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Protein

Pyruvate kinase

Gene

At5g63680

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 5 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase GAPC2, cytosolic (GAPC2), Glyceraldehyde-3-phosphate dehydrogenase GAPC1, cytosolic (GAPC1)
  2. no protein annotated in this organism
  3. Probable 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 2 (At3g08590), 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 1 (PGM1)
  4. Enolase 1, chloroplastic (ENO1), Cytosolic enolase 3 (ENO3), Bifunctional enolase 2/transcriptional activator (ENO2)
  5. Pyruvate kinase (At5g08570), Pyruvate kinase (At5g56350), Pyruvate kinase (F1I16_60), Pyruvate kinase (At5g63680), Pyruvate kinase (At3g25960), Plastidial pyruvate kinase 3, chloroplastic (PKP3), Pyruvate kinase (At3g52990), Pyruvate kinase (At2g36580), Pyruvate kinase, Probable pyruvate kinase, cytosolic isozyme (At4g26390), Pyruvate kinase (F8J2_160), Pyruvate kinase (At3g52990), Plastidial pyruvate kinase 2 (PKP2), Pyruvate kinase (T11I18.16), Pyruvate kinase (F1I16_220), Plastidial pyruvate kinase 1, chloroplastic (PKP1), Pyruvate kinase (At5g63680), Pyruvate kinase, Plastidial pyruvate kinase 4, chloroplastic (PKP4)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

  • response to cadmium ion Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationImported, Transferase

Keywords - Biological processi

GlycolysisUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, PyruvateImported

Enzyme and pathway databases

BioCyciARA:AT5G63680-MONOMER.
ReactomeiR-ATH-70171. Glycolysis.
UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinaseUniRule annotation (EC:2.7.1.40UniRule annotation)
Gene namesi
Ordered Locus Names:At5g63680Imported
ORF Names:AXX17_AT5G63250Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G63680.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: TAIR
  • plasma membrane Source: TAIR
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G63680.1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 364345PKInterPro annotationAdd
BLAST
Domaini380 – 506127PK_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the pyruvate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2323. Eukaryota.
COG0469. LUCA.
KOiK00873.
OMAiIDYPYVA.
OrthoDBiEOG093607JW.

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProiIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9FFP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNIDIEGIL KELPNDGRTP KTKIVCTLGP ASRSVTMIEK LLKAGMNVAR
60 70 80 90 100
FNFSHGSHEY HQETLDNLRT AMQNTGILAA VMLDTKGPEI RTGFLKDGNP
110 120 130 140 150
IQLKEGQEIT ITTDYDIKGD EKTISMSYKK LPVDVKPGNT ILCADGSISL
160 170 180 190 200
AVVSCDPNAG TVICRCENTA MLGERKNVNL PGVVVDLPTL TDKDVEDILK
210 220 230 240 250
WGVPNNIDMI ALSFVRKGSD LVNVRKVLGS HSKSIMLMSK VENQEGVLNF
260 270 280 290 300
DEILRETDAF MVARGDLGME IPIEKIFLAQ KMMIYKCNLA GKPVVTATQM
310 320 330 340 350
LESMIKSPRP TRAEATDVAN AVLDGTDCVM LSGESAAGAY PEIAVKTMAK
360 370 380 390 400
ICIEAESSLD YNTIFKEMIR ATPLPMSTLE SLASSAVRTA NKAKAKLIIV
410 420 430 440 450
LTRGGTTAKL VAKYRPAVPI LSVVVPVFTS DTFNWSCSDE SPARHSLIYR
460 470 480 490 500
GLIPVLGEGS AKATDSESTE EIIESALKSA TEKGLCNHGD AVVALHRIGA
510
ASVIKICVVK
Length:510
Mass (Da):55,018
Last modified:March 1, 2001 - v1
Checksum:iE28669060911080C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002688 Genomic DNA. Translation: AED97785.1.
AB005234 Genomic DNA. Translation: BAB10461.1.
LUHQ01000005 Genomic DNA. Translation: OAO92448.1.
RefSeqiNP_201173.1. NM_125763.2.
UniGeneiAt.43057.

Genome annotation databases

EnsemblPlantsiAT5G63680.1; AT5G63680.1; AT5G63680.
GeneIDi836488.
GrameneiAT5G63680.1; AT5G63680.1; AT5G63680.
KEGGiath:AT5G63680.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002688 Genomic DNA. Translation: AED97785.1.
AB005234 Genomic DNA. Translation: BAB10461.1.
LUHQ01000005 Genomic DNA. Translation: OAO92448.1.
RefSeqiNP_201173.1. NM_125763.2.
UniGeneiAt.43057.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT5G63680.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G63680.1; AT5G63680.1; AT5G63680.
GeneIDi836488.
GrameneiAT5G63680.1; AT5G63680.1; AT5G63680.
KEGGiath:AT5G63680.

Organism-specific databases

TAIRiAT5G63680.

Phylogenomic databases

eggNOGiKOG2323. Eukaryota.
COG0469. LUCA.
KOiK00873.
OMAiIDYPYVA.
OrthoDBiEOG093607JW.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00188.
BioCyciARA:AT5G63680-MONOMER.
ReactomeiR-ATH-70171. Glycolysis.

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProiIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9FFP6_ARATH
AccessioniPrimary (citable) accession number: Q9FFP6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.