Q9FJT8 (HATB_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone acetyltransferase type B catalytic subunit
Short name=HAT B
EC=2.3.1.48

Gene names

Name:	HAG2
Synonyms:	HAT1
Ordered Locus Names:	At5g56740
ORF Names:	MIK19.19

Organism

Arabidopsis thaliana (Mouse-ear cress) [Reference proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	467 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Acetylates soluble but not nucleosomal H4 By similarity. Acetylates 'Lys-12' of histone H4. Ref.4
Catalytic activity	Acetyl-CoA + [histone] = CoA + acetyl-[histone].
Subcellular location	Nucleus By similarity. Cytoplasm By similarity.
Sequence similarities	Belongs to the HAT1 family.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chromatin silencing at telomere Inferred from electronic annotation. Source: InterPro
Cellular_component	cytosol Inferred from direct assay PubMed 21166475. Source: TAIR nucleus Inferred from direct assay PubMed 17877703. Source: TAIR
Molecular_function	H4 histone acetyltransferase activity Inferred from direct assay PubMed 17877703. Source: TAIR
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 467	467	Histone acetyltransferase type B catalytic subunit		PRO_0000232125

Sequences

	Sequence		Length	Mass (Da)
	Q9FJT8 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 2B8A0465D6451662	FASTA	467	52,738
	10 20 30 40 50 60 MVQKQQASAG PGTEPKKRRR VGFSPADTGV EANECIKIYL VSSKEEVDSS DISSVKPVDL 70 80 90 100 110 120 NDFFDGDGKI YGYQGLKINV WINSISLHSY ADITYQSTIN GDKGITDLKS ALQNIFAETI 130 140 150 160 170 180 VDTKDEFLQT FSTQRDFIRN MVSNGEVMHA GATDGSSKNA EVVPSDPQVI RMEIGSPNAG 190 200 210 220 230 240 LLYSRLVPLV LLFVDGSNPI DVTDPDWHLY LLIQKKEEKE DPLYRIVGFT AIYKFYRYPD 250 260 270 280 290 300 RLRMRLSQIL VLPSFQGKGL GSYLMEVVNN VAITENVYDL TVEEPSEKFQ HIRTCIDINR 310 320 330 340 350 360 LRSFDPIKPD IDSAVQTLTK GKLSKKAQIP RFTPPLNAIE KVRESLKINK KQFLKCWEIL 370 380 390 400 410 420 IYLALDPIDK YMEDYTSVIT NHVRTDILGK DIETPKKQVV DVPSSFEPEA SFVVFKSVNG 430 440 450 460 EEANTNVQVD ENKPDQEQQL KQLVEERIRE IKLVAEKVSK SGQTLKV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structural analysis of Arabidopsis thaliana chromosome 5. VI. Sequence features of the regions of 1,367,185 bp covered by 19 physically assigned P1 and TAC clones." Kotani H., Nakamura Y., Sato S., Asamizu E., Kaneko T., Miyajima N., Tabata S. DNA Res. 5:203-216(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[3]	"Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes." Pandey R., Mueller A., Napoli C.A., Selinger D.A., Pikaard C.S., Richards E.J., Bender J., Mount D.W., Jorgensen R.A. Nucleic Acids Res. 30:5036-5055(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-251, NOMENCLATURE.
[4]	"Erasure of histone acetylation by Arabidopsis HDA6 mediates large-scale gene silencing in nucleolar dominance." Earley K., Lawrence R.J., Pontes O., Reuther R., Enciso A.J., Silva M., Neves N., Gross M., Viegas W., Pikaard C.S. Genes Dev. 20:1283-1293(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB013392 Genomic DNA. Translation: BAB09892.1. CP002688 Genomic DNA. Translation: AED96802.1. AF512724 mRNA. Translation: AAM70417.1.
IPI	IPI00547670.
RefSeq	NP_200485.1. NM_125057.3.
UniGene	At.27567.
3D structure databases
ProteinModelPortal	Q9FJT8.
SMR	Q9FJT8. Positions 23-363.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-8062959.
Proteomic databases
PaxDb	Q9FJT8.
PRIDE	Q9FJT8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT5G56740.1; AT5G56740.1; AT5G56740.
GeneID	835775.
KEGG	ath:AT5G56740.
Organism-specific databases
TAIR	At5g56740.
Phylogenomic databases
eggNOG	NOG326277.
HOGENOM	HOG000084749.
InParanoid	Q9FJT8.
KO	K11303.
OMA	TAGPLHI.
PhylomeDB	Q9FJT8.
ProtClustDB	CLSN2687357.
Gene expression databases
ArrayExpress	Q9FJT8.
Genevestigator	Q9FJT8.
GermOnline	AT5G56740. Arabidopsis thaliana.
Family and domain databases
Gene3D	3.40.630.30. 1 hit. 3.90.360.10. 2 hits.
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR000182. GNAT_dom. IPR019467. Hat1_N. IPR017380. Hist_AcTrfase_B-typ_cat-su. [Graphical view]
PANTHER	PTHR12046. PTHR12046. 1 hit.
Pfam	PF00583. Acetyltransf_1. 1 hit. PF10394. Hat1_N. 1 hit. [Graphical view]
PIRSF	PIRSF038084. HAT-B_cat. 1 hit.
SUPFAM	SSF55729. Acyl_CoA_acyltransferase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HATB_ARATH

Accession

Primary (citable) accession number: Q9FJT8
Secondary accession number(s): Q8LKJ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	March 1, 2001
Last modified:	May 29, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program