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Protein

Cation/H(+) antiporter 18

Gene

CHX18

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May operate as a cation/H+ antiporter.By similarity

GO - Molecular functioni

GO - Biological processi

  • potassium ion transport Source: UniProtKB-KW
  • regulation of pH Source: TAIR
Complete GO annotation...

Keywords - Biological processi

Antiport, Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Cation/H(+) antiporter 18
Alternative name(s):
Protein CATION/H+ EXCHANGER 18
Short name:
AtCHX18
Gene namesi
Name:CHX18
Ordered Locus Names:At5g41610
ORF Names:MBK23.12
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G41610.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei29 – 4921HelicalSequence analysisAdd
BLAST
Transmembranei59 – 7618HelicalSequence analysisAdd
BLAST
Transmembranei91 – 11121HelicalSequence analysisAdd
BLAST
Transmembranei126 – 14621HelicalSequence analysisAdd
BLAST
Transmembranei157 – 17721HelicalSequence analysisAdd
BLAST
Transmembranei193 – 21321HelicalSequence analysisAdd
BLAST
Transmembranei223 – 24321HelicalSequence analysisAdd
BLAST
Transmembranei277 – 29721HelicalSequence analysisAdd
BLAST
Transmembranei314 – 33421HelicalSequence analysisAdd
BLAST
Transmembranei343 – 36321HelicalSequence analysisAdd
BLAST
Transmembranei374 – 39421HelicalSequence analysisAdd
BLAST
Transmembranei406 – 42621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • late endosome Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 810810Cation/H(+) antiporter 18PRO_0000394988Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei804 – 8041PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9FFR9.
PRIDEiQ9FFR9.

Expressioni

Tissue specificityi

Expressed in roots.1 Publication

Gene expression databases

GenevisibleiQ9FFR9. AT.

Interactioni

Protein-protein interaction databases

BioGridi19414. 4 interactions.
STRINGi3702.AT5G41610.1.

Structurei

3D structure databases

ProteinModelPortaliQ9FFR9.
SMRiQ9FFR9. Positions 35-437.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi680 – 6856Poly-Asn

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1650. Eukaryota.
COG0475. LUCA.
HOGENOMiHOG000131548.
InParanoidiQ9FFR9.
OMAiCHEGEPI.
PhylomeDBiQ9FFR9.

Family and domain databases

InterProiIPR006153. Cation/H_exchanger.
[Graphical view]
PfamiPF00999. Na_H_Exchanger. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9FFR9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATNSTKACP APMKATSNGV FQGDNPIDFA LPLAILQIVI VIVLTRVLAY
60 70 80 90 100
LLRPLRQPRV IAEVIGGIML GPSLLGRSKA FLDAVFPKKS LTVLETLANL
110 120 130 140 150
GLLFFLFLAG LEIDTKALRR TGKKALGIAL AGITLPFALG IGSSFVLKAT
160 170 180 190 200
ISKGVNSTAF LVFMGVALSI TAFPVLARIL AELKLLTTEI GRLAMSAAAV
210 220 230 240 250
NDVAAWILLA LAIALSGSNT SPLVSLWVFL SGCAFVIGAS FIIPPIFRWI
260 270 280 290 300
SRRCHEGEPI EETYICATLA VVLVCGFITD AIGIHSMFGA FVVGVLIPKE
310 320 330 340 350
GPFAGALVEK VEDLVSGLFL PLYFVASGLK TNVATIQGAQ SWGLLVLVTA
360 370 380 390 400
TACFGKILGT LGVSLAFKIP MREAITLGFL MNTKGLVELI VLNIGKDRKV
410 420 430 440 450
LNDQTFAIMV LMALFTTFIT TPVVMAVYKP ARRAKKEGEY KHRAVERENT
460 470 480 490 500
NTQLRILTCF HGAGSIPSMI NLLEASRGIE KGEGLCVYAL HLRELSERSS
510 520 530 540 550
AILMVHKVRK NGMPFWNRRG VNADADQVVV AFQAFQQLSR VNVRPMTAIS
560 570 580 590 600
SMSDIHEDIC TTAVRKKAAI VILPFHKHQQ LDGSLETTRG DYRWVNRRVL
610 620 630 640 650
LQAPCSVGIF VDRGLGGSSQ VSAQDVSYSV VVLFFGGPDD REALAYGLRM
660 670 680 690 700
AEHPGIVLTV FRFVVSPERV GEIVNVEVSN NNNENQSVKN LKSDEEIMSE
710 720 730 740 750
IRKISSVDES VKFVEKQIEN AAVDVRSAIE EVRRSNLFLV GRMPGGEIAL
760 770 780 790 800
AIRENSECPE LGPVGSLLIS PESSTKASVL VIQQYNGTGI APDLGAAETE
810
VLTSTDKDSD
Length:810
Mass (Da):87,383
Last modified:March 1, 2001 - v1
Checksum:i4FADAD2DD49917E2
GO
Isoform 2 (identifier: Q9FFR9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: Missing.

Note: Derived from EST data. No experimental confirmation available.
Show »
Length:742
Mass (Da):80,131
Checksum:i66F3A036164C0883
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6868Missing in isoform 2. CuratedVSP_039314Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB005233 Genomic DNA. Translation: BAB11467.1.
CP002688 Genomic DNA. Translation: AED94697.1.
CP002688 Genomic DNA. Translation: AED94698.1.
AY926474 mRNA. Translation: AAX49546.1.
RefSeqiNP_198976.3. NM_123525.3. [Q9FFR9-1]
NP_974866.1. NM_203137.1. [Q9FFR9-2]
UniGeneiAt.43453.

Genome annotation databases

EnsemblPlantsiAT5G41610.1; AT5G41610.1; AT5G41610. [Q9FFR9-1]
GeneIDi834163.
KEGGiath:AT5G41610.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB005233 Genomic DNA. Translation: BAB11467.1.
CP002688 Genomic DNA. Translation: AED94697.1.
CP002688 Genomic DNA. Translation: AED94698.1.
AY926474 mRNA. Translation: AAX49546.1.
RefSeqiNP_198976.3. NM_123525.3. [Q9FFR9-1]
NP_974866.1. NM_203137.1. [Q9FFR9-2]
UniGeneiAt.43453.

3D structure databases

ProteinModelPortaliQ9FFR9.
SMRiQ9FFR9. Positions 35-437.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi19414. 4 interactions.
STRINGi3702.AT5G41610.1.

Proteomic databases

PaxDbiQ9FFR9.
PRIDEiQ9FFR9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G41610.1; AT5G41610.1; AT5G41610. [Q9FFR9-1]
GeneIDi834163.
KEGGiath:AT5G41610.

Organism-specific databases

TAIRiAT5G41610.

Phylogenomic databases

eggNOGiKOG1650. Eukaryota.
COG0475. LUCA.
HOGENOMiHOG000131548.
InParanoidiQ9FFR9.
OMAiCHEGEPI.
PhylomeDBiQ9FFR9.

Miscellaneous databases

PROiQ9FFR9.

Gene expression databases

GenevisibleiQ9FFR9. AT.

Family and domain databases

InterProiIPR006153. Cation/H_exchanger.
[Graphical view]
PfamiPF00999. Na_H_Exchanger. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis of Arabidopsis thaliana chromosome 5. I. Sequence features of the 1.6 Mb regions covered by twenty physically assigned P1 clones."
    Sato S., Kotani H., Nakamura Y., Kaneko T., Asamizu E., Fukami M., Miyajima N., Tabata S.
    DNA Res. 4:215-230(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Expression patterns of a novel AtCHX gene family highlight potential roles in osmotic adjustment and K+ homeostasis in pollen development."
    Sze H., Padmanaban S., Cellier F., Honys D., Cheng N.-H., Bock K.W., Conejero G., Li X., Twell D., Ward J.M., Hirschi K.D.
    Plant Physiol. 136:2532-2547(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-808 (ISOFORM 1), TISSUE SPECIFICITY, GENE FAMILY, NOMENCLATURE.
    Tissue: Pollen.
  4. Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiCHX18_ARATH
AccessioniPrimary (citable) accession number: Q9FFR9
Secondary accession number(s): Q3E7L5, Q58P65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: March 1, 2001
Last modified: July 6, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.