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Protein

Sorting nexin 1

Gene

SNX1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in vesicular protein sorting. Acts at the crossroads between the secretory and endocytic pathways. Is involved in the endosome to vacuole protein transport via its interaction with the BLOS1/2 proteins and, as component of the membrane-associated retromer complex, is also involved in endosome-to-Golgi retrograde transport. Required for the auxin-carrier protein PIN2 sorting to the lytic vacuolar pathway and the trafficking of several plasma membrane proteins. Also involved in the efficient sorting of seed storage protein globulin 12S.5 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei67Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei93Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei109Phosphatidylinositol 3-phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

  • auxin homeostasis Source: TAIR
  • endocytosis Source: GO_Central
  • endosome to lysosome transport Source: TAIR
  • Golgi to vacuole transport Source: TAIR
  • positive gravitropism Source: TAIR
  • protein targeting to vacuole Source: TAIR
  • root development Source: TAIR
  • vesicle organization Source: GO_Central

Keywordsi

Biological processProtein transport, Transport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin 1
Short name:
AtSNX1
Alternative name(s):
Vacuolar protein sorting-associated protein 5 homolog
Gene namesi
Name:SNX1
Synonyms:VPS5
Ordered Locus Names:At5g06140
ORF Names:K16F4.11, MBL20
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G06140
TAIRilocus:2152850 AT5G06140

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Disruption phenotypei

Shorter primary roots, fewer secondary roots and an altered root gravitropic response. Accumulation of storage protein globulin 12S in dry seeds.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004147191 – 402Sorting nexin 1Add BLAST402

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9FG38
PRIDEiQ9FG38

PTM databases

iPTMnetiQ9FG38

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

ExpressionAtlasiQ9FG38 baseline and differential
GenevisibleiQ9FG38 AT

Interactioni

Subunit structurei

Homodimer. Heterodimer with SNX2A or SNX2B. Component of the retromer complex which consists of VPS29 (MAG1), VPS26 (VPS26A or VPS26B), VPS35 (VPS35A or VPS35B or VPS35C), VPS5/17 (SNX1 or SNX2A or SNX2B). Interacts with BLOS1 and BLOS2.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi15780, 4 interactors
IntActiQ9FG38, 6 interactors
STRINGi3702.AT5G06140.1

Structurei

3D structure databases

ProteinModelPortaliQ9FG38
SMRiQ9FG38
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 143PXPROSITE-ProRule annotationAdd BLAST120
Domaini160 – 402BARAdd BLAST243

Domaini

The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization.

Sequence similaritiesi

Belongs to the sorting nexin family.Curated

Phylogenomic databases

eggNOGiKOG2273 Eukaryota
COG5391 LUCA
HOGENOMiHOG000238494
InParanoidiQ9FG38
KOiK17917
OMAiFLMQLDA
OrthoDBiEOG09360DQK
PhylomeDBiQ9FG38

Family and domain databases

Gene3Di1.20.1270.60, 1 hit
3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR001683 Phox
IPR036871 PX_dom_sf
IPR015404 Vps5_C
PfamiView protein in Pfam
PF00787 PX, 1 hit
PF09325 Vps5, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit

Sequencei

Sequence statusi: Complete.

Q9FG38-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESTEQPRNI SGSMQSPRSP SSHPYLSVSV TDPVKLGNGV QAYISYRVIT
60 70 80 90 100
KTNLPEYQGP EKIVIRRYSD FVWLRDRLFE KYKGIFIPPL PEKSAVEKFR
110 120 130 140 150
FSAEFIEMRR AALDIFVNRI ALHPELQQSE DLRTFLQADE ETMDRFRFQE
160 170 180 190 200
TSIFKKPADL MQMFRDVQSK VSDAVLGKEK PVEETTADYE KLKHYIFELE
210 220 230 240 250
NHLTEAQKHA YRLVKRHREL GQSLLDFGKA VKLLGACEGE PTGKAFSDLG
260 270 280 290 300
TKSELLSIKL QKEAQQVLMN FEEPLKDYVR YVQSIKATIA ERGTAFKQHC
310 320 330 340 350
ELSETTKLKE INLDKLMLTR SDKVGEAEIE YREIKAESEE ATRRFERIVK
360 370 380 390 400
RMEDEIVRFQ EQKTEEMGVA FHQFAKGQAR LANSVADAWR SLLPKLEASY

SV
Length:402
Mass (Da):46,523
Last modified:March 1, 2001 - v1
Checksum:i42EC6B67942F7D20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP002030, AP002544 Genomic DNA Translation: BAB10207.1
CP002688 Genomic DNA Translation: AED90975.1
BT029777 mRNA Translation: ABM06047.1
AY080809 mRNA Translation: AAL87289.1
RefSeqiNP_196232.1, NM_120696.4
UniGeneiAt.27700

Genome annotation databases

EnsemblPlantsiAT5G06140.1; AT5G06140.1; AT5G06140
GeneIDi830501
GrameneiAT5G06140.1; AT5G06140.1; AT5G06140
KEGGiath:AT5G06140

Similar proteinsi

Entry informationi

Entry nameiSNX1_ARATH
AccessioniPrimary (citable) accession number: Q9FG38
Secondary accession number(s): Q8RXM2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 14, 2011
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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