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Q9FJD5

- LAC17_ARATH

UniProt

Q9FJD5 - LAC17_ARATH

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Protein
Laccase-17
Gene
LAC17, At5g60020, MMN10.27
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products By similarity.

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Binds 4 copper ions per monomer By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi80 – 801Copper 1; type 2 By similarity
Metal bindingi82 – 821Copper 2; type 3 By similarity
Metal bindingi125 – 1251Copper 2; type 3 By similarity
Metal bindingi127 – 1271Copper 3; type 3 By similarity
Metal bindingi478 – 4781Copper 4; type 1 By similarity
Metal bindingi481 – 4811Copper 1; type 2 By similarity
Metal bindingi483 – 4831Copper 3; type 3 By similarity
Metal bindingi540 – 5401Copper 3; type 3 By similarity
Metal bindingi541 – 5411Copper 4; type 1 By similarity
Metal bindingi542 – 5421Copper 2; type 3 By similarity
Metal bindingi546 – 5461Copper 4; type 1 By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC
  3. oxidoreductase activity Source: TAIR

GO - Biological processi

  1. lignin biosynthetic process Source: TAIR
  2. lignin catabolic process Source: UniProtKB-KW
  3. phenylpropanoid metabolic process Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT5G60020-MONOMER.
MetaCyc:AT5G60020-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-17 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 17
Diphenol oxidase 17
Urishiol oxidase 17
Gene namesi
Name:LAC17
Ordered Locus Names:At5g60020
ORF Names:MMN10.27
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G60020.

Subcellular locationi

Secretedextracellular spaceapoplast Reviewed prediction

GO - Cellular componenti

  1. apoplast Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed prediction
Add
BLAST
Chaini23 – 577555Laccase-17
PRO_0000283645Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi35 – 351N-linked (GlcNAc...) Reviewed prediction
Glycosylationi76 – 761N-linked (GlcNAc...) Reviewed prediction
Glycosylationi112 – 1121N-linked (GlcNAc...) Reviewed prediction
Glycosylationi185 – 1851N-linked (GlcNAc...) Reviewed prediction
Glycosylationi201 – 2011N-linked (GlcNAc...) Reviewed prediction
Glycosylationi237 – 2371N-linked (GlcNAc...) Reviewed prediction
Glycosylationi297 – 2971N-linked (GlcNAc...) Reviewed prediction
Glycosylationi335 – 3351N-linked (GlcNAc...) Reviewed prediction
Glycosylationi383 – 3831N-linked (GlcNAc...) Reviewed prediction
Glycosylationi391 – 3911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi401 – 4011N-linked (GlcNAc...) Reviewed prediction
Glycosylationi437 – 4371N-linked (GlcNAc...) Reviewed prediction
Glycosylationi444 – 4441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi450 – 4501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi460 – 4601N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9FJD5.
PRIDEiQ9FJD5.

Expressioni

Tissue specificityi

Ubiquitous with higher levels in the inflorescence stem.2 Publications

Gene expression databases

GenevestigatoriQ9FJD5.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G60020.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9FJD5.
SMRiQ9FJD5. Positions 22-556.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 146117Plastocyanin-like 1
Add
BLAST
Domaini156 – 309154Plastocyanin-like 2
Add
BLAST
Domaini427 – 561135Plastocyanin-like 3
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG2132.
HOGENOMiHOG000241916.
InParanoidiQ9FJD5.
OMAiWYHAHIS.
PhylomeDBiQ9FJD5.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9FJD5-1 [UniParc]FASTAAdd to Basket

« Hide

MALQLLLAVF SCVLLLPQPA FGITRHYTLE IKMQNVTRLC HTKSLVSVNG    50
QFPGPKLIAR EGDQVLIKVV NQVPNNISLH WHGIRQLRSG WADGPAYITQ 100
CPIQTGQSYV YNYTIVGQRG TLWYHAHISW LRSTVYGPLI ILPKRGVPYP 150
FAKPHKEVPM IFGEWFNADT EAIIRQATQT GGGPNVSDAY TINGLPGPLY 200
NCSAKDTFRL RVKPGKTYLL RLINAALNDE LFFSIANHTV TVVEADAIYV 250
KPFETETILI APGQTTNVLL KTKSSYPSAS FFMTARPYVT GQGTFDNSTV 300
AGILEYEPPK QTKGAHSRTS IKNLQLFKPI LPALNDTNFA TKFSNKLRSL 350
NSKNFPANVP LNVDRKFFFT VGLGTNPCNH KNNQTCQGPT NTTMFAASIS 400
NISFTMPTKA LLQSHYSGQS HGVYSPKFPW SPIVPFNYTG TPPNNTMVSN 450
GTNLMVLPYN TSVELVMQDT SILGAESHPL HLHGFNFFVV GQGFGNFDPN 500
KDPRNFNLVD PIERNTVGVP SGGWAAIRFL ADNPGVWFMH CHLEVHTSWG 550
LRMAWLVLDG DKPDQKLLPP PADLPKC 577
Length:577
Mass (Da):63,958
Last modified:March 1, 2001 - v1
Checksum:i1EE10D890EF6D261
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB015475 Genomic DNA. Translation: BAB08370.1.
CP002688 Genomic DNA. Translation: AED97267.1.
BT015359 mRNA. Translation: AAU05482.1.
BT015890 mRNA. Translation: AAU95426.1.
RefSeqiNP_200810.1. NM_125395.3.
UniGeneiAt.7684.

Genome annotation databases

EnsemblPlantsiAT5G60020.1; AT5G60020.1; AT5G60020.
GeneIDi836124.
KEGGiath:AT5G60020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB015475 Genomic DNA. Translation: BAB08370.1 .
CP002688 Genomic DNA. Translation: AED97267.1 .
BT015359 mRNA. Translation: AAU05482.1 .
BT015890 mRNA. Translation: AAU95426.1 .
RefSeqi NP_200810.1. NM_125395.3.
UniGenei At.7684.

3D structure databases

ProteinModelPortali Q9FJD5.
SMRi Q9FJD5. Positions 22-556.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT5G60020.1-P.

Proteomic databases

PaxDbi Q9FJD5.
PRIDEi Q9FJD5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G60020.1 ; AT5G60020.1 ; AT5G60020 .
GeneIDi 836124.
KEGGi ath:AT5G60020.

Organism-specific databases

TAIRi AT5G60020.

Phylogenomic databases

eggNOGi COG2132.
HOGENOMi HOG000241916.
InParanoidi Q9FJD5.
OMAi WYHAHIS.
PhylomeDBi Q9FJD5.

Enzyme and pathway databases

BioCyci ARA:AT5G60020-MONOMER.
MetaCyc:AT5G60020-MONOMER.

Gene expression databases

Genevestigatori Q9FJD5.

Family and domain databases

Gene3Di 2.60.40.420. 3 hits.
InterProi IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view ]
Pfami PF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 3 hits.
TIGRFAMsi TIGR03389. laccase. 1 hit.
PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis of Arabidopsis thaliana chromosome 5. VII. Sequence features of the regions of 1,013,767 bp covered by sixteen physically assigned P1 and TAC clones."
    Nakamura Y., Sato S., Asamizu E., Kaneko T., Kotani H., Miyajima N., Tabata S.
    DNA Res. 5:297-308(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Arabidopsis ORF clones."
    Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Gene structure and molecular analysis of the laccase-like multicopper oxidase (LMCO) gene family in Arabidopsis thaliana."
    McCaig B.C., Meagher R.B., Dean J.F.D.
    Planta 221:619-636(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. "Mutant identification and characterization of the laccase gene family in Arabidopsis."
    Cai X., Davis E.J., Ballif J., Liang M., Bushman E., Haroldsen V., Torabinejad J., Wu Y.
    J. Exp. Bot. 57:2563-2569(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiLAC17_ARATH
AccessioniPrimary (citable) accession number: Q9FJD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 1, 2001
Last modified: May 14, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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