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Q9FG59 (DHAR4_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative glutathione S-transferase DHAR4

EC=2.5.1.18
Alternative name(s):
Chloride intracellular channel homolog 4
Short name=CLIC homolog 4
Glutathione-dependent dehydroascorbate reductase 4
Short name=AtDHAR4
Short name=GSH-dependent dehydroascorbate reductase 4
Gene names
Name:DHAR4
Ordered Locus Names:At5g36270
ORF Names:T30G6.13
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length217 AA.
Sequence statusComplete.
Protein existenceUncertain

General annotation (Comments)

Function

Exhibits glutathione-dependent thiol transferase and dehydroascorbate (DHA) reductase activities By similarity.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasmcytosol Potential.

Sequence similarities

Belongs to the GST superfamily. DHAR family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Caution

Could be the product of a pseudogene.

Ontologies

Keywords
   Biological processDetoxification
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processresponse to toxic substance

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytosol

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglutathione transferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 217217Putative glutathione S-transferase DHAR4
PRO_0000395484

Regions

Domain10 – 8576GST N-terminal
Domain86 – 217132GST C-terminal
Region20 – 212Glutathione binding By similarity
Region46 – 472Glutathione binding By similarity
Region59 – 602Glutathione binding By similarity
Region74 – 752Glutathione binding By similarity
Motif20 – 256Glutathione-binding Potential

Sites

Active site201 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9FG59 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: FA21044464FDB0EA

FASTA21724,060
        10         20         30         40         50         60 
MGIEVCVKAA SGAPDVLGDC PFGQRILLTL EDKKLPYKTH LIDVSLKPDW FLAISPKGKL 

        70         80         90        100        110        120 
PLVKFDEDEN WVADSDLIVG IIEEKYPEPS LVTFPPEFAS VGSKIIGAFV MFLTSKDHAN 

       130        140        150        160        170        180 
DGSDMALLDE LEALDHHLKT HVGPFVAGDK VTVVDLSLAP KLYHLETTLG HFMDWCVPES 

       190        200        210 
LTNVRDYMKV LFSLESFEKT KAAKEYLIAS WAPKLDV 

« Hide

References

« Hide 'large scale' references
[1]"Structural analysis of Arabidopsis thaliana chromosome 5. XI."
Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H., Tabata S.
Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]"Functional divergence in the glutathione transferase superfamily in plants. Identification of two classes with putative functions in redox homeostasis in Arabidopsis thaliana."
Dixon D.P., Davis B.G., Edwards R.
J. Biol. Chem. 277:30859-30869(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB026661 Genomic DNA. Translation: BAB09367.1.

3D structure databases

ProteinModelPortalQ9FG59.
SMRQ9FG59. Positions 20-184.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

TAIRAT5G36270.

Gene expression databases

GenevestigatorQ9FG59.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDHAR4_ARATH
AccessionPrimary (citable) accession number: Q9FG59
Entry history
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names