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Q9FF80 (SUVH1_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH1

EC=2.1.1.43
Alternative name(s):
Histone H3-K9 methyltransferase 1
Short name=H3-K9-HMTase 1
Protein SET DOMAIN GROUP 32
Suppressor of variegation 3-9 homolog protein 1
Short name=Su(var)3-9 homolog protein 1
Gene names
Name:SUVH1
Synonyms:SDG32, SET32
Ordered Locus Names:At5g04940
ORF Names:MUG13.20
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length670 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Histone methyltransferase. Methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. Ref.4

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Subcellular location

Nucleus. Chromosomecentromere. Note: Associates with centromeric constitutive heterochromatin. Ref.1 Ref.4

Tissue specificity

Expressed in leaves stems and flowers. Ref.1

Domain

Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity.

Sequence similarities

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.

Contains 1 post-SET domain.

Contains 1 pre-SET domain.

Contains 1 SET domain.

Contains 1 YDG domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 670670Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH1
PRO_0000186072

Regions

Domain211 – 357147YDG
Domain432 – 49261Pre-SET
Domain495 – 639145SET
Domain654 – 67017Post-SET

Sequences

Sequence LengthMass (Da)Tools
Q9FF80 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: C92CE89FF5C630F1

FASTA67074,471
        10         20         30         40         50         60 
MERNGGHYTD KTRVLDIKPL RTLRPVFPSG NQAPPFVCAP PFGPFPPGFS SFYPFSSSQA 

        70         80         90        100        110        120 
NQHTPDLNQA QYPPQHQQPQ NPPPVYQQQP PQHASEPSLV TPLRSFRSPD VSNGNAELEG 

       130        140        150        160        170        180 
STVKRRIPKK RPISRPENMN FESGINVADR ENGNRELVLS VLMRFDALRR RFAQLEDAKE 

       190        200        210        220        230        240 
AVSGIIKRPD LKSGSTCMGR GVRTNTKKRP GIVPGVEIGD VFFFRFEMCL VGLHSPSMAG 

       250        260        270        280        290        300 
IDYLVVKGET EEEPIATSIV SSGYYDNDEG NPDVLIYTGQ GGNADKDKQS SDQKLERGNL 

       310        320        330        340        350        360 
ALEKSLRRDS AVRVIRGLKE ASHNAKIYIY DGLYEIKESW VEKGKSGHNT FKYKLVRAPG 

       370        380        390        400        410        420 
QPPAFASWTA IQKWKTGVPS RQGLILPDMT SGVESIPVSL VNEVDTDNGP AYFTYSTTVK 

       430        440        450        460        470        480 
YSESFKLMQP SFGCDCANLC KPGNLDCHCI RKNGGDFPYT GNGILVSRKP MIYECSPSCP 

       490        500        510        520        530        540 
CSTCKNKVTQ MGVKVRLEVF KTANRGWGLR SWDAIRAGSF ICIYVGEAKD KSKVQQTMAN 

       550        560        570        580        590        600 
DDYTFDTTNV YNPFKWNYEP GLADEDACEE MSEESEIPLP LIISAKNVGN VARFMNHSCS 

       610        620        630        640        650        660 
PNVFWQPVSY ENNSQLFVHV AFFAISHIPP MTELTYDYGV SRPSGTQNGN PLYGKRKCFC 

       670 
GSAYCRGSFG 

« Hide

References

« Hide 'large scale' references
[1]"The Arabidopsis thaliana genome contains at least 29 active genes encoding SET domain proteins that can be assigned to four evolutionarily conserved classes."
Baumbusch L.O., Thorstensen T., Krauss V., Fischer A., Naumann K., Assalkhou R., Schulz I., Reuter G., Aalen R.B.
Nucleic Acids Res. 29:4319-4333(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, NOMENCLATURE, TISSUE SPECIFICITY.
[2]"Structural analysis of Arabidopsis thaliana chromosome 5. I. Sequence features of the 1.6 Mb regions covered by twenty physically assigned P1 clones."
Sato S., Kotani H., Nakamura Y., Kaneko T., Asamizu E., Fukami M., Miyajima N., Tabata S.
DNA Res. 4:215-230(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[3]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[4]"Pivotal role of AtSUVH2 in heterochromatic histone methylation and gene silencing in Arabidopsis."
Naumann K., Fischer A., Hofmann I., Krauss V., Phalke S., Irmler K., Hause G., Aurich A.-C., Dorn R., Jenuwein T., Reuter G.
EMBO J. 24:1418-1429(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[5]"Heterochromatin proteins and the control of heterochromatic gene silencing in Arabidopsis."
Fischer A., Hofmann I., Naumann K., Reuter G.
J. Plant Physiol. 163:358-368(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF344444 mRNA. Translation: AAK28966.1.
AB005245 Genomic DNA. Translation: BAB11516.1.
CP002688 Genomic DNA. Translation: AED90806.1.
CP002688 Genomic DNA. Translation: AED90807.1.
RefSeqNP_196113.1. NM_120576.1.
NP_850767.1. NM_180436.1.
UniGeneAt.8375.

3D structure databases

ProteinModelPortalQ9FF80.
SMRQ9FF80. Positions 211-362, 370-670.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ9FF80.
PRIDEQ9FF80.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT5G04940.1; AT5G04940.1; AT5G04940.
AT5G04940.2; AT5G04940.2; AT5G04940.
GeneID830376.
KEGGath:AT5G04940.

Organism-specific databases

TAIRAT5G04940.

Phylogenomic databases

eggNOGCOG2940.
HOGENOMHOG000238382.
InParanoidQ9FF80.
KOK11420.
OMARENGNRE.
PhylomeDBQ9FF80.
ProtClustDBCLSN2686453.

Enzyme and pathway databases

BioCycARA:AT5G04940-MONOMER.
ARA:GQT-1962-MONOMER.

Gene expression databases

GenevestigatorQ9FF80.

Family and domain databases

Gene3D2.30.280.10. 1 hit.
InterProIPR025794. Hist-Lys_N-MeTrfase_plant.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR015947. PUA-like_domain.
IPR001214. SET_dom.
IPR003105. SRA_YDG.
[Graphical view]
PfamPF05033. Pre-SET. 1 hit.
PF02182. SAD_SRA. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTSM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
SM00466. SRA. 1 hit.
[Graphical view]
SUPFAMSSF88697. SSF88697. 1 hit.
PROSITEPS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS51575. SAM_MT43_SUVAR39_2. 1 hit.
PS50280. SET. 1 hit.
PS51015. YDG. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSUVH1_ARATH
AccessionPrimary (citable) accession number: Q9FF80
Entry history
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names