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Reviewed, UniProtKB/Swiss-Prot Q9FH09 (HDA7_ARATH)

Last modified October 13, 2009. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Histone deacetylase 7
    EC=3.5.1.98
Gene names
Name: HDA7
Ordered Locus Names: At5g35600
ORF Names: K2K18.5
OrganismArabidopsis thaliana (Mouse-ear cress) [Complete proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

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Protein attributes

Sequence length409 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. May be involved in flowering induction. Histone deacetylases act via the formation of large multiprotein complexes By similarity.

Catalytic activity

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Subcellular location

Nucleus By similarity.

Tissue specificity

Low expression in flowers. Ref.4

Sequence similarities

Belongs to the histone deacetylase family. Type 1 subfamily.

Sequence caution

The sequence ABK28721.1 differs from that shown. Reason: Erroneous termination at position 410. Translated as stop.

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Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Molecular functionChromatin regulator
Hydrolase
Repressor
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processhistone deacetylation

Inferred from electronic annotation. Source: InterPro

regulation of transcription

Inferred from electronic annotation. Source: UniProtKB-KW

transcription

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionhistone deacetylase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 409409Histone deacetylase 7
PRO_0000280086

Regions

Region11 – 324314Histone deacetylase
Compositional bias302 – 3054Poly-Gly

Sites

Active site1481 By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q9FH09-1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 56A4FFAF9A0734AE

FASTA40946,017
        10         20         30         40         50         60 
MASLADGGKR RVSYFYEPMI GDYYYGVNQP TKPQRIRVTH NLILSYNLHR HMEINHPDLA 

        70         80         90        100        110        120 
DASDFEKFHS LEYINFLKSV TPETVTDPHP SVSENLKRFN VDVDWDGPVF HNLFDYCRAY 

       130        140        150        160        170        180 
AGGSISAAAK LNRQEADIAI NWAGGMHHVK KDKASGFGYV NDVVLAILEL LKSFKRVLYI 

       190        200        210        220        230        240 
EIGFPHGDEV EEAFKDTDRV MTVSFHKVGD TGDISDYGEG KGQYYSLNAP LKDGLDDFSL 

       250        260        270        280        290        300 
RGLFIPVIHR AMEIYEPEVI VLQCGADSLA GDPFGTFNLS IKGHGDCLQY VRSFNVPLMI 

       310        320        330        340        350        360 
LGGGGYTLPN VARCWCYETA IAVGEQLDND LPGNDYMKYF RPDYKLHILP TNRQNLNTRL 

       370        380        390        400 
DIITMRETLL AQLSLVMHAP SVPFQDTPSS SQATEAAEVD MEKRNDPRI

« Hide

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References

« Hide 'large scale' references
[1]"Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes."
Pandey R., Mueller A., Napoli C.A., Selinger D.A., Pikaard C.S., Richards E.J., Bender J., Mount D.W., Jorgensen R.A.
Nucleic Acids Res. 30:5036-5055(2002) [PubMed: 12466527] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, NOMENCLATURE.
Strain: cv. Columbia.
[2]"Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence features of the regions of 3,076,755 bp covered by sixty P1 and TAC clones."
Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H., Tabata S.
DNA Res. 7:31-63(2000) [PubMed: 10718197] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[3]"Simultaneous high-throughput recombinational cloning of open reading frames in closed and open configurations."
Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.
Plant Biotechnol. J. 4:317-324(2006) [PubMed: 17147637] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[4]"Arabidopsis thaliana histone deacetylase 1 (AtHD1) is localized in euchromatic regions and demonstrates histone deacetylase activity in vitro."
Fong P.M., Tian L., Chen Z.J.
Cell Res. 16:479-488(2006) [PubMed: 16699543] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AF510166 mRNA. Translation: AAM49768.1.
AB023031 Genomic DNA. Translation: BAB09994.1.
DQ447001 mRNA. Translation: ABE66192.1.
DQ653319 mRNA. Translation: ABK28721.1. Sequence problems.
IPIIPI00544887.
RefSeqNP_198410.1.
UniGeneAt.30589

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID833525.
GenomeReviewsGene locus AT5G35600 in contig BA000015_GR.
KEGGath:AT5G35600.
NMPDRfig|3702.1.peg.25258.

Organism-specific databases

TAIRAt5g35600.

Gene expression databases

GenevestigatorQ9FH09.

Family and domain databases

InterProIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
[Graphical view]
Gene3DG3DSA:3.40.800.20. His_deacetylse. 1 hit.
PANTHERPTHR10625. His_deacetylse. 1 hit.
PTHR10625:SF28. His_deacetylse_1. 1 hit.
PfamPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSPR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNetSearch...

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Entry information

Entry nameHDA7_ARATH
AccessionPrimary (citable) accession number: Q9FH09
Secondary accession number(s): A0MFJ3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 1, 2001
Last modified: October 13, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectPPAP (Plant Proteome Annotation Project)

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Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents