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Protein

Auxin transporter-like protein 1

Gene

LAX1

Organism
Medicago truncatula (Barrel medic) (Medicago tribuloides)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Carrier protein involved in proton-driven auxin influx. Mediates the formation of auxin gradient from developing leaves (site of auxin biosynthesis) to tips by contributing to the loading of auxin in vascular tissues and facilitating acropetal (base to tip) auxin transport within inner tissues of the root apex, and basipetal (tip to base) auxin transport within outer tissues of the root apex (By similarity). May be involved in lateral roots and nodules formation.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAmino-acid transport, Auxin signaling pathway, Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Auxin transporter-like protein 1
Alternative name(s):
AUX1-like protein 1
MtLAX1
Gene namesi
Name:LAX1
OrganismiMedicago truncatula (Barrel medic) (Medicago tribuloides)
Taxonomic identifieri3880 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeTrifolieaeMedicago

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 58CytoplasmicSequence analysisAdd BLAST58
Transmembranei59 – 76HelicalSequence analysisAdd BLAST18
Topological domaini77 – 78ExtracellularSequence analysis2
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Topological domaini100 – 134CytoplasmicSequence analysisAdd BLAST35
Transmembranei135 – 155HelicalSequence analysisAdd BLAST21
Topological domaini156 – 171ExtracellularSequence analysisAdd BLAST16
Transmembranei172 – 192HelicalSequence analysisAdd BLAST21
Topological domaini193 – 195CytoplasmicSequence analysis3
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Topological domaini217 – 231ExtracellularSequence analysisAdd BLAST15
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21
Topological domaini253 – 265CytoplasmicSequence analysisAdd BLAST13
Transmembranei266 – 286HelicalSequence analysisAdd BLAST21
Topological domaini287 – 313ExtracellularSequence analysisAdd BLAST27
Transmembranei314 – 334HelicalSequence analysisAdd BLAST21
Topological domaini335 – 355CytoplasmicSequence analysisAdd BLAST21
Transmembranei356 – 376HelicalSequence analysisAdd BLAST21
Topological domaini377ExtracellularSequence analysis1
Transmembranei378 – 398HelicalSequence analysisAdd BLAST21
Topological domaini399 – 421CytoplasmicSequence analysisAdd BLAST23
Transmembranei422 – 442HelicalSequence analysisAdd BLAST21
Topological domaini443 – 479ExtracellularSequence analysisAdd BLAST37

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000938451 – 479Auxin transporter-like protein 1Add BLAST479

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi474N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Shoots and roots of nodulating plants. Higher levels in roots, flowers and stems, lower in nodules, leaves, petioles and shoot apices.2 Publications

Developmental stagei

In primary roots, mostly localized in tips and to a lower extent in vasculature of older regions. In root tips, mostly expressed in the central tissues of the elongating zone (developing vasculature), in the starch-filled cells of the root cap and in some cortical cells. During lateral root development, striking expression in the proximal region of the primordium, close to the primary root central cylinder, and then in elongating cells of the developing vasculature and in developing root cap. During nodule formation, expressed in young elongated primordium, mostly in cells close to the root vasculature. In later stages, confined in small cells rich in amyloplasts with small nuclei. Near the periphery of developing nodules strong expression at the base that tapers off toward the apex. Not expressed in mature nodules.1 Publication

Inductioni

Transient induction in roots by S.meliloti.1 Publication

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK13946.
OMAiLMYVINA.
OrthoDBiEOG0936078P.

Family and domain databases

InterProiView protein in InterPro
IPR013057. AA_transpt_TM.
PfamiView protein in Pfam
PF01490. Aa_trans. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9FEL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSEKQGEET MMSSLNETIE LNEEREEEKG ASPGSGFKNF LWHGGSVYDA
60 70 80 90 100
WFSCASNQVA QVLLTLPYSF SQLGMISGII FQVFYGLMGS WTAYLISILY
110 120 130 140 150
VEYRSRKEKE NVSFKNHVIQ WFEVLEGLLG PYWKAIGLAF NCTFLLFGSV
160 170 180 190 200
IQLIACASNI YYINDHLDKR TWTYIFGACC ATTVFIPSFH NYRIWSFLGL
210 220 230 240 250
GMTTYTAWYM TIAAIVHGQV ENVVHSGPKK MVWYFTGATN ILYTFGGHAV
260 270 280 290 300
TVEIMHAMWK PQKFKAIYFF ATLYVFTLTL PSAIAVYWAF GDQLLDHSNA
310 320 330 340 350
FSLLPRNAWR DAGVILMLIH QFITFGFACT PLYFVWEKVI GMHDTKSIFL
360 370 380 390 400
RALARLPVVI PIWFLAIIFP FFGPINSAVG ALLVSFTVYV IPASAHMLTY
410 420 430 440 450
RSASARQNAA EKLPKVIPSW TLMYVINAFV VIWVTIVGFG FGGWASMTNF
460 470
IKQVDTFGLF AKCYQCPPKL PASNHTMHH
Length:479
Mass (Da):54,259
Last modified:March 1, 2001 - v1
Checksum:i6887C4F5837F5A3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ299397 mRNA. Translation: CAC12995.1.
AY115841 Genomic DNA. Translation: AAM55302.1.
RefSeqiXP_003616599.1. XM_003616551.2.
UniGeneiMtr.125.

Genome annotation databases

EnsemblPlantsiAES99557; AES99557; MTR_5g082220.
GeneIDi11406709.
GrameneiAES99557; AES99557; MTR_5g082220.
KEGGimtr:MTR_5g082220.

Similar proteinsi

Entry informationi

Entry nameiLAX1_MEDTR
AccessioniPrimary (citable) accession number: Q9FEL8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: March 1, 2001
Last modified: June 7, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Caution

Because of the similarity in sequence, the probe used to describe the developmental stages did not discriminate among the various MtLAX mRNAs.Curated

Documents

  1. SIMILARITY comments
    Index of protein domains and families