Reviewed, UniProtKB/Swiss-Prot Q9FK35 (KAD2_ARATH)

Names and origin

Protein names

Recommended name:
    Adenylate kinase 2
      Short name=AK 2
    EC=2.7.4.3
Alternative name(s):
    ATP-AMP transphosphorylase 2

Gene names

Name:	ADK2
Ordered Locus Names:	At5g50370
ORF Names:	MXI22.8

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

Protein attributes

Sequence length	248 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	This small ubiquitous enzyme is essential for maintenance and cell growth.
Catalytic activity	ATP + AMP = 2 ADP.
Sequence similarities	Belongs to the adenylate kinase family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	mitochondrion Inferred from direct assay. Source: TAIR plasma membrane Inferred from direct assay. Source: TAIR plastid Inferred from direct assay. Source: TAIR
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 248	248	Adenylate kinase 2		PRO_0000158941
Experimental info
	Sequence conflict	224	1	E → G in AAM63345. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q9FK35-1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 4A6C578ED637443D	FASTA	248	27,335
	10 20 30 40 50 60 MATSSAASVD MEDIQTVDLM SELLRRMKCA SKPDKRLVFI GPPGSGKGTQ SPVIKDEFCL 70 80 90 100 110 120 CHLSTGDMLR AAVAAKTPLG VKAKEAMDKG ELVSDDLVVG IMDEAMNRPK CQKGFILDGF 130 140 150 160 170 180 PRTVTQAEKL DEMLNRRGAQ IDKVLNFAID DSVLEERITG RWIHPSSGRS YHTKFAPPKV 190 200 210 220 230 240 PGVDDLTGEP LIQRKDDNAD VLRSRLDAFH KQTQPVIDYY AKKENLVNIP AEKAPEEVTK VVKKVVST

References

[1]	"Structural analysis of Arabidopsis thaliana chromosome 5. VI. Sequence features of the regions of 1,367,185 bp covered by 19 physically assigned P1 and TAC clones." Kotani H., Nakamura Y., Sato S., Asamizu E., Kaneko T., Miyajima N., Tabata S. DNA Res. 5:203-216(1998) [PubMed: 9734815] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	"Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R. Science 302:842-846(2003) [PubMed: 14593172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[3]	"Full-length cDNA from Arabidopsis thaliana." Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB012248 Genomic DNA. Translation: BAB09456.1. BT004811 mRNA. Translation: AAO44077.1. AY086140 mRNA. Translation: AAM63345.1.
IPI	IPI00537884.
RefSeq	NP_199848.1.
UniGene	At.43295
3D structure databases
HSSP	HSSP built from PDB template 3AKY based on UniProtKB P07170.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9FK35.
Proteomic databases
PRIDE	Q9FK35.
Genome annotation databases
GeneID	835104.
GenomeReviews	Gene locus AT5G50370 in contig BA000015_GR.
KEGG	ath:AT5G50370.
NMPDR	fig|3702.1.peg.26892.
Organism-specific databases
GeneFarm	4388. 444.
TAIR	At5g50370.
Phylogenomic databases
OMA	RQTAPLV.
Enzyme and pathway databases
BRENDA	2.7.4.3. 302.
Gene expression databases
ArrayExpress	Q9FK35.
Genevestigator	Q9FK35.
GermOnline	AT5G50370. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR006259. Adenyl_kin_sub. IPR000850. Adenylate_kin. IPR007862. Adenylate_kinase_Znf_lid. [Graphical view]
PANTHER	PTHR23359. Adenylate_kin. 1 hit.
Pfam	PF00406. ADK. 1 hit. PF05191. ADK_lid. 1 hit. [Graphical view]
PRINTS	PR00094. ADENYLTKNASE.
ProDom	PD000657. Adenylate_kin. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01351. adk. 1 hit.
PROSITE	PS00113. ADENYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAD2_ARATH

Accession

Primary (citable) accession number: Q9FK35
Secondary accession number(s): Q8LD90

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 28, 2003
Last sequence update:	March 1, 2001
Last modified:	November 3, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)