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Q9FJP9

- SDHB3_ARATH

UniProt

Q9FJP9 - SDHB3_ARATH

Protein

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit 3, mitochondrial

Gene

SDH2-3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

    Catalytic activityi

    Succinate + a quinone = fumarate + a quinol.

    Cofactori

    Binds 1 2Fe-2S cluster.By similarity
    Binds 1 3Fe-4S cluster.By similarity
    Binds 1 4Fe-4S cluster.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi120 – 1201Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi125 – 1251Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi128 – 1281Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi140 – 1401Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi212 – 2121Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi215 – 2151Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi218 – 2181Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi222 – 2221Iron-sulfur 3 (3Fe-4S)By similarity
    Binding sitei227 – 2271Ubiquinone; shared with DHSDBy similarity
    Metal bindingi270 – 2701Iron-sulfur 3 (3Fe-4S)By similarity
    Metal bindingi276 – 2761Iron-sulfur 3 (3Fe-4S)By similarity
    Metal bindingi280 – 2801Iron-sulfur 2 (4Fe-4S)By similarity

    GO - Molecular functioni

    1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
    2. 3 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    3. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    4. electron carrier activity Source: TAIR
    5. metal ion binding Source: UniProtKB-KW
    6. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
    7. succinate dehydrogenase activity Source: TAIR

    GO - Biological processi

    1. mitochondrial electron transport, succinate to ubiquinone Source: TAIR
    2. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Transport, Tricarboxylic acid cycle

    Keywords - Ligandi

    2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00223; UER01006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Succinate dehydrogenase [ubiquinone] iron-sulfur subunit 3, mitochondrial (EC:1.3.5.1)
    Alternative name(s):
    Iron-sulfur subunit of complex II
    Short name:
    Ip
    Gene namesi
    Name:SDH2-3
    Ordered Locus Names:At5g65165
    ORF Names:MQN23.10
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 5

    Organism-specific databases

    TAIRiAT5G65165.

    Subcellular locationi

    Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB-SubCell
    2. mitochondrion Source: TAIR
    3. succinate dehydrogenase complex Source: TAIR

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2222MitochondrionSequence AnalysisAdd
    BLAST
    Chaini23 – 309287Succinate dehydrogenase [ubiquinone] iron-sulfur subunit 3, mitochondrialPRO_0000247597Add
    BLAST

    Proteomic databases

    PaxDbiQ9FJP9.
    PRIDEiQ9FJP9.

    Expressioni

    Developmental stagei

    Expressed during seed development. Detected during seed maturation and decreased during germination.1 Publication

    Gene expression databases

    GenevestigatoriQ9FJP9.

    Interactioni

    Subunit structurei

    Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b composed of a large and a small subunit.By similarity

    Protein-protein interaction databases

    MINTiMINT-8067094.
    STRINGi3702.AT5G65165.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9FJP9.
    SMRiQ9FJP9. Positions 67-294.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini69 – 160922Fe-2S ferredoxin-typeAdd
    BLAST
    Domaini202 – 232314Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 4Fe-4S ferredoxin-type domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0479.
    HOGENOMiHOG000160590.
    InParanoidiQ9FJP9.
    KOiK00235.
    OMAiGREHRQS.
    PhylomeDBiQ9FJP9.

    Family and domain databases

    Gene3Di3.10.20.30. 1 hit.
    InterProiIPR001041. 2Fe-2S_ferredoxin-type.
    IPR006058. 2Fe2S_fd_BS.
    IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR012675. Beta-grasp_dom.
    IPR009051. Helical_ferredxn.
    IPR004489. Succ_DH/fum_Rdtase_Fe-S.
    IPR025192. Succ_DH/fum_Rdtase_N.
    [Graphical view]
    PfamiPF13085. Fer2_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF46548. SSF46548. 1 hit.
    SSF54292. SSF54292. 1 hit.
    TIGRFAMsiTIGR00384. dhsB. 1 hit.
    PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
    PS00198. 4FE4S_FER_1. 1 hit.
    PS51379. 4FE4S_FER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9FJP9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSVLRLLGR RICNPAAEKV RLSSSLSGGG DFPILNGHKA AQDLSKDTLK    50
    SQDITKEKEG QHKEVKKEFK IYRWNPDKPN SKPFLQSFFV DLSSCGPMVL 100
    DVLQKIKAED DASLSYRRSC REGICGSCSM NIDGTNTVAC LKPINPNTSK 150
    PTIITPLPHM YVIKDLVVDL TNFYQQYKSM EPWLKTRKPP KDGREHRQSP 200
    KDRKKLDGLY ECILCACCTT SCPSYWWNPE EFPGPAALLQ AYRWISDSRD 250
    EYREERLQAI TESETKVYRC RAIKNCTATC PKGLNPASAI LKMKSKHLLS 300
    DPLVRTESV 309
    Length:309
    Mass (Da):34,983
    Last modified:March 1, 2001 - v1
    Checksum:iF69189C234D87A1D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ278912 mRNA. Translation: CAC19857.1.
    AB013395 Genomic DNA. Translation: BAB11652.1.
    CP002688 Genomic DNA. Translation: AED98011.1.
    RefSeqiNP_680465.2. NM_148160.2.
    UniGeneiAt.45474.

    Genome annotation databases

    EnsemblPlantsiAT5G65165.1; AT5G65165.1; AT5G65165.
    GeneIDi836640.
    KEGGiath:AT5G65165.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ278912 mRNA. Translation: CAC19857.1 .
    AB013395 Genomic DNA. Translation: BAB11652.1 .
    CP002688 Genomic DNA. Translation: AED98011.1 .
    RefSeqi NP_680465.2. NM_148160.2.
    UniGenei At.45474.

    3D structure databases

    ProteinModelPortali Q9FJP9.
    SMRi Q9FJP9. Positions 67-294.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-8067094.
    STRINGi 3702.AT5G65165.1-P.

    Proteomic databases

    PaxDbi Q9FJP9.
    PRIDEi Q9FJP9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT5G65165.1 ; AT5G65165.1 ; AT5G65165 .
    GeneIDi 836640.
    KEGGi ath:AT5G65165.

    Organism-specific databases

    GeneFarmi 2172. 175.
    TAIRi AT5G65165.

    Phylogenomic databases

    eggNOGi COG0479.
    HOGENOMi HOG000160590.
    InParanoidi Q9FJP9.
    KOi K00235.
    OMAi GREHRQS.
    PhylomeDBi Q9FJP9.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER01006 .

    Gene expression databases

    Genevestigatori Q9FJP9.

    Family and domain databases

    Gene3Di 3.10.20.30. 1 hit.
    InterProi IPR001041. 2Fe-2S_ferredoxin-type.
    IPR006058. 2Fe2S_fd_BS.
    IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR012675. Beta-grasp_dom.
    IPR009051. Helical_ferredxn.
    IPR004489. Succ_DH/fum_Rdtase_Fe-S.
    IPR025192. Succ_DH/fum_Rdtase_N.
    [Graphical view ]
    Pfami PF13085. Fer2_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46548. SSF46548. 1 hit.
    SSF54292. SSF54292. 1 hit.
    TIGRFAMsi TIGR00384. dhsB. 1 hit.
    PROSITEi PS00197. 2FE2S_FER_1. 1 hit.
    PS00198. 4FE4S_FER_1. 1 hit.
    PS51379. 4FE4S_FER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Three different genes encode the iron-sulphur subunit of succinate dehydrogenase in Arabidopsis thaliana."
      Figueroa P., Leon G., Elorza A., Holuigue L., Jordana X.
      Plant Mol. Biol. 46:241-250(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Columbia.
      Tissue: Leaf.
    2. "Structural analysis of Arabidopsis thaliana chromosome 5. VI. Sequence features of the regions of 1,367,185 bp covered by 19 physically assigned P1 and TAC clones."
      Kotani H., Nakamura Y., Sato S., Asamizu E., Kaneko T., Miyajima N., Tabata S.
      DNA Res. 5:203-216(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "A nuclear gene for the iron-sulfur subunit of mitochondrial complex II is specifically expressed during Arabidopsis seed development and germination."
      Elorza A., Roschzttardtz H., Gomez I., Mouras A., Holuigue L., Araya A., Jordana X.
      Plant Cell Physiol. 47:14-21(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiSDHB3_ARATH
    AccessioniPrimary (citable) accession number: Q9FJP9
    Secondary accession number(s): Q9G3L8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3