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Q9FJD5 (LAC17_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Laccase-17
EC=1.10.3.2
Alternative name(s):
Benzenediol:oxygen oxidoreductase 17
Diphenol oxidase 17
Urishiol oxidase 17
Gene names
Name:LAC17
Ordered Locus Names:At5g60020
ORF Names:MMN10.27
OrganismArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length577 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Lignin degradation and detoxification of lignin-derived products By similarity.

Catalytic activity

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactor

Binds 4 copper ions per monomer By similarity.

Subcellular location

Secreted › extracellular space › apoplast Potential.

Tissue specificity

Ubiquitous with higher levels in the inflorescence stem. Ref.4 Ref.5

Sequence similarities

Belongs to the multicopper oxidase family.

Contains 3 plastocyanin-like domains.

Ontologies

Keywords
   Biological processLignin degradation
   Cellular componentApoplast
Secreted
   DomainRepeat
Signal
   LigandCopper
Metal-binding
   Molecular functionOxidoreductase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processlignin biosynthetic process

Inferred from mutant phenotype. Source: TAIR

lignin catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentapoplast

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functioncopper ion binding

Inferred from electronic annotation. Source: InterPro

hydroquinone:oxygen oxidoreductase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 577555Laccase-17
PRO_0000283645

Regions

Domain30 – 146117Plastocyanin-like 1
Domain156 – 309154Plastocyanin-like 2
Domain427 – 561135Plastocyanin-like 3

Sites

Metal binding801Copper 1; type 2 By similarity
Metal binding821Copper 2; type 3 By similarity
Metal binding1251Copper 2; type 3 By similarity
Metal binding1271Copper 3; type 3 By similarity
Metal binding4781Copper 4; type 1 By similarity
Metal binding4811Copper 1; type 2 By similarity
Metal binding4831Copper 3; type 3 By similarity
Metal binding5401Copper 3; type 3 By similarity
Metal binding5411Copper 4; type 1 By similarity
Metal binding5421Copper 2; type 3 By similarity
Metal binding5461Copper 4; type 1 By similarity

Amino acid modifications

Glycosylation351N-linked (GlcNAc...) Potential
Glycosylation761N-linked (GlcNAc...) Potential
Glycosylation1121N-linked (GlcNAc...) Potential
Glycosylation1851N-linked (GlcNAc...) Potential
Glycosylation2011N-linked (GlcNAc...) Potential
Glycosylation2371N-linked (GlcNAc...) Potential
Glycosylation2971N-linked (GlcNAc...) Potential
Glycosylation3351N-linked (GlcNAc...) Potential
Glycosylation3831N-linked (GlcNAc...) Potential
Glycosylation3911N-linked (GlcNAc...) Potential
Glycosylation4011N-linked (GlcNAc...) Potential
Glycosylation4371N-linked (GlcNAc...) Potential
Glycosylation4441N-linked (GlcNAc...) Potential
Glycosylation4501N-linked (GlcNAc...) Potential
Glycosylation4601N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9FJD5 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 1EE10D890EF6D261

FASTA57763,958
        10         20         30         40         50         60 
MALQLLLAVF SCVLLLPQPA FGITRHYTLE IKMQNVTRLC HTKSLVSVNG QFPGPKLIAR 

        70         80         90        100        110        120 
EGDQVLIKVV NQVPNNISLH WHGIRQLRSG WADGPAYITQ CPIQTGQSYV YNYTIVGQRG 

       130        140        150        160        170        180 
TLWYHAHISW LRSTVYGPLI ILPKRGVPYP FAKPHKEVPM IFGEWFNADT EAIIRQATQT 

       190        200        210        220        230        240 
GGGPNVSDAY TINGLPGPLY NCSAKDTFRL RVKPGKTYLL RLINAALNDE LFFSIANHTV 

       250        260        270        280        290        300 
TVVEADAIYV KPFETETILI APGQTTNVLL KTKSSYPSAS FFMTARPYVT GQGTFDNSTV 

       310        320        330        340        350        360 
AGILEYEPPK QTKGAHSRTS IKNLQLFKPI LPALNDTNFA TKFSNKLRSL NSKNFPANVP 

       370        380        390        400        410        420 
LNVDRKFFFT VGLGTNPCNH KNNQTCQGPT NTTMFAASIS NISFTMPTKA LLQSHYSGQS 

       430        440        450        460        470        480 
HGVYSPKFPW SPIVPFNYTG TPPNNTMVSN GTNLMVLPYN TSVELVMQDT SILGAESHPL 

       490        500        510        520        530        540 
HLHGFNFFVV GQGFGNFDPN KDPRNFNLVD PIERNTVGVP SGGWAAIRFL ADNPGVWFMH 

       550        560        570 
CHLEVHTSWG LRMAWLVLDG DKPDQKLLPP PADLPKC

« Hide

References

« Hide 'large scale' references
[1]"Structural analysis of Arabidopsis thaliana chromosome 5. VII. Sequence features of the regions of 1,013,767 bp covered by sixteen physically assigned P1 and TAC clones."
Nakamura Y., Sato S., Asamizu E., Kaneko T., Kotani H., Miyajima N., Tabata S.
DNA Res. 5:297-308(1998) [PubMed: 9872454] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Arabidopsis ORF clones."
Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[4]"Gene structure and molecular analysis of the laccase-like multicopper oxidase (LMCO) gene family in Arabidopsis thaliana."
McCaig B.C., Meagher R.B., Dean J.F.D.
Planta 221:619-636(2005) [PubMed: 15940465] [Abstract]
Cited for: TISSUE SPECIFICITY.
[5]"Mutant identification and characterization of the laccase gene family in Arabidopsis."
Cai X., Davis E.J., Ballif J., Liang M., Bushman E., Haroldsen V., Torabinejad J., Wu Y.
J. Exp. Bot. 57:2563-2569(2006) [PubMed: 16804053] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB015475 Genomic DNA. Translation: BAB08370.1.
CP002688 Genomic DNA. Translation: AED97267.1.
BT015359 mRNA. Translation: AAU05482.1.
BT015890 mRNA. Translation: AAU95426.1.
IPIIPI00539440.
RefSeqNP_200810.1. NM_125395.3.
UniGeneAt.7684.

3D structure databases

HSSPHSSP built from PDB template 1AOZ based on UniProtKB P37064.
ProteinModelPortalQ9FJD5.
SMRQ9FJD5. Positions 17-562.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9FJD5.

Proteomic databases

PRIDEQ9FJD5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT5G60020.1; AT5G60020.1; AT5G60020.
GeneID836124.
GenomeReviewsGene locus AT5G60020 in contig BA000015_GR.
KEGGath:AT5G60020.
NMPDRfig|3702.1.peg.28007.

Organism-specific databases

TAIRAt5g60020.

Phylogenomic databases

eggNOGKOG1263.
GeneTreeEPGT00050000000260.
HOGENOMHBG749556.
InParanoidQ9FJD5.
OMARMAWLVL.
PhylomeDBQ9FJD5.
ProtClustDBCLSN2916294.

Enzyme and pathway databases

BioCycMetaCyc:AT5G60020-MONOMER.

Gene expression databases

GenevestigatorQ9FJD5.

Family and domain databases

InterProIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
Gene3DG3DSA:2.60.40.420. Cupredoxin. 3 hits.
PANTHERPTHR11709:SF9. PTHR11709:SF9. 1 hit.
PfamPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMSSF49503. Cupredoxin. 3 hits.
TIGRFAMsTIGR03389. Laccase. 1 hit.
PROSITEPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLAC17_ARATH
AccessionPrimary (citable) accession number: Q9FJD5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 1, 2001
Last modified: November 16, 2011
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents