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Q9FJD5

- LAC17_ARATH

UniProt

Q9FJD5 - LAC17_ARATH

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Protein

Laccase-17

Gene

LAC17

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Binds 4 copper ions per monomer.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi80 – 801Copper 1; type 2By similarity
Metal bindingi82 – 821Copper 2; type 3By similarity
Metal bindingi125 – 1251Copper 2; type 3By similarity
Metal bindingi127 – 1271Copper 3; type 3By similarity
Metal bindingi478 – 4781Copper 4; type 1By similarity
Metal bindingi481 – 4811Copper 1; type 2By similarity
Metal bindingi483 – 4831Copper 3; type 3By similarity
Metal bindingi540 – 5401Copper 3; type 3By similarity
Metal bindingi541 – 5411Copper 4; type 1By similarity
Metal bindingi542 – 5421Copper 2; type 3By similarity
Metal bindingi546 – 5461Copper 4; type 1By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC
  3. oxidoreductase activity Source: TAIR

GO - Biological processi

  1. lignin biosynthetic process Source: TAIR
  2. lignin catabolic process Source: UniProtKB-KW
  3. phenylpropanoid metabolic process Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT5G60020-MONOMER.
MetaCyc:AT5G60020-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-17 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 17
Diphenol oxidase 17
Urishiol oxidase 17
Gene namesi
Name:LAC17
Ordered Locus Names:At5g60020
ORF Names:MMN10.27
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G60020.

Subcellular locationi

GO - Cellular componenti

  1. apoplast Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 577555Laccase-17PRO_0000283645Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi35 – 351N-linked (GlcNAc...)Sequence Analysis
Glycosylationi76 – 761N-linked (GlcNAc...)Sequence Analysis
Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence Analysis
Glycosylationi201 – 2011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi237 – 2371N-linked (GlcNAc...)Sequence Analysis
Glycosylationi297 – 2971N-linked (GlcNAc...)Sequence Analysis
Glycosylationi335 – 3351N-linked (GlcNAc...)Sequence Analysis
Glycosylationi383 – 3831N-linked (GlcNAc...)Sequence Analysis
Glycosylationi391 – 3911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi401 – 4011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi437 – 4371N-linked (GlcNAc...)Sequence Analysis
Glycosylationi444 – 4441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi450 – 4501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi460 – 4601N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9FJD5.
PRIDEiQ9FJD5.

Expressioni

Tissue specificityi

Ubiquitous with higher levels in the inflorescence stem.2 Publications

Gene expression databases

GenevestigatoriQ9FJD5.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G60020.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9FJD5.
SMRiQ9FJD5. Positions 22-556.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 146117Plastocyanin-like 1Add
BLAST
Domaini156 – 309154Plastocyanin-like 2Add
BLAST
Domaini427 – 561135Plastocyanin-like 3Add
BLAST

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated
Contains 3 plastocyanin-like domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG2132.
HOGENOMiHOG000241916.
InParanoidiQ9FJD5.
OMAiWYHAHIS.
PhylomeDBiQ9FJD5.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9FJD5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALQLLLAVF SCVLLLPQPA FGITRHYTLE IKMQNVTRLC HTKSLVSVNG
60 70 80 90 100
QFPGPKLIAR EGDQVLIKVV NQVPNNISLH WHGIRQLRSG WADGPAYITQ
110 120 130 140 150
CPIQTGQSYV YNYTIVGQRG TLWYHAHISW LRSTVYGPLI ILPKRGVPYP
160 170 180 190 200
FAKPHKEVPM IFGEWFNADT EAIIRQATQT GGGPNVSDAY TINGLPGPLY
210 220 230 240 250
NCSAKDTFRL RVKPGKTYLL RLINAALNDE LFFSIANHTV TVVEADAIYV
260 270 280 290 300
KPFETETILI APGQTTNVLL KTKSSYPSAS FFMTARPYVT GQGTFDNSTV
310 320 330 340 350
AGILEYEPPK QTKGAHSRTS IKNLQLFKPI LPALNDTNFA TKFSNKLRSL
360 370 380 390 400
NSKNFPANVP LNVDRKFFFT VGLGTNPCNH KNNQTCQGPT NTTMFAASIS
410 420 430 440 450
NISFTMPTKA LLQSHYSGQS HGVYSPKFPW SPIVPFNYTG TPPNNTMVSN
460 470 480 490 500
GTNLMVLPYN TSVELVMQDT SILGAESHPL HLHGFNFFVV GQGFGNFDPN
510 520 530 540 550
KDPRNFNLVD PIERNTVGVP SGGWAAIRFL ADNPGVWFMH CHLEVHTSWG
560 570
LRMAWLVLDG DKPDQKLLPP PADLPKC
Length:577
Mass (Da):63,958
Last modified:March 1, 2001 - v1
Checksum:i1EE10D890EF6D261
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB015475 Genomic DNA. Translation: BAB08370.1.
CP002688 Genomic DNA. Translation: AED97267.1.
BT015359 mRNA. Translation: AAU05482.1.
BT015890 mRNA. Translation: AAU95426.1.
RefSeqiNP_200810.1. NM_125395.3.
UniGeneiAt.7684.

Genome annotation databases

EnsemblPlantsiAT5G60020.1; AT5G60020.1; AT5G60020.
GeneIDi836124.
KEGGiath:AT5G60020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB015475 Genomic DNA. Translation: BAB08370.1 .
CP002688 Genomic DNA. Translation: AED97267.1 .
BT015359 mRNA. Translation: AAU05482.1 .
BT015890 mRNA. Translation: AAU95426.1 .
RefSeqi NP_200810.1. NM_125395.3.
UniGenei At.7684.

3D structure databases

ProteinModelPortali Q9FJD5.
SMRi Q9FJD5. Positions 22-556.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT5G60020.1-P.

Proteomic databases

PaxDbi Q9FJD5.
PRIDEi Q9FJD5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G60020.1 ; AT5G60020.1 ; AT5G60020 .
GeneIDi 836124.
KEGGi ath:AT5G60020.

Organism-specific databases

TAIRi AT5G60020.

Phylogenomic databases

eggNOGi COG2132.
HOGENOMi HOG000241916.
InParanoidi Q9FJD5.
OMAi WYHAHIS.
PhylomeDBi Q9FJD5.

Enzyme and pathway databases

BioCyci ARA:AT5G60020-MONOMER.
MetaCyc:AT5G60020-MONOMER.

Gene expression databases

Genevestigatori Q9FJD5.

Family and domain databases

Gene3Di 2.60.40.420. 3 hits.
InterProi IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view ]
Pfami PF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 3 hits.
TIGRFAMsi TIGR03389. laccase. 1 hit.
PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis of Arabidopsis thaliana chromosome 5. VII. Sequence features of the regions of 1,013,767 bp covered by sixteen physically assigned P1 and TAC clones."
    Nakamura Y., Sato S., Asamizu E., Kaneko T., Kotani H., Miyajima N., Tabata S.
    DNA Res. 5:297-308(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Arabidopsis ORF clones."
    Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Gene structure and molecular analysis of the laccase-like multicopper oxidase (LMCO) gene family in Arabidopsis thaliana."
    McCaig B.C., Meagher R.B., Dean J.F.D.
    Planta 221:619-636(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. "Mutant identification and characterization of the laccase gene family in Arabidopsis."
    Cai X., Davis E.J., Ballif J., Liang M., Bushman E., Haroldsen V., Torabinejad J., Wu Y.
    J. Exp. Bot. 57:2563-2569(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiLAC17_ARATH
AccessioniPrimary (citable) accession number: Q9FJD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3