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Q9FH09

- HDA7_ARATH

UniProt

Q9FH09 - HDA7_ARATH

Protein

Histone deacetylase 7

Gene

HDA7

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. May be involved in flowering induction. Histone deacetylases act via the formation of large multiprotein complexes By similarity.By similarity

    Catalytic activityi

    Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei148 – 1481By similarity

    GO - Molecular functioni

    1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
    2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
    3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
    4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Hydrolase, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    BioCyciARA:AT5G35600-MONOMER.
    ReactomeiREACT_187702. G0 and Early G1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone deacetylase 7 (EC:3.5.1.98)
    Gene namesi
    Name:HDA7
    Ordered Locus Names:At5g35600
    ORF Names:K2K18.5
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 5

    Organism-specific databases

    TAIRiAT5G35600.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 409409Histone deacetylase 7PRO_0000280086Add
    BLAST

    Proteomic databases

    PaxDbiQ9FH09.
    PRIDEiQ9FH09.

    Expressioni

    Tissue specificityi

    Low expression in flowers.1 Publication

    Gene expression databases

    GenevestigatoriQ9FH09.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9FH09.
    SMRiQ9FH09. Positions 8-376.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni11 – 324314Histone deacetylaseAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi302 – 3054Poly-Gly

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0123.
    HOGENOMiHOG000225180.
    InParanoidiQ9FH09.
    KOiK06067.
    OMAiWCYETAI.
    PhylomeDBiQ9FH09.

    Family and domain databases

    Gene3Di3.40.800.20. 1 hit.
    InterProiIPR000286. His_deacetylse.
    IPR003084. His_deacetylse_1.
    IPR023801. His_deacetylse_dom.
    [Graphical view]
    PANTHERiPTHR10625. PTHR10625. 1 hit.
    PfamiPF00850. Hist_deacetyl. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
    PRINTSiPR01270. HDASUPER.
    PR01271. HISDACETLASE.

    Sequencei

    Sequence statusi: Complete.

    Q9FH09-1 [UniParc]FASTAAdd to Basket

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    MASLADGGKR RVSYFYEPMI GDYYYGVNQP TKPQRIRVTH NLILSYNLHR    50
    HMEINHPDLA DASDFEKFHS LEYINFLKSV TPETVTDPHP SVSENLKRFN 100
    VDVDWDGPVF HNLFDYCRAY AGGSISAAAK LNRQEADIAI NWAGGMHHVK 150
    KDKASGFGYV NDVVLAILEL LKSFKRVLYI EIGFPHGDEV EEAFKDTDRV 200
    MTVSFHKVGD TGDISDYGEG KGQYYSLNAP LKDGLDDFSL RGLFIPVIHR 250
    AMEIYEPEVI VLQCGADSLA GDPFGTFNLS IKGHGDCLQY VRSFNVPLMI 300
    LGGGGYTLPN VARCWCYETA IAVGEQLDND LPGNDYMKYF RPDYKLHILP 350
    TNRQNLNTRL DIITMRETLL AQLSLVMHAP SVPFQDTPSS SQATEAAEVD 400
    MEKRNDPRI 409
    Length:409
    Mass (Da):46,017
    Last modified:March 1, 2001 - v1
    Checksum:i56A4FFAF9A0734AE
    GO

    Sequence cautioni

    The sequence ABK28721.1 differs from that shown. Reason: Erroneous termination at position 410. Translated as stop.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF510166 mRNA. Translation: AAM49768.1.
    AB023031 Genomic DNA. Translation: BAB09994.1.
    CP002688 Genomic DNA. Translation: AED93985.1.
    DQ447001 mRNA. Translation: ABE66192.1.
    DQ653319 mRNA. Translation: ABK28721.1. Sequence problems.
    RefSeqiNP_198410.1. NM_122951.1.
    UniGeneiAt.30589.

    Genome annotation databases

    EnsemblPlantsiAT5G35600.1; AT5G35600.1; AT5G35600.
    GeneIDi833525.
    KEGGiath:AT5G35600.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF510166 mRNA. Translation: AAM49768.1 .
    AB023031 Genomic DNA. Translation: BAB09994.1 .
    CP002688 Genomic DNA. Translation: AED93985.1 .
    DQ447001 mRNA. Translation: ABE66192.1 .
    DQ653319 mRNA. Translation: ABK28721.1 . Sequence problems.
    RefSeqi NP_198410.1. NM_122951.1.
    UniGenei At.30589.

    3D structure databases

    ProteinModelPortali Q9FH09.
    SMRi Q9FH09. Positions 8-376.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q9FH09.
    PRIDEi Q9FH09.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT5G35600.1 ; AT5G35600.1 ; AT5G35600 .
    GeneIDi 833525.
    KEGGi ath:AT5G35600.

    Organism-specific databases

    TAIRi AT5G35600.

    Phylogenomic databases

    eggNOGi COG0123.
    HOGENOMi HOG000225180.
    InParanoidi Q9FH09.
    KOi K06067.
    OMAi WCYETAI.
    PhylomeDBi Q9FH09.

    Enzyme and pathway databases

    BioCyci ARA:AT5G35600-MONOMER.
    Reactomei REACT_187702. G0 and Early G1.

    Gene expression databases

    Genevestigatori Q9FH09.

    Family and domain databases

    Gene3Di 3.40.800.20. 1 hit.
    InterProi IPR000286. His_deacetylse.
    IPR003084. His_deacetylse_1.
    IPR023801. His_deacetylse_dom.
    [Graphical view ]
    PANTHERi PTHR10625. PTHR10625. 1 hit.
    Pfami PF00850. Hist_deacetyl. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037913. His_deacetylse_1. 1 hit.
    PRINTSi PR01270. HDASUPER.
    PR01271. HISDACETLASE.
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes."
      Pandey R., Mueller A., Napoli C.A., Selinger D.A., Pikaard C.S., Richards E.J., Bender J., Mount D.W., Jorgensen R.A.
      Nucleic Acids Res. 30:5036-5055(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, NOMENCLATURE.
      Strain: cv. Columbia.
    2. "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence features of the regions of 3,076,755 bp covered by sixty P1 and TAC clones."
      Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H., Tabata S.
      DNA Res. 7:31-63(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Simultaneous high-throughput recombinational cloning of open reading frames in closed and open configurations."
      Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.
      Plant Biotechnol. J. 4:317-324(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "Arabidopsis thaliana histone deacetylase 1 (AtHD1) is localized in euchromatic regions and demonstrates histone deacetylase activity in vitro."
      Fong P.M., Tian L., Chen Z.J.
      Cell Res. 16:479-488(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiHDA7_ARATH
    AccessioniPrimary (citable) accession number: Q9FH09
    Secondary accession number(s): A0MFJ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 6, 2007
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3