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Q9FJT8

- HATB_ARATH

UniProt

Q9FJT8 - HATB_ARATH

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Protein

Histone acetyltransferase type B catalytic subunit

Gene

HAG2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Acetylates soluble but not nucleosomal H4 (By similarity). Acetylates 'Lys-12' of histone H4.By similarity1 Publication

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei207 – 2071Interaction with histone H4 N-terminusBy similarity
Active sitei283 – 2831Proton donor/acceptorBy similarity

GO - Molecular functioni

  1. H4 histone acetyltransferase activity Source: TAIR

GO - Biological processi

  1. chromatin silencing at telomere Source: InterPro
  2. histone H4 acetylation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciARA:AT5G56740-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase type B catalytic subunit (EC:2.3.1.48By similarity)
Short name:
HAT B
Gene namesi
Name:HAG2
Synonyms:HAT1
Ordered Locus Names:At5g56740
ORF Names:MIK19.19
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G56740.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity

GO - Cellular componenti

  1. cytosol Source: TAIR
  2. nucleus Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 467467Histone acetyltransferase type B catalytic subunitPRO_0000232125Add
BLAST

Proteomic databases

PaxDbiQ9FJT8.
PRIDEiQ9FJT8.

Expressioni

Gene expression databases

GenevestigatoriQ9FJT8.

Interactioni

Protein-protein interaction databases

BioGridi21019. 1 interaction.
MINTiMINT-8062959.

Structurei

3D structure databases

ProteinModelPortaliQ9FJT8.
SMRiQ9FJT8. Positions 23-363.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni249 – 2513Acetyl-CoA bindingBy similarity
Regioni256 – 2627Acetyl-CoA bindingBy similarity

Sequence similaritiesi

Belongs to the HAT1 family.Curated

Phylogenomic databases

eggNOGiNOG326277.
HOGENOMiHOG000084749.
InParanoidiQ9FJT8.
KOiK11303.
OMAiKEANFKP.
PhylomeDBiQ9FJT8.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
3.90.360.10. 2 hits.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR019467. Hat1_N.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
[Graphical view]
PANTHERiPTHR12046. PTHR12046. 1 hit.
PfamiPF00583. Acetyltransf_1. 1 hit.
PF10394. Hat1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF038084. HAT-B_cat. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9FJT8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVQKQQASAG PGTEPKKRRR VGFSPADTGV EANECIKIYL VSSKEEVDSS
60 70 80 90 100
DISSVKPVDL NDFFDGDGKI YGYQGLKINV WINSISLHSY ADITYQSTIN
110 120 130 140 150
GDKGITDLKS ALQNIFAETI VDTKDEFLQT FSTQRDFIRN MVSNGEVMHA
160 170 180 190 200
GATDGSSKNA EVVPSDPQVI RMEIGSPNAG LLYSRLVPLV LLFVDGSNPI
210 220 230 240 250
DVTDPDWHLY LLIQKKEEKE DPLYRIVGFT AIYKFYRYPD RLRMRLSQIL
260 270 280 290 300
VLPSFQGKGL GSYLMEVVNN VAITENVYDL TVEEPSEKFQ HIRTCIDINR
310 320 330 340 350
LRSFDPIKPD IDSAVQTLTK GKLSKKAQIP RFTPPLNAIE KVRESLKINK
360 370 380 390 400
KQFLKCWEIL IYLALDPIDK YMEDYTSVIT NHVRTDILGK DIETPKKQVV
410 420 430 440 450
DVPSSFEPEA SFVVFKSVNG EEANTNVQVD ENKPDQEQQL KQLVEERIRE
460
IKLVAEKVSK SGQTLKV
Length:467
Mass (Da):52,738
Last modified:March 1, 2001 - v1
Checksum:i2B8A0465D6451662
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB013392 Genomic DNA. Translation: BAB09892.1.
CP002688 Genomic DNA. Translation: AED96802.1.
AF512724 mRNA. Translation: AAM70417.1.
RefSeqiNP_200485.1. NM_125057.3.
UniGeneiAt.27567.

Genome annotation databases

EnsemblPlantsiAT5G56740.1; AT5G56740.1; AT5G56740.
GeneIDi835775.
KEGGiath:AT5G56740.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB013392 Genomic DNA. Translation: BAB09892.1 .
CP002688 Genomic DNA. Translation: AED96802.1 .
AF512724 mRNA. Translation: AAM70417.1 .
RefSeqi NP_200485.1. NM_125057.3.
UniGenei At.27567.

3D structure databases

ProteinModelPortali Q9FJT8.
SMRi Q9FJT8. Positions 23-363.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 21019. 1 interaction.
MINTi MINT-8062959.

Proteomic databases

PaxDbi Q9FJT8.
PRIDEi Q9FJT8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G56740.1 ; AT5G56740.1 ; AT5G56740 .
GeneIDi 835775.
KEGGi ath:AT5G56740.

Organism-specific databases

TAIRi AT5G56740.

Phylogenomic databases

eggNOGi NOG326277.
HOGENOMi HOG000084749.
InParanoidi Q9FJT8.
KOi K11303.
OMAi KEANFKP.
PhylomeDBi Q9FJT8.

Enzyme and pathway databases

BioCyci ARA:AT5G56740-MONOMER.

Miscellaneous databases

PROi Q9FJT8.

Gene expression databases

Genevestigatori Q9FJT8.

Family and domain databases

Gene3Di 3.40.630.30. 1 hit.
3.90.360.10. 2 hits.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR019467. Hat1_N.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
[Graphical view ]
PANTHERi PTHR12046. PTHR12046. 1 hit.
Pfami PF00583. Acetyltransf_1. 1 hit.
PF10394. Hat1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF038084. HAT-B_cat. 1 hit.
SUPFAMi SSF55729. SSF55729. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis of Arabidopsis thaliana chromosome 5. VI. Sequence features of the regions of 1,367,185 bp covered by 19 physically assigned P1 and TAC clones."
    Kotani H., Nakamura Y., Sato S., Asamizu E., Kaneko T., Miyajima N., Tabata S.
    DNA Res. 5:203-216(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes."
    Pandey R., Mueller A., Napoli C.A., Selinger D.A., Pikaard C.S., Richards E.J., Bender J., Mount D.W., Jorgensen R.A.
    Nucleic Acids Res. 30:5036-5055(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-251, NOMENCLATURE.
  4. "Erasure of histone acetylation by Arabidopsis HDA6 mediates large-scale gene silencing in nucleolar dominance."
    Earley K., Lawrence R.J., Pontes O., Reuther R., Enciso A.J., Silva M., Neves N., Gross M., Viegas W., Pikaard C.S.
    Genes Dev. 20:1283-1293(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiHATB_ARATH
AccessioniPrimary (citable) accession number: Q9FJT8
Secondary accession number(s): Q8LKJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3