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Q9FGR9

- CEP1_ARATH

UniProt

Q9FGR9 - CEP1_ARATH

Protein

KDEL-tailed cysteine endopeptidase CEP1

Gene

CEP1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Involved in the final stage of developmental programmed cell death and in intercalation of new cells. Cleaves extensins, thus probably supporing the final cell collapse By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei150 – 1501By similarity
    Active sitei286 – 2861By similarity
    Active sitei307 – 3071By similarity

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Enzyme and pathway databases

    BioCyciARA:AT5G50260-MONOMER.

    Protein family/group databases

    MEROPSiC01.A03.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KDEL-tailed cysteine endopeptidase CEP1 (EC:3.4.22.-)
    Alternative name(s):
    Cysteine proteinase CP56
    Short name:
    AtCP56
    Gene namesi
    Name:CEP1
    Synonyms:CP56
    Ordered Locus Names:At5g50260
    ORF Names:K6A12.12
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 5

    Organism-specific databases

    TAIRiAT5G50260.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 361341KDEL-tailed cysteine endopeptidase CEP1PRO_0000403789Add
    BLAST

    Proteomic databases

    PaxDbiQ9FGR9.
    PRIDEiQ9FGR9.

    Expressioni

    Tissue specificityi

    Expressed in roots, stems, flowers, buds and green siliques. Found within columella, lateral root cap cells, and in the endodermis, the cortex and the epidermis during lateral root formation. Expressed in the abscission zones of the flower organs.1 Publication

    Developmental stagei

    Expressed when organs wither and separate from the fruit or the green silique. Expressed in unpollinated, degrading ovules.1 Publication

    Gene expression databases

    GenevestigatoriQ9FGR9.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT5G50260.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9FGR9.
    SMRiQ9FGR9. Positions 31-350.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi358 – 3614Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the peptidase C1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4870.
    HOGENOMiHOG000230773.
    InParanoidiQ9FGR9.
    KOiK16292.
    OMAiAEDAYPY.
    PhylomeDBiQ9FGR9.

    Family and domain databases

    InterProiIPR025661. Pept_asp_AS.
    IPR000169. Pept_cys_AS.
    IPR025660. Pept_his_AS.
    IPR013128. Peptidase_C1A.
    IPR000668. Peptidase_C1A_C.
    IPR013201. Prot_inhib_I29.
    [Graphical view]
    PANTHERiPTHR12411. PTHR12411. 1 hit.
    PfamiPF08246. Inhibitor_I29. 1 hit.
    PF00112. Peptidase_C1. 1 hit.
    [Graphical view]
    PRINTSiPR00705. PAPAIN.
    SMARTiSM00848. Inhibitor_I29. 1 hit.
    SM00645. Pept_C1. 1 hit.
    [Graphical view]
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS00640. THIOL_PROTEASE_ASN. 1 hit.
    PS00139. THIOL_PROTEASE_CYS. 1 hit.
    PS00639. THIOL_PROTEASE_HIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9FGR9-1 [UniParc]FASTAAdd to Basket

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    MKRFIVLALC MLMVLETTKG LDFHNKDVES ENSLWELYER WRSHHTVARS    50
    LEEKAKRFNV FKHNVKHIHE TNKKDKSYKL KLNKFGDMTS EEFRRTYAGS 100
    NIKHHRMFQG EKKATKSFMY ANVNTLPTSV DWRKNGAVTP VKNQGQCGSC 150
    WAFSTVVAVE GINQIRTKKL TSLSEQELVD CDTNQNQGCN GGLMDLAFEF 200
    IKEKGGLTSE LVYPYKASDE TCDTNKENAP VVSIDGHEDV PKNSEDDLMK 250
    AVANQPVSVA IDAGGSDFQF YSEGVFTGRC GTELNHGVAV VGYGTTIDGT 300
    KYWIVKNSWG EEWGEKGYIR MQRGIRHKEG LCGIAMEASY PLKNSNTNPS 350
    RLSLDSLKDE L 361
    Length:361
    Mass (Da):40,708
    Last modified:March 1, 2001 - v1
    Checksum:iA622234BC3E7367A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HM367092 mRNA. Translation: ADO14465.1.
    AB024031 Genomic DNA. Translation: BAB09397.1.
    CP002688 Genomic DNA. Translation: AED95919.1.
    AY091087 mRNA. Translation: AAM13907.1.
    RefSeqiNP_568722.1. NM_124405.2.
    UniGeneiAt.7918.

    Genome annotation databases

    EnsemblPlantsiAT5G50260.1; AT5G50260.1; AT5G50260.
    GeneIDi835091.
    KEGGiath:AT5G50260.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HM367092 mRNA. Translation: ADO14465.1 .
    AB024031 Genomic DNA. Translation: BAB09397.1 .
    CP002688 Genomic DNA. Translation: AED95919.1 .
    AY091087 mRNA. Translation: AAM13907.1 .
    RefSeqi NP_568722.1. NM_124405.2.
    UniGenei At.7918.

    3D structure databases

    ProteinModelPortali Q9FGR9.
    SMRi Q9FGR9. Positions 31-350.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT5G50260.1-P.

    Protein family/group databases

    MEROPSi C01.A03.

    Proteomic databases

    PaxDbi Q9FGR9.
    PRIDEi Q9FGR9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT5G50260.1 ; AT5G50260.1 ; AT5G50260 .
    GeneIDi 835091.
    KEGGi ath:AT5G50260.

    Organism-specific databases

    TAIRi AT5G50260.

    Phylogenomic databases

    eggNOGi COG4870.
    HOGENOMi HOG000230773.
    InParanoidi Q9FGR9.
    KOi K16292.
    OMAi AEDAYPY.
    PhylomeDBi Q9FGR9.

    Enzyme and pathway databases

    BioCyci ARA:AT5G50260-MONOMER.

    Gene expression databases

    Genevestigatori Q9FGR9.

    Family and domain databases

    InterProi IPR025661. Pept_asp_AS.
    IPR000169. Pept_cys_AS.
    IPR025660. Pept_his_AS.
    IPR013128. Peptidase_C1A.
    IPR000668. Peptidase_C1A_C.
    IPR013201. Prot_inhib_I29.
    [Graphical view ]
    PANTHERi PTHR12411. PTHR12411. 1 hit.
    Pfami PF08246. Inhibitor_I29. 1 hit.
    PF00112. Peptidase_C1. 1 hit.
    [Graphical view ]
    PRINTSi PR00705. PAPAIN.
    SMARTi SM00848. Inhibitor_I29. 1 hit.
    SM00645. Pept_C1. 1 hit.
    [Graphical view ]
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS00640. THIOL_PROTEASE_ASN. 1 hit.
    PS00139. THIOL_PROTEASE_CYS. 1 hit.
    PS00639. THIOL_PROTEASE_HIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Function analysis of an Arabidopsis cysteine proteinase gene AtCP56 and the promoter ProCP56 in anther development."
      Lv X., Li F., Lu H.
      Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence features of the regions of 3,076,755 bp covered by sixty P1 and TAC clones."
      Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H., Tabata S.
      DNA Res. 7:31-63(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "KDEL-tailed cysteine endopeptidases involved in programmed cell death, intercalation of new cells, and dismantling of extensin scaffolds."
      Helm M., Schmid M., Hierl G., Terneus K., Tan L., Lottspeich F., Kieliszewski M.J., Gietl C.
      Am. J. Bot. 95:1049-1062(2008)
      Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiCEP1_ARATH
    AccessioniPrimary (citable) accession number: Q9FGR9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2011
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3