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Protein

Ubiquitin carboxyl-terminal hydrolase 21

Gene

UBP21

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei172NucleophilePROSITE-ProRule annotation1
Active sitei428Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Protein family/group databases

MEROPSiC19.A15

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 21 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 21
Short name:
AtUBP21
Ubiquitin thioesterase 21
Ubiquitin-specific-processing protease 21
Gene namesi
Name:UBP21
Ordered Locus Names:At5g46740
ORF Names:MZA15.16
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G46740
TAIRilocus:2178535 AT5G46740

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003130471 – 732Ubiquitin carboxyl-terminal hydrolase 21Add BLAST732

Proteomic databases

PaxDbiQ9FIQ1
PRIDEiQ9FIQ1

PTM databases

iPTMnetiQ9FIQ1

Expressioni

Gene expression databases

ExpressionAtlasiQ9FIQ1 baseline and differential
GenevisibleiQ9FIQ1 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G46740.1

Structurei

3D structure databases

ProteinModelPortaliQ9FIQ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini163 – 469USPAdd BLAST307

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi86 – 91Poly-Ser6

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Phylogenomic databases

eggNOGiKOG1865 Eukaryota
ENOG410XQ92 LUCA
HOGENOMiHOG000154757
InParanoidiQ9FIQ1
KOiK11855
OMAiAFVEHIG
OrthoDBiEOG093605EL
PhylomeDBiQ9FIQ1

Family and domain databases

InterProiView protein in InterPro
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF00443 UCH, 1 hit
PROSITEiView protein in PROSITE
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9FIQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEFSDPPPS NLSSSHKLTK PNQTLDESSP TAPIRDLVTN SLSLSSPIRQ
60 70 80 90 100
IQALSPAKPD GSSSSPPDKT LNFNPEENRD VNPDESSSSP SDKTLIAPPA
110 120 130 140 150
QISPVSNNNH LRITNTSDSY LYRPPRRYIE YESDDDELNK MEPTKPLQLS
160 170 180 190 200
WWYPRIEPTG VGAGLYNSGN TCFIASVLQC FTHTVPLIDS LRSFMYGNPC
210 220 230 240 250
NCGNEKFCVM QALRDHIELA LRSSGYGINI DRFRDNLTYF SSDFMINHQE
260 270 280 290 300
DAHEFLQSFL DKLERCCLDP KNQLGSVSSQ DLNIVDNVFG GGLMSTLCCC
310 320 330 340 350
NCNSVSNTFE PSLGWSLEIE DVNTLWKALE SFTCVEKLED QLTCDNCKEK
360 370 380 390 400
VTKEKQLRFD KLPPVATFHL KRFTNDGVTM EKIFDHIEFP LELDLSPFMS
410 420 430 440 450
SNHDPEVSTR YHLYAFVEHI GIRATFGHYS SYVRSAPETW HNFDDSKVTR
460 470 480 490 500
ISEERVLSRP AYILFYAREG TPWFSSTFEQ LKTVFEATPL HFSPVSVLDN
510 520 530 540 550
SYESVDNSSK ACNDSVGVSI PDVKWPDSCC QEPKEEVFHS AESSNNEDSS
560 570 580 590 600
AMIDALGSPQ SEKPFAETSQ QTEPESCPTE NKAYIDKSEK PFAETSQPKE
610 620 630 640 650
PKPFADRASI DAPLLKVQNQ DISPKRKAGE RATLGGPKLK YQKPNSHQKR
660 670 680 690 700
QGTFQIQRAH LQTKKQEESR KTKRPLFRSN VAASAPDPKY KNHALSYLNR
710 720 730
AQTPRARKLA NALSDSPTKK KKSSNMRRSI KL
Length:732
Mass (Da):82,417
Last modified:March 1, 2001 - v1
Checksum:iFDEEDE5B92703F08
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti732L → LWRVSY in AAG42759 (PubMed:11115897).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF302669 mRNA Translation: AAG42759.1
AB016882 Genomic DNA Translation: BAB08918.1
CP002688 Genomic DNA Translation: AED95420.1
RefSeqiNP_568667.1, NM_124044.2
UniGeneiAt.7737

Genome annotation databases

EnsemblPlantsiAT5G46740.1; AT5G46740.1; AT5G46740
GeneIDi834717
GrameneiAT5G46740.1; AT5G46740.1; AT5G46740
KEGGiath:AT5G46740

Similar proteinsi

Entry informationi

Entry nameiUBP21_ARATH
AccessioniPrimary (citable) accession number: Q9FIQ1
Secondary accession number(s): Q9FPS6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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