Q9FKB3 (PANC_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pantoate--beta-alanine ligase
EC=6.3.2.1

Alternative name(s):
Pantoate-activating enzyme
Pantothenate synthetase

Gene names

Ordered Locus Names:	At5g48840
ORF Names:	K24G6.18

Organism

Arabidopsis thaliana (Mouse-ear cress) [Reference proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	310 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.
Pathway	Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.
Subunit structure	Homodimer Potential.
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the pantothenate synthetase family.

Ontologies

Keywords
Biological process	Pantothenate biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	embryo development ending in seed dormancy Inferred from mutant phenotype PubMed 17932772. Source: TAIR pantothenate biosynthetic process Inferred from mutant phenotype PubMed 17932772. Source: TAIR
Cellular_component	cytosol Inferred from direct assay PubMed 14675432. Source: TAIR
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantoate-beta-alanine ligase activity Inferred from direct assay PubMed 17040917. Source: TAIR protein homodimerization activity Inferred from direct assay PubMed 17040917. Source: TAIR
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 310	310	Pantoate--beta-alanine ligase		PRO_0000128299

Sequences

	Sequence		Length	Mass (Da)
	Q9FKB3 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: AD07D927625AD1A6	FASTA	310	34,137
	10 20 30 40 50 60 MEPEVIRDKD SMRKWSRAMR SQGKTIGLVP TMGYLHEGHL SLVRQSLALT DVTVVSIYVN 70 80 90 100 110 120 PGQFSPTEDL STYPSDFSGD LTKLAALSGG KVVVFNPKNL YDYGGETKKI NDGGGNGGRV 130 140 150 160 170 180 VSCVEEGGLG HETWIRVERL EKGFCGKSRP VFFRGVATIV TKLFNIVEPD VALFGKKDYQ 190 200 210 220 230 240 QWRIIQRMVR DLNFGIEIVG SDIAREKDGL AMSSRNVRLS DEERQRALSI SRSLAMAKAS 250 260 270 280 290 300 VAEGKTNCAE LKDMIIQQVV GSAGRVDYVE IVDQETLEGV EEIKSGVVIC VAAWFGTVRL 310 IDNIEINVSL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structural analysis of Arabidopsis thaliana chromosome 5. VI. Sequence features of the regions of 1,367,185 bp covered by 19 physically assigned P1 and TAC clones." Kotani H., Nakamura Y., Sato S., Asamizu E., Kaneko T., Miyajima N., Tabata S. DNA Res. 5:203-216(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[3]	"Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs." Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K. , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K. Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB012242 Genomic DNA. Translation: BAB09437.1. CP002688 Genomic DNA. Translation: AED95732.1. AK175238 mRNA. Translation: BAD43001.1.
IPI	IPI00542247.
RefSeq	NP_199695.1. NM_124261.3.
UniGene	At.29821.
3D structure databases
ProteinModelPortal	Q9FKB3.
SMR	Q9FKB3. Positions 5-303.
ModBase	Search...
Proteomic databases
PaxDb	Q9FKB3.
PRIDE	Q9FKB3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT5G48840.1; AT5G48840.1; AT5G48840.
GeneID	834942.
KEGG	ath:AT5G48840.
Organism-specific databases
TAIR	At5g48840.
Phylogenomic databases
eggNOG	COG0414.
HOGENOM	HOG000175516.
InParanoid	Q9FKB3.
KO	K01918.
OMA	EDFGSYP.
PhylomeDB	Q9FKB3.
ProtClustDB	PLN02660.
Enzyme and pathway databases
BioCyc	ARA:AT5G48840-MONOMER. MetaCyc:AT5G48840-MONOMER.
UniPathway	UPA00028; UER00005.
Gene expression databases
ArrayExpress	Q9FKB3.
Genevestigator	Q9FKB3.
GermOnline	AT5G48840. Arabidopsis thaliana.
Family and domain databases
Gene3D	3.40.50.620. 1 hit.
InterPro	IPR003721. Pantoate_ligase. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
PANTHER	PTHR21299:SF1. PTHR21299:SF1. 1 hit.
Pfam	PF02569. Pantoate_ligase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00018. panC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PANC_ARATH

Accession

Primary (citable) accession number: Q9FKB3
Secondary accession number(s): Q682X9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2002
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program