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Q9FJP9

- SDHB3_ARATH

UniProt

Q9FJP9 - SDHB3_ARATH

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Protein

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit 3, mitochondrial

Gene

SDH2-3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

Protein has several cofactor binding sites:

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi120 – 1201Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi125 – 1251Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi128 – 1281Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi140 – 1401Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi212 – 2121Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi215 – 2151Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi218 – 2181Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi222 – 2221Iron-sulfur 3 (3Fe-4S)By similarity
Binding sitei227 – 2271Ubiquinone; shared with DHSDBy similarity
Metal bindingi270 – 2701Iron-sulfur 3 (3Fe-4S)By similarity
Metal bindingi276 – 2761Iron-sulfur 3 (3Fe-4S)By similarity
Metal bindingi280 – 2801Iron-sulfur 2 (4Fe-4S)By similarity

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
  2. 3 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  3. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  4. electron carrier activity Source: TAIR
  5. metal ion binding Source: UniProtKB-KW
  6. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
  7. succinate dehydrogenase activity Source: TAIR

GO - Biological processi

  1. mitochondrial electron transport, succinate to ubiquinone Source: TAIR
  2. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit 3, mitochondrial (EC:1.3.5.1)
Alternative name(s):
Iron-sulfur subunit of complex II
Short name:
Ip
Gene namesi
Name:SDH2-3
Ordered Locus Names:At5g65165
ORF Names:MQN23.10
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G65165.

Subcellular locationi

Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB-KW
  2. mitochondrion Source: TAIR
  3. succinate dehydrogenase complex Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2222MitochondrionSequence AnalysisAdd
BLAST
Chaini23 – 309287Succinate dehydrogenase [ubiquinone] iron-sulfur subunit 3, mitochondrialPRO_0000247597Add
BLAST

Proteomic databases

PaxDbiQ9FJP9.
PRIDEiQ9FJP9.

Expressioni

Developmental stagei

Expressed during seed development. Detected during seed maturation and decreased during germination.1 Publication

Gene expression databases

GenevestigatoriQ9FJP9.

Interactioni

Subunit structurei

Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b composed of a large and a small subunit.By similarity

Protein-protein interaction databases

MINTiMINT-8067094.
STRINGi3702.AT5G65165.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9FJP9.
SMRiQ9FJP9. Positions 67-294.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini69 – 160922Fe-2S ferredoxin-typeAdd
BLAST
Domaini202 – 232314Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 4Fe-4S ferredoxin-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0479.
HOGENOMiHOG000160590.
InParanoidiQ9FJP9.
KOiK00235.
OMAiGREHRQS.
PhylomeDBiQ9FJP9.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamiPF13085. Fer2_3. 1 hit.
[Graphical view]
SUPFAMiSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR00384. dhsB. 1 hit.
PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9FJP9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSVLRLLGR RICNPAAEKV RLSSSLSGGG DFPILNGHKA AQDLSKDTLK
60 70 80 90 100
SQDITKEKEG QHKEVKKEFK IYRWNPDKPN SKPFLQSFFV DLSSCGPMVL
110 120 130 140 150
DVLQKIKAED DASLSYRRSC REGICGSCSM NIDGTNTVAC LKPINPNTSK
160 170 180 190 200
PTIITPLPHM YVIKDLVVDL TNFYQQYKSM EPWLKTRKPP KDGREHRQSP
210 220 230 240 250
KDRKKLDGLY ECILCACCTT SCPSYWWNPE EFPGPAALLQ AYRWISDSRD
260 270 280 290 300
EYREERLQAI TESETKVYRC RAIKNCTATC PKGLNPASAI LKMKSKHLLS

DPLVRTESV
Length:309
Mass (Da):34,983
Last modified:March 1, 2001 - v1
Checksum:iF69189C234D87A1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278912 mRNA. Translation: CAC19857.1.
AB013395 Genomic DNA. Translation: BAB11652.1.
CP002688 Genomic DNA. Translation: AED98011.1.
RefSeqiNP_680465.2. NM_148160.2.
UniGeneiAt.45474.

Genome annotation databases

EnsemblPlantsiAT5G65165.1; AT5G65165.1; AT5G65165.
GeneIDi836640.
KEGGiath:AT5G65165.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278912 mRNA. Translation: CAC19857.1 .
AB013395 Genomic DNA. Translation: BAB11652.1 .
CP002688 Genomic DNA. Translation: AED98011.1 .
RefSeqi NP_680465.2. NM_148160.2.
UniGenei At.45474.

3D structure databases

ProteinModelPortali Q9FJP9.
SMRi Q9FJP9. Positions 67-294.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-8067094.
STRINGi 3702.AT5G65165.1-P.

Proteomic databases

PaxDbi Q9FJP9.
PRIDEi Q9FJP9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G65165.1 ; AT5G65165.1 ; AT5G65165 .
GeneIDi 836640.
KEGGi ath:AT5G65165.

Organism-specific databases

GeneFarmi 2172. 175.
TAIRi AT5G65165.

Phylogenomic databases

eggNOGi COG0479.
HOGENOMi HOG000160590.
InParanoidi Q9FJP9.
KOi K00235.
OMAi GREHRQS.
PhylomeDBi Q9FJP9.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER01006 .

Gene expression databases

Genevestigatori Q9FJP9.

Family and domain databases

Gene3Di 3.10.20.30. 1 hit.
InterProi IPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view ]
Pfami PF13085. Fer2_3. 1 hit.
[Graphical view ]
SUPFAMi SSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsi TIGR00384. dhsB. 1 hit.
PROSITEi PS00197. 2FE2S_FER_1. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Three different genes encode the iron-sulphur subunit of succinate dehydrogenase in Arabidopsis thaliana."
    Figueroa P., Leon G., Elorza A., Holuigue L., Jordana X.
    Plant Mol. Biol. 46:241-250(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Columbia.
    Tissue: Leaf.
  2. "Structural analysis of Arabidopsis thaliana chromosome 5. VI. Sequence features of the regions of 1,367,185 bp covered by 19 physically assigned P1 and TAC clones."
    Kotani H., Nakamura Y., Sato S., Asamizu E., Kaneko T., Miyajima N., Tabata S.
    DNA Res. 5:203-216(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "A nuclear gene for the iron-sulfur subunit of mitochondrial complex II is specifically expressed during Arabidopsis seed development and germination."
    Elorza A., Roschzttardtz H., Gomez I., Mouras A., Holuigue L., Araya A., Jordana X.
    Plant Cell Physiol. 47:14-21(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiSDHB3_ARATH
AccessioniPrimary (citable) accession number: Q9FJP9
Secondary accession number(s): Q9G3L8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 1, 2001
Last modified: November 26, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3