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Q9FK60

- SODC3_ARATH

UniProt

Q9FK60 - SODC3_ARATH

Protein

Superoxide dismutase [Cu-Zn] 3

Gene

CSD3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Destroys radicals which are normally produced within the cells and which are toxic to biological systems.By similarity

    Catalytic activityi

    2 superoxide + 2 H+ = O2 + H2O2.

    Cofactori

    Binds 1 copper ion per subunit.By similarity
    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi51 – 511Copper; catalyticBy similarity
    Metal bindingi53 – 531Copper; catalyticBy similarity
    Metal bindingi68 – 681Copper; catalyticBy similarity
    Metal bindingi68 – 681Zinc; structuralBy similarity
    Metal bindingi76 – 761Zinc; structuralBy similarity
    Metal bindingi85 – 851Zinc; structuralBy similarity
    Metal bindingi88 – 881Zinc; structuralBy similarity
    Metal bindingi125 – 1251Copper; catalyticBy similarity

    GO - Molecular functioni

    1. copper ion binding Source: RefGenome
    2. superoxide dismutase activity Source: RefGenome
    3. zinc ion binding Source: RefGenome

    GO - Biological processi

    1. cellular response to high light intensity Source: UniProtKB
    2. cellular response to light intensity Source: UniProtKB
    3. cellular response to ozone Source: UniProtKB
    4. cellular response to salt stress Source: UniProtKB
    5. cellular response to UV-B Source: UniProtKB
    6. oxidation-reduction process Source: RefGenome
    7. removal of superoxide radicals Source: RefGenome
    8. response to oxidative stress Source: TAIR

    Keywords - Molecular functioni

    Antioxidant, Oxidoreductase

    Keywords - Ligandi

    Copper, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_180046. Detoxification of Reactive Oxygen Species.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Superoxide dismutase [Cu-Zn] 3 (EC:1.15.1.1)
    Alternative name(s):
    Copper/zinc superoxide dismutase 3
    Gene namesi
    Name:CSD3
    Ordered Locus Names:At5g18100
    ORF Names:MRG7.6
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 5

    Organism-specific databases

    TAIRiAT5G18100.

    Subcellular locationi

    Peroxisome 2 Publications

    GO - Cellular componenti

    1. extracellular region Source: RefGenome
    2. peroxisome Source: TAIR
    3. vacuole Source: TAIR

    Keywords - Cellular componenti

    Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 164164Superoxide dismutase [Cu-Zn] 3PRO_0000419143Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi62 ↔ 151By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ9FK60.

    Expressioni

    Tissue specificityi

    Expressed in leaves (at protein level).1 Publication

    Inductioni

    Upon photosynthetically active radiation (PAR) (e.g. light fluence) increase or after high-light pulse, and UV-B treatment. Accumulates in response to ozone fumigation, during recovery. Repressed by salt stress.2 Publications

    Gene expression databases

    GenevestigatoriQ9FK60.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    IntActiQ9FK60. 1 interaction.
    STRINGi3702.AT5G18100.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9FK60.
    SMRiQ9FK60. Positions 9-157.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi162 – 1643Peroxisome localization signalBy similarity

    Sequence similaritiesi

    Belongs to the Cu-Zn superoxide dismutase family.Curated

    Phylogenomic databases

    eggNOGiCOG2032.
    HOGENOMiHOG000263447.
    InParanoidiQ9FK60.
    KOiK04565.
    OMAiEEERHAG.
    PhylomeDBiQ9FK60.

    Family and domain databases

    Gene3Di2.60.40.200. 1 hit.
    InterProiIPR018152. SOD_Cu/Zn_BS.
    IPR001424. SOD_Cu_Zn_dom.
    [Graphical view]
    PfamiPF00080. Sod_Cu. 1 hit.
    [Graphical view]
    PRINTSiPR00068. CUZNDISMTASE.
    SUPFAMiSSF49329. SSF49329. 1 hit.
    PROSITEiPS00332. SOD_CU_ZN_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9FK60-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEAPRGNLRA VALIAGDNNV RGCLQFVQDI SGTTHVTGKI SGLSPGFHGF    50
    HIHSFGDTTN GCISTGPHFN PLNRVHGPPN EEERHAGDLG NILAGSNGVA 100
    EILIKDKHIP LSGQYSILGR AVVVHADPDD LGKGGHKLSK STGNAGSRVG 150
    CGIIGLQSSA DAKL 164
    Length:164
    Mass (Da):16,941
    Last modified:March 1, 2001 - v1
    Checksum:iA80B9F4A79D0F365
    GO
    Isoform 2 (identifier: Q9FK60-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         135-137: GHK → TKH
         138-164: Missing.

    Note: Derived from EST data. No experimental confirmation available.

    Show »
    Length:137
    Mass (Da):14,412
    Checksum:iBBD55B91BCC424BD
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei135 – 1373GHK → TKH in isoform 2. CuratedVSP_044111
    Alternative sequencei138 – 16427Missing in isoform 2. CuratedVSP_044112Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF061520 mRNA. Translation: AAC24833.1.
    AB012246 Genomic DNA. Translation: BAB09468.1.
    CP002688 Genomic DNA. Translation: AED92506.1.
    CP002688 Genomic DNA. Translation: AED92507.1.
    AK117742 mRNA. Translation: BAC42391.1.
    BT003689 mRNA. Translation: AAO39917.1.
    PIRiT51731.
    RefSeqiNP_001119245.1. NM_001125773.1. [Q9FK60-2]
    NP_197311.1. NM_121815.3. [Q9FK60-1]
    UniGeneiAt.49035.
    At.7547.

    Genome annotation databases

    EnsemblPlantsiAT5G18100.1; AT5G18100.1; AT5G18100. [Q9FK60-1]
    GeneIDi831928.
    KEGGiath:AT5G18100.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF061520 mRNA. Translation: AAC24833.1 .
    AB012246 Genomic DNA. Translation: BAB09468.1 .
    CP002688 Genomic DNA. Translation: AED92506.1 .
    CP002688 Genomic DNA. Translation: AED92507.1 .
    AK117742 mRNA. Translation: BAC42391.1 .
    BT003689 mRNA. Translation: AAO39917.1 .
    PIRi T51731.
    RefSeqi NP_001119245.1. NM_001125773.1. [Q9FK60-2 ]
    NP_197311.1. NM_121815.3. [Q9FK60-1 ]
    UniGenei At.49035.
    At.7547.

    3D structure databases

    ProteinModelPortali Q9FK60.
    SMRi Q9FK60. Positions 9-157.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9FK60. 1 interaction.
    STRINGi 3702.AT5G18100.1-P.

    Proteomic databases

    PRIDEi Q9FK60.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT5G18100.1 ; AT5G18100.1 ; AT5G18100 . [Q9FK60-1 ]
    GeneIDi 831928.
    KEGGi ath:AT5G18100.

    Organism-specific databases

    TAIRi AT5G18100.

    Phylogenomic databases

    eggNOGi COG2032.
    HOGENOMi HOG000263447.
    InParanoidi Q9FK60.
    KOi K04565.
    OMAi EEERHAG.
    PhylomeDBi Q9FK60.

    Enzyme and pathway databases

    Reactomei REACT_180046. Detoxification of Reactive Oxygen Species.

    Gene expression databases

    Genevestigatori Q9FK60.

    Family and domain databases

    Gene3Di 2.60.40.200. 1 hit.
    InterProi IPR018152. SOD_Cu/Zn_BS.
    IPR001424. SOD_Cu_Zn_dom.
    [Graphical view ]
    Pfami PF00080. Sod_Cu. 1 hit.
    [Graphical view ]
    PRINTSi PR00068. CUZNDISMTASE.
    SUPFAMi SSF49329. SSF49329. 1 hit.
    PROSITEi PS00332. SOD_CU_ZN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structural analysis of Arabidopsis thaliana chromosome 5. VI. Sequence features of the regions of 1,367,185 bp covered by 19 physically assigned P1 and TAC clones."
      Kotani H., Nakamura Y., Sato S., Asamizu E., Kaneko T., Miyajima N., Tabata S.
      DNA Res. 5:203-216(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: cv. Columbia.
    4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: cv. Columbia.
    5. "Superoxide dismutase in Arabidopsis: an eclectic enzyme family with disparate regulation and protein localization."
      Kliebenstein D.J., Monde R.A., Last R.L.
      Plant Physiol. 118:637-650(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-164 (ISOFORM 1), TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INDUCTION BY LIGHT; UV-B AND OZONE, GENE FAMILY.
      Strain: cv. Columbia.
    6. "Proteome analysis of Arabidopsis leaf peroxisomes reveals novel targeting peptides, metabolic pathways, and defense mechanisms."
      Reumann S., Babujee L., Ma C., Wienkoop S., Siemsen T., Antonicelli G.E., Rasche N., Lueder F., Weckwerth W., Jahn O.
      Plant Cell 19:3170-3193(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 85-105 AND 108-120, SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    7. "Long-term effects of mild salt stress on growth, ion accumulation and superoxide dismutase expression of Arabidopsis rosette leaves."
      Attia H., Arnaud N., Karray N., Lachaal M.
      Physiol. Plantarum 132:293-305(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION BY SALT.
      Strain: cv. Columbia.

    Entry informationi

    Entry nameiSODC3_ARATH
    AccessioniPrimary (citable) accession number: Q9FK60
    Secondary accession number(s): B3H6P9, O81236
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2012
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3