Reviewed, UniProtKB/Swiss-Prot Q9FG08 (ATXR4_ARATH)

Names and origin

Protein names

Recommended name:
    Histone-lysine N-methyltransferase ATXR4
    EC=2.1.1.43
Alternative name(s):
    Trithorax-related protein 4
      Short name=TRX-related protein 4
    Protein SET DOMAIN GROUP 38

Gene names

Name:	ATXR4
Synonyms:	SDG38, SET38
Ordered Locus Names:	At5g06620
ORF Names:	F15M7.15

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Arabidopsis

Protein attributes

Sequence length	325 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Histone methyltransferase By similarity.
Catalytic activity	S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily. Contains 1 SET domain.
Sequence caution	The sequence BAB11411.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Signal
Ligand	S-adenosyl-L-methionine
Molecular function	Chromatin regulator Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	histone-lysine N-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 30	30	Potential
	Chain	31 – 325	295	Histone-lysine N-methyltransferase ATXR4		PRO_0000233361
Regions
	Domain	180 – 299	120	SET

Sequences

	Sequence		Length	Mass (Da)
	Q9FG08-1 [UniParc]. Last modified March 24, 2009. Version 2. Checksum: 0695D0EE9599B0A2	FASTA	325	36,134
	10 20 30 40 50 60 MSRLALNRYS RCFSRLKTLT TPLFFSSSAA SNRDGDYQIG PPPIRVGLTE SAGRAVFATR 70 80 90 100 110 120 KIGAGDLIHT AKPVVACPSL LKLDSVCYLC LKKLMGSAKF EDRGVSYCSQ ECQENSKGFL 130 140 150 160 170 180 DVETRADWSS FDDYCRTHNF KYPLMVKRLC CMIISGARPA DCLDILQPAV LSSEMISKIE 190 200 210 220 230 240 DGYGLLWNAF RKANFKDDDV AFLTKQWYTA ILARIRINAF RIDLVGGSCG EDLLSLAAAS 250 260 270 280 290 300 VEGEGAVGHA VYMLPSFYNH DCDPNAHIIW LHNADARLNT LRDVEEGEEL RICYIDASMG 310 320 YEARQTILSQ GFGFLCNCLR CQSTD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structural analysis of Arabidopsis thaliana chromosome 5. XI." Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H., Tabata S. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	"The Arabidopsis thaliana genome contains at least 29 active genes encoding SET domain proteins that can be assigned to four evolutionarily conserved classes." Baumbusch L.O., Thorstensen T., Krauss V., Fischer A., Naumann K., Assalkhou R., Schulz I., Reuter G., Aalen R.B. Nucleic Acids Res. 29:4319-4333(2001) [PubMed: 11691919] [Abstract] Cited for: NOMENCLATURE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP002543 Genomic DNA. Translation: BAB11411.1. Sequence problems.
IPI	IPI00529979.
RefSeq	NP_196280.2.
UniGene	At.32832
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q9FG08.
Genome annotation databases
GeneID	830550.
GenomeReviews	Gene locus AT5G06620 in contig BA000015_GR.
KEGG	ath:AT5G06620.
NMPDR	fig|3702.1.peg.22792.
Organism-specific databases
TAIR	At5g06620.
Phylogenomic databases
eggNOG	KOG2084.
HOGENOM	HBG609419.
OMA	EELRICY.
Enzyme and pathway databases
BRENDA	2.1.1.43. 302.
Gene expression databases
Genevestigator	Q9FG08.
Family and domain databases
InterPro	IPR001214. SET_dom. [Graphical view]
Pfam	PF00856. SET. 1 hit. [Graphical view]
SMART	SM00317. SET. 1 hit. [Graphical view]
PROSITE	PS50280. SET. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATXR4_ARATH

Accession

Primary (citable) accession number: Q9FG08

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2006
Last sequence update:	March 24, 2009
Last modified:	February 9, 2010
This is version 47 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)