Histone deacetylase 7 - Arabidopsis thaliana (Mouse-ear cress)

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Q9FH09 (HDA7_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 72. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Histone deacetylase 7
EC=3.5.1.98

Gene names

Name:	HDA7
Ordered Locus Names:	At5g35600
ORF Names:	K2K18.5

Organism

Arabidopsis thaliana (Mouse-ear cress) [Reference proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	409 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. May be involved in flowering induction. Histone deacetylases act via the formation of large multiprotein complexes By similarity. Ref.5
Catalytic activity	Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
Subcellular location	Nucleus By similarity.
Tissue specificity	Low expression in flowers. Ref.5
Sequence similarities	Belongs to the histone deacetylase family. HD type 1 subfamily.
Sequence caution	The sequence ABK28721.1 differs from that shown. Reason: Erroneous termination at position 410. Translated as stop.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Molecular function	Chromatin regulator Hydrolase Repressor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	histone H3 deacetylation Inferred from electronic annotation. Source: GOC histone H4 deacetylation Inferred from electronic annotation. Source: GOC regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	NAD-dependent histone deacetylase activity (H3-K14 specific) Inferred from electronic annotation. Source: EC NAD-dependent histone deacetylase activity (H3-K18 specific) Inferred from electronic annotation. Source: EC NAD-dependent histone deacetylase activity (H3-K9 specific) Inferred from electronic annotation. Source: EC NAD-dependent histone deacetylase activity (H4-K16 specific) Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 409

409

Histone deacetylase 7

PRO_0000280086

Regions

Region

11 – 324

314

Histone deacetylase

Compositional bias

302 – 305

Poly-Gly

Sites

Active site

148

By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q9FH09 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 56A4FFAF9A0734AE
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FASTA

409

46,017

        10         20         30         40         50         60 
MASLADGGKR RVSYFYEPMI GDYYYGVNQP TKPQRIRVTH NLILSYNLHR HMEINHPDLA 

        70         80         90        100        110        120 
DASDFEKFHS LEYINFLKSV TPETVTDPHP SVSENLKRFN VDVDWDGPVF HNLFDYCRAY 

       130        140        150        160        170        180 
AGGSISAAAK LNRQEADIAI NWAGGMHHVK KDKASGFGYV NDVVLAILEL LKSFKRVLYI 

       190        200        210        220        230        240 
EIGFPHGDEV EEAFKDTDRV MTVSFHKVGD TGDISDYGEG KGQYYSLNAP LKDGLDDFSL 

       250        260        270        280        290        300 
RGLFIPVIHR AMEIYEPEVI VLQCGADSLA GDPFGTFNLS IKGHGDCLQY VRSFNVPLMI 

       310        320        330        340        350        360 
LGGGGYTLPN VARCWCYETA IAVGEQLDND LPGNDYMKYF RPDYKLHILP TNRQNLNTRL 

       370        380        390        400 
DIITMRETLL AQLSLVMHAP SVPFQDTPSS SQATEAAEVD MEKRNDPRI

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes." Pandey R., Mueller A., Napoli C.A., Selinger D.A., Pikaard C.S., Richards E.J., Bender J., Mount D.W., Jorgensen R.A. Nucleic Acids Res. 30:5036-5055(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, NOMENCLATURE. Strain: cv. Columbia.
[2]	"Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence features of the regions of 3,076,755 bp covered by sixty P1 and TAC clones." Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H., Tabata S. DNA Res. 7:31-63(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[3]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[4]	"Simultaneous high-throughput recombinational cloning of open reading frames in closed and open configurations." Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P. Plant Biotechnol. J. 4:317-324(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[5]	"Arabidopsis thaliana histone deacetylase 1 (AtHD1) is localized in euchromatic regions and demonstrates histone deacetylase activity in vitro." Fong P.M., Tian L., Chen Z.J. Cell Res. 16:479-488(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF510166 mRNA. Translation: AAM49768.1. AB023031 Genomic DNA. Translation: BAB09994.1. CP002688 Genomic DNA. Translation: AED93985.1. DQ447001 mRNA. Translation: ABE66192.1. DQ653319 mRNA. Translation: ABK28721.1. Sequence problems.
IPI	IPI00544887.
RefSeq	NP_198410.1. NM_122951.1.
UniGene	At.30589.
3D structure databases
HSSP	HSSP built from PDB template 1VKG based on UniProtKB Q9BY41.
ProteinModelPortal	Q9FH09.
SMR	Q9FH09. Positions 9-376.
ModBase	Search...
Proteomic databases
PaxDb	Q9FH09.
PRIDE	Q9FH09.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT5G35600.1; AT5G35600.1; AT5G35600.
GeneID	833525.
KEGG	ath:AT5G35600.
Organism-specific databases
TAIR	At5g35600.
Phylogenomic databases
eggNOG	COG0123.
HOGENOM	HOG000225180.
InParanoid	Q9FH09.
KO	K06067.
OMA	WCYETAI.
PhylomeDB	Q9FH09.
Gene expression databases
Genevestigator	Q9FH09.
Family and domain databases
Gene3D	3.40.800.20. 1 hit.
InterPro	IPR000286. His_deacetylse. IPR003084. His_deacetylse_1. IPR023801. His_deacetylse_dom. [Graphical view]
PANTHER	PTHR10625. PTHR10625. 1 hit.
Pfam	PF00850. Hist_deacetyl. 1 hit. [Graphical view]
PIRSF	PIRSF037913. His_deacetylse_1. 1 hit.
PRINTS	PR01270. HDASUPER. PR01271. HISDACETLASE.
ProtoNet	Search...

Entry information

Entry name

HDA7_ARATH

Accession

Primary (citable) accession number: Q9FH09
Secondary accession number(s): A0MFJ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 6, 2007
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program

Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Entry information

Relevant documents