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Q9FH09 (HDA7_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone deacetylase 7

EC=3.5.1.98
Gene names
Name:HDA7
Ordered Locus Names:At5g35600
ORF Names:K2K18.5
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length409 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. May be involved in flowering induction. Histone deacetylases act via the formation of large multiprotein complexes By similarity. Ref.5

Catalytic activity

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Subcellular location

Nucleus By similarity.

Tissue specificity

Low expression in flowers. Ref.5

Sequence similarities

Belongs to the histone deacetylase family. HD type 1 subfamily.

Sequence caution

The sequence ABK28721.1 differs from that shown. Reason: Erroneous termination at position 410. Translated as stop.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 409409Histone deacetylase 7
PRO_0000280086

Regions

Region11 – 324314Histone deacetylase
Compositional bias302 – 3054Poly-Gly

Sites

Active site1481 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9FH09 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 56A4FFAF9A0734AE

FASTA40946,017
        10         20         30         40         50         60 
MASLADGGKR RVSYFYEPMI GDYYYGVNQP TKPQRIRVTH NLILSYNLHR HMEINHPDLA 

        70         80         90        100        110        120 
DASDFEKFHS LEYINFLKSV TPETVTDPHP SVSENLKRFN VDVDWDGPVF HNLFDYCRAY 

       130        140        150        160        170        180 
AGGSISAAAK LNRQEADIAI NWAGGMHHVK KDKASGFGYV NDVVLAILEL LKSFKRVLYI 

       190        200        210        220        230        240 
EIGFPHGDEV EEAFKDTDRV MTVSFHKVGD TGDISDYGEG KGQYYSLNAP LKDGLDDFSL 

       250        260        270        280        290        300 
RGLFIPVIHR AMEIYEPEVI VLQCGADSLA GDPFGTFNLS IKGHGDCLQY VRSFNVPLMI 

       310        320        330        340        350        360 
LGGGGYTLPN VARCWCYETA IAVGEQLDND LPGNDYMKYF RPDYKLHILP TNRQNLNTRL 

       370        380        390        400 
DIITMRETLL AQLSLVMHAP SVPFQDTPSS SQATEAAEVD MEKRNDPRI 

« Hide

References

« Hide 'large scale' references
[1]"Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes."
Pandey R., Mueller A., Napoli C.A., Selinger D.A., Pikaard C.S., Richards E.J., Bender J., Mount D.W., Jorgensen R.A.
Nucleic Acids Res. 30:5036-5055(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, NOMENCLATURE.
Strain: cv. Columbia.
[2]"Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence features of the regions of 3,076,755 bp covered by sixty P1 and TAC clones."
Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H., Tabata S.
DNA Res. 7:31-63(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[3]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[4]"Simultaneous high-throughput recombinational cloning of open reading frames in closed and open configurations."
Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.
Plant Biotechnol. J. 4:317-324(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[5]"Arabidopsis thaliana histone deacetylase 1 (AtHD1) is localized in euchromatic regions and demonstrates histone deacetylase activity in vitro."
Fong P.M., Tian L., Chen Z.J.
Cell Res. 16:479-488(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF510166 mRNA. Translation: AAM49768.1.
AB023031 Genomic DNA. Translation: BAB09994.1.
CP002688 Genomic DNA. Translation: AED93985.1.
DQ447001 mRNA. Translation: ABE66192.1.
DQ653319 mRNA. Translation: ABK28721.1. Sequence problems.
RefSeqNP_198410.1. NM_122951.1.
UniGeneAt.30589.

3D structure databases

ProteinModelPortalQ9FH09.
SMRQ9FH09. Positions 8-376.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ9FH09.
PRIDEQ9FH09.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT5G35600.1; AT5G35600.1; AT5G35600.
GeneID833525.
KEGGath:AT5G35600.

Organism-specific databases

TAIRAT5G35600.

Phylogenomic databases

eggNOGCOG0123.
HOGENOMHOG000225180.
InParanoidQ9FH09.
KOK06067.
OMAWCYETAI.
PhylomeDBQ9FH09.

Enzyme and pathway databases

BioCycARA:AT5G35600-MONOMER.

Gene expression databases

GenevestigatorQ9FH09.

Family and domain databases

Gene3D3.40.800.20. 1 hit.
InterProIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERPTHR10625. PTHR10625. 1 hit.
PfamPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSPR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNetSearch...

Entry information

Entry nameHDA7_ARATH
AccessionPrimary (citable) accession number: Q9FH09
Secondary accession number(s): A0MFJ3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names