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Protein

Adenylate kinase isoenzyme 6 homolog

Gene

AAK6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Preferred phosphate donor and acceptor are ATP and AMP, respectively. Has also ATPase activity (By similarity).By similarity1 Publication

Catalytic activityi

ATP + AMP = 2 ADP.UniRule annotation1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei49AMPUniRule annotation1
Binding sitei89ATPUniRule annotation1
Binding sitei115ATPUniRule annotation1
Binding sitei119ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi23 – 28ATPUniRule annotation6

GO - Molecular functioni

  • adenylate kinase activity Source: UniProtKB
  • ATP binding Source: GO_Central

GO - Biological processi

  • developmental vegetative growth Source: UniProtKB
  • multicellular organism development Source: UniProtKB-KW
  • nucleotide phosphorylation Source: TAIR
  • regulation of growth Source: UniProtKB-KW
  • unidimensional cell growth Source: TAIR

Keywordsi

Molecular functionDevelopmental protein, Kinase, Transferase
Biological processGrowth regulation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT5G60340-MONOMER
ReactomeiR-ATH-499943 Interconversion of nucleotide di- and triphosphates

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate kinase isoenzyme 6 homologUniRule annotation (EC:2.7.4.3UniRule annotation)
Short name:
AK6UniRule annotation
Alternative name(s):
Dual activity adenylate kinase/ATPaseUniRule annotation
Short name:
AK/ATPaseUniRule annotation
Gene namesi
Name:AAK6
Ordered Locus Names:At5g60340
ORF Names:K9B18.5
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G60340
TAIRilocus:2158299 AT5G60340

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Decreased stem growth.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004211711 – 178Adenylate kinase isoenzyme 6 homologAdd BLAST178

Proteomic databases

PaxDbiQ9FJI1

Expressioni

Gene expression databases

ExpressionAtlasiQ9FJI1 baseline and differential

Interactioni

Subunit structurei

Interacts with RPS14A.1 Publication

Protein-protein interaction databases

BioGridi21400, 8 interactors
IntActiQ9FJI1, 11 interactors
STRINGi3702.AT5G60340.1

Structurei

3D structure databases

ProteinModelPortaliQ9FJI1
SMRiQ9FJI1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni43 – 66NMPbindUniRule annotationAdd BLAST24
Regioni118 – 128LIDUniRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the adenylate kinase family. AK6 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG3347 Eukaryota
COG1936 LUCA
HOGENOMiHOG000224472
InParanoidiQ9FJI1
KOiK18532
OMAiDNVQCEI
OrthoDBiEOG09360PTQ

Family and domain databases

HAMAPiMF_00039 Adenylate_kinase_AK6, 1 hit
InterProiView protein in InterPro
IPR020618 Adenyl_kinase_AK6
IPR027417 P-loop_NTPase
PANTHERiPTHR12595:SF0 PTHR12595:SF0, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9FJI1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARRNRGVTR RERPNLLITG TPGTGKSTTA SALAEATNLR YICIGDLVKE
60 70 80 90 100
KEFYHGWDNE LECHFINEDS VIDELDDAMI EGGNIVDYHG CDFFPQRWFD
110 120 130 140 150
RVVVLRTENS VLYDRLTNRG YSGTKLSNNL QCEMYQVLLE EAHDSYDEEI
160 170
VTELQSNTIE DISNNVSTLT DWINAWQP
Length:178
Mass (Da):20,444
Last modified:March 1, 2001 - v1
Checksum:iE0A3446FB10C0F4B
GO
Isoform 2 (identifier: Q9FJI1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     120-127: GYSGTKLS → SDFQIHQM
     128-178: Missing.

Note: No experimental confirmation available.
Show »
Length:127
Mass (Da):14,697
Checksum:iD68ACCE6360E88F3
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_045290120 – 127GYSGTKLS → SDFQIHQM in isoform 2. 1 Publication8
Alternative sequenceiVSP_045291128 – 178Missing in isoform 2. 1 PublicationAdd BLAST51

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015471 Genomic DNA Translation: BAB10972.1
CP002688 Genomic DNA Translation: AED97311.1
AY079019 mRNA Translation: AAL84974.1
AY093748 mRNA Translation: AAM10372.1
AK117598 mRNA Translation: BAC42255.1
AK318621 mRNA Translation: BAH56736.1
RefSeqiNP_200842.2, NM_125427.3 [Q9FJI1-1]
UniGeneiAt.27572

Genome annotation databases

EnsemblPlantsiAT5G60340.1; AT5G60340.1; AT5G60340 [Q9FJI1-1]
GeneIDi836156
GrameneiAT5G60340.1; AT5G60340.1; AT5G60340 [Q9FJI1-1]
KEGGiath:AT5G60340

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiKAD6_ARATH
AccessioniPrimary (citable) accession number: Q9FJI1
Secondary accession number(s): C0Z207
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2013
Last sequence update: March 1, 2001
Last modified: April 25, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health