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Q9FJD5

- LAC17_ARATH

UniProt

Q9FJD5 - LAC17_ARATH

Protein

Laccase-17

Gene

LAC17

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Lignin degradation and detoxification of lignin-derived products.By similarity

    Catalytic activityi

    4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

    Cofactori

    Binds 4 copper ions per monomer.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi80 – 801Copper 1; type 2By similarity
    Metal bindingi82 – 821Copper 2; type 3By similarity
    Metal bindingi125 – 1251Copper 2; type 3By similarity
    Metal bindingi127 – 1271Copper 3; type 3By similarity
    Metal bindingi478 – 4781Copper 4; type 1By similarity
    Metal bindingi481 – 4811Copper 1; type 2By similarity
    Metal bindingi483 – 4831Copper 3; type 3By similarity
    Metal bindingi540 – 5401Copper 3; type 3By similarity
    Metal bindingi541 – 5411Copper 4; type 1By similarity
    Metal bindingi542 – 5421Copper 2; type 3By similarity
    Metal bindingi546 – 5461Copper 4; type 1By similarity

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC
    3. oxidoreductase activity Source: TAIR

    GO - Biological processi

    1. lignin biosynthetic process Source: TAIR
    2. lignin catabolic process Source: UniProtKB-KW
    3. phenylpropanoid metabolic process Source: TAIR

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Lignin degradation

    Keywords - Ligandi

    Copper, Metal-binding

    Enzyme and pathway databases

    BioCyciARA:AT5G60020-MONOMER.
    MetaCyc:AT5G60020-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Laccase-17 (EC:1.10.3.2)
    Alternative name(s):
    Benzenediol:oxygen oxidoreductase 17
    Diphenol oxidase 17
    Urishiol oxidase 17
    Gene namesi
    Name:LAC17
    Ordered Locus Names:At5g60020
    ORF Names:MMN10.27
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 5

    Organism-specific databases

    TAIRiAT5G60020.

    Subcellular locationi

    GO - Cellular componenti

    1. apoplast Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Apoplast, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 577555Laccase-17PRO_0000283645Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi35 – 351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi76 – 761N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi201 – 2011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi237 – 2371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi297 – 2971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi335 – 3351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi383 – 3831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi391 – 3911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi401 – 4011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi437 – 4371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi444 – 4441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi450 – 4501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi460 – 4601N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9FJD5.
    PRIDEiQ9FJD5.

    Expressioni

    Tissue specificityi

    Ubiquitous with higher levels in the inflorescence stem.2 Publications

    Gene expression databases

    GenevestigatoriQ9FJD5.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT5G60020.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9FJD5.
    SMRiQ9FJD5. Positions 22-556.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 146117Plastocyanin-like 1Add
    BLAST
    Domaini156 – 309154Plastocyanin-like 2Add
    BLAST
    Domaini427 – 561135Plastocyanin-like 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the multicopper oxidase family.Curated
    Contains 3 plastocyanin-like domains.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG2132.
    HOGENOMiHOG000241916.
    InParanoidiQ9FJD5.
    OMAiWYHAHIS.
    PhylomeDBiQ9FJD5.

    Family and domain databases

    Gene3Di2.60.40.420. 3 hits.
    InterProiIPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    IPR017761. Laccase.
    [Graphical view]
    PfamiPF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 3 hits.
    TIGRFAMsiTIGR03389. laccase. 1 hit.
    PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
    PS00080. MULTICOPPER_OXIDASE2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9FJD5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALQLLLAVF SCVLLLPQPA FGITRHYTLE IKMQNVTRLC HTKSLVSVNG    50
    QFPGPKLIAR EGDQVLIKVV NQVPNNISLH WHGIRQLRSG WADGPAYITQ 100
    CPIQTGQSYV YNYTIVGQRG TLWYHAHISW LRSTVYGPLI ILPKRGVPYP 150
    FAKPHKEVPM IFGEWFNADT EAIIRQATQT GGGPNVSDAY TINGLPGPLY 200
    NCSAKDTFRL RVKPGKTYLL RLINAALNDE LFFSIANHTV TVVEADAIYV 250
    KPFETETILI APGQTTNVLL KTKSSYPSAS FFMTARPYVT GQGTFDNSTV 300
    AGILEYEPPK QTKGAHSRTS IKNLQLFKPI LPALNDTNFA TKFSNKLRSL 350
    NSKNFPANVP LNVDRKFFFT VGLGTNPCNH KNNQTCQGPT NTTMFAASIS 400
    NISFTMPTKA LLQSHYSGQS HGVYSPKFPW SPIVPFNYTG TPPNNTMVSN 450
    GTNLMVLPYN TSVELVMQDT SILGAESHPL HLHGFNFFVV GQGFGNFDPN 500
    KDPRNFNLVD PIERNTVGVP SGGWAAIRFL ADNPGVWFMH CHLEVHTSWG 550
    LRMAWLVLDG DKPDQKLLPP PADLPKC 577
    Length:577
    Mass (Da):63,958
    Last modified:March 1, 2001 - v1
    Checksum:i1EE10D890EF6D261
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB015475 Genomic DNA. Translation: BAB08370.1.
    CP002688 Genomic DNA. Translation: AED97267.1.
    BT015359 mRNA. Translation: AAU05482.1.
    BT015890 mRNA. Translation: AAU95426.1.
    RefSeqiNP_200810.1. NM_125395.3.
    UniGeneiAt.7684.

    Genome annotation databases

    EnsemblPlantsiAT5G60020.1; AT5G60020.1; AT5G60020.
    GeneIDi836124.
    KEGGiath:AT5G60020.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB015475 Genomic DNA. Translation: BAB08370.1 .
    CP002688 Genomic DNA. Translation: AED97267.1 .
    BT015359 mRNA. Translation: AAU05482.1 .
    BT015890 mRNA. Translation: AAU95426.1 .
    RefSeqi NP_200810.1. NM_125395.3.
    UniGenei At.7684.

    3D structure databases

    ProteinModelPortali Q9FJD5.
    SMRi Q9FJD5. Positions 22-556.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT5G60020.1-P.

    Proteomic databases

    PaxDbi Q9FJD5.
    PRIDEi Q9FJD5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT5G60020.1 ; AT5G60020.1 ; AT5G60020 .
    GeneIDi 836124.
    KEGGi ath:AT5G60020.

    Organism-specific databases

    TAIRi AT5G60020.

    Phylogenomic databases

    eggNOGi COG2132.
    HOGENOMi HOG000241916.
    InParanoidi Q9FJD5.
    OMAi WYHAHIS.
    PhylomeDBi Q9FJD5.

    Enzyme and pathway databases

    BioCyci ARA:AT5G60020-MONOMER.
    MetaCyc:AT5G60020-MONOMER.

    Gene expression databases

    Genevestigatori Q9FJD5.

    Family and domain databases

    Gene3Di 2.60.40.420. 3 hits.
    InterProi IPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    IPR017761. Laccase.
    [Graphical view ]
    Pfami PF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 3 hits.
    TIGRFAMsi TIGR03389. laccase. 1 hit.
    PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
    PS00080. MULTICOPPER_OXIDASE2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structural analysis of Arabidopsis thaliana chromosome 5. VII. Sequence features of the regions of 1,013,767 bp covered by sixteen physically assigned P1 and TAC clones."
      Nakamura Y., Sato S., Asamizu E., Kaneko T., Kotani H., Miyajima N., Tabata S.
      DNA Res. 5:297-308(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Arabidopsis ORF clones."
      Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Gene structure and molecular analysis of the laccase-like multicopper oxidase (LMCO) gene family in Arabidopsis thaliana."
      McCaig B.C., Meagher R.B., Dean J.F.D.
      Planta 221:619-636(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    5. "Mutant identification and characterization of the laccase gene family in Arabidopsis."
      Cai X., Davis E.J., Ballif J., Liang M., Bushman E., Haroldsen V., Torabinejad J., Wu Y.
      J. Exp. Bot. 57:2563-2569(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiLAC17_ARATH
    AccessioniPrimary (citable) accession number: Q9FJD5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3