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Q9FIW4

- BGL42_ARATH

UniProt

Q9FIW4 - BGL42_ARATH

Protein

Beta-glucosidase 42

Gene

BGLU42

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei35 – 351SubstrateBy similarity
    Binding sitei137 – 1371SubstrateBy similarity
    Binding sitei182 – 1821SubstrateBy similarity
    Active sitei183 – 1831Proton donorBy similarity
    Binding sitei317 – 3171SubstrateBy similarity
    Active sitei388 – 3881NucleophileBy similarity
    Binding sitei437 – 4371SubstrateBy similarity

    GO - Molecular functioni

    1. beta-glucosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular response to ethylene stimulus Source: TAIR
    2. cellular response to iron ion Source: TAIR
    3. cellular response to nitric oxide Source: TAIR
    4. cellulose catabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Enzyme and pathway databases

    BioCyciARA:AT5G36890-MONOMER.
    ARA:GQT-2098-MONOMER.

    Protein family/group databases

    CAZyiGH1. Glycoside Hydrolase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-glucosidase 42 (EC:3.2.1.21)
    Short name:
    AtBGLU42
    Gene namesi
    Name:BGLU42
    Ordered Locus Names:At5g36890
    ORF Names:MLF18.1
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 5

    Organism-specific databases

    TAIRiAT5G36890.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: TAIR

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 490490Beta-glucosidase 42PRO_0000390315Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi420 – 4201N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9FIW4.
    PRIDEiQ9FIW4.

    Interactioni

    Protein-protein interaction databases

    BioGridi18907. 1 interaction.
    STRINGi3702.AT5G36890.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9FIW4.
    SMRiQ9FIW4. Positions 18-480.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni444 – 4452Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 1 family.Curated

    Phylogenomic databases

    eggNOGiCOG2723.
    HOGENOMiHOG000088630.
    InParanoidiQ9FIW4.
    KOiK01188.
    OMAiENGACDN.
    PhylomeDBiQ9FIW4.

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    InterProiIPR001360. Glyco_hydro_1.
    IPR018120. Glyco_hydro_1_AS.
    IPR017736. Glyco_hydro_1_beta-glucosidase.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR10353. PTHR10353. 1 hit.
    PfamiPF00232. Glyco_hydro_1. 1 hit.
    [Graphical view]
    PRINTSiPR00131. GLHYDRLASE1.
    SUPFAMiSSF51445. SSF51445. 1 hit.
    TIGRFAMsiTIGR03356. BGL. 1 hit.
    PROSITEiPS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9FIW4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAQKLNLLNL AVPPVTHRSN FPSTFTFGVA TSAYQIEGGW NEGKKGPSIW    50
    DKFTHIEGKI LDGSNGDVAV DHYHRYKEDV DLIGQLGFGA YRFSISWSRI 100
    FPDGLGTEVN EEGIAFYNDL INTLLEKGIQ PYVTLYHWDL PSHLQEAIGG 150
    WTNRKIVDYF GLYADACFAN FGDRVKHWIT LNEPLQTSVN GHCIGIFAPG 200
    RNEKPLIEPY LVSHHQVLAH ATAVSIYRSK YKESQGGQIG LSVDCEWAEP 250
    NSEKPEDKVA ADRRIDFQLG WFLDPLFFGD YPASMRQKLG DNLPRFTPEE 300
    KEFMLQNSWD FLGLNHYTSR LISHVSNKEA ESNFYQAQEL ERIVELENGD 350
    LIGERAASDW LYAVPWGIRK TLNYMSKKYN HPPIFITENG MDDEDDGSAS 400
    IHDMLDDKRR VDYFKSYLAN VSQAIEDGVD IKGYFAWSLL DNFEWAQGYT 450
    KRFGLVYVDY KNGLTRHPKS SAYWFMKFLK GDEENKGKKE 490
    Length:490
    Mass (Da):56,077
    Last modified:March 1, 2001 - v1
    Checksum:i50DED68FBF06D538
    GO
    Isoform 2 (identifier: Q9FIW4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         487-487: G → E
         488-490: Missing.

    Note: Derived from EST data. No experimental confirmation available.

    Show »
    Length:487
    Mass (Da):55,763
    Checksum:i5CDF06D538287988
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei487 – 4871G → E in isoform 2. CuratedVSP_038498
    Alternative sequencei488 – 4903Missing in isoform 2. CuratedVSP_038499

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB016877 Genomic DNA. Translation: BAB11630.1.
    CP002688 Genomic DNA. Translation: AED94122.1.
    CP002688 Genomic DNA. Translation: AED94123.1.
    BT010611 mRNA. Translation: AAQ89633.1.
    AK175760 mRNA. Translation: BAD43523.1.
    RefSeqiNP_001031975.1. NM_001036898.1. [Q9FIW4-2]
    NP_198505.2. NM_123047.3. [Q9FIW4-1]
    UniGeneiAt.30531.

    Genome annotation databases

    EnsemblPlantsiAT5G36890.1; AT5G36890.1; AT5G36890. [Q9FIW4-1]
    GeneIDi833656.
    KEGGiath:AT5G36890.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB016877 Genomic DNA. Translation: BAB11630.1 .
    CP002688 Genomic DNA. Translation: AED94122.1 .
    CP002688 Genomic DNA. Translation: AED94123.1 .
    BT010611 mRNA. Translation: AAQ89633.1 .
    AK175760 mRNA. Translation: BAD43523.1 .
    RefSeqi NP_001031975.1. NM_001036898.1. [Q9FIW4-2 ]
    NP_198505.2. NM_123047.3. [Q9FIW4-1 ]
    UniGenei At.30531.

    3D structure databases

    ProteinModelPortali Q9FIW4.
    SMRi Q9FIW4. Positions 18-480.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 18907. 1 interaction.
    STRINGi 3702.AT5G36890.1-P.

    Protein family/group databases

    CAZyi GH1. Glycoside Hydrolase Family 1.

    Proteomic databases

    PaxDbi Q9FIW4.
    PRIDEi Q9FIW4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT5G36890.1 ; AT5G36890.1 ; AT5G36890 . [Q9FIW4-1 ]
    GeneIDi 833656.
    KEGGi ath:AT5G36890.

    Organism-specific databases

    TAIRi AT5G36890.

    Phylogenomic databases

    eggNOGi COG2723.
    HOGENOMi HOG000088630.
    InParanoidi Q9FIW4.
    KOi K01188.
    OMAi ENGACDN.
    PhylomeDBi Q9FIW4.

    Enzyme and pathway databases

    BioCyci ARA:AT5G36890-MONOMER.
    ARA:GQT-2098-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    InterProi IPR001360. Glyco_hydro_1.
    IPR018120. Glyco_hydro_1_AS.
    IPR017736. Glyco_hydro_1_beta-glucosidase.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR10353. PTHR10353. 1 hit.
    Pfami PF00232. Glyco_hydro_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00131. GLHYDRLASE1.
    SUPFAMi SSF51445. SSF51445. 1 hit.
    TIGRFAMsi TIGR03356. BGL. 1 hit.
    PROSITEi PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structural analysis of Arabidopsis thaliana chromosome 5. VIII. Sequence features of the regions of 1,081,958 bp covered by seventeen physically assigned P1 and TAC clones."
      Asamizu E., Sato S., Kaneko T., Nakamura Y., Kotani H., Miyajima N., Tabata S.
      DNA Res. 5:379-391(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Arabidopsis ORF clones."
      Cheuk R.F., Chen H., Kim C.J., Shinn P., Carninci P., Hayashizaki Y., Ishida J., Kamiya A., Kawai J., Narusaka M., Sakurai T., Satou M., Seki M., Shinozaki K., Ecker J.R.
      Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: cv. Columbia.
    4. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
      Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
      , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
      Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: cv. Columbia.
    5. Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiBGL42_ARATH
    AccessioniPrimary (citable) accession number: Q9FIW4
    Secondary accession number(s): Q2V330
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 2009
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3