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Protein

Ubiquitin-conjugating enzyme E2 22

Gene

UBC22

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.1 Publication

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei94Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • protein polyubiquitination Source: GO_Central
  • ubiquitin-dependent protein catabolic process Source: TAIR

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-ATH-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 22 (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme 22
Ubiquitin carrier protein 22
Gene namesi
Name:UBC22
Ordered Locus Names:At5g05080
ORF Names:MUG13.6
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G05080
TAIRilocus:2175359 AT5G05080

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003451881 – 251Ubiquitin-conjugating enzyme E2 22Add BLAST251

Post-translational modificationi

Self-ubiquitinated.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ9FF66
PRIDEiQ9FF66

Expressioni

Tissue specificityi

Expressed in seeds, pistils, siliques, hypocotyls and leaves.1 Publication

Inductioni

By the herbicide isoxaben.1 Publication

Gene expression databases

ExpressionAtlasiQ9FF66 baseline and differential
GenevisibleiQ9FF66 AT

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi3702.AT5G05080.1

Structurei

3D structure databases

ProteinModelPortaliQ9FF66
SMRiQ9FF66
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili230 – 251Sequence analysisAdd BLAST22

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0423 Eukaryota
COG5078 LUCA
HOGENOMiHOG000233455
InParanoidiQ9FF66
KOiK10583
OMAiSTANKAF
OrthoDBiEOG09360K55
PhylomeDBiQ9FF66

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9FF66-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASNENLPPN VIKQLAKELK SLDESPPDGI KVVVNDEDFS QICADIEGPV
60 70 80 90 100
GTPYENGLFR MKLALSHDFP HSPPKGYFMT KIFHPNVASN GEICVNTLKK
110 120 130 140 150
DWNPSLGLRH VLSVVRCLLI EPFPESALNE QAGKMLLENY DEYARHARLY
160 170 180 190 200
TGIHAKPKPK FKTGAISEST TALNVGQTNN ETPGAATAIP SSMTDIKRVT
210 220 230 240 250
TSAQDQQHVA NVVVAASASV VTTTQKREAG LAKVQADKKK VDARKKSLKR

L
Length:251
Mass (Da):27,399
Last modified:March 1, 2001 - v1
Checksum:i3A335129A16D616E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ027036 mRNA Translation: AAY44862.1
AB005245 Genomic DNA Translation: BAB11530.1
CP002688 Genomic DNA Translation: AED90825.1
CP002688 Genomic DNA Translation: AED90826.1
CP002688 Genomic DNA Translation: ANM71122.1
CP002688 Genomic DNA Translation: ANM71123.1
AY116948 mRNA Translation: AAM51582.1
AF428320 mRNA Translation: AAL16250.1
AY088106 mRNA Translation: AAM65652.1
RefSeqiNP_001078530.1, NM_001085061.1
NP_001332673.1, NM_001342802.1
NP_001332674.1, NM_001342801.1
NP_568148.1, NM_120590.3
UniGeneiAt.23123

Genome annotation databases

EnsemblPlantsiAT5G05080.1; AT5G05080.1; AT5G05080
AT5G05080.2; AT5G05080.2; AT5G05080
AT5G05080.3; AT5G05080.3; AT5G05080
AT5G05080.4; AT5G05080.4; AT5G05080
GeneIDi830390
GrameneiAT5G05080.1; AT5G05080.1; AT5G05080
AT5G05080.2; AT5G05080.2; AT5G05080
AT5G05080.3; AT5G05080.3; AT5G05080
AT5G05080.4; AT5G05080.4; AT5G05080
KEGGiath:AT5G05080

Similar proteinsi

Entry informationi

Entry nameiUBC22_ARATH
AccessioniPrimary (citable) accession number: Q9FF66
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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