Q9FGX2 (BZIP1_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Basic leucine zipper 1
Short name=AtbZIP1
Short name=bZIP protein 1

Gene names

Name:	BZIP1
Ordered Locus Names:	At5g49450
ORF Names:	K7J8.13

Organism

Arabidopsis thaliana (Mouse-ear cress) [Reference proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	145 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcription factor that binds to the C-box-like motif (5'-TGCTGACGTCA-3') and G-box-like motif (5'-CCACGTGGCC-3'), ABRE elements, of gene promoters involved in sugar signaling. Activated by low energy stress both at transcriptional and post-transcriptional mechanisms. Promotes dark-induced senescence and participates in the transcriptional reprogramming of amino acid metabolism during the dark-induced starvation response. Ref.9 Ref.10
Subunit structure	Interacts with ZFP7, BZIP4, BZIP9, BZIP10, BZIP11, BZIP25, BZIP42, BZIP44, BZIP53, BZIP58 and BZIP63. Ref.7 Ref.9 Ref.10
Subcellular location	Nucleus By similarity.
Tissue specificity	Expressed in both shoots, including young leaves, stipulae and trichomes (except in cotyledons and hypocotyl), and roots, including vascular tissues (e.g. in both the phloem and the xylem). Present in seeds and pollen. Restricted to vasculatures and roots in the presence of sucrose or glucose. Ref.8 Ref.9
Developmental stage	Expressed in seeds during late stage of development. Ref.8
Induction	Reversibly repressed by glucose and mannose. Slowly induced by Pseudomonas syringae. Induced in roots upon cold and salt stress but then repressed in leaves. Promoted by low energy stress and dark-induced starvation. Ref.8 Ref.9 Ref.10
Disruption phenotype	Reduced requirement for exogenous sugar for seedling growth and higher rates of true leaf development. Ref.9
Sequence similarities	Belongs to the bZIP family. Contains 1 bZIP (basic-leucine zipper) domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	anther dehiscence Inferred from mutant phenotype PubMed 18502975. Source: TAIR cellular response to glucose stimulus Inferred from expression pattern Ref.8. Source: UniProtKB cellular response to starvation Inferred from expression pattern Ref.10. Source: UniProtKB positive regulation of transcription, DNA-dependent Inferred from direct assay PubMed 21938515. Source: TAIR regulation of cellular amino acid metabolic process Inferred from mutant phenotype Ref.10. Source: UniProtKB response to bacterium Inferred from expression pattern Ref.8. Source: UniProtKB response to salt stress Inferred from mutant phenotype PubMed 21938515. Source: TAIR sugar mediated signaling pathway Inferred from mutant phenotype Ref.9. Source: UniProtKB transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from direct assay PubMed 21938515. Source: TAIR
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from direct assay Ref.9. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
BZIP10	O22763	3	EBI-942623,EBI-942648
BZIP25	Q9M1G6	4	EBI-942623,EBI-942696
BZIP63	B9DGI8	4	EBI-942623,EBI-942713
BZIP9	Q9FUD3	3	EBI-942623,EBI-942633
F1B16.8	Q9FWS7	4	EBI-942623,EBI-942804
GBF6	P94060	5	EBI-942623,EBI-942769

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 145	145	Basic leucine zipper 1		PRO_0000416557
Regions
	Domain	14 – 77	64	bZIP
	Region	16 – 37	22	Basic motif By similarity
	Region	46 – 53	8	Leucine-zipper By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9FGX2 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 5137A1CCE8638C0A	FASTA	145	16,224
	10 20 30 40 50 60 MANAEKTSSG SDIDEKKRKR KLSNRESARR SRLKKQKLME DTIHEISSLE RRIKENSERC 70 80 90 100 110 120 RAVKQRLDSV ETENAGLRSE KIWLSSYVSD LENMIATTSL TLTQSGGGDC VDDQNANAGI 130 140 AVGDCRRTPW KLSCGSLQPM ASFKT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"AtbZIP1, a transcription factor in Arabidopsis thaliana." Wang X., Droege-Laser W. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence features of the regions of 3,076,755 bp covered by sixty P1 and TAC clones." Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H., Tabata S. DNA Res. 7:31-63(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[3]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[4]	"Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R. Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[5]	"Full-length cDNA from Arabidopsis thaliana." Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"bZIP transcription factors in Arabidopsis." Jakoby M., Weisshaar B., Droege-Laser W., Vicente-Carbajosa J., Tiedemann J., Kroj T., Parcy F. Trends Plant Sci. 7:106-111(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.
[7]	"Two-hybrid protein-protein interaction analysis in Arabidopsis protoplasts: establishment of a heterodimerization map of group C and group S bZIP transcription factors." Ehlert A., Weltmeier F., Wang X., Mayer C.S., Smeekens S., Vicente-Carbajosa J., Droege-Laser W. Plant J. 46:890-900(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH BZIP4; BZIP9; BZIP10; BZIP11; BZIP25; BZIP42; BZIP44; BZIP58 AND BZIP63.
[8]	"Expression patterns within the Arabidopsis C/S1 bZIP transcription factor network: availability of heterodimerization partners controls gene expression during stress response and development." Weltmeier F., Rahmani F., Ehlert A., Dietrich K., Schuetze K., Wang X., Chaban C., Hanson J., Teige M., Harter K., Vicente-Carbajosa J., Smeekens S., Droege-Laser W. Plant Mol. Biol. 69:107-119(2009) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION BY GLUCOSE AND PSEUDOMONAS SYRINGAE. Strain: cv. Columbia.
[9]	"The arabidopsis bZIP1 transcription factor is involved in sugar signaling, protein networking, and DNA binding." Kang S.G., Price J., Lin P.-C., Hong J.C., Jang J.-C. Mol. Plant 3:361-373(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, DISRUPTION PHENOTYPE, INDUCTION BY GLUCOSE AND MANNOSE, TISSUE SPECIFICITY, INTERACTION WITH ZFP7; BZIP10; BZIP11; BZIP25; BZIP44 AND BZIP63.
[10]	"Heterodimers of the Arabidopsis transcription factors bZIP1 and bZIP53 reprogram amino acid metabolism during low energy stress." Dietrich K., Weltmeier F., Ehlert A., Weiste C., Stahl M., Harter K., Droege-Laser W. Plant Cell 23:381-395(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH BZIP53, INDUCTION BY STARVATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF400618 mRNA. Translation: AAK94022.1. AB023034 Genomic DNA. Translation: BAB09915.1. CP002688 Genomic DNA. Translation: AED95813.1. AY136307 mRNA. Translation: AAM96973.1. BT000400 mRNA. Translation: AAN15719.1. AY088207 mRNA. Translation: AAM65749.1.
IPI	IPI00530823.
RefSeq	NP_199756.1. NM_124322.3.
UniGene	At.26573.
3D structure databases
ProteinModelPortal	Q9FGX2.
SMR	Q9FGX2. Positions 14-67.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9FGX2. 19 interactions.
STRING	3702.AT5G49450.1-P.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT5G49450.1; AT5G49450.1; AT5G49450.
GeneID	835005.
KEGG	ath:AT5G49450.
Organism-specific databases
TAIR	At5g49450.
Phylogenomic databases
eggNOG	NOG82287.
HOGENOM	HOG000237945.
InParanoid	Q9FGX2.
OMA	LENMIAT.
PhylomeDB	Q9FGX2.
ProtClustDB	CLSN2916484.
Gene expression databases
Genevestigator	Q9FGX2.
Family and domain databases
InterPro	IPR004827. bZIP. [Graphical view]
Pfam	PF07716. bZIP_2. 1 hit. [Graphical view]
SMART	SM00338. BRLZ. 1 hit. [Graphical view]
PROSITE	PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BZIP1_ARATH

Accession

Primary (citable) accession number: Q9FGX2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 18, 2012
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program