number: Q9FKL2
Secondary accession number(s): Q9ZTE6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 17, 2016
Last sequence update: March 1, 2001
Last modified: November 22, 2017
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names