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Q9FGX2

- BZIP1_ARATH

UniProt

Q9FGX2 - BZIP1_ARATH

Protein

Basic leucine zipper 1

Gene

BZIP1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Transcription factor that binds to the C-box-like motif (5'-TGCTGACGTCA-3') and G-box-like motif (5'-CCACGTGGCC-3'), ABRE elements, of gene promoters involved in sugar signaling. Activated by low energy stress both at transcriptional and post-transcriptional mechanisms. Promotes dark-induced senescence and participates in the transcriptional reprogramming of amino acid metabolism during the dark-induced starvation response.2 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. protein heterodimerization activity Source: UniProtKB
    3. sequence-specific DNA binding Source: InterPro
    4. sequence-specific DNA binding transcription factor activity Source: UniProtKB

    GO - Biological processi

    1. anther dehiscence Source: TAIR
    2. cellular response to glucose stimulus Source: UniProtKB
    3. cellular response to starvation Source: UniProtKB
    4. positive regulation of transcription, DNA-templated Source: TAIR
    5. regulation of cellular amino acid metabolic process Source: UniProtKB
    6. response to bacterium Source: UniProtKB
    7. response to osmotic stress Source: TAIR
    8. response to salt stress Source: TAIR
    9. sugar mediated signaling pathway Source: UniProtKB
    10. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Basic leucine zipper 1
    Short name:
    AtbZIP1
    Short name:
    bZIP protein 1
    Gene namesi
    Name:BZIP1
    Ordered Locus Names:At5g49450
    ORF Names:K7J8.13
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 5

    Organism-specific databases

    TAIRiAT5G49450.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: TAIR

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Reduced requirement for exogenous sugar for seedling growth and higher rates of true leaf development.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 145145Basic leucine zipper 1PRO_0000416557Add
    BLAST

    Proteomic databases

    PRIDEiQ9FGX2.

    Expressioni

    Tissue specificityi

    Expressed in both shoots, including young leaves, stipulae and trichomes (except in cotyledons and hypocotyl), and roots, including vascular tissues (e.g. in both the phloem and the xylem). Present in seeds and pollen. Restricted to vasculatures and roots in the presence of sucrose or glucose.2 Publications

    Developmental stagei

    Expressed in seeds during late stage of development.1 Publication

    Inductioni

    Reversibly repressed by glucose and mannose. Slowly induced by Pseudomonas syringae. Induced in roots upon cold and salt stress but then repressed in leaves. Promoted by low energy stress and dark-induced starvation.3 Publications

    Gene expression databases

    GenevestigatoriQ9FGX2.

    Interactioni

    Subunit structurei

    Interacts with ZFP7, BZIP4, BZIP9, BZIP10, BZIP11, BZIP25, BZIP42, BZIP44, BZIP53, BZIP58 and BZIP63.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ATB2P940605EBI-942623,EBI-942769
    BZIP10O227633EBI-942623,EBI-942648
    BZIP25Q9M1G64EBI-942623,EBI-942696
    BZIP63B9DGI84EBI-942623,EBI-942713
    BZIP9Q9FUD33EBI-942623,EBI-942633
    F1B16.8Q9FWS74EBI-942623,EBI-942804

    Protein-protein interaction databases

    IntActiQ9FGX2. 19 interactions.
    STRINGi3702.AT5G49450.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9FGX2.
    SMRiQ9FGX2. Positions 16-69.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini14 – 7764bZIPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni16 – 3722Basic motifPROSITE-ProRule annotationAdd
    BLAST
    Regioni46 – 538Leucine-zipperPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the bZIP family.Curated
    Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG82287.
    HOGENOMiHOG000237945.
    InParanoidiQ9FGX2.
    OMAiLENMIAT.
    PhylomeDBiQ9FGX2.

    Family and domain databases

    InterProiIPR004827. bZIP.
    [Graphical view]
    PfamiPF07716. bZIP_2. 1 hit.
    [Graphical view]
    SMARTiSM00338. BRLZ. 1 hit.
    [Graphical view]
    PROSITEiPS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9FGX2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANAEKTSSG SDIDEKKRKR KLSNRESARR SRLKKQKLME DTIHEISSLE    50
    RRIKENSERC RAVKQRLDSV ETENAGLRSE KIWLSSYVSD LENMIATTSL 100
    TLTQSGGGDC VDDQNANAGI AVGDCRRTPW KLSCGSLQPM ASFKT 145
    Length:145
    Mass (Da):16,224
    Last modified:March 1, 2001 - v1
    Checksum:i5137A1CCE8638C0A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF400618 mRNA. Translation: AAK94022.1.
    AB023034 Genomic DNA. Translation: BAB09915.1.
    CP002688 Genomic DNA. Translation: AED95813.1.
    AY136307 mRNA. Translation: AAM96973.1.
    BT000400 mRNA. Translation: AAN15719.1.
    AY088207 mRNA. Translation: AAM65749.1.
    RefSeqiNP_199756.1. NM_124322.3.
    UniGeneiAt.26573.

    Genome annotation databases

    EnsemblPlantsiAT5G49450.1; AT5G49450.1; AT5G49450.
    GeneIDi835005.
    KEGGiath:AT5G49450.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF400618 mRNA. Translation: AAK94022.1 .
    AB023034 Genomic DNA. Translation: BAB09915.1 .
    CP002688 Genomic DNA. Translation: AED95813.1 .
    AY136307 mRNA. Translation: AAM96973.1 .
    BT000400 mRNA. Translation: AAN15719.1 .
    AY088207 mRNA. Translation: AAM65749.1 .
    RefSeqi NP_199756.1. NM_124322.3.
    UniGenei At.26573.

    3D structure databases

    ProteinModelPortali Q9FGX2.
    SMRi Q9FGX2. Positions 16-69.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9FGX2. 19 interactions.
    STRINGi 3702.AT5G49450.1-P.

    Proteomic databases

    PRIDEi Q9FGX2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT5G49450.1 ; AT5G49450.1 ; AT5G49450 .
    GeneIDi 835005.
    KEGGi ath:AT5G49450.

    Organism-specific databases

    TAIRi AT5G49450.

    Phylogenomic databases

    eggNOGi NOG82287.
    HOGENOMi HOG000237945.
    InParanoidi Q9FGX2.
    OMAi LENMIAT.
    PhylomeDBi Q9FGX2.

    Gene expression databases

    Genevestigatori Q9FGX2.

    Family and domain databases

    InterProi IPR004827. bZIP.
    [Graphical view ]
    Pfami PF07716. bZIP_2. 1 hit.
    [Graphical view ]
    SMARTi SM00338. BRLZ. 1 hit.
    [Graphical view ]
    PROSITEi PS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "AtbZIP1, a transcription factor in Arabidopsis thaliana."
      Wang X., Droege-Laser W.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence features of the regions of 3,076,755 bp covered by sixty P1 and TAC clones."
      Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H., Tabata S.
      DNA Res. 7:31-63(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "Full-length cDNA from Arabidopsis thaliana."
      Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. Cited for: GENE FAMILY, NOMENCLATURE.
    7. "Two-hybrid protein-protein interaction analysis in Arabidopsis protoplasts: establishment of a heterodimerization map of group C and group S bZIP transcription factors."
      Ehlert A., Weltmeier F., Wang X., Mayer C.S., Smeekens S., Vicente-Carbajosa J., Droege-Laser W.
      Plant J. 46:890-900(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BZIP4; BZIP9; BZIP10; BZIP11; BZIP25; BZIP42; BZIP44; BZIP58 AND BZIP63.
    8. "Expression patterns within the Arabidopsis C/S1 bZIP transcription factor network: availability of heterodimerization partners controls gene expression during stress response and development."
      Weltmeier F., Rahmani F., Ehlert A., Dietrich K., Schuetze K., Wang X., Chaban C., Hanson J., Teige M., Harter K., Vicente-Carbajosa J., Smeekens S., Droege-Laser W.
      Plant Mol. Biol. 69:107-119(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION BY GLUCOSE AND PSEUDOMONAS SYRINGAE.
      Strain: cv. Columbia.
    9. "The arabidopsis bZIP1 transcription factor is involved in sugar signaling, protein networking, and DNA binding."
      Kang S.G., Price J., Lin P.-C., Hong J.C., Jang J.-C.
      Mol. Plant 3:361-373(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE, INDUCTION BY GLUCOSE AND MANNOSE, TISSUE SPECIFICITY, INTERACTION WITH ZFP7; BZIP10; BZIP11; BZIP25; BZIP44 AND BZIP63.
    10. "Heterodimers of the Arabidopsis transcription factors bZIP1 and bZIP53 reprogram amino acid metabolism during low energy stress."
      Dietrich K., Weltmeier F., Ehlert A., Weiste C., Stahl M., Harter K., Droege-Laser W.
      Plant Cell 23:381-395(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH BZIP53, INDUCTION BY STARVATION.

    Entry informationi

    Entry nameiBZIP1_ARATH
    AccessioniPrimary (citable) accession number: Q9FGX2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 18, 2012
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3