Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Histone deacetylase 7

Gene

HDA7

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. May be involved in flowering induction. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).By similarity

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei148 – 1481By similarity

GO - Molecular functioni

  1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC

GO - Biological processi

  1. embryo development ending in seed dormancy Source: TAIR
  2. embryo sac development Source: TAIR
  3. regulation of transcription, DNA-templated Source: UniProtKB-KW
  4. seed germination Source: TAIR
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciARA:AT5G35600-MONOMER.
ReactomeiREACT_187702. G0 and Early G1.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 7 (EC:3.5.1.98)
Gene namesi
Name:HDA7
Ordered Locus Names:At5g35600
ORF Names:K2K18.5
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G35600.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 409409Histone deacetylase 7PRO_0000280086Add
BLAST

Proteomic databases

PaxDbiQ9FH09.
PRIDEiQ9FH09.

Expressioni

Tissue specificityi

Low expression in flowers.1 Publication

Gene expression databases

GenevestigatoriQ9FH09.

Structurei

3D structure databases

ProteinModelPortaliQ9FH09.
SMRiQ9FH09. Positions 8-376.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni11 – 324314Histone deacetylaseAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi302 – 3054Poly-Gly

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0123.
HOGENOMiHOG000225180.
InParanoidiQ9FH09.
KOiK06067.
OMAiWCYETAI.
PhylomeDBiQ9FH09.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

Q9FH09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLADGGKR RVSYFYEPMI GDYYYGVNQP TKPQRIRVTH NLILSYNLHR
60 70 80 90 100
HMEINHPDLA DASDFEKFHS LEYINFLKSV TPETVTDPHP SVSENLKRFN
110 120 130 140 150
VDVDWDGPVF HNLFDYCRAY AGGSISAAAK LNRQEADIAI NWAGGMHHVK
160 170 180 190 200
KDKASGFGYV NDVVLAILEL LKSFKRVLYI EIGFPHGDEV EEAFKDTDRV
210 220 230 240 250
MTVSFHKVGD TGDISDYGEG KGQYYSLNAP LKDGLDDFSL RGLFIPVIHR
260 270 280 290 300
AMEIYEPEVI VLQCGADSLA GDPFGTFNLS IKGHGDCLQY VRSFNVPLMI
310 320 330 340 350
LGGGGYTLPN VARCWCYETA IAVGEQLDND LPGNDYMKYF RPDYKLHILP
360 370 380 390 400
TNRQNLNTRL DIITMRETLL AQLSLVMHAP SVPFQDTPSS SQATEAAEVD

MEKRNDPRI
Length:409
Mass (Da):46,017
Last modified:March 1, 2001 - v1
Checksum:i56A4FFAF9A0734AE
GO

Sequence cautioni

The sequence ABK28721.1 differs from that shown. Reason: Erroneous termination at position 410. Translated as stop.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF510166 mRNA. Translation: AAM49768.1.
AB023031 Genomic DNA. Translation: BAB09994.1.
CP002688 Genomic DNA. Translation: AED93985.1.
DQ447001 mRNA. Translation: ABE66192.1.
DQ653319 mRNA. Translation: ABK28721.1. Sequence problems.
RefSeqiNP_198410.1. NM_122951.1.
UniGeneiAt.30589.

Genome annotation databases

EnsemblPlantsiAT5G35600.1; AT5G35600.1; AT5G35600.
GeneIDi833525.
KEGGiath:AT5G35600.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF510166 mRNA. Translation: AAM49768.1.
AB023031 Genomic DNA. Translation: BAB09994.1.
CP002688 Genomic DNA. Translation: AED93985.1.
DQ447001 mRNA. Translation: ABE66192.1.
DQ653319 mRNA. Translation: ABK28721.1. Sequence problems.
RefSeqiNP_198410.1. NM_122951.1.
UniGeneiAt.30589.

3D structure databases

ProteinModelPortaliQ9FH09.
SMRiQ9FH09. Positions 8-376.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ9FH09.
PRIDEiQ9FH09.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G35600.1; AT5G35600.1; AT5G35600.
GeneIDi833525.
KEGGiath:AT5G35600.

Organism-specific databases

TAIRiAT5G35600.

Phylogenomic databases

eggNOGiCOG0123.
HOGENOMiHOG000225180.
InParanoidiQ9FH09.
KOiK06067.
OMAiWCYETAI.
PhylomeDBiQ9FH09.

Enzyme and pathway databases

BioCyciARA:AT5G35600-MONOMER.
ReactomeiREACT_187702. G0 and Early G1.

Gene expression databases

GenevestigatoriQ9FH09.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes."
    Pandey R., Mueller A., Napoli C.A., Selinger D.A., Pikaard C.S., Richards E.J., Bender J., Mount D.W., Jorgensen R.A.
    Nucleic Acids Res. 30:5036-5055(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, NOMENCLATURE.
    Strain: cv. Columbia.
  2. "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence features of the regions of 3,076,755 bp covered by sixty P1 and TAC clones."
    Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H., Tabata S.
    DNA Res. 7:31-63(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Simultaneous high-throughput recombinational cloning of open reading frames in closed and open configurations."
    Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.
    Plant Biotechnol. J. 4:317-324(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Arabidopsis thaliana histone deacetylase 1 (AtHD1) is localized in euchromatic regions and demonstrates histone deacetylase activity in vitro."
    Fong P.M., Tian L., Chen Z.J.
    Cell Res. 16:479-488(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiHDA7_ARATH
AccessioniPrimary (citable) accession number: Q9FH09
Secondary accession number(s): A0MFJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 1, 2001
Last modified: January 7, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.