ID   BZIP1_ARATH             Reviewed;         145 AA.
AC   Q9FGX2;
DT   18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   24-JAN-2024, entry version 150.
DE   RecName: Full=Basic leucine zipper 1;
DE            Short=AtbZIP1;
DE            Short=bZIP protein 1;
GN   Name=BZIP1; OrderedLocusNames=At5g49450; ORFNames=K7J8.13;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Wang X., Droege-Laser W.;
RT   "AtbZIP1, a transcription factor in Arabidopsis thaliana.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10718197; DOI=10.1093/dnares/7.1.31;
RA   Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence
RT   features of the regions of 3,076,755 bp covered by sixty P1 and TAC
RT   clones.";
RL   DNA Res. 7:31-63(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=11906833; DOI=10.1016/s1360-1385(01)02223-3;
RA   Jakoby M., Weisshaar B., Droege-Laser W., Vicente-Carbajosa J.,
RA   Tiedemann J., Kroj T., Parcy F.;
RT   "bZIP transcription factors in Arabidopsis.";
RL   Trends Plant Sci. 7:106-111(2002).
RN   [7]
RP   INTERACTION WITH BZIP4; BZIP9; BZIP10; BZIP11; BZIP25; BZIP42; BZIP44;
RP   BZIP58 AND BZIP63.
RX   PubMed=16709202; DOI=10.1111/j.1365-313x.2006.02731.x;
RA   Ehlert A., Weltmeier F., Wang X., Mayer C.S., Smeekens S.,
RA   Vicente-Carbajosa J., Droege-Laser W.;
RT   "Two-hybrid protein-protein interaction analysis in Arabidopsis
RT   protoplasts: establishment of a heterodimerization map of group C and group
RT   S bZIP transcription factors.";
RL   Plant J. 46:890-900(2006).
RN   [8]
RP   TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND INDUCTION BY GLUCOSE AND
RP   PSEUDOMONAS SYRINGAE.
RC   STRAIN=cv. Columbia;
RX   PubMed=18841482; DOI=10.1007/s11103-008-9410-9;
RA   Weltmeier F., Rahmani F., Ehlert A., Dietrich K., Schuetze K., Wang X.,
RA   Chaban C., Hanson J., Teige M., Harter K., Vicente-Carbajosa J.,
RA   Smeekens S., Droege-Laser W.;
RT   "Expression patterns within the Arabidopsis C/S1 bZIP transcription factor
RT   network: availability of heterodimerization partners controls gene
RT   expression during stress response and development.";
RL   Plant Mol. Biol. 69:107-119(2009).
RN   [9]
RP   FUNCTION, DISRUPTION PHENOTYPE, INDUCTION BY GLUCOSE AND MANNOSE, TISSUE
RP   SPECIFICITY, AND INTERACTION WITH ZFP7; BZIP10; BZIP11; BZIP25; BZIP44 AND
RP   BZIP63.
RX   PubMed=20080816; DOI=10.1093/mp/ssp115;
RA   Kang S.G., Price J., Lin P.-C., Hong J.C., Jang J.-C.;
RT   "The arabidopsis bZIP1 transcription factor is involved in sugar signaling,
RT   protein networking, and DNA binding.";
RL   Mol. Plant 3:361-373(2010).
RN   [10]
RP   FUNCTION, INTERACTION WITH BZIP53, AND INDUCTION BY STARVATION.
RX   PubMed=21278122; DOI=10.1105/tpc.110.075390;
RA   Dietrich K., Weltmeier F., Ehlert A., Weiste C., Stahl M., Harter K.,
RA   Droege-Laser W.;
RT   "Heterodimers of the Arabidopsis transcription factors bZIP1 and bZIP53
RT   reprogram amino acid metabolism during low energy stress.";
RL   Plant Cell 23:381-395(2011).
RN   [11]
RP   FUNCTION.
RX   PubMed=24243147; DOI=10.1007/s11103-013-0154-9;
RA   Kim W.C., Reca I.B., Kim Y., Park S., Thomashow M.F., Keegstra K.,
RA   Han K.H.;
RT   "Transcription factors that directly regulate the expression of CSLA9
RT   encoding mannan synthase in Arabidopsis thaliana.";
RL   Plant Mol. Biol. 84:577-587(2014).
RN   [12]
RP   INTERACTION WITH BZIP63.
RX   PubMed=26263501; DOI=10.7554/elife.05828;
RA   Mair A., Pedrotti L., Wurzinger B., Anrather D., Simeunovic A., Weiste C.,
RA   Valerio C., Dietrich K., Kirchler T., Naegele T., Vicente Carbajosa J.,
RA   Hanson J., Baena-Gonzalez E., Chaban C., Weckwerth W., Droege-Laser W.,
RA   Teige M.;
RT   "SnRK1-triggered switch of bZIP63 dimerization mediates the low-energy
RT   response in plants.";
RL   Elife 4:0-0(2015).
CC   -!- FUNCTION: Transcription factor that binds to the C-box-like motif (5'-
CC       TGCTGACGTCA-3') and G-box-like motif (5'-CCACGTGGCC-3'), ABRE elements,
CC       of gene promoters involved in sugar signaling. Activated by low energy
CC       stress both at transcriptional and post-transcriptional mechanisms.
CC       Promotes dark-induced senescence and participates in the
CC       transcriptional reprogramming of amino acid metabolism during the dark-
CC       induced starvation response (PubMed:20080816, PubMed:21278122).
CC       Transcription activator of the mannan synthase CSLA9. Recognizes and
CC       binds to DNA-specific sequence of CSLA9 promoter (PubMed:24243147).
CC       {ECO:0000269|PubMed:20080816, ECO:0000269|PubMed:21278122,
CC       ECO:0000269|PubMed:24243147}.
CC   -!- SUBUNIT: Interacts with ZFP7, BZIP4, BZIP9, BZIP10, BZIP11, BZIP25,
CC       BZIP42, BZIP44, BZIP53, BZIP58 and BZIP63.
CC       {ECO:0000269|PubMed:16709202, ECO:0000269|PubMed:20080816,
CC       ECO:0000269|PubMed:21278122, ECO:0000269|PubMed:26263501}.
CC   -!- INTERACTION:
CC       Q9FGX2; O22763: BZIP10; NbExp=3; IntAct=EBI-942623, EBI-942648;
CC       Q9FGX2; O65683: BZIP11; NbExp=5; IntAct=EBI-942623, EBI-942769;
CC       Q9FGX2; Q9M1G6: BZIP25; NbExp=6; IntAct=EBI-942623, EBI-942696;
CC       Q9FGX2; C0Z2L5: BZIP44; NbExp=5; IntAct=EBI-942623, EBI-942804;
CC       Q9FGX2; B9DGI8: BZIP63; NbExp=4; IntAct=EBI-942623, EBI-942713;
CC       Q9FGX2; Q9FUD3: BZIP9; NbExp=3; IntAct=EBI-942623, EBI-942633;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
CC   -!- TISSUE SPECIFICITY: Expressed in both shoots, including young leaves,
CC       stipulae and trichomes (except in cotyledons and hypocotyl), and roots,
CC       including vascular tissues (e.g. in both the phloem and the xylem).
CC       Present in seeds and pollen. Restricted to vasculatures and roots in
CC       the presence of sucrose or glucose. {ECO:0000269|PubMed:18841482,
CC       ECO:0000269|PubMed:20080816}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in seeds during late stage of
CC       development. {ECO:0000269|PubMed:18841482}.
CC   -!- INDUCTION: Reversibly repressed by glucose and mannose. Slowly induced
CC       by Pseudomonas syringae. Induced in roots upon cold and salt stress but
CC       then repressed in leaves. Promoted by low energy stress and dark-
CC       induced starvation. {ECO:0000269|PubMed:18841482,
CC       ECO:0000269|PubMed:20080816, ECO:0000269|PubMed:21278122}.
CC   -!- DISRUPTION PHENOTYPE: Reduced requirement for exogenous sugar for
CC       seedling growth and higher rates of true leaf development.
CC       {ECO:0000269|PubMed:20080816}.
CC   -!- SIMILARITY: Belongs to the bZIP family. {ECO:0000305}.
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DR   EMBL; AF400618; AAK94022.1; -; mRNA.
DR   EMBL; AB023034; BAB09915.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED95813.1; -; Genomic_DNA.
DR   EMBL; AY136307; AAM96973.1; -; mRNA.
DR   EMBL; BT000400; AAN15719.1; -; mRNA.
DR   EMBL; AY088207; AAM65749.1; -; mRNA.
DR   RefSeq; NP_199756.1; NM_124322.3.
DR   AlphaFoldDB; Q9FGX2; -.
DR   SMR; Q9FGX2; -.
DR   BioGRID; 20251; 18.
DR   IntAct; Q9FGX2; 21.
DR   STRING; 3702.Q9FGX2; -.
DR   iPTMnet; Q9FGX2; -.
DR   PaxDb; 3702-AT5G49450-1; -.
DR   ProteomicsDB; 240255; -.
DR   EnsemblPlants; AT5G49450.1; AT5G49450.1; AT5G49450.
DR   GeneID; 835005; -.
DR   Gramene; AT5G49450.1; AT5G49450.1; AT5G49450.
DR   KEGG; ath:AT5G49450; -.
DR   Araport; AT5G49450; -.
DR   TAIR; AT5G49450; BZIP1.
DR   eggNOG; ENOG502R7IP; Eukaryota.
DR   HOGENOM; CLU_1779969_0_0_1; -.
DR   InParanoid; Q9FGX2; -.
DR   OMA; LMEDTIH; -.
DR   OrthoDB; 665822at2759; -.
DR   PhylomeDB; Q9FGX2; -.
DR   PRO; PR:Q9FGX2; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9FGX2; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IDA:TAIR.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:UniProtKB.
DR   GO; GO:0046982; F:protein heterodimerization activity; IPI:UniProtKB.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IPI:TAIR.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR   GO; GO:0009901; P:anther dehiscence; IMP:TAIR.
DR   GO; GO:0071333; P:cellular response to glucose stimulus; IEP:UniProtKB.
DR   GO; GO:0009267; P:cellular response to starvation; IEP:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of DNA-templated transcription; IDA:TAIR.
DR   GO; GO:0006521; P:regulation of cellular amino acid metabolic process; IMP:UniProtKB.
DR   GO; GO:0009617; P:response to bacterium; IEP:UniProtKB.
DR   GO; GO:0006970; P:response to osmotic stress; IMP:TAIR.
DR   GO; GO:0009651; P:response to salt stress; IMP:TAIR.
DR   GO; GO:0010182; P:sugar mediated signaling pathway; IMP:UniProtKB.
DR   CDD; cd14702; bZIP_plant_GBF1; 1.
DR   InterPro; IPR004827; bZIP.
DR   InterPro; IPR045314; bZIP_plant_GBF1.
DR   InterPro; IPR046347; bZIP_sf.
DR   PANTHER; PTHR45764:SF31; BASIC LEUCINE ZIPPER 1; 1.
DR   PANTHER; PTHR45764; BZIP TRANSCRIPTION FACTOR 44; 1.
DR   Pfam; PF07716; bZIP_2; 1.
DR   SMART; SM00338; BRLZ; 1.
DR   SUPFAM; SSF57959; Leucine zipper domain; 1.
DR   PROSITE; PS50217; BZIP; 1.
DR   PROSITE; PS00036; BZIP_BASIC; 1.
DR   Genevisible; Q9FGX2; AT.
PE   1: Evidence at protein level;
KW   Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..145
FT                   /note="Basic leucine zipper 1"
FT                   /id="PRO_0000416557"
FT   DOMAIN          14..77
FT                   /note="bZIP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          16..37
FT                   /note="Basic motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          46..53
FT                   /note="Leucine-zipper"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
SQ   SEQUENCE   145 AA;  16224 MW;  5137A1CCE8638C0A CRC64;
     MANAEKTSSG SDIDEKKRKR KLSNRESARR SRLKKQKLME DTIHEISSLE RRIKENSERC
     RAVKQRLDSV ETENAGLRSE KIWLSSYVSD LENMIATTSL TLTQSGGGDC VDDQNANAGI
     AVGDCRRTPW KLSCGSLQPM ASFKT
//