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Protein

Glutathione S-transferase T3

Gene

GSTT3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

GO - Biological processi

  • response to toxic substance Source: UniProtKB-KW
  • toxin catabolic process Source: TAIR

Keywordsi

Molecular functionTransferase
Biological processDetoxification

Enzyme and pathway databases

BioCyciARA:AT5G41220-MONOMER.
ReactomeiR-ATH-156590. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase T3 (EC:2.5.1.18)
Short name:
AtGSTT3
Alternative name(s):
GST class-theta member 3
Glutathione S-transferase 10C
Gene namesi
Name:GSTT3
Synonyms:GST10C
Ordered Locus Names:At5g41220
ORF Names:K1O13.1
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRilocus:2155090. AT5G41220.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: TAIR
  • nucleus Source: UniProtKB-SubCell

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004135761 – 590Glutathione S-transferase T3Add BLAST590

Proteomic databases

PaxDbiQ9FHE1.
PRIDEiQ9FHE1.

Expressioni

Gene expression databases

GenevisibleiQ9FHE1. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G41220.1.

Structurei

3D structure databases

ProteinModelPortaliQ9FHE1.
SMRiQ9FHE1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 82GST N-terminalAdd BLAST82
Domaini89 – 232GST C-terminalAdd BLAST144
Domaini265 – 336Myb-likePROSITE-ProRule annotationAdd BLAST72

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni11 – 12Glutathione bindingBy similarity2
Regioni40 – 41Glutathione bindingBy similarity2
Regioni53 – 54Glutathione bindingBy similarity2
Regioni66 – 67Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Theta family.Curated

Phylogenomic databases

eggNOGiKOG0867. Eukaryota.
COG0625. LUCA.
HOGENOMiHOG000148624.
InParanoidiQ9FHE1.
OrthoDBiEOG09360L2Z.
PhylomeDBiQ9FHE1.

Family and domain databases

InterProiView protein in InterPro
IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR017877. Myb-like_dom.
IPR012336. Thioredoxin-like_fold.
PfamiView protein in Pfam
PF02798. GST_N. 1 hit.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
PS50090. MYB_LIKE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9FHE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLKVYADRM SQPSRAVLIF CKVNEIQFDE ILIYLANRQQ LSPEFKDINP
60 70 80 90 100
MGKVPAIVDG KLKLSESHAI LIYLSSAYPS VVDHWYPTDL SKRARIHSVL
110 120 130 140 150
DWHHTNLRPG AAGYVLNSVL GPALGLPLNP KAAAEAEQLL TKSLTTLDTF
160 170 180 190 200
WLKGNAMFLL GSNQPSIADL SLVCELTQLQ VLDDKDRLRL LSPHKNVEQW
210 220 230 240 250
IENTRKATMP HFDEVHEVLF RAKDRCQKQR EMATASKPGP QSKIIQFSTI
260 270 280 290 300
GEKSDDPNLV QNTTDRRKHR RKWSRAEDAI LISAWLNTSK DPIVDNEHKA
310 320 330 340 350
CAFWKRIGAY FNNSASLANL PKREPSHCKQ RWSKLNDKVC KFVGCYDQAL
360 370 380 390 400
NQRSSGQSED DVFQVAYQVY TNNYKSNFTL EHAWRELRHS KKWCSLYPFE
410 420 430 440 450
NSKGGGSSKR TKLNNGDRVY SSSSNPESVP IALDEEEQVM DLPLGVKSSK
460 470 480 490 500
QKEKKVATII TIEEREADSG SRLENLWVLD EEEQVMDRPL GVKSLEQKEN
510 520 530 540 550
KVAPKPTIEE REAADSRSRL ENLWALKEKE EREADSRSRL ENLWALKEKD
560 570 580 590
IEEQKKLTRM EVLKSLLGRT TDQLSEKEDI LKNKLIDEML
Length:590
Mass (Da):67,555
Last modified:March 1, 2001 - v1
Checksum:iE85F66525F6C7AF5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019225 Genomic DNA. Translation: BAB11098.1.
CP002688 Genomic DNA. Translation: AED94655.1.
AK222098 mRNA. Translation: BAD95009.1.
RefSeqiNP_198938.1. NM_123487.4.
UniGeneiAt.30245.

Genome annotation databases

EnsemblPlantsiAT5G41220.1; AT5G41220.1; AT5G41220.
GeneIDi834124.
GrameneiAT5G41220.1; AT5G41220.1; AT5G41220.
KEGGiath:AT5G41220.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019225 Genomic DNA. Translation: BAB11098.1.
CP002688 Genomic DNA. Translation: AED94655.1.
AK222098 mRNA. Translation: BAD95009.1.
RefSeqiNP_198938.1. NM_123487.4.
UniGeneiAt.30245.

3D structure databases

ProteinModelPortaliQ9FHE1.
SMRiQ9FHE1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT5G41220.1.

Proteomic databases

PaxDbiQ9FHE1.
PRIDEiQ9FHE1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G41220.1; AT5G41220.1; AT5G41220.
GeneIDi834124.
GrameneiAT5G41220.1; AT5G41220.1; AT5G41220.
KEGGiath:AT5G41220.

Organism-specific databases

AraportiAT5G41220.
TAIRilocus:2155090. AT5G41220.

Phylogenomic databases

eggNOGiKOG0867. Eukaryota.
COG0625. LUCA.
HOGENOMiHOG000148624.
InParanoidiQ9FHE1.
OrthoDBiEOG09360L2Z.
PhylomeDBiQ9FHE1.

Enzyme and pathway databases

BioCyciARA:AT5G41220-MONOMER.
ReactomeiR-ATH-156590. Glutathione conjugation.

Miscellaneous databases

PROiPR:Q9FHE1.

Gene expression databases

GenevisibleiQ9FHE1. AT.

Family and domain databases

InterProiView protein in InterPro
IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR017877. Myb-like_dom.
IPR012336. Thioredoxin-like_fold.
PfamiView protein in Pfam
PF02798. GST_N. 1 hit.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
PS50090. MYB_LIKE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGSTT3_ARATH
AccessioniPrimary (citable) accession number: Q9FHE1
Secondary accession number(s): Q56WE4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: March 1, 2001
Last modified: May 10, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.