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Protein

Probable protein phosphatase 2C 78

Gene

SAG113

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as negative regulator of abscisic acid (ABA) signaling for stomatal closure in leaves, and controls water loss during leaf senescence (PubMed:22007837, PubMed:22184656). Activated by the NAC029/NAP transcription factor during ABA signaling in senescing leaves (PubMed:22184656). Functions as negative regulator of osmotic stress and ABA signaling (PubMed:22198272). Acts as negative regulator of response to drought (PubMed:22829320).4 Publications

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.PROSITE-ProRule annotation

Cofactori

Mg2+PROSITE-ProRule annotation, Mn2+PROSITE-ProRule annotationNote: Binds 2 magnesium or manganese ions per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi153Manganese 1By similarity1
Metal bindingi153Manganese 2By similarity1
Metal bindingi154Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi327Manganese 2By similarity1
Metal bindingi400Manganese 2By similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • protein serine/threonine phosphatase activity Source: TAIR

GO - Biological processi

  • chloroplast organization Source: TAIR
  • leaf senescence Source: TAIR
  • negative regulation of abscisic acid-activated signaling pathway Source: TAIR
  • response to abscisic acid Source: TAIR
  • response to water deprivation Source: TAIR
  • stomatal movement Source: TAIR

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandMagnesium, Manganese, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.3.16 399

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 2C 78 (EC:3.1.3.16PROSITE-ProRule annotation)
Short name:
AtPP2C78
Alternative name(s):
Protein HIGHLY ABA-INDUCED 11 Publication
Protein SENESCENCE-ASSOCIATED GENE 1131 Publication
Gene namesi
Name:SAG1131 Publication
Synonyms:HAI11 Publication
Ordered Locus Names:At5g59220
ORF Names:MNC17.110
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G59220
TAIRilocus:2168449 AT5G59220

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus, Nucleus

Pathology & Biotechi

Disruption phenotypei

Delayed senescence. Increased sensitivity to abscisic acid (ABA).1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003679971 – 413Probable protein phosphatase 2C 78Add BLAST413

Proteomic databases

PaxDbiQ9FIF5
PRIDEiQ9FIF5

Expressioni

Inductioni

By abscisic acid (ABA) (PubMed:22007837, PubMed:22198272). Induced during leaf senescence (PubMed:22007837). Induced by osmotic stress (PubMed:22198272).2 Publications

Gene expression databases

ExpressionAtlasiQ9FIF5 baseline and differential
GenevisibleiQ9FIF5 AT

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi21284, 35 interactors
DIPiDIP-48992N
IntActiQ9FIF5, 6 interactors
STRINGi3702.AT5G59220.1

Structurei

3D structure databases

ProteinModelPortaliQ9FIF5
SMRiQ9FIF5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini111 – 409PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST299

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi66 – 70Poly-Arg5

Sequence similaritiesi

Belongs to the PP2C family.Curated

Phylogenomic databases

eggNOGiKOG0698 Eukaryota
COG0631 LUCA
HOGENOMiHOG000233896
InParanoidiQ9FIF5
KOiK14497
OMAiAEICYEN
OrthoDBiEOG09360IAR
PhylomeDBiQ9FIF5

Family and domain databases

CDDicd00143 PP2Cc, 1 hit
Gene3Di3.60.40.10, 1 hit
InterProiView protein in InterPro
IPR015655 PP2C
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom
PANTHERiPTHR13832 PTHR13832, 1 hit
PfamiView protein in Pfam
PF00481 PP2C, 1 hit
SMARTiView protein in SMART
SM00331 PP2C_SIG, 1 hit
SM00332 PP2Cc, 1 hit
SUPFAMiSSF81606 SSF81606, 2 hits
PROSITEiView protein in PROSITE
PS51746 PPM_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9FIF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEICYENET MMIETTATVV KKATTTTRRR ERSSSQAARR RRMEIRRFKF
60 70 80 90 100
VSGEQEPVFV DGDLQRRRRR ESTVAASTST VFYETAKEVV VLCESLSSTV
110 120 130 140 150
VALPDPEAYP KYGVASVCGR RREMEDAVAV HPFFSRHQTE YSSTGFHYCG
160 170 180 190 200
VYDGHGCSHV AMKCRERLHE LVREEFEADA DWEKSMARSF TRMDMEVVAL
210 220 230 240 250
NADGAAKCRC ELQRPDCDAV GSTAVVSVLT PEKIIVANCG DSRAVLCRNG
260 270 280 290 300
KAIALSSDHK PDRPDELDRI QAAGGRVIYW DGPRVLGVLA MSRAIGDNYL
310 320 330 340 350
KPYVISRPEV TVTDRANGDD FLILASDGLW DVVSNETACS VVRMCLRGKV
360 370 380 390 400
NGQVSSSPER EMTGVGAGNV VVGGGDLPDK ACEEASLLLT RLALARQSSD
410
NVSVVVVDLR RDT
Length:413
Mass (Da):45,538
Last modified:March 1, 2001 - v1
Checksum:i649CF986D17A92D7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti103L → F in AAL16163 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016890 Genomic DNA Translation: BAB09767.1
CP002688 Genomic DNA Translation: AED97159.1
AF428395 mRNA Translation: AAL16163.1
AY054163 mRNA Translation: AAL06824.1
AY074555 mRNA Translation: AAL67095.1
RefSeqiNP_200730.1, NM_125312.3
UniGeneiAt.22149

Genome annotation databases

EnsemblPlantsiAT5G59220.1; AT5G59220.1; AT5G59220
GeneIDi836040
GrameneiAT5G59220.1; AT5G59220.1; AT5G59220
KEGGiath:AT5G59220

Similar proteinsi

Entry informationi

Entry nameiP2C78_ARATH
AccessioniPrimary (citable) accession number: Q9FIF5
Secondary accession number(s): Q944I7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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