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Protein

Histone acetyltransferase type B catalytic subunit

Gene

HAG2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acetylates soluble but not nucleosomal H4 (By similarity). Acetylates 'Lys-12' of histone H4.By similarity1 Publication

Catalytic activityi

Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei283Proton donor/acceptorBy similarity1

GO - Molecular functioni

  • H4 histone acetyltransferase activity Source: TAIR
  • histone binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-ATH-3214847 HATs acetylate histones

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase type B catalytic subunit (EC:2.3.1.48By similarity)
Short name:
HAT B
Gene namesi
Name:HAG2
Synonyms:HAT1
Ordered Locus Names:At5g56740
ORF Names:MIK19.19
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G56740
TAIRilocus:2165091 AT5G56740

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002321251 – 467Histone acetyltransferase type B catalytic subunitAdd BLAST467

Proteomic databases

PaxDbiQ9FJT8

PTM databases

iPTMnetiQ9FJT8

Expressioni

Gene expression databases

ExpressionAtlasiQ9FJT8 baseline and differential
GenevisibleiQ9FJT8 AT

Interactioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei207Interaction with histone H4 N-terminusBy similarity1

GO - Molecular functioni

Protein-protein interaction databases

BioGridi21019, 3 interactors
STRINGi3702.AT5G56740.1

Structurei

3D structure databases

ProteinModelPortaliQ9FJT8
SMRiQ9FJT8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni249 – 251Acetyl-CoA bindingBy similarity3
Regioni256 – 262Acetyl-CoA bindingBy similarity7

Sequence similaritiesi

Belongs to the HAT1 family.Curated

Phylogenomic databases

eggNOGiKOG2696 Eukaryota
ENOG410XPH4 LUCA
HOGENOMiHOG000084749
InParanoidiQ9FJT8
KOiK11303
OMAiMAHQIFG
OrthoDBiEOG09360BJ7
PhylomeDBiQ9FJT8

Family and domain databases

Gene3Di3.90.360.10, 2 hits
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR000182 GNAT_dom
IPR019467 Hat1_N
IPR037113 Hat1_N_sf
IPR017380 Hist_AcTrfase_B-typ_cat-su
PANTHERiPTHR12046 PTHR12046, 1 hit
PfamiView protein in Pfam
PF00583 Acetyltransf_1, 1 hit
PF10394 Hat1_N, 1 hit
PIRSFiPIRSF038084 HAT-B_cat, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit

Sequencei

Sequence statusi: Complete.

Q9FJT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQKQQASAG PGTEPKKRRR VGFSPADTGV EANECIKIYL VSSKEEVDSS
60 70 80 90 100
DISSVKPVDL NDFFDGDGKI YGYQGLKINV WINSISLHSY ADITYQSTIN
110 120 130 140 150
GDKGITDLKS ALQNIFAETI VDTKDEFLQT FSTQRDFIRN MVSNGEVMHA
160 170 180 190 200
GATDGSSKNA EVVPSDPQVI RMEIGSPNAG LLYSRLVPLV LLFVDGSNPI
210 220 230 240 250
DVTDPDWHLY LLIQKKEEKE DPLYRIVGFT AIYKFYRYPD RLRMRLSQIL
260 270 280 290 300
VLPSFQGKGL GSYLMEVVNN VAITENVYDL TVEEPSEKFQ HIRTCIDINR
310 320 330 340 350
LRSFDPIKPD IDSAVQTLTK GKLSKKAQIP RFTPPLNAIE KVRESLKINK
360 370 380 390 400
KQFLKCWEIL IYLALDPIDK YMEDYTSVIT NHVRTDILGK DIETPKKQVV
410 420 430 440 450
DVPSSFEPEA SFVVFKSVNG EEANTNVQVD ENKPDQEQQL KQLVEERIRE
460
IKLVAEKVSK SGQTLKV
Length:467
Mass (Da):52,738
Last modified:March 1, 2001 - v1
Checksum:i2B8A0465D6451662
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013392 Genomic DNA Translation: BAB09892.1
CP002688 Genomic DNA Translation: AED96802.1
AF512724 mRNA Translation: AAM70417.1
RefSeqiNP_200485.1, NM_125057.4
UniGeneiAt.27567

Genome annotation databases

EnsemblPlantsiAT5G56740.1; AT5G56740.1; AT5G56740
GeneIDi835775
GrameneiAT5G56740.1; AT5G56740.1; AT5G56740
KEGGiath:AT5G56740

Similar proteinsi

Entry informationi

Entry nameiHATB_ARATH
AccessioniPrimary (citable) accession number: Q9FJT8
Secondary accession number(s): Q8LKJ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: March 1, 2001
Last modified: April 25, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health