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Protein

Probable glutathione S-transferase DHAR4

Gene

DHAR4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Exhibits glutathione-dependent thiol transferase and dehydroascorbate (DHA) reductase activities.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.Curated
2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei8AscorbateBy similarity1
Binding sitei8GlutathioneBy similarity1
Binding sitei19AscorbateBy similarity1
Binding sitei19GlutathioneBy similarity1
Active sitei20NucleophileBy similarity1
Binding sitei47GlutathioneBy similarity1
Binding sitei75GlutathioneBy similarity1
Binding sitei164GlutathioneBy similarity1
Binding sitei211GlutathioneBy similarity1
Binding sitei214AscorbateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Transferase
Biological processDetoxification

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutathione S-transferase DHAR4 (EC:2.5.1.18Curated)
Alternative name(s):
Chloride intracellular channel homolog 4
Short name:
CLIC homolog 4
Glutathione-dependent dehydroascorbate reductase 4Curated (EC:1.8.5.1Curated)
Short name:
AtDHAR4Curated
Short name:
GSH-dependent dehydroascorbate reductase 4
Gene namesi
Name:DHAR4
Ordered Locus Names:At5g36270
ORF Names:T30G6.13
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G36270.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003954841 – 217Probable glutathione S-transferase DHAR4Add BLAST217

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9FG59.
SMRiQ9FG59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 85GST N-terminalAdd BLAST76
Domaini86 – 217GST C-terminalAdd BLAST132

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi20 – 25Glutathione-bindingSequence analysis6

Sequence similaritiesi

Belongs to the GST superfamily. DHAR family.Curated

Phylogenomic databases

InParanoidiQ9FG59.

Family and domain databases

InterProiView protein in InterPro
IPR010987. Glutathione-S-Trfase_C-like.
IPR036282. Glutathione-S-Trfase_C_sf.
IPR004045. Glutathione_S-Trfase_N.
IPR036249. Thioredoxin-like_sf.
PfamiView protein in Pfam
PF13417. GST_N_3. 1 hit.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9FG59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIEVCVKAA SGAPDVLGDC PFGQRILLTL EDKKLPYKTH LIDVSLKPDW
60 70 80 90 100
FLAISPKGKL PLVKFDEDEN WVADSDLIVG IIEEKYPEPS LVTFPPEFAS
110 120 130 140 150
VGSKIIGAFV MFLTSKDHAN DGSDMALLDE LEALDHHLKT HVGPFVAGDK
160 170 180 190 200
VTVVDLSLAP KLYHLETTLG HFMDWCVPES LTNVRDYMKV LFSLESFEKT
210
KAAKEYLIAS WAPKLDV
Length:217
Mass (Da):24,060
Last modified:March 1, 2001 - v1
Checksum:iFA21044464FDB0EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026661 Genomic DNA. Translation: BAB09367.1.
CP002688 Genomic DNA. No translation available.

Similar proteinsi

Entry informationi

Entry nameiDHAR4_ARATH
AccessioniPrimary (citable) accession number: Q9FG59
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: March 1, 2001
Last modified: November 22, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families