Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine/threonine-protein kinase SRK2H

Gene

SRK2H

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATPPROSITE-ProRule annotation1
Active sitei123Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • kinase activity Source: TAIR
  • protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

  • intracellular signal transduction Source: GO_Central
  • protein phosphorylation Source: GO_Central
  • response to osmotic stress Source: TAIR
  • response to salt stress Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-163680. AMPK inhibits chREBP transcriptional activation activity.
R-ATH-200425. Import of palmitoyl-CoA into the mitochondrial matrix.
R-ATH-380972. Energy dependent regulation of mTOR by LKB1-AMPK.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase SRK2H (EC:2.7.11.1)
Alternative name(s):
OST1-kinase-like 9
SNF1-related kinase 2.5
Short name:
SnRK2.5
Gene namesi
Name:SRK2H
Synonyms:OSKL9, SNRK2.5
Ordered Locus Names:At5g63650
ORF Names:MBK5.13
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G63650.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • nucleus Source: TAIR
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003451621 – 360Serine/threonine-protein kinase SRK2HAdd BLAST360

Proteomic databases

PaxDbiQ9FFP9.

PTM databases

iPTMnetiQ9FFP9.

Expressioni

Tissue specificityi

Expressed in seedlings.1 Publication

Inductioni

By salt and osmotic stress (at protein level).1 Publication

Gene expression databases

GenevisibleiQ9FFP9. AT.

Interactioni

Protein-protein interaction databases

BioGridi21727. 2 interactors.
STRINGi3702.AT5G63650.1.

Structurei

3D structure databases

ProteinModelPortaliQ9FFP9.
SMRiQ9FFP9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 260Protein kinasePROSITE-ProRule annotationAdd BLAST257

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi316 – 350Glu-richAdd BLAST35

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0583. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000233016.
InParanoidiQ9FFP9.
KOiK14498.
OMAiAYYKRET.
OrthoDBiEOG09360EKZ.
PhylomeDBiQ9FFP9.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9FFP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKYEVVKDL GAGNFGVARL LRHKETKELV AMKYIERGRK IDENVAREII
60 70 80 90 100
NHRSLRHPNI IRFKEVILTP THLAIVMEYA SGGELFERIC NAGRFSEAEA
110 120 130 140 150
RYFFQQLICG VDYCHSLQIC HRDLKLENTL LDGSPAPLLK ICDFGYSKSS
160 170 180 190 200
LLHSRPKSTV GTPAYIAPEV LSRREYDGKH ADVWSCGVTL YVMLVGGYPF
210 220 230 240 250
EDPDDPRNFR KTIQRIMAVQ YKIPDYVHIS QECRHLLSRI FVTNSAKRIT
260 270 280 290 300
LKEIKKHPWY LKNLPKELTE PAQAAYYKRE TPSFSLQSVE DIMKIVGEAR
310 320 330 340 350
NPAPSSNAVK GFDDDEEDVE DEVEEEEEEE EEEEEEEEEE EDEYEKHVKE
360
AHSCQEPPKA
Length:360
Mass (Da):41,554
Last modified:March 1, 2001 - v1
Checksum:iD4ECB111E954A5A8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti174R → K in BAE99712 (Ref. 3) Curated1
Sequence conflicti335E → V in BAE99712 (Ref. 3) Curated1
Sequence conflicti340 – 341Missing in AAM65503 (Ref. 4) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB005234 Genomic DNA. Translation: BAB10458.1.
CP002688 Genomic DNA. Translation: AED97781.1.
AK227726 mRNA. Translation: BAE99712.1.
AY087955 mRNA. Translation: AAM65503.1.
RefSeqiNP_201170.1. NM_125760.2.
UniGeneiAt.28988.

Genome annotation databases

EnsemblPlantsiAT5G63650.1; AT5G63650.1; AT5G63650.
GeneIDi836485.
GrameneiAT5G63650.1; AT5G63650.1; AT5G63650.
KEGGiath:AT5G63650.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB005234 Genomic DNA. Translation: BAB10458.1.
CP002688 Genomic DNA. Translation: AED97781.1.
AK227726 mRNA. Translation: BAE99712.1.
AY087955 mRNA. Translation: AAM65503.1.
RefSeqiNP_201170.1. NM_125760.2.
UniGeneiAt.28988.

3D structure databases

ProteinModelPortaliQ9FFP9.
SMRiQ9FFP9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi21727. 2 interactors.
STRINGi3702.AT5G63650.1.

PTM databases

iPTMnetiQ9FFP9.

Proteomic databases

PaxDbiQ9FFP9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G63650.1; AT5G63650.1; AT5G63650.
GeneIDi836485.
GrameneiAT5G63650.1; AT5G63650.1; AT5G63650.
KEGGiath:AT5G63650.

Organism-specific databases

TAIRiAT5G63650.

Phylogenomic databases

eggNOGiKOG0583. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000233016.
InParanoidiQ9FFP9.
KOiK14498.
OMAiAYYKRET.
OrthoDBiEOG09360EKZ.
PhylomeDBiQ9FFP9.

Enzyme and pathway databases

ReactomeiR-ATH-163680. AMPK inhibits chREBP transcriptional activation activity.
R-ATH-200425. Import of palmitoyl-CoA into the mitochondrial matrix.
R-ATH-380972. Energy dependent regulation of mTOR by LKB1-AMPK.

Miscellaneous databases

PROiQ9FFP9.

Gene expression databases

GenevisibleiQ9FFP9. AT.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSRK2H_ARATH
AccessioniPrimary (citable) accession number: Q9FFP9
Secondary accession number(s): Q0WT36, Q8LA99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.