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Protein

Probable 6-phosphogluconolactonase 4

Gene

At5g24410

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.By similarity

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase 3, chloroplastic (At1g24280), Glucose-6-phosphate 1-dehydrogenase 1, chloroplastic (APG1), Glucose-6-phosphate 1-dehydrogenase (At3g27300), Glucose-6-phosphate 1-dehydrogenase (AXX17_At3g29760), Glucose-6-phosphate 1-dehydrogenase (G6PD4), Glucose-6-phosphate 1-dehydrogenase 2, chloroplastic (At5g13110), Glucose-6-phosphate 1-dehydrogenase (AXX17_At1g25530), Glucose-6-phosphate 1-dehydrogenase (At5g35790), Glucose-6-phosphate 1-dehydrogenase (AXX17_At5g33080), Glucose-6-phosphate 1-dehydrogenase (AXX17_At5g33080), Glucose-6-phosphate 1-dehydrogenase (AXX17_At5g12520), Glucose-6-phosphate 1-dehydrogenase (G6PD5), Glucose-6-phosphate 1-dehydrogenase (G6PD5), Glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform 2 (ACG12), Glucose-6-phosphate 1-dehydrogenase (At1g09420), Glucose-6-phosphate 1-dehydrogenase (AXX17_At5g38480), Glucose-6-phosphate 1-dehydrogenase (AXX17_At1g09330), Glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform 1 (ACG9), Glucose-6-phosphate 1-dehydrogenase (At5g40760), Glucose-6-phosphate 1-dehydrogenase 4, chloroplastic (At1g09420)
  2. Probable 6-phosphogluconolactonase 5, chloroplastic (EMB2024), Probable 6-phosphogluconolactonase 3 (At5g24420), Probable 6-phosphogluconolactonase 4 (At5g24410), Probable 6-phosphogluconolactonase 1 (At1g13700), Probable 6-phosphogluconolactonase 2 (At3g49360)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (AXX17_At5g39410), 6-phosphogluconate dehydrogenase, decarboxylating (AXX17_At3g01580), 6-phosphogluconate dehydrogenase, decarboxylating 2, chloroplastic (At5g41670), 6-phosphogluconate dehydrogenase, decarboxylating 3 (At3g02360), 6-phosphogluconate dehydrogenase, decarboxylating 1, chloroplastic (At1g64190), 6-phosphogluconate dehydrogenase, decarboxylating (AXX17_At1g57660)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciARA:AT5G24410-MONOMER
BRENDAi3.1.1.31 399
ReactomeiR-ATH-71336 Pentose phosphate pathway (hexose monophosphate shunt)
UniPathwayiUPA00115; UER00409

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 6-phosphogluconolactonase 4 (EC:3.1.1.31)
Short name:
6PGL 4
Gene namesi
Ordered Locus Names:At5g24410
ORF Names:K16H17.12
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G24410
TAIRilocus:2152911 AT5G24410

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002886711 – 261Probable 6-phosphogluconolactonase 4Add BLAST261

Proteomic databases

PaxDbiQ9FIN1

PTM databases

iPTMnetiQ9FIN1

Expressioni

Gene expression databases

ExpressionAtlasiQ9FIN1 baseline and differential
GenevisibleiQ9FIN1 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G24410.1

Structurei

3D structure databases

ProteinModelPortaliQ9FIN1
SMRiQ9FIN1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3147 Eukaryota
COG0363 LUCA
HOGENOMiHOG000256285
InParanoidiQ9FIN1
KOiK01057
OMAiMAVCDEA
OrthoDBiEOG09360PR9
PhylomeDBiQ9FIN1

Family and domain databases

CDDicd01400 6PGL, 1 hit
InterProiView protein in InterPro
IPR005900 6-phosphogluconolactonase_DevB
IPR006148 Glc/Gal-6P_isomerase
IPR037171 NagB/RpiA_transferase-like
PfamiView protein in Pfam
PF01182 Glucosamine_iso, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit
TIGRFAMsiTIGR01198 pgl, 1 hit

Sequencei

Sequence statusi: Complete.

Q9FIN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVLEKTKS KKIVFPTKKE LSEAMATYTA NLSAKFCKER GYFTVVLSGG
60 70 80 90 100
DLISWLSELL EPKYQESIEW SKWHIFWVDE RVVPLDHEDS NYKLAFDGFL
110 120 130 140 150
SKVPIPIANI YPIDKDCAAL GDAKSAALLY EECLKRLVNR NIIRTYKSSG
160 170 180 190 200
FPQFDLQLLG MGPDGHMASL FPGHYQIKEK ANLVTYITDS PKPPPKRITF
210 220 230 240 250
TLPVINCASY NLMAVCDEAQ ADAVAKVFNH NFDLPAAWLT ADVEAIWFLD
260
QAAASKIPKG L
Length:261
Mass (Da):29,244
Last modified:March 1, 2001 - v1
Checksum:i69C2570CF46D73F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016884 Genomic DNA Translation: BAB11234.1
CP002688 Genomic DNA Translation: AED93308.1
BT010945 mRNA Translation: AAR24723.1
BT012199 mRNA Translation: AAS76686.1
RefSeqiNP_197829.1, NM_122349.4
UniGeneiAt.23941

Genome annotation databases

EnsemblPlantsiAT5G24410.1; AT5G24410.1; AT5G24410
GeneIDi832512
GrameneiAT5G24410.1; AT5G24410.1; AT5G24410
KEGGiath:AT5G24410

Similar proteinsi

Entry informationi

Entry namei6PGL4_ARATH
AccessioniPrimary (citable) accession number: Q9FIN1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 1, 2001
Last modified: April 25, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health