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Protein

Membrin-12

Gene

MEMB12

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.By similarity

GO - Molecular functioni

  1. SNAP receptor activity Source: GO_Central
  2. SNARE binding Source: GO_Central

GO - Biological processi

  1. ER to Golgi vesicle-mediated transport Source: GO_Central
  2. Golgi to vacuole transport Source: GO_Central
  3. intra-Golgi vesicle-mediated transport Source: GO_Central
  4. protein targeting to vacuole Source: GO_Central
  5. regulation of innate immune response Source: TAIR
  6. regulation of protein secretion Source: TAIR
  7. retrograde transport, endosome to Golgi Source: GO_Central
  8. vesicle fusion with Golgi apparatus Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Membrin-12
Short name:
AtMEMB12
Alternative name(s):
Golgi SNAP receptor complex member 2-2
Gene namesi
Name:MEMB12
Ordered Locus Names:At5g50440
ORF Names:MXI22.16
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G50440.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 197196CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei198 – 21518Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
BLAST
Topological domaini216 – 2194VesicularSequence Analysis

GO - Cellular componenti

  1. cis-Golgi network Source: TAIR
  2. endoplasmic reticulum membrane Source: GO_Central
  3. ER to Golgi transport vesicle membrane Source: GO_Central
  4. Golgi apparatus Source: GO_Central
  5. Golgi membrane Source: UniProtKB-SubCell
  6. Golgi stack Source: InterPro
  7. integral component of membrane Source: UniProtKB-KW
  8. late endosome membrane Source: GO_Central
  9. SNARE complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 219218Membrin-12PRO_0000212555Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9FK28.
PRIDEiQ9FK28.

Expressioni

Gene expression databases

GenevestigatoriQ9FK28.

Interactioni

Protein-protein interaction databases

BioGridi20358. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9FK28.
SMRiQ9FK28. Positions 131-187.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GOSR2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148687.
HOGENOMiHOG000264938.
InParanoidiQ9FK28.
KOiK08496.
OMAiEVYSSAK.
PhylomeDBiQ9FK28.

Family and domain databases

InterProiIPR027027. GOSR2/Membrin/Bos1.
[Graphical view]
PIRSFiPIRSF028865. Membrin-2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9FK28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGTVGGLS EVYSSAKRIL LRARNGIEKL ERFDSDPTDL ASSVKRDITE
60 70 80 90 100
VQSLCSNMDG LWRSIPVKSQ RDLWRRKSEQ VGEEAEYLNQ SLEKYMWRNQ
110 120 130 140 150
RKMLEAKERA DLLGRGSGEG AHILQIFDEE AQGMNSVKNS KRMLEDSFQS
160 170 180 190 200
GVAILSKYAE QRDRLKSAQR KALDVLNTVG LSNSVLRLIE RRNRVDTWIK
210
YAGMIATLVI LYLFIRWTR
Length:219
Mass (Da):25,105
Last modified:March 1, 2001 - v1
Checksum:i9885F002AF89B4EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012248 Genomic DNA. Translation: BAB09463.1.
CP002688 Genomic DNA. Translation: AED95946.1.
BT004999 mRNA. Translation: AAO50532.1.
RefSeqiNP_199855.1. NM_124426.4.
UniGeneiAt.29730.

Genome annotation databases

EnsemblPlantsiAT5G50440.1; AT5G50440.1; AT5G50440.
GeneIDi835112.
KEGGiath:AT5G50440.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012248 Genomic DNA. Translation: BAB09463.1.
CP002688 Genomic DNA. Translation: AED95946.1.
BT004999 mRNA. Translation: AAO50532.1.
RefSeqiNP_199855.1. NM_124426.4.
UniGeneiAt.29730.

3D structure databases

ProteinModelPortaliQ9FK28.
SMRiQ9FK28. Positions 131-187.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi20358. 1 interaction.

Proteomic databases

PaxDbiQ9FK28.
PRIDEiQ9FK28.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G50440.1; AT5G50440.1; AT5G50440.
GeneIDi835112.
KEGGiath:AT5G50440.

Organism-specific databases

GeneFarmi4298. 433.
TAIRiAT5G50440.

Phylogenomic databases

eggNOGiNOG148687.
HOGENOMiHOG000264938.
InParanoidiQ9FK28.
KOiK08496.
OMAiEVYSSAK.
PhylomeDBiQ9FK28.

Gene expression databases

GenevestigatoriQ9FK28.

Family and domain databases

InterProiIPR027027. GOSR2/Membrin/Bos1.
[Graphical view]
PIRSFiPIRSF028865. Membrin-2. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis of Arabidopsis thaliana chromosome 5. VI. Sequence features of the regions of 1,367,185 bp covered by 19 physically assigned P1 and TAC clones."
    Kotani H., Nakamura Y., Sato S., Asamizu E., Kaneko T., Miyajima N., Tabata S.
    DNA Res. 5:203-216(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.

Entry informationi

Entry nameiMEM12_ARATH
AccessioniPrimary (citable) accession number: Q9FK28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: March 1, 2001
Last modified: April 1, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.