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Q9FF80

- SUVH1_ARATH

UniProt

Q9FF80 - SUVH1_ARATH

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Protein
Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH1
Gene
SUVH1, SDG32, SET32, At5g04940, MUG13.20
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Histone methyltransferase. Methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression.1 Publication

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi434 – 4341Zinc 1 By similarity
Metal bindingi434 – 4341Zinc 2 By similarity
Metal bindingi436 – 4361Zinc 1 By similarity
Metal bindingi440 – 4401Zinc 1 By similarity
Metal bindingi440 – 4401Zinc 3 By similarity
Metal bindingi447 – 4471Zinc 1 By similarity
Metal bindingi449 – 4491Zinc 2 By similarity
Metal bindingi475 – 4751Zinc 2 By similarity
Metal bindingi475 – 4751Zinc 3 By similarity
Metal bindingi479 – 4791Zinc 2 By similarity
Metal bindingi481 – 4811Zinc 3 By similarity
Metal bindingi484 – 4841Zinc 3 By similarity
Binding sitei541 – 5411S-adenosyl-L-methionine By similarity
Binding sitei543 – 5431S-adenosyl-L-methionine By similarity
Binding sitei593 – 5931S-adenosyl-L-methionine By similarity
Metal bindingi599 – 5991Zinc 4 By similarity
Metal bindingi658 – 6581Zinc 4 By similarity
Metal bindingi660 – 6601Zinc 4 By similarity
Metal bindingi665 – 6651Zinc 4 By similarity

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. regulation of gene expression, epigenetic Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Transferase

Keywords - Ligandi

Metal-binding, S-adenosyl-L-methionine, Zinc

Enzyme and pathway databases

BioCyciARA:AT5G04940-MONOMER.
ARA:GQT-1962-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH1 (EC:2.1.1.43)
Alternative name(s):
Histone H3-K9 methyltransferase 1
Short name:
H3-K9-HMTase 1
Protein SET DOMAIN GROUP 32
Suppressor of variegation 3-9 homolog protein 1
Short name:
Su(var)3-9 homolog protein 1
Gene namesi
Name:SUVH1
Synonyms:SDG32, SET32
Ordered Locus Names:At5g04940
ORF Names:MUG13.20
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G04940.

Subcellular locationi

Nucleus. Chromosomecentromere
Note: Associates with centromeric constitutive heterochromatin.2 Publications

GO - Cellular componenti

  1. chromosome, centromeric region Source: UniProtKB-SubCell
  2. nucleus Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 670670Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH1
PRO_0000186072Add
BLAST

Proteomic databases

PaxDbiQ9FF80.
PRIDEiQ9FF80.

Expressioni

Tissue specificityi

Expressed in leaves stems and flowers.1 Publication

Gene expression databases

GenevestigatoriQ9FF80.

Structurei

3D structure databases

ProteinModelPortaliQ9FF80.
SMRiQ9FF80. Positions 149-670.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini211 – 357147YDG
Add
BLAST
Domaini432 – 49261Pre-SET
Add
BLAST
Domaini495 – 639145SET
Add
BLAST
Domaini654 – 67017Post-SET
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni505 – 5073S-adenosyl-L-methionine binding By similarity
Regioni596 – 5972S-adenosyl-L-methionine binding By similarity

Domaini

Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity.
In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster By similarity.

Sequence similaritiesi

Contains 1 post-SET domain.
Contains 1 pre-SET domain.
Contains 1 SET domain.
Contains 1 YDG domain.

Phylogenomic databases

eggNOGiCOG2940.
HOGENOMiHOG000238382.
InParanoidiQ9FF80.
KOiK11420.
OMAiRENGNRE.
PhylomeDBiQ9FF80.

Family and domain databases

Gene3Di2.30.280.10. 1 hit.
InterProiIPR025794. Hist-Lys_N-MeTrfase_plant.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR015947. PUA-like_domain.
IPR001214. SET_dom.
IPR003105. SRA_YDG.
[Graphical view]
PfamiPF05033. Pre-SET. 1 hit.
PF02182. SAD_SRA. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
SM00466. SRA. 1 hit.
[Graphical view]
SUPFAMiSSF88697. SSF88697. 1 hit.
PROSITEiPS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS51575. SAM_MT43_SUVAR39_2. 1 hit.
PS50280. SET. 1 hit.
PS51015. YDG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9FF80-1 [UniParc]FASTAAdd to Basket

« Hide

MERNGGHYTD KTRVLDIKPL RTLRPVFPSG NQAPPFVCAP PFGPFPPGFS    50
SFYPFSSSQA NQHTPDLNQA QYPPQHQQPQ NPPPVYQQQP PQHASEPSLV 100
TPLRSFRSPD VSNGNAELEG STVKRRIPKK RPISRPENMN FESGINVADR 150
ENGNRELVLS VLMRFDALRR RFAQLEDAKE AVSGIIKRPD LKSGSTCMGR 200
GVRTNTKKRP GIVPGVEIGD VFFFRFEMCL VGLHSPSMAG IDYLVVKGET 250
EEEPIATSIV SSGYYDNDEG NPDVLIYTGQ GGNADKDKQS SDQKLERGNL 300
ALEKSLRRDS AVRVIRGLKE ASHNAKIYIY DGLYEIKESW VEKGKSGHNT 350
FKYKLVRAPG QPPAFASWTA IQKWKTGVPS RQGLILPDMT SGVESIPVSL 400
VNEVDTDNGP AYFTYSTTVK YSESFKLMQP SFGCDCANLC KPGNLDCHCI 450
RKNGGDFPYT GNGILVSRKP MIYECSPSCP CSTCKNKVTQ MGVKVRLEVF 500
KTANRGWGLR SWDAIRAGSF ICIYVGEAKD KSKVQQTMAN DDYTFDTTNV 550
YNPFKWNYEP GLADEDACEE MSEESEIPLP LIISAKNVGN VARFMNHSCS 600
PNVFWQPVSY ENNSQLFVHV AFFAISHIPP MTELTYDYGV SRPSGTQNGN 650
PLYGKRKCFC GSAYCRGSFG 670
Length:670
Mass (Da):74,471
Last modified:March 1, 2001 - v1
Checksum:iC92CE89FF5C630F1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF344444 mRNA. Translation: AAK28966.1.
AB005245 Genomic DNA. Translation: BAB11516.1.
CP002688 Genomic DNA. Translation: AED90806.1.
CP002688 Genomic DNA. Translation: AED90807.1.
RefSeqiNP_196113.1. NM_120576.1.
NP_850767.1. NM_180436.1.
UniGeneiAt.8375.

Genome annotation databases

EnsemblPlantsiAT5G04940.1; AT5G04940.1; AT5G04940.
AT5G04940.2; AT5G04940.2; AT5G04940.
GeneIDi830376.
KEGGiath:AT5G04940.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF344444 mRNA. Translation: AAK28966.1 .
AB005245 Genomic DNA. Translation: BAB11516.1 .
CP002688 Genomic DNA. Translation: AED90806.1 .
CP002688 Genomic DNA. Translation: AED90807.1 .
RefSeqi NP_196113.1. NM_120576.1.
NP_850767.1. NM_180436.1.
UniGenei At.8375.

3D structure databases

ProteinModelPortali Q9FF80.
SMRi Q9FF80. Positions 149-670.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q9FF80.
PRIDEi Q9FF80.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G04940.1 ; AT5G04940.1 ; AT5G04940 .
AT5G04940.2 ; AT5G04940.2 ; AT5G04940 .
GeneIDi 830376.
KEGGi ath:AT5G04940.

Organism-specific databases

TAIRi AT5G04940.

Phylogenomic databases

eggNOGi COG2940.
HOGENOMi HOG000238382.
InParanoidi Q9FF80.
KOi K11420.
OMAi RENGNRE.
PhylomeDBi Q9FF80.

Enzyme and pathway databases

BioCyci ARA:AT5G04940-MONOMER.
ARA:GQT-1962-MONOMER.

Gene expression databases

Genevestigatori Q9FF80.

Family and domain databases

Gene3Di 2.30.280.10. 1 hit.
InterProi IPR025794. Hist-Lys_N-MeTrfase_plant.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR015947. PUA-like_domain.
IPR001214. SET_dom.
IPR003105. SRA_YDG.
[Graphical view ]
Pfami PF05033. Pre-SET. 1 hit.
PF02182. SAD_SRA. 1 hit.
PF00856. SET. 1 hit.
[Graphical view ]
SMARTi SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
SM00466. SRA. 1 hit.
[Graphical view ]
SUPFAMi SSF88697. SSF88697. 1 hit.
PROSITEi PS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS51575. SAM_MT43_SUVAR39_2. 1 hit.
PS50280. SET. 1 hit.
PS51015. YDG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Arabidopsis thaliana genome contains at least 29 active genes encoding SET domain proteins that can be assigned to four evolutionarily conserved classes."
    Baumbusch L.O., Thorstensen T., Krauss V., Fischer A., Naumann K., Assalkhou R., Schulz I., Reuter G., Aalen R.B.
    Nucleic Acids Res. 29:4319-4333(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, NOMENCLATURE, TISSUE SPECIFICITY.
  2. "Structural analysis of Arabidopsis thaliana chromosome 5. I. Sequence features of the 1.6 Mb regions covered by twenty physically assigned P1 clones."
    Sato S., Kotani H., Nakamura Y., Kaneko T., Asamizu E., Fukami M., Miyajima N., Tabata S.
    DNA Res. 4:215-230(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Pivotal role of AtSUVH2 in heterochromatic histone methylation and gene silencing in Arabidopsis."
    Naumann K., Fischer A., Hofmann I., Krauss V., Phalke S., Irmler K., Hause G., Aurich A.-C., Dorn R., Jenuwein T., Reuter G.
    EMBO J. 24:1418-1429(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  5. "Heterochromatin proteins and the control of heterochromatic gene silencing in Arabidopsis."
    Fischer A., Hofmann I., Naumann K., Reuter G.
    J. Plant Physiol. 163:358-368(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY.

Entry informationi

Entry nameiSUVH1_ARATH
AccessioniPrimary (citable) accession number: Q9FF80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: March 1, 2001
Last modified: June 11, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi