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Protein

Histone deacetylase 7

Gene

HDA7

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. May be involved in flowering induction. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).By similarity1 Publication

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei148By similarity1

GO - Molecular functioni

GO - Biological processi

  • embryo development ending in seed dormancy Source: TAIR
  • embryo sac development Source: TAIR
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • seed germination Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionChromatin regulator, Hydrolase, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-ATH-1538133 G0 and Early G1
R-ATH-4551638 SUMOylation of chromatin organization proteins
R-ATH-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 7 (EC:3.5.1.98)
Gene namesi
Name:HDA7
Ordered Locus Names:At5g35600
ORF Names:K2K18.5
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi

Organism-specific databases

AraportiAT5G35600
TAIRilocus:2157111 AT5G35600

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002800861 – 409Histone deacetylase 7Add BLAST409

Proteomic databases

PaxDbiQ9FH09

Expressioni

Tissue specificityi

Low expression in flowers.1 Publication

Gene expression databases

ExpressionAtlasiQ9FH09 baseline and differential
GenevisibleiQ9FH09 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G35600.1

Structurei

3D structure databases

ProteinModelPortaliQ9FH09
SMRiQ9FH09
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni11 – 324Histone deacetylaseAdd BLAST314

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi302 – 305Poly-Gly4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1342 Eukaryota
COG0123 LUCA
HOGENOMiHOG000225180
InParanoidiQ9FH09
KOiK06067
OMAiDITINWS
OrthoDBiEOG093609CH
PhylomeDBiQ9FH09

Family and domain databases

Gene3Di3.40.800.20, 1 hit
InterProiView protein in InterPro
IPR000286 His_deacetylse
IPR003084 His_deacetylse_1
IPR023801 His_deacetylse_dom
IPR037138 His_deacetylse_dom_sf
IPR023696 Ureohydrolase_dom_sf
PANTHERiPTHR10625 PTHR10625, 1 hit
PfamiView protein in Pfam
PF00850 Hist_deacetyl, 1 hit
PIRSFiPIRSF037913 His_deacetylse_1, 1 hit
PRINTSiPR01270 HDASUPER
PR01271 HISDACETLASE
SUPFAMiSSF52768 SSF52768, 1 hit

Sequencei

Sequence statusi: Complete.

Q9FH09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLADGGKR RVSYFYEPMI GDYYYGVNQP TKPQRIRVTH NLILSYNLHR
60 70 80 90 100
HMEINHPDLA DASDFEKFHS LEYINFLKSV TPETVTDPHP SVSENLKRFN
110 120 130 140 150
VDVDWDGPVF HNLFDYCRAY AGGSISAAAK LNRQEADIAI NWAGGMHHVK
160 170 180 190 200
KDKASGFGYV NDVVLAILEL LKSFKRVLYI EIGFPHGDEV EEAFKDTDRV
210 220 230 240 250
MTVSFHKVGD TGDISDYGEG KGQYYSLNAP LKDGLDDFSL RGLFIPVIHR
260 270 280 290 300
AMEIYEPEVI VLQCGADSLA GDPFGTFNLS IKGHGDCLQY VRSFNVPLMI
310 320 330 340 350
LGGGGYTLPN VARCWCYETA IAVGEQLDND LPGNDYMKYF RPDYKLHILP
360 370 380 390 400
TNRQNLNTRL DIITMRETLL AQLSLVMHAP SVPFQDTPSS SQATEAAEVD

MEKRNDPRI
Length:409
Mass (Da):46,017
Last modified:March 1, 2001 - v1
Checksum:i56A4FFAF9A0734AE
GO

Sequence cautioni

The sequence ABK28721 differs from that shown. Reason: Erroneous termination at position 410. Translated as stop.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF510166 mRNA Translation: AAM49768.1
AB023031 Genomic DNA Translation: BAB09994.1
CP002688 Genomic DNA Translation: AED93985.1
DQ447001 mRNA Translation: ABE66192.1
DQ653319 mRNA Translation: ABK28721.1 Sequence problems.
RefSeqiNP_198410.1, NM_122951.1
UniGeneiAt.30589

Genome annotation databases

EnsemblPlantsiAT5G35600.1; AT5G35600.1; AT5G35600
GeneIDi833525
GrameneiAT5G35600.1; AT5G35600.1; AT5G35600
KEGGiath:AT5G35600

Entry informationi

Entry nameiHDA7_ARATH
AccessioniPrimary (citable) accession number: Q9FH09
Secondary accession number(s): A0MFJ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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