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Protein

5-oxoprolinase

Gene

OXP1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. Acts in the glutathione degradation pathway.1 Publication

Catalytic activityi

ATP + 5-oxo-L-proline + 2 H2O = ADP + phosphate + L-glutamate.

GO - Molecular functioni

  • 5-oxoprolinase (ATP-hydrolyzing) activity Source: TAIR
  • ATP binding Source: UniProtKB-KW

GO - Biological processi

  • glutathione catabolic process Source: TAIR

Keywordsi

Molecular functionHydrolase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT5G37830-MONOMER
BRENDAi3.5.2.9 399
ReactomeiR-ATH-174403 Glutathione synthesis and recycling

Names & Taxonomyi

Protein namesi
Recommended name:
5-oxoprolinase (EC:3.5.2.9)
Alternative name(s):
5-oxo-L-prolinase
Short name:
5-OPase
Protein OXOPROLINASE 1
Pyroglutamase
Gene namesi
Name:OXP1
Ordered Locus Names:At5g37830
ORF Names:K22F20.70
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G37830
TAIRilocus:2156030 AT5G37830

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

No morphological phenotype, but high accumulation of 5-oxoproline and decreased concentration of glutamate.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003806741 – 12665-oxoprolinaseAdd BLAST1266

Proteomic databases

PaxDbiQ9FIZ7
PRIDEiQ9FIZ7

PTM databases

iPTMnetiQ9FIZ7

Expressioni

Tissue specificityi

Expressed in roots, stems, leaves, flowers and siliques.

Gene expression databases

ExpressionAtlasiQ9FIZ7 baseline and differential
GenevisibleiQ9FIZ7 AT

Interactioni

Protein-protein interaction databases

BioGridi19012, 1 interactor
STRINGi3702.AT5G37830.1

Structurei

3D structure databases

ProteinModelPortaliQ9FIZ7
SMRiQ9FIZ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi148 – 152Poly-Asp5
Compositional biasi1258 – 1263Poly-Gly6

Sequence similaritiesi

Belongs to the oxoprolinase family.Curated

Phylogenomic databases

eggNOGiENOG410JXJJ Eukaryota
KOG1939 Eukaryota
COG0145 LUCA
COG0146 LUCA
HOGENOMiHOG000047200
InParanoidiQ9FIZ7
KOiK01469
OMAiPLTVTDC
OrthoDBiEOG093600CA
PhylomeDBiQ9FIZ7

Family and domain databases

InterProiView protein in InterPro
IPR008040 Hydant_A_N
IPR002821 Hydantoinase_A
IPR003692 Hydantoinase_B
PfamiView protein in Pfam
PF05378 Hydant_A_N, 1 hit
PF01968 Hydantoinase_A, 1 hit
PF02538 Hydantoinase_B, 1 hit

Sequencei

Sequence statusi: Complete.

Q9FIZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTVIEGKLR FCIDRGGTFT DVYAEIPGHS DGHVLKLLSV DPSNYDDAPV
60 70 80 90 100
EGIRRILEEY TGKKIPRTSK IPTDKIQWIR MGTTVATNAL LERKGERIAL
110 120 130 140 150
CVTKGFKDLL QIGNQARPDI FDLTVAKPSN LYEEVIEVDE RVVLALEDDD
160 170 180 190 200
DDEGSLIKGV SGEFLRVVKP FDGEGLKPLL KGLLDKGISC LAVVLMHSYT
210 220 230 240 250
YPKHEMDVEK LALEMGFRHV SLSSALTPMV RAVPRGLTAT VDAYLTPVIK
260 270 280 290 300
EYLSGFISKF DDDLGKVNVL FMQSDGGLAP ESRFSGHKAV LSGPAGGVVG
310 320 330 340 350
YSQTLFGLET EKPLIGFDMG GTSTDVSRYD GSYEQVIETQ IAGTIIQAPQ
360 370 380 390 400
LDINTVAAGG GSKLKFQFGA FRVGPDSVGA HPGPVCYRKG GELAVTDANL
410 420 430 440 450
VLGFVIPDYF PSIFGPNEDQ PLDVAATREA FEKLAGQINI YRKSQDPSAK
460 470 480 490 500
DMSVEEIAMG FVSVANETMC RPIRQLTEMK GHETKNHALA CFGGAGPQHA
510 520 530 540 550
CAIARSLGMK EVLVHRYCGI LSAYGMGLAD VIEDAQEPYS AVYGPESLSE
560 570 580 590 600
VFRRETVLLR EVREKLQEQG FGDGNISTET YLNLRYDGTD TAIMVKGKKT
610 620 630 640 650
GDGSAFDYAA EFLKLFEQEY GFKLQNRNLL ICDVRVRGIG VTSILKPRAV
660 670 680 690 700
EAAPVTPKVE RHYKVYFEGG WHDTPLFKLE NLGFGHEILG PAIIMNGNST
710 720 730 740 750
VIVEPQCKAI ITKYGNIKIE VEPATSSVKL AENVADVVQL SIFNHRFMGI
760 770 780 790 800
AEQMGRTLQR TSISTNIKER LDFSCALFSP DGGLVANAPH VPVHLGAMSS
810 820 830 840 850
TVRWQLKHWG ENLNEGDVLV TNHPCAGGSH LPDITVITPV FDKGKLVFFV
860 870 880 890 900
ASRGHHAEVG GITPGSMPPF SKAIWEEGAA IKAFKVVEKG VFQEEGIVKL
910 920 930 940 950
LQFPSSDETT TKIPGTRRIQ DNLSDLQAQI AANQRGISLI KELIEQYGLG
960 970 980 990 1000
TVQAYMKYVQ LNAEEAVREM LKSVANRVSS ETPNSRVGNS VTIEEEDYMD
1010 1020 1030 1040 1050
DGSIIHLKLT IDADKGEASF DFTGTSPEVY GNWNAPEAVT SAAVIYCLRC
1060 1070 1080 1090 1100
LVNVDIPLNQ GCLAPVEIRI PAGSFLSPSE KAAVVGGNVL TSQRVTDVVL
1110 1120 1130 1140 1150
TAFQACACSQ GCMNNLTFGD DTFGYYETIG GGCGAGPTWN GTSGVQCHMT
1160 1170 1180 1190 1200
NTRMTDPEIF EQRYPVLLHR FGLRENSGGN GLHKGGDGLV REIEFRKPVV
1210 1220 1230 1240 1250
VSILSERRVH SPRGLNGGQN GLRGANYLIT KDKRRIYLGG KNTVHVEAGE
1260
ILQILTPGGG GFGSNI
Length:1,266
Mass (Da):137,531
Last modified:March 1, 2001 - v1
Checksum:i77E862B3E4EB7395
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016873 Genomic DNA Translation: BAB10362.1
CP002688 Genomic DNA Translation: AED94237.1
AY102096 mRNA Translation: AAM26666.1
BT004510 mRNA Translation: AAO42756.1
AK228904 mRNA Translation: BAF00793.1
RefSeqiNP_198599.1, NM_123142.5
UniGeneiAt.30461

Genome annotation databases

EnsemblPlantsiAT5G37830.1; AT5G37830.1; AT5G37830
GeneIDi833761
GrameneiAT5G37830.1; AT5G37830.1; AT5G37830
KEGGiath:AT5G37830

Similar proteinsi

Entry informationi

Entry nameiOPLA_ARATH
AccessioniPrimary (citable) accession number: Q9FIZ7
Secondary accession number(s): Q0WQ06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 1, 2001
Last modified: April 25, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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