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Protein

Structural maintenance of chromosomes protein 4

Gene

SMC4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Also involved in chromosome segregation in meiosis.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi55 – 628ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • embryo development ending in seed dormancy Source: UniProtKB
  • meiotic cell cycle Source: UniProtKB-KW
  • mitotic chromosome condensation Source: UniProtKB
  • mitotic sister chromatid segregation Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, DNA condensation, Meiosis, Mitosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-2299718. Condensation of Prophase Chromosomes.
R-ATH-2514853. Condensation of Prometaphase Chromosomes.

Names & Taxonomyi

Protein namesi
Recommended name:
Structural maintenance of chromosomes protein 4
Short name:
AtSMC4
Short name:
SMC protein 4
Short name:
SMC-4
Alternative name(s):
Chromosome-associated protein C
Short name:
AtCAP-C
Gene namesi
Name:SMC4
Synonyms:CAP-C
Ordered Locus Names:At5g48600
ORF Names:K15N18.7
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G48600.

Subcellular locationi

  • Nucleus

  • Note: Associates with chromatin.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12411241Structural maintenance of chromosomes protein 4PRO_0000284896Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9FJL0.
PRIDEiQ9FJL0.

PTM databases

iPTMnetiQ9FJL0.

Expressioni

Tissue specificityi

Highly expressed in seedlings and inflorescences.1 Publication

Gene expression databases

ExpressionAtlasiQ9FJL0. baseline and differential.
GenevisibleiQ9FJL0. AT.

Interactioni

Subunit structurei

Forms a heterodimer with a SMC2 subfamily member. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: CAPH, CAPD2 and CAPG.

Protein-protein interaction databases

STRINGi3702.AT5G48600.2.

Structurei

3D structure databases

ProteinModelPortaliQ9FJL0.
SMRiQ9FJL0. Positions 25-340, 426-818, 932-1229.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 12241200Zinc-hookAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni553 – 718166Flexible hingeAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili201 – 552352Sequence analysisAdd
BLAST
Coiled coili719 – 1085367Sequence analysisAdd
BLAST

Domaini

The hinge domain, which separates the large intramolecular coiled coil regions, allows the heterodimerization with a SMC2 subfamily member, forming a V-shaped heterodimer.

Sequence similaritiesi

Belongs to the SMC family. SMC4 subfamily.Curated
Contains 1 zinc-hook domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0996. Eukaryota.
COG1196. LUCA.
HOGENOMiHOG000184777.
InParanoidiQ9FJL0.
KOiK06675.
PhylomeDBiQ9FJL0.

Family and domain databases

Gene3Di3.40.50.300. 6 hits.
InterProiIPR027417. P-loop_NTPase.
IPR003395. RecF/RecN/SMC_N.
IPR024704. SMC.
IPR010935. SMC_hinge.
[Graphical view]
PfamiPF06470. SMC_hinge. 1 hit.
PF02463. SMC_N. 1 hit.
[Graphical view]
PIRSFiPIRSF005719. SMC. 1 hit.
SMARTiSM00968. SMC_hinge. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF75553. SSF75553. 1 hit.

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: Q9FJL0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEDEPMGGG ESEPEQRKSG TPRLYIKELV MRNFKSYAGE QRVGPFHKSF
60 70 80 90 100
SAVVGPNGSG KSNVIDAMLF VFGKRAKQMR LNKVSELIHN STNHQNLDSA
110 120 130 140 150
GVSVQFEEII DLENGLYETV PGSDFMITRV AFRDNSSKYY INERSSNFTE
160 170 180 190 200
VTKKLKGKGV DLDNNRFLIL QGEVEQISLM KPKAQGPHDE GFLEYLEDII
210 220 230 240 250
GTNKYVEKID ELNKQLETLN ESRSGVVQMV KLAEKERDNL EGLKDEAETY
260 270 280 290 300
MLKELSHLKW QEKATKMAYE DTVAKITEQR DSLQNLENSL KDERVKMDES
310 320 330 340 350
NEELKKFESV HEKHKKRQEV LDNELRACKE KFKEFERQDV KHREDLKHVK
360 370 380 390 400
QKIKKLEDKL EKDSSKIGDM TKESEDSSNL IPKLQENIPK LQKVLLDEEK
410 420 430 440 450
KLEEIKAIAK VETEGYRSEL TKIRAELEPW EKDLIVHRGK LDVASSESEL
460 470 480 490 500
LSKKHEAALK AFTDAQKQLS DISTRKKEKA AATTSWKADI KKKKQEAIEA
510 520 530 540 550
RKVEEESLKE QETLVPQEQA AREKVAELKS AMNSEKSQNE VLKAVLRAKE
560 570 580 590 600
NNQIEGIYGR MGDLGAIDAK YDVAISTACA GLDYIVVETT SSAQACVELL
610 620 630 640 650
RKGNLGFATF MILEKQTDHI HKLKEKVKTP EDVPRLFDLV RVKDERMKLA
660 670 680 690 700
FYAALGNTVV AKDLDQATRI AYGGNREFRR VVALDGALFE KSGTMSGGGG
710 720 730 740 750
KARGGRMGTS IRATGVSGEA VANAENELSK IVDMLNNIRE KVGNAVRQYR
760 770 780 790 800
AAENEVSGLE MELAKSQREI ESLNSEHNYL EKQLASLEAA SQPKTDEIDR
810 820 830 840 850
LKELKKIISK EEKEIENLEK GSKQLKDKLQ TNIENAGGEK LKGQKAKVEK
860 870 880 890 900
IQTDIDKNNT EINRCNVQIE TNQKLIKKLT KGIEEATREK ERLEGEKENL
910 920 930 940 950
HVTFKDITQK AFEIQETYKK TQQLIDEHKD VLTGAKSDYE NLKKSVDELK
960 970 980 990 1000
ASRVDAEFKV QDMKKKYNEL EMREKGYKKK LNDLQIAFTK HMEQIQKDLV
1010 1020 1030 1040 1050
DPDKLQATLM DNNLNEACDL KRALEMVALL EAQLKELNPN LDSIAEYRSK
1060 1070 1080 1090 1100
VELYNGRVDE LNSVTQERDD TRKQYDELRK RRLDEFMAGF NTISLKLKEM
1110 1120 1130 1140 1150
YQMITLGGDA ELELVDSLDP FSEGVVFSVR PPKKSWKNIA NLSGGEKTLS
1160 1170 1180 1190 1200
SLALVFALHH YKPTPLYVMD EIDAALDFKN VSIVGHYVKD RTKDAQFIII
1210 1220 1230 1240
SLRNNMFELA DRLVGIYKTD NCTKSITINP GSFAVCQKTP A
Length:1,241
Mass (Da):141,130
Last modified:March 1, 2001 - v1
Checksum:iAB5D6A1B35F053F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015468 Genomic DNA. Translation: BAB10693.1.
CP002688 Genomic DNA. Translation: AED95694.1.
RefSeqiNP_199671.1. NM_124236.3. [Q9FJL0-1]
UniGeneiAt.29839.

Genome annotation databases

EnsemblPlantsiAT5G48600.1; AT5G48600.1; AT5G48600. [Q9FJL0-1]
GeneIDi834917.
KEGGiath:AT5G48600.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015468 Genomic DNA. Translation: BAB10693.1.
CP002688 Genomic DNA. Translation: AED95694.1.
RefSeqiNP_199671.1. NM_124236.3. [Q9FJL0-1]
UniGeneiAt.29839.

3D structure databases

ProteinModelPortaliQ9FJL0.
SMRiQ9FJL0. Positions 25-340, 426-818, 932-1229.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT5G48600.2.

PTM databases

iPTMnetiQ9FJL0.

Proteomic databases

PaxDbiQ9FJL0.
PRIDEiQ9FJL0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G48600.1; AT5G48600.1; AT5G48600. [Q9FJL0-1]
GeneIDi834917.
KEGGiath:AT5G48600.

Organism-specific databases

TAIRiAT5G48600.

Phylogenomic databases

eggNOGiKOG0996. Eukaryota.
COG1196. LUCA.
HOGENOMiHOG000184777.
InParanoidiQ9FJL0.
KOiK06675.
PhylomeDBiQ9FJL0.

Enzyme and pathway databases

ReactomeiR-ATH-2299718. Condensation of Prophase Chromosomes.
R-ATH-2514853. Condensation of Prometaphase Chromosomes.

Miscellaneous databases

PROiQ9FJL0.

Gene expression databases

ExpressionAtlasiQ9FJL0. baseline and differential.
GenevisibleiQ9FJL0. AT.

Family and domain databases

Gene3Di3.40.50.300. 6 hits.
InterProiIPR027417. P-loop_NTPase.
IPR003395. RecF/RecN/SMC_N.
IPR024704. SMC.
IPR010935. SMC_hinge.
[Graphical view]
PfamiPF06470. SMC_hinge. 1 hit.
PF02463. SMC_N. 1 hit.
[Graphical view]
PIRSFiPIRSF005719. SMC. 1 hit.
SMARTiSM00968. SMC_hinge. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF75553. SSF75553. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSMC4_ARATH
AccessioniPrimary (citable) accession number: Q9FJL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.