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Q9FF80

- SUVH1_ARATH

UniProt

Q9FF80 - SUVH1_ARATH

Protein

Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH1

Gene

SUVH1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Histone methyltransferase. Methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression.1 Publication

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi434 – 4341Zinc 1By similarity
    Metal bindingi434 – 4341Zinc 2By similarity
    Metal bindingi436 – 4361Zinc 1By similarity
    Metal bindingi440 – 4401Zinc 1By similarity
    Metal bindingi440 – 4401Zinc 3By similarity
    Metal bindingi447 – 4471Zinc 1By similarity
    Metal bindingi449 – 4491Zinc 2By similarity
    Metal bindingi475 – 4751Zinc 2By similarity
    Metal bindingi475 – 4751Zinc 3By similarity
    Metal bindingi479 – 4791Zinc 2By similarity
    Metal bindingi481 – 4811Zinc 3By similarity
    Metal bindingi484 – 4841Zinc 3By similarity
    Binding sitei541 – 5411S-adenosyl-L-methioninePROSITE-ProRule annotation
    Binding sitei543 – 5431S-adenosyl-L-methioninePROSITE-ProRule annotation
    Binding sitei593 – 5931S-adenosyl-L-methioninePROSITE-ProRule annotation
    Metal bindingi599 – 5991Zinc 4By similarity
    Metal bindingi658 – 6581Zinc 4By similarity
    Metal bindingi660 – 6601Zinc 4By similarity
    Metal bindingi665 – 6651Zinc 4By similarity

    GO - Molecular functioni

    1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. regulation of gene expression, epigenetic Source: TAIR

    Keywords - Molecular functioni

    Chromatin regulator, Methyltransferase, Transferase

    Keywords - Ligandi

    Metal-binding, S-adenosyl-L-methionine, Zinc

    Enzyme and pathway databases

    BioCyciARA:AT5G04940-MONOMER.
    ARA:GQT-1962-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH1 (EC:2.1.1.43)
    Alternative name(s):
    Histone H3-K9 methyltransferase 1
    Short name:
    H3-K9-HMTase 1
    Protein SET DOMAIN GROUP 32
    Suppressor of variegation 3-9 homolog protein 1
    Short name:
    Su(var)3-9 homolog protein 1
    Gene namesi
    Name:SUVH1
    Synonyms:SDG32, SET32
    Ordered Locus Names:At5g04940
    ORF Names:MUG13.20
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 5

    Organism-specific databases

    TAIRiAT5G04940.

    Subcellular locationi

    Nucleus. Chromosomecentromere
    Note: Associates with centromeric constitutive heterochromatin.

    GO - Cellular componenti

    1. chromosome, centromeric region Source: UniProtKB-SubCell
    2. nucleus Source: TAIR

    Keywords - Cellular componenti

    Centromere, Chromosome, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 670670Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH1PRO_0000186072Add
    BLAST

    Proteomic databases

    PaxDbiQ9FF80.
    PRIDEiQ9FF80.

    Expressioni

    Tissue specificityi

    Expressed in leaves stems and flowers.1 Publication

    Gene expression databases

    GenevestigatoriQ9FF80.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9FF80.
    SMRiQ9FF80. Positions 149-670.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini211 – 357147YDGPROSITE-ProRule annotationAdd
    BLAST
    Domaini432 – 49261Pre-SETPROSITE-ProRule annotationAdd
    BLAST
    Domaini495 – 639145SETPROSITE-ProRule annotationAdd
    BLAST
    Domaini654 – 67017Post-SETPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni505 – 5073S-adenosyl-L-methionine bindingBy similarity
    Regioni596 – 5972S-adenosyl-L-methionine bindingBy similarity

    Domaini

    Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity.
    In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.By similarity

    Sequence similaritiesi

    Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.PROSITE-ProRule annotation
    Contains 1 post-SET domain.PROSITE-ProRule annotation
    Contains 1 pre-SET domain.PROSITE-ProRule annotation
    Contains 1 SET domain.PROSITE-ProRule annotation
    Contains 1 YDG domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG2940.
    HOGENOMiHOG000238382.
    InParanoidiQ9FF80.
    KOiK11420.
    OMAiRENGNRE.
    PhylomeDBiQ9FF80.

    Family and domain databases

    Gene3Di2.30.280.10. 1 hit.
    InterProiIPR025794. Hist-Lys_N-MeTrfase_plant.
    IPR003616. Post-SET_dom.
    IPR007728. Pre-SET_dom.
    IPR015947. PUA-like_domain.
    IPR001214. SET_dom.
    IPR003105. SRA_YDG.
    [Graphical view]
    PfamiPF05033. Pre-SET. 1 hit.
    PF02182. SAD_SRA. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view]
    SMARTiSM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    SM00466. SRA. 1 hit.
    [Graphical view]
    SUPFAMiSSF88697. SSF88697. 1 hit.
    PROSITEiPS50868. POST_SET. 1 hit.
    PS50867. PRE_SET. 1 hit.
    PS51575. SAM_MT43_SUVAR39_2. 1 hit.
    PS50280. SET. 1 hit.
    PS51015. YDG. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9FF80-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERNGGHYTD KTRVLDIKPL RTLRPVFPSG NQAPPFVCAP PFGPFPPGFS    50
    SFYPFSSSQA NQHTPDLNQA QYPPQHQQPQ NPPPVYQQQP PQHASEPSLV 100
    TPLRSFRSPD VSNGNAELEG STVKRRIPKK RPISRPENMN FESGINVADR 150
    ENGNRELVLS VLMRFDALRR RFAQLEDAKE AVSGIIKRPD LKSGSTCMGR 200
    GVRTNTKKRP GIVPGVEIGD VFFFRFEMCL VGLHSPSMAG IDYLVVKGET 250
    EEEPIATSIV SSGYYDNDEG NPDVLIYTGQ GGNADKDKQS SDQKLERGNL 300
    ALEKSLRRDS AVRVIRGLKE ASHNAKIYIY DGLYEIKESW VEKGKSGHNT 350
    FKYKLVRAPG QPPAFASWTA IQKWKTGVPS RQGLILPDMT SGVESIPVSL 400
    VNEVDTDNGP AYFTYSTTVK YSESFKLMQP SFGCDCANLC KPGNLDCHCI 450
    RKNGGDFPYT GNGILVSRKP MIYECSPSCP CSTCKNKVTQ MGVKVRLEVF 500
    KTANRGWGLR SWDAIRAGSF ICIYVGEAKD KSKVQQTMAN DDYTFDTTNV 550
    YNPFKWNYEP GLADEDACEE MSEESEIPLP LIISAKNVGN VARFMNHSCS 600
    PNVFWQPVSY ENNSQLFVHV AFFAISHIPP MTELTYDYGV SRPSGTQNGN 650
    PLYGKRKCFC GSAYCRGSFG 670
    Length:670
    Mass (Da):74,471
    Last modified:March 1, 2001 - v1
    Checksum:iC92CE89FF5C630F1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF344444 mRNA. Translation: AAK28966.1.
    AB005245 Genomic DNA. Translation: BAB11516.1.
    CP002688 Genomic DNA. Translation: AED90806.1.
    CP002688 Genomic DNA. Translation: AED90807.1.
    RefSeqiNP_196113.1. NM_120576.1.
    NP_850767.1. NM_180436.1.
    UniGeneiAt.8375.

    Genome annotation databases

    EnsemblPlantsiAT5G04940.1; AT5G04940.1; AT5G04940.
    AT5G04940.2; AT5G04940.2; AT5G04940.
    GeneIDi830376.
    KEGGiath:AT5G04940.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF344444 mRNA. Translation: AAK28966.1 .
    AB005245 Genomic DNA. Translation: BAB11516.1 .
    CP002688 Genomic DNA. Translation: AED90806.1 .
    CP002688 Genomic DNA. Translation: AED90807.1 .
    RefSeqi NP_196113.1. NM_120576.1.
    NP_850767.1. NM_180436.1.
    UniGenei At.8375.

    3D structure databases

    ProteinModelPortali Q9FF80.
    SMRi Q9FF80. Positions 149-670.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q9FF80.
    PRIDEi Q9FF80.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT5G04940.1 ; AT5G04940.1 ; AT5G04940 .
    AT5G04940.2 ; AT5G04940.2 ; AT5G04940 .
    GeneIDi 830376.
    KEGGi ath:AT5G04940.

    Organism-specific databases

    TAIRi AT5G04940.

    Phylogenomic databases

    eggNOGi COG2940.
    HOGENOMi HOG000238382.
    InParanoidi Q9FF80.
    KOi K11420.
    OMAi RENGNRE.
    PhylomeDBi Q9FF80.

    Enzyme and pathway databases

    BioCyci ARA:AT5G04940-MONOMER.
    ARA:GQT-1962-MONOMER.

    Gene expression databases

    Genevestigatori Q9FF80.

    Family and domain databases

    Gene3Di 2.30.280.10. 1 hit.
    InterProi IPR025794. Hist-Lys_N-MeTrfase_plant.
    IPR003616. Post-SET_dom.
    IPR007728. Pre-SET_dom.
    IPR015947. PUA-like_domain.
    IPR001214. SET_dom.
    IPR003105. SRA_YDG.
    [Graphical view ]
    Pfami PF05033. Pre-SET. 1 hit.
    PF02182. SAD_SRA. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view ]
    SMARTi SM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    SM00466. SRA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF88697. SSF88697. 1 hit.
    PROSITEi PS50868. POST_SET. 1 hit.
    PS50867. PRE_SET. 1 hit.
    PS51575. SAM_MT43_SUVAR39_2. 1 hit.
    PS50280. SET. 1 hit.
    PS51015. YDG. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Arabidopsis thaliana genome contains at least 29 active genes encoding SET domain proteins that can be assigned to four evolutionarily conserved classes."
      Baumbusch L.O., Thorstensen T., Krauss V., Fischer A., Naumann K., Assalkhou R., Schulz I., Reuter G., Aalen R.B.
      Nucleic Acids Res. 29:4319-4333(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, NOMENCLATURE, TISSUE SPECIFICITY.
    2. "Structural analysis of Arabidopsis thaliana chromosome 5. I. Sequence features of the 1.6 Mb regions covered by twenty physically assigned P1 clones."
      Sato S., Kotani H., Nakamura Y., Kaneko T., Asamizu E., Fukami M., Miyajima N., Tabata S.
      DNA Res. 4:215-230(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Pivotal role of AtSUVH2 in heterochromatic histone methylation and gene silencing in Arabidopsis."
      Naumann K., Fischer A., Hofmann I., Krauss V., Phalke S., Irmler K., Hause G., Aurich A.-C., Dorn R., Jenuwein T., Reuter G.
      EMBO J. 24:1418-1429(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    5. "Heterochromatin proteins and the control of heterochromatic gene silencing in Arabidopsis."
      Fischer A., Hofmann I., Naumann K., Reuter G.
      J. Plant Physiol. 163:358-368(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY.

    Entry informationi

    Entry nameiSUVH1_ARATH
    AccessioniPrimary (citable) accession number: Q9FF80
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 9, 2003
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3