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Protein

Alcohol dehydrogenase-like 7

Gene

At5g42250

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.By similarity

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi56Zinc 1; catalyticBy similarity1
Metal bindingi58Zinc 1By similarity1
Binding sitei58NADBy similarity1
Binding sitei58SubstrateBy similarity1
Metal bindingi78Zinc 1; catalyticBy similarity1
Binding sitei78SubstrateBy similarity1
Metal bindingi108Zinc 2By similarity1
Metal bindingi111Zinc 2By similarity1
Metal bindingi114Zinc 2By similarity1
Metal bindingi122Zinc 2By similarity1
Metal bindingi187Zinc 1; catalyticBy similarity1
Binding sitei236NADBy similarity1
Binding sitei241NADBy similarity1
Binding sitei334NAD; via amide nitrogenBy similarity1
Binding sitei384NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi212 – 217NADBy similarity6
Nucleotide bindingi306 – 308NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciARA:AT5G42250-MONOMER.
ReactomeiR-ATH-2161541. Abacavir metabolism.
R-ATH-5365859. RA biosynthesis pathway.
R-ATH-71384. Ethanol oxidation.

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase-like 7 (EC:1.1.1.1By similarity)
Gene namesi
Ordered Locus Names:At5g42250
ORF Names:K5J14.5
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRilocus:2157627. AT5G42250.

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002991891 – 390Alcohol dehydrogenase-like 7Add BLAST390

Proteomic databases

PaxDbiQ9FH04.
PRIDEiQ9FH04.

Expressioni

Gene expression databases

ExpressionAtlasiQ9FH04. baseline and differential.
GenevisibleiQ9FH04. AT.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi3702.AT5G42250.1.

Structurei

3D structure databases

ProteinModelPortaliQ9FH04.
SMRiQ9FH04.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0022. Eukaryota.
COG1062. LUCA.
HOGENOMiHOG000294674.
InParanoidiQ9FH04.
KOiK00121.
OMAiGRPTMCR.
OrthoDBiEOG09360CLU.
PhylomeDBiQ9FH04.

Family and domain databases

InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9FH04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENGNSSSDN KSSHKPIRCK AAVSRKAGEP LVMEEIMVAP PQPFEVRIRI
60 70 80 90 100
ICTALCHSDV TFWKLQVPPA CFPRILGHEA IGVVESVGEN VKEVVEGDTV
110 120 130 140 150
LPTFMPDCGD CVDCKSHKSN LCSKFPFKVS PWMPRYDNSS RFTDLNGETL
160 170 180 190 200
FHFLNVSSFS EYTVLDVANV VKIDSSIPPS RACLLSCGVS TGVGAAWETA
210 220 230 240 250
KVEKGSTVVI FGLGSIGLAV AEGARLCGAS RIIGVDINPT KFQVGQKFGV
260 270 280 290 300
TEFVNSMTCE KNRVSEVINE MTDGGADYCF ECVGSSSLVQ EAYACCRQGW
310 320 330 340 350
GKTITLGVDK PGSQICLDSF DVLHHGKILM GSLFGGLKAK THIPILLKRY
360 370 380 390
LSNELELDKF VTHEMKFEEI NDAFQLLLEG KCIRCVLWMG
Length:390
Mass (Da):42,568
Last modified:March 1, 2001 - v1
Checksum:iA7E3939C4D702438
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023032 Genomic DNA. Translation: BAB10198.1.
CP002688 Genomic DNA. Translation: AED94788.1.
AY081332 mRNA. Translation: AAL91221.1.
AY128827 mRNA. Translation: AAM91227.1.
RefSeqiNP_199040.1. NM_123590.6.
UniGeneiAt.43887.

Genome annotation databases

EnsemblPlantsiAT5G42250.1; AT5G42250.1; AT5G42250.
GeneIDi834230.
GrameneiAT5G42250.1; AT5G42250.1; AT5G42250.
KEGGiath:AT5G42250.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023032 Genomic DNA. Translation: BAB10198.1.
CP002688 Genomic DNA. Translation: AED94788.1.
AY081332 mRNA. Translation: AAL91221.1.
AY128827 mRNA. Translation: AAM91227.1.
RefSeqiNP_199040.1. NM_123590.6.
UniGeneiAt.43887.

3D structure databases

ProteinModelPortaliQ9FH04.
SMRiQ9FH04.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT5G42250.1.

Proteomic databases

PaxDbiQ9FH04.
PRIDEiQ9FH04.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G42250.1; AT5G42250.1; AT5G42250.
GeneIDi834230.
GrameneiAT5G42250.1; AT5G42250.1; AT5G42250.
KEGGiath:AT5G42250.

Organism-specific databases

AraportiAT5G42250.
TAIRilocus:2157627. AT5G42250.

Phylogenomic databases

eggNOGiKOG0022. Eukaryota.
COG1062. LUCA.
HOGENOMiHOG000294674.
InParanoidiQ9FH04.
KOiK00121.
OMAiGRPTMCR.
OrthoDBiEOG09360CLU.
PhylomeDBiQ9FH04.

Enzyme and pathway databases

BioCyciARA:AT5G42250-MONOMER.
ReactomeiR-ATH-2161541. Abacavir metabolism.
R-ATH-5365859. RA biosynthesis pathway.
R-ATH-71384. Ethanol oxidation.

Miscellaneous databases

PROiPR:Q9FH04.

Gene expression databases

ExpressionAtlasiQ9FH04. baseline and differential.
GenevisibleiQ9FH04. AT.

Family and domain databases

InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADHL7_ARATH
AccessioniPrimary (citable) accession number: Q9FH04
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2001
Last modified: June 7, 2017
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.