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Q9FK60

- SODC3_ARATH

UniProt

Q9FK60 - SODC3_ARATH

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Protein

Superoxide dismutase [Cu-Zn] 3

Gene
CSD3, At5g18100, MRG7.6
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems By similarity.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Binds 1 copper ion per subunit By similarity.
Binds 1 zinc ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi51 – 511Copper; catalytic By similarity
Metal bindingi53 – 531Copper; catalytic By similarity
Metal bindingi68 – 681Copper; catalytic By similarity
Metal bindingi68 – 681Zinc; structural By similarity
Metal bindingi76 – 761Zinc; structural By similarity
Metal bindingi85 – 851Zinc; structural By similarity
Metal bindingi88 – 881Zinc; structural By similarity
Metal bindingi125 – 1251Copper; catalytic By similarity

GO - Molecular functioni

  1. copper ion binding Source: RefGenome
  2. superoxide dismutase activity Source: RefGenome
  3. zinc ion binding Source: RefGenome

GO - Biological processi

  1. cellular response to high light intensity Source: UniProtKB
  2. cellular response to light intensity Source: UniProtKB
  3. cellular response to ozone Source: UniProtKB
  4. cellular response to salt stress Source: UniProtKB
  5. cellular response to UV-B Source: UniProtKB
  6. oxidation-reduction process Source: RefGenome
  7. removal of superoxide radicals Source: RefGenome
  8. response to oxidative stress Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Antioxidant, Oxidoreductase

Keywords - Ligandi

Copper, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_180046. Detoxification of Reactive Oxygen Species.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn] 3 (EC:1.15.1.1)
Alternative name(s):
Copper/zinc superoxide dismutase 3
Gene namesi
Name:CSD3
Ordered Locus Names:At5g18100
ORF Names:MRG7.6
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G18100.

Subcellular locationi

Peroxisome 2 Publications

GO - Cellular componenti

  1. extracellular region Source: RefGenome
  2. peroxisome Source: TAIR
  3. vacuole Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 164164Superoxide dismutase [Cu-Zn] 3PRO_0000419143Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi62 ↔ 151 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ9FK60.

Expressioni

Tissue specificityi

Expressed in leaves (at protein level).1 Publication

Inductioni

Upon photosynthetically active radiation (PAR) (e.g. light fluence) increase or after high-light pulse, and UV-B treatment. Accumulates in response to ozone fumigation, during recovery. Repressed by salt stress.2 Publications

Gene expression databases

GenevestigatoriQ9FK60.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

IntActiQ9FK60. 1 interaction.
STRINGi3702.AT5G18100.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9FK60.
SMRiQ9FK60. Positions 9-157.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi162 – 1643Peroxisome localization signal By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2032.
HOGENOMiHOG000263447.
InParanoidiQ9FK60.
KOiK04565.
OMAiEEERHAG.
PhylomeDBiQ9FK60.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
PRINTSiPR00068. CUZNDISMTASE.
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9FK60-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEAPRGNLRA VALIAGDNNV RGCLQFVQDI SGTTHVTGKI SGLSPGFHGF    50
HIHSFGDTTN GCISTGPHFN PLNRVHGPPN EEERHAGDLG NILAGSNGVA 100
EILIKDKHIP LSGQYSILGR AVVVHADPDD LGKGGHKLSK STGNAGSRVG 150
CGIIGLQSSA DAKL 164
Length:164
Mass (Da):16,941
Last modified:March 1, 2001 - v1
Checksum:iA80B9F4A79D0F365
GO
Isoform 2 (identifier: Q9FK60-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     135-137: GHK → TKH
     138-164: Missing.

Note: Derived from EST data. No experimental confirmation available.

Show »
Length:137
Mass (Da):14,412
Checksum:iBBD55B91BCC424BD
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei135 – 1373GHK → TKH in isoform 2. VSP_044111
Alternative sequencei138 – 16427Missing in isoform 2. VSP_044112Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF061520 mRNA. Translation: AAC24833.1.
AB012246 Genomic DNA. Translation: BAB09468.1.
CP002688 Genomic DNA. Translation: AED92506.1.
CP002688 Genomic DNA. Translation: AED92507.1.
AK117742 mRNA. Translation: BAC42391.1.
BT003689 mRNA. Translation: AAO39917.1.
PIRiT51731.
RefSeqiNP_001119245.1. NM_001125773.1. [Q9FK60-2]
NP_197311.1. NM_121815.3. [Q9FK60-1]
UniGeneiAt.49035.
At.7547.

Genome annotation databases

EnsemblPlantsiAT5G18100.1; AT5G18100.1; AT5G18100. [Q9FK60-1]
GeneIDi831928.
KEGGiath:AT5G18100.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF061520 mRNA. Translation: AAC24833.1 .
AB012246 Genomic DNA. Translation: BAB09468.1 .
CP002688 Genomic DNA. Translation: AED92506.1 .
CP002688 Genomic DNA. Translation: AED92507.1 .
AK117742 mRNA. Translation: BAC42391.1 .
BT003689 mRNA. Translation: AAO39917.1 .
PIRi T51731.
RefSeqi NP_001119245.1. NM_001125773.1. [Q9FK60-2 ]
NP_197311.1. NM_121815.3. [Q9FK60-1 ]
UniGenei At.49035.
At.7547.

3D structure databases

ProteinModelPortali Q9FK60.
SMRi Q9FK60. Positions 9-157.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9FK60. 1 interaction.
STRINGi 3702.AT5G18100.1-P.

Proteomic databases

PRIDEi Q9FK60.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G18100.1 ; AT5G18100.1 ; AT5G18100 . [Q9FK60-1 ]
GeneIDi 831928.
KEGGi ath:AT5G18100.

Organism-specific databases

TAIRi AT5G18100.

Phylogenomic databases

eggNOGi COG2032.
HOGENOMi HOG000263447.
InParanoidi Q9FK60.
KOi K04565.
OMAi EEERHAG.
PhylomeDBi Q9FK60.

Enzyme and pathway databases

Reactomei REACT_180046. Detoxification of Reactive Oxygen Species.

Gene expression databases

Genevestigatori Q9FK60.

Family and domain databases

Gene3Di 2.60.40.200. 1 hit.
InterProi IPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view ]
Pfami PF00080. Sod_Cu. 1 hit.
[Graphical view ]
PRINTSi PR00068. CUZNDISMTASE.
SUPFAMi SSF49329. SSF49329. 1 hit.
PROSITEi PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis of Arabidopsis thaliana chromosome 5. VI. Sequence features of the regions of 1,367,185 bp covered by 19 physically assigned P1 and TAC clones."
    Kotani H., Nakamura Y., Sato S., Asamizu E., Kaneko T., Miyajima N., Tabata S.
    DNA Res. 5:203-216(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: cv. Columbia.
  5. "Superoxide dismutase in Arabidopsis: an eclectic enzyme family with disparate regulation and protein localization."
    Kliebenstein D.J., Monde R.A., Last R.L.
    Plant Physiol. 118:637-650(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-164 (ISOFORM 1), TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INDUCTION BY LIGHT; UV-B AND OZONE, GENE FAMILY.
    Strain: cv. Columbia.
  6. "Proteome analysis of Arabidopsis leaf peroxisomes reveals novel targeting peptides, metabolic pathways, and defense mechanisms."
    Reumann S., Babujee L., Ma C., Wienkoop S., Siemsen T., Antonicelli G.E., Rasche N., Lueder F., Weckwerth W., Jahn O.
    Plant Cell 19:3170-3193(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 85-105 AND 108-120, SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  7. "Long-term effects of mild salt stress on growth, ion accumulation and superoxide dismutase expression of Arabidopsis rosette leaves."
    Attia H., Arnaud N., Karray N., Lachaal M.
    Physiol. Plantarum 132:293-305(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY SALT.
    Strain: cv. Columbia.

Entry informationi

Entry nameiSODC3_ARATH
AccessioniPrimary (citable) accession number: Q9FK60
Secondary accession number(s): B3H6P9, O81236
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2012
Last sequence update: March 1, 2001
Last modified: September 3, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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