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Q9FHE1

- GSTT3_ARATH

UniProt

Q9FHE1 - GSTT3_ARATH

Protein

Glutathione S-transferase T3

Gene

GSTT3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.By similarity

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. glutathione transferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. response to toxic substance Source: UniProtKB-KW
    2. toxin catabolic process Source: TAIR

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Detoxification

    Enzyme and pathway databases

    BioCyciARA:AT5G41220-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase T3 (EC:2.5.1.18)
    Short name:
    AtGSTT3
    Alternative name(s):
    GST class-theta member 3
    Glutathione S-transferase 10C
    Gene namesi
    Name:GSTT3
    Synonyms:GST10C
    Ordered Locus Names:At5g41220
    ORF Names:K1O13.1
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 5

    Organism-specific databases

    TAIRiAT5G41220.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: TAIR
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 590590Glutathione S-transferase T3PRO_0000413576Add
    BLAST

    Proteomic databases

    PRIDEiQ9FHE1.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9FHE1.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT5G41220.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9FHE1.
    SMRiQ9FHE1. Positions 1-224.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 8282GST N-terminalAdd
    BLAST
    Domaini89 – 232144GST C-terminalAdd
    BLAST
    Domaini265 – 33672Myb-likePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni11 – 122Glutathione bindingBy similarity
    Regioni40 – 412Glutathione bindingBy similarity
    Regioni53 – 542Glutathione bindingBy similarity
    Regioni66 – 672Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Theta family.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated
    Contains 1 Myb-like domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0625.
    HOGENOMiHOG000148624.
    InParanoidiQ9FHE1.
    PhylomeDBiQ9FHE1.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR009057. Homeodomain-like.
    IPR017877. Myb-like_dom.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF02798. GST_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    PS50090. MYB_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9FHE1-1 [UniParc]FASTAAdd to Basket

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    MKLKVYADRM SQPSRAVLIF CKVNEIQFDE ILIYLANRQQ LSPEFKDINP    50
    MGKVPAIVDG KLKLSESHAI LIYLSSAYPS VVDHWYPTDL SKRARIHSVL 100
    DWHHTNLRPG AAGYVLNSVL GPALGLPLNP KAAAEAEQLL TKSLTTLDTF 150
    WLKGNAMFLL GSNQPSIADL SLVCELTQLQ VLDDKDRLRL LSPHKNVEQW 200
    IENTRKATMP HFDEVHEVLF RAKDRCQKQR EMATASKPGP QSKIIQFSTI 250
    GEKSDDPNLV QNTTDRRKHR RKWSRAEDAI LISAWLNTSK DPIVDNEHKA 300
    CAFWKRIGAY FNNSASLANL PKREPSHCKQ RWSKLNDKVC KFVGCYDQAL 350
    NQRSSGQSED DVFQVAYQVY TNNYKSNFTL EHAWRELRHS KKWCSLYPFE 400
    NSKGGGSSKR TKLNNGDRVY SSSSNPESVP IALDEEEQVM DLPLGVKSSK 450
    QKEKKVATII TIEEREADSG SRLENLWVLD EEEQVMDRPL GVKSLEQKEN 500
    KVAPKPTIEE REAADSRSRL ENLWALKEKE EREADSRSRL ENLWALKEKD 550
    IEEQKKLTRM EVLKSLLGRT TDQLSEKEDI LKNKLIDEML 590
    Length:590
    Mass (Da):67,555
    Last modified:March 1, 2001 - v1
    Checksum:iE85F66525F6C7AF5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB019225 Genomic DNA. Translation: BAB11098.1.
    CP002688 Genomic DNA. Translation: AED94655.1.
    AK222098 mRNA. Translation: BAD95009.1.
    RefSeqiNP_198938.1. NM_123487.3.
    UniGeneiAt.30245.

    Genome annotation databases

    EnsemblPlantsiAT5G41220.1; AT5G41220.1; AT5G41220.
    GeneIDi834124.
    KEGGiath:AT5G41220.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB019225 Genomic DNA. Translation: BAB11098.1 .
    CP002688 Genomic DNA. Translation: AED94655.1 .
    AK222098 mRNA. Translation: BAD95009.1 .
    RefSeqi NP_198938.1. NM_123487.3.
    UniGenei At.30245.

    3D structure databases

    ProteinModelPortali Q9FHE1.
    SMRi Q9FHE1. Positions 1-224.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT5G41220.1-P.

    Proteomic databases

    PRIDEi Q9FHE1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT5G41220.1 ; AT5G41220.1 ; AT5G41220 .
    GeneIDi 834124.
    KEGGi ath:AT5G41220.

    Organism-specific databases

    TAIRi AT5G41220.

    Phylogenomic databases

    eggNOGi COG0625.
    HOGENOMi HOG000148624.
    InParanoidi Q9FHE1.
    PhylomeDBi Q9FHE1.

    Enzyme and pathway databases

    BioCyci ARA:AT5G41220-MONOMER.

    Gene expression databases

    Genevestigatori Q9FHE1.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR009057. Homeodomain-like.
    IPR017877. Myb-like_dom.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF02798. GST_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    PS50090. MYB_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence features of the regions of 3,076,755 bp covered by sixty P1 and TAC clones."
      Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H., Tabata S.
      DNA Res. 7:31-63(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
      Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
      , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 249-590.
      Strain: cv. Columbia.
    4. "Enzyme activities and subcellular localization of members of the Arabidopsis glutathione transferase superfamily."
      Dixon D.P., Hawkins T., Hussey P.J., Edwards R.
      J. Exp. Bot. 60:1207-1218(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    5. "Probing the diversity of the Arabidopsis glutathione S-transferase gene family."
      Wagner U., Edwards R., Dixon D.P., Mauch F.
      Plant Mol. Biol. 49:515-532(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiGSTT3_ARATH
    AccessioniPrimary (citable) accession number: Q9FHE1
    Secondary accession number(s): Q56WE4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2011
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3