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Q9FGR9

- CEP1_ARATH

UniProt

Q9FGR9 - CEP1_ARATH

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Protein
KDEL-tailed cysteine endopeptidase CEP1
Gene
CEP1, CP56, At5g50260, K6A12.12
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in the final stage of developmental programmed cell death and in intercalation of new cells. Cleaves extensins, thus probably supporing the final cell collapse By similarity.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei150 – 1501 By similarity
Active sitei286 – 2861 By similarity
Active sitei307 – 3071 By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Enzyme and pathway databases

BioCyciARA:AT5G50260-MONOMER.

Protein family/group databases

MEROPSiC01.A03.

Names & Taxonomyi

Protein namesi
Recommended name:
KDEL-tailed cysteine endopeptidase CEP1 (EC:3.4.22.-)
Alternative name(s):
Cysteine proteinase CP56
Short name:
AtCP56
Gene namesi
Name:CEP1
Synonyms:CP56
Ordered Locus Names:At5g50260
ORF Names:K6A12.12
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G50260.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 361341KDEL-tailed cysteine endopeptidase CEP1
PRO_0000403789Add
BLAST

Proteomic databases

PaxDbiQ9FGR9.
PRIDEiQ9FGR9.

Expressioni

Tissue specificityi

Expressed in roots, stems, flowers, buds and green siliques. Found within columella, lateral root cap cells, and in the endodermis, the cortex and the epidermis during lateral root formation. Expressed in the abscission zones of the flower organs.1 Publication

Developmental stagei

Expressed when organs wither and separate from the fruit or the green silique. Expressed in unpollinated, degrading ovules.1 Publication

Gene expression databases

GenevestigatoriQ9FGR9.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G50260.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9FGR9.
SMRiQ9FGR9. Positions 31-350.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi358 – 3614Prevents secretion from ER Reviewed prediction

Sequence similaritiesi

Belongs to the peptidase C1 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4870.
HOGENOMiHOG000230773.
InParanoidiQ9FGR9.
KOiK16292.
OMAiAEDAYPY.
PhylomeDBiQ9FGR9.

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9FGR9-1 [UniParc]FASTAAdd to Basket

« Hide

MKRFIVLALC MLMVLETTKG LDFHNKDVES ENSLWELYER WRSHHTVARS    50
LEEKAKRFNV FKHNVKHIHE TNKKDKSYKL KLNKFGDMTS EEFRRTYAGS 100
NIKHHRMFQG EKKATKSFMY ANVNTLPTSV DWRKNGAVTP VKNQGQCGSC 150
WAFSTVVAVE GINQIRTKKL TSLSEQELVD CDTNQNQGCN GGLMDLAFEF 200
IKEKGGLTSE LVYPYKASDE TCDTNKENAP VVSIDGHEDV PKNSEDDLMK 250
AVANQPVSVA IDAGGSDFQF YSEGVFTGRC GTELNHGVAV VGYGTTIDGT 300
KYWIVKNSWG EEWGEKGYIR MQRGIRHKEG LCGIAMEASY PLKNSNTNPS 350
RLSLDSLKDE L 361
Length:361
Mass (Da):40,708
Last modified:March 1, 2001 - v1
Checksum:iA622234BC3E7367A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HM367092 mRNA. Translation: ADO14465.1.
AB024031 Genomic DNA. Translation: BAB09397.1.
CP002688 Genomic DNA. Translation: AED95919.1.
AY091087 mRNA. Translation: AAM13907.1.
RefSeqiNP_568722.1. NM_124405.2.
UniGeneiAt.7918.

Genome annotation databases

EnsemblPlantsiAT5G50260.1; AT5G50260.1; AT5G50260.
GeneIDi835091.
KEGGiath:AT5G50260.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HM367092 mRNA. Translation: ADO14465.1 .
AB024031 Genomic DNA. Translation: BAB09397.1 .
CP002688 Genomic DNA. Translation: AED95919.1 .
AY091087 mRNA. Translation: AAM13907.1 .
RefSeqi NP_568722.1. NM_124405.2.
UniGenei At.7918.

3D structure databases

ProteinModelPortali Q9FGR9.
SMRi Q9FGR9. Positions 31-350.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT5G50260.1-P.

Protein family/group databases

MEROPSi C01.A03.

Proteomic databases

PaxDbi Q9FGR9.
PRIDEi Q9FGR9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G50260.1 ; AT5G50260.1 ; AT5G50260 .
GeneIDi 835091.
KEGGi ath:AT5G50260.

Organism-specific databases

TAIRi AT5G50260.

Phylogenomic databases

eggNOGi COG4870.
HOGENOMi HOG000230773.
InParanoidi Q9FGR9.
KOi K16292.
OMAi AEDAYPY.
PhylomeDBi Q9FGR9.

Enzyme and pathway databases

BioCyci ARA:AT5G50260-MONOMER.

Gene expression databases

Genevestigatori Q9FGR9.

Family and domain databases

InterProi IPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view ]
PANTHERi PTHR12411. PTHR12411. 1 hit.
Pfami PF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view ]
PRINTSi PR00705. PAPAIN.
SMARTi SM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view ]
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Function analysis of an Arabidopsis cysteine proteinase gene AtCP56 and the promoter ProCP56 in anther development."
    Lv X., Li F., Lu H.
    Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence features of the regions of 3,076,755 bp covered by sixty P1 and TAC clones."
    Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H., Tabata S.
    DNA Res. 7:31-63(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "KDEL-tailed cysteine endopeptidases involved in programmed cell death, intercalation of new cells, and dismantling of extensin scaffolds."
    Helm M., Schmid M., Hierl G., Terneus K., Tan L., Lottspeich F., Kieliszewski M.J., Gietl C.
    Am. J. Bot. 95:1049-1062(2008)
    Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiCEP1_ARATH
AccessioniPrimary (citable) accession number: Q9FGR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: March 1, 2001
Last modified: May 14, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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